Keywords
Last Name
Institution

Justin T. Gass

Title
InstitutionMedical University of South Carolina
DepartmentNeuroscience
AddressP.O. Box MSC 861
IOPN 469
67 President St.
Phone843-792-5159
Fax843-792-7353
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    The main focus of Dr. Gass's current research is to determine how glutamate receptors alter the reinforcing properties of alcohol-related cues. Studies from his laboratory have demonstrated that modulation of the mGluR5 receptor can facilitate the extinction of alcohol-seeking behavior, prevent relapse induced by exposure to alcohol cues, and alter both structural and functional plasticity in the prefrontal cortex. Furthermore, his research has shown that blockade of mGluR5 can attenuate the reinforcing properties of alcohol and prevent various forms of alcohol-seeking behavior. Ongoing studies in his laboratory also suggest that the manipulation of alcohol memories during the 'reconsolidation' period can also attenuate alcohol-seeking behavior. These novel findings are being pursued as a possible pharmacological therapy to be used in conjunction with current behavioral therapies for the treatment of alcoholism.

    Collapse keywords
    Addiction, alcohol, glutamate, drug cues, relapse

    Collapse ORNG Applications 
    Collapse studies/trials

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Macht VA, Kelly SJ, Gass JT. Sex-specific effects of developmental alcohol exposure on cocaine-induced place preference in adulthood. Behav Brain Res. 2017 08 14; 332:259-268. PMID: 28600000.
      View in: PubMed
    2. Cannady R, McGonigal JT, Newsom RJ, Woodward JJ, Mulholland PJ, Gass JT. Prefrontal Cortex KCa2 Channels Regulate mGlu5-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior. J Neurosci. 2017 04 19; 37(16):4359-4369. PMID: 28320841.
      View in: PubMed
    3. Gass JT, McGonigal JT, Chandler LJ. Deficits in the extinction of ethanol-seeking behavior following chronic intermittent ethanol exposure are attenuated with positive allosteric modulation of mGlu5. Neuropharmacology. 2017 02; 113(Pt A):198-205. PMID: 27725153.
      View in: PubMed
    4. Trantham-Davidson H, Centanni SW, Garr SC, New NN, Mulholland PJ, Gass JT, Glover EJ, Floresco SB, Crews FT, Krishnan HR, Pandey SC, Chandler LJ. Binge-Like Alcohol Exposure During Adolescence Disrupts Dopaminergic Neurotransmission in the Adult Prelimbic Cortex. Neuropsychopharmacology. 2017 Apr; 42(5):1024-1036. PMID: 27620551.
      View in: PubMed
    5. McGuier NS, Griffin WC, Gass JT, Padula AE, Chesler EJ, Mulholland PJ. Kv7 channels in the nucleus accumbens are altered by chronic drinking and are targets for reducing alcohol consumption. Addict Biol. 2016 11; 21(6):1097-1112. PMID: 26104325.
      View in: PubMed
    6. Olive MF, Gass JT. Editorial: structural plasticity induced by drugs of abuse. Front Pharmacol. 2015; 6:88. PMID: 26029104.
      View in: PubMed
    7. Uys JD, McGuier NS, Gass JT, Griffin WC, Ball LE, Mulholland PJ. Chronic intermittent ethanol exposure and withdrawal leads to adaptations in nucleus accumbens core postsynaptic density proteome and dendritic spines. Addict Biol. 2016 May; 21(3):560-74. PMID: 25787124.
      View in: PubMed
    8. LaCrosse AL, Taylor SB, Nemirovsky NE, Gass JT, Olive MF. mGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal Cortex. CNS Neurol Disord Drug Targets. 2015; 14(4):476-85. PMID: 25921744.
      View in: PubMed
    9. Gass JT, Trantham-Davidson H, Kassab AS, Glen WB, Olive MF, Chandler LJ. Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex. J Neurosci. 2014 May 28; 34(22):7562-74. PMID: 24872560.
      View in: PubMed
    10. Gass JT, Glen WB, McGonigal JT, Trantham-Davidson H, Lopez MF, Randall PK, Yaxley R, Floresco SB, Chandler LJ. Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood. Neuropsychopharmacology. 2014 Oct; 39(11):2570-83. PMID: 24820536.
      View in: PubMed
    11. Trantham-Davidson H, Burnett EJ, Gass JT, Lopez MF, Mulholland PJ, Centanni SW, Floresco SB, Chandler LJ. Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex. J Neurosci. 2014 Mar 05; 34(10):3706-18. PMID: 24599469.
      View in: PubMed
    12. Gass JT, Chandler LJ. The Plasticity of Extinction: Contribution of the Prefrontal Cortex in Treating Addiction through Inhibitory Learning. Front Psychiatry. 2013; 4:46. PMID: 23750137.
      View in: PubMed
    13. Kroener S, Mulholland PJ, New NN, Gass JT, Becker HC, Chandler LJ. Chronic alcohol exposure alters behavioral and synaptic plasticity of the rodent prefrontal cortex. PLoS One. 2012; 7(5):e37541. PMID: 22666364.
      View in: PubMed
    14. Gass JT, Olive MF. Neurochemical and neurostructural plasticity in alcoholism. ACS Chem Neurosci. 2012 Jul 18; 3(7):494-504. PMID: 22896799.
      View in: PubMed
    15. Sinclair CM, Cleva RM, Hood LE, Olive MF, Gass JT. mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior. Pharmacol Biochem Behav. 2012 May; 101(3):329-35. PMID: 22296815.
      View in: PubMed
    16. Widholm JJ, Gass JT, Cleva RM, Olive MF. The mGluR5 Positive Allosteric Modulator CDPPB Does Not Alter Extinction or Contextual Reinstatement of Methamphetamine-Seeking Behavior in Rats. J Addict Res Ther. 2011 Dec 24; S1(4). PMID: 22428090.
      View in: PubMed
    17. Cleva RM, Hicks MP, Gass JT, Wischerath KC, Plasters ET, Widholm JJ, Olive MF. mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration. Behav Neurosci. 2011 Feb; 125(1):10-9. PMID: 21319882.
      View in: PubMed
    18. Cleva RM, Gass JT, Widholm JJ, Olive MF. Glutamatergic targets for enhancing extinction learning in drug addiction. Curr Neuropharmacol. 2010 Dec; 8(4):394-408. PMID: 21629446.
      View in: PubMed
    19. Gass JT, Sinclair CM, Cleva RM, Widholm JJ, Olive MF. Alcohol-seeking behavior is associated with increased glutamate transmission in basolateral amygdala and nucleus accumbens as measured by glutamate-oxidase-coated biosensors. Addict Biol. 2011 Apr; 16(2):215-28. PMID: 21054692.
      View in: PubMed
    20. Arolfo MP, Overstreet DH, Yao L, Fan P, Lawrence AJ, Tao G, Keung WM, Vallee BL, Olive MF, Gass JT, Rubin E, Anni H, Hodge CW, Besheer J, Zablocki J, Leung K, Blackburn BK, Lange LG, Diamond I. Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor. Alcohol Clin Exp Res. 2009 Nov; 33(11):1935-44. PMID: 19673742.
      View in: PubMed
    21. Gass JT, Olive MF. Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell. Psychopharmacology (Berl). 2009 Jul; 204(4):587-97. PMID: 19225761.
      View in: PubMed
    22. Moussawi K, Pacchioni A, Moran M, Olive MF, Gass JT, Lavin A, Kalivas PW. N-Acetylcysteine reverses cocaine-induced metaplasticity. Nat Neurosci. 2009 Feb; 12(2):182-9. PMID: 19136971.
      View in: PubMed
    23. Gass JT, Olive MF. Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory. Biol Psychiatry. 2009 Apr 15; 65(8):717-20. PMID: 19100966.
      View in: PubMed
    24. Gass JT, Osborne MP, Watson NL, Brown JL, Olive MF. mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats. Neuropsychopharmacology. 2009 Mar; 34(4):820-33. PMID: 18800068.
      View in: PubMed
    25. Burattini C, McGeehan AJ, Griffin WC, Gass JT, Kinder JR, Janak PH, Olive MF. A microdialysis study of extracellular levels of acamprosate and naltrexone in the rat brain following acute and repeated administration. Addict Biol. 2008 Mar; 13(1):70-9. PMID: 18269381.
      View in: PubMed
    26. Gass JT, Olive MF. Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEP. Eur J Pharmacol. 2008 Apr 28; 584(2-3):253-62. PMID: 18346726.
      View in: PubMed
    27. Gass JT, Jenkins WJ, Marino MD, Lugo JN, Kelly SJ. Alcohol exposure during development: analysis of effects on female sexual behavior. Alcohol Clin Exp Res. 2007 Dec; 31(12):2065-72. PMID: 17949467.
      View in: PubMed
    28. Bowers MS, Chen BT, Chou JK, Osborne MP, Gass JT, See RE, Bonci A, Janak PH, Olive MF. Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in rats. Psychopharmacology (Berl). 2007 Dec; 195(3):397-406. PMID: 17764007.
      View in: PubMed
    29. Gass JT, Olive MF. Reinstatement of ethanol-seeking behavior following intravenous self-administration in Wistar rats. Alcohol Clin Exp Res. 2007 Sep; 31(9):1441-5. PMID: 17666107.
      View in: PubMed
    30. Gass JT, Olive MF. Glutamatergic substrates of drug addiction and alcoholism. Biochem Pharmacol. 2008 Jan 01; 75(1):218-65. PMID: 17706608.
      View in: PubMed
    31. Grillo CA, Tamashiro KL, Piroli GG, Melhorn S, Gass JT, Newsom RJ, Reznikov LR, Smith A, Wilson SP, Sakai RR, Reagan LP. Lentivirus-mediated downregulation of hypothalamic insulin receptor expression. Physiol Behav. 2007 Nov 23; 92(4):691-701. PMID: 17585961.
      View in: PubMed
    32. Lugo JN, Marino MD, Gass JT, Wilson MA, Kelly SJ. Ethanol exposure during development reduces resident aggression and testosterone in rats. Physiol Behav. 2006 Feb 28; 87(2):330-7. PMID: 16336982.
      View in: PubMed
    33. Brown RW, Gass JT, Kostrzewa RM. Ontogenetic quinpirole treatments produce spatial memory deficits and enhance skilled reaching in adult rats. Pharmacol Biochem Behav. 2002 Jun; 72(3):591-600. PMID: 12175456.
      View in: PubMed
    Gass's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _