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Joseph P Schacht

Title
InstitutionMedical University of South Carolina
DepartmentPsychiatry and Behavioral Sciences
AddressP.O. Box MSC 861
IOP 466N
67 President St.
Phone843-792-7497
Fax843-792-7353
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    Collapse Biography 
    Collapse education and training
    University of Colorado, Boulder, COPh.D.08/2010Clinical Psychology and Neuroscience
    University of Michigan, Ann Arbor, MIA.B.05/2004Psychology and Philosophy

    Collapse Overview 
    Collapse overview
    Dr. Schacht’s training and research experience encompass both basic and clinical neuroscience, and he has pushed to build a program of research that translates from basic neurobiological processes to behavioral and treatment outcomes. He has previously been funded by individual (F31) and institutional (T32) training fellowships from the National Institute on Drug Abuse (NIDA) and the National on Alcohol Abuse and Alcoholism (NIAAA). His current work, funded by an NIAAA K99/R00 Pathway to Independence award, focuses on the neurobiological substrates of the transition from heavy drinking to alcohol dependence. He is particularly known for his work in using behavioral genetics and functional neuroimaging to understand alcohol and drug craving and cue reactivity.

    Collapse keywords
    Alcohol, Genetics, Brain, Smoking, Substance Use

    Collapse ORNG Applications 
    Collapse studies/trials

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Prisciandaro JJ, Schacht JP, Prescot AP, Brenner HM, Renshaw PF, Brown TR, Anton RF. Evidence for a unique association between fronto-cortical glycine levels and recent heavy drinking in treatment naïve individuals with alcohol use disorder. Neurosci Lett. 2019 07 27; 706:207-210. PMID: 31108129.
      View in: PubMed
    2. Karoly HC, Schacht JP, Jacobus J, Meredith LR, Taylor CT, Tapert SF, Gray KM, Squeglia LM. Preliminary evidence that computerized approach avoidance training is not associated with changes in fMRI cannabis cue reactivity in non-treatment-seeking adolescent cannabis users. Drug Alcohol Depend. 2019 Jul 01; 200:145-152. PMID: 31132681.
      View in: PubMed
    3. Prisciandaro JJ, Schacht JP, Prescot AP, Renshaw PF, Brown TR, Anton RF. Brain Glutamate, GABA, and Glutamine Levels and Associations with Recent Drinking in Treatment-Naïve Individuals with Alcohol Use Disorder Versus Light Drinkers. Alcohol Clin Exp Res. 2019 Feb; 43(2):221-226. PMID: 30537347.
      View in: PubMed
    4. Schacht JP, Anton RF, McNamara PJ, Im Y, King AC. The dopamine transporter VNTR polymorphism moderates the relationship between acute response to alcohol and future alcohol use disorder symptoms. Addict Biol. 2018 Sep 18. PMID: 30230123.
      View in: PubMed
    5. Karoly HC, Schacht JP, Meredith LR, Jacobus J, Tapert SF, Gray KM, Squeglia LM. Investigating a novel fMRI cannabis cue reactivity task in youth. Addict Behav. 2019 Feb; 89:20-28. PMID: 30243035.
      View in: PubMed
    6. Schacht JP. Parsing Cannabis Exposure and Predisposing Risk Effects: Does Adolescent Cannabis Use Cause Neurocognitive Impairment, or Result From It? Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 08; 3(8):654-656. PMID: 30092915.
      View in: PubMed
    7. Anton RF, Latham PK, Voronin KE, Randall PK, Book SW, Hoffman M, Schacht JP. Nicotine-Use/Smoking Is Associated with the Efficacy of Naltrexone in the Treatment of Alcohol Dependence. Alcohol Clin Exp Res. 2018 Apr; 42(4):751-760. PMID: 29431852.
      View in: PubMed
    8. Nguyen-Louie TT, Simmons AN, Squeglia LM, Alejandra Infante M, Schacht JP, Tapert SF. Earlier alcohol use onset prospectively predicts changes in functional connectivity. Psychopharmacology (Berl). 2018 04; 235(4):1041-1054. PMID: 29306963.
      View in: PubMed
    9. Schacht JP, Voronin KE, Randall PK, Anton RF. Dopaminergic Genetic Variation Influences Aripiprazole Effects on Alcohol Self-Administration and the Neural Response to Alcohol Cues in a Randomized Trial. Neuropsychopharmacology. 2018 05; 43(6):1247-1256. PMID: 29362512.
      View in: PubMed
    10. Schacht JP, Randall PK, Latham PK, Voronin KE, Book SW, Myrick H, Anton RF. Predictors of Naltrexone Response in a Randomized Trial: Reward-Related Brain Activation, OPRM1 Genotype, and Smoking Status. Neuropsychopharmacology. 2017 12; 42(13):2654. PMID: 29123234.
      View in: PubMed
    11. Anton RF, Schacht JP, Voronin KE, Randall PK. Aripiprazole Suppression of Drinking in a Clinical Laboratory Paradigm: Influence of Impulsivity and Self-Control. Alcohol Clin Exp Res. 2017 Jul; 41(7):1370-1380. PMID: 28493623.
      View in: PubMed
    12. Schacht JP, Randall PK, Latham PK, Voronin KE, Book SW, Myrick H, Anton RF. Predictors of Naltrexone Response in a Randomized Trial: Reward-Related Brain Activation, OPRM1 Genotype, and Smoking Status. Neuropsychopharmacology. 2017 Dec; 42(13):2640-2653. PMID: 28409564.
      View in: PubMed
    13. Schacht JP. COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review. Pharmacogenomics J. 2016 10; 16(5):430-8. PMID: 27241058.
      View in: PubMed
    14. Boyd SJ, Schacht JP, Prisciandaro JJ, Voronin K, Anton RF. Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals. Alcohol Alcohol. 2016 Sep; 51(5):549-54. PMID: 27117237.
      View in: PubMed
    15. Adams ZW, Schacht JP, Randall P, Anton RF. The Reasons for Heavy Drinking Questionnaire: Factor Structure and Validity in Alcohol-Dependent Adults Involved in Clinical Trials. J Stud Alcohol Drugs. 2016 Mar; 77(2):354-61. PMID: 26997195.
      View in: PubMed
    16. Prisciandaro JJ, Schacht JP, Prescot AP, Renshaw PF, Brown TR, Anton RF. Associations Between Recent Heavy Drinking and Dorsal Anterior Cingulate N-Acetylaspartate and Glutamate Concentrations in Non-Treatment-Seeking Individuals with Alcohol Dependence. Alcohol Clin Exp Res. 2016 Mar; 40(3):491-6. PMID: 26853538.
      View in: PubMed
    17. Courtney KE, Schacht JP, Hutchison K, Roche DJ, Ray LA. Neural substrates of cue reactivity: association with treatment outcomes and relapse. Addict Biol. 2016 Jan; 21(1):3-22. PMID: 26435524.
      View in: PubMed
    18. Schacht JP, Anton RF, Randall PK, Li X, Henderson S, Myrick H. Varenicline effects on drinking, craving and neural reward processing among non-treatment-seeking alcohol-dependent individuals. Psychopharmacology (Berl). 2014 Sep; 231(18):3799-807. PMID: 24647921.
      View in: PubMed
    19. Anton RF, Schacht JP, Book SW. Pharmacologic treatment of alcoholism. Handb Clin Neurol. 2014; 125:527-42. PMID: 25307594.
      View in: PubMed
    20. Schacht JP, Anton RF, Randall PK, Li X, Henderson S, Myrick H. Effects of a GABA-ergic medication combination and initial alcohol withdrawal severity on cue-elicited brain activation among treatment-seeking alcoholics. Psychopharmacology (Berl). 2013 Jun; 227(4):627-37. PMID: 23389755.
      View in: PubMed
    21. Schacht JP, Anton RF, Voronin KE, Randall PK, Li X, Henderson S, Myrick H. Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues. Neuropsychopharmacology. 2013 Feb; 38(3):414-22. PMID: 23032071.
      View in: PubMed
    22. Schacht JP, Hutchison KE, Filbey FM. Associations between cannabinoid receptor-1 (CNR1) variation and hippocampus and amygdala volumes in heavy cannabis users. Neuropsychopharmacology. 2012 Oct; 37(11):2368-76. PMID: 22669173.
      View in: PubMed
    23. Schacht JP, Anton RF, Myrick H. Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review. Addict Biol. 2013 Jan; 18(1):121-33. PMID: 22574861.
      View in: PubMed
    24. Schacht JP, Randall PK, Waid LR, Baros AM, Latham PK, Wright TM, Myrick H, Anton RF. Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence. Alcohol Clin Exp Res. 2011 Nov; 35(11):2030-8. PMID: 21631542.
      View in: PubMed
    25. Schacht JP, Anton RF, Randall PK, Li X, Henderson S, Myrick H. Stability of fMRI striatal response to alcohol cues: a hierarchical linear modeling approach. Neuroimage. 2011 May 01; 56(1):61-8. PMID: 21316465.
      View in: PubMed
    26. Filbey FM, Schacht JP, Myers US, Chavez RS, Hutchison KE. Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues. Neuropsychopharmacology. 2010 Mar; 35(4):967-75. PMID: 20010552.
      View in: PubMed
    27. Filbey FM, Schacht JP, Myers US, Chavez RS, Hutchison KE. Marijuana craving in the brain. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):13016-21. PMID: 19651613.
      View in: PubMed
    28. Schacht JP, Selling RE, Hutchison KE. Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. Psychopharmacology (Berl). 2009 Apr; 203(3):511-7. PMID: 19002671.
      View in: PubMed
    29. Haughey HM, Marshall E, Schacht JP, Louis A, Hutchison KE. Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes. Addiction. 2008 Oct; 103(10):1678-86. PMID: 18705688.
      View in: PubMed
    30. Hutchison KE, Haughey H, Niculescu M, Schacht J, Kaiser A, Stitzel J, Horton WJ, Filbey F. The incentive salience of alcohol: translating the effects of genetic variant in CNR1. Arch Gen Psychiatry. 2008 Jul; 65(7):841-50. PMID: 18606956.
      View in: PubMed
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