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Joseph A. Helpern

Title
InstitutionMedical University of South Carolina
DepartmentNeuroscience
AddressP.O. Box MSC 510
BE 210
Bioengineering Bldg - 68 President St.
Phone843-876-2460
Fax843-876-2469
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    Collapse Biography 
    Collapse awards and honors
    1977Citation for Outstanding Accomplishments, American Chemical Society
    1978 - 1979Research Assistantship, University of North Carolina, Chapel Hill
    1992 - 1993Shannon Award, National Institutes of Health
    2000Excellence in Research Award, New York State, Office of Mental Health
    2005Fellow (elected), International Society for Magnetic Resonance in Medicine
    2008Wyeth Research Lecturer, Temple University
    2012Distinguished Investigator, Academy of Radiology Research
    2013Distinguished Alumni Achievement Award, Oakland University

    Collapse Overview 
    Collapse overview
    Helpern’s area of specialty is brain imaging from a perspective of a physicist. “I do medical research as a physicist by developing new imaging technologies.”

    Helpern, Ph.D., is no newcomer to imaging. The director of MUSC’s Center for Biomedical Imaging is credited with building the first 3-Tesla MRI, a high-field version today considered state-of-the-art clinically. Recently, he and long-time collaborator Dr. Jens H. Jensen, also a physicist, developed diffusional kurtosis imaging (DKI), a new and important tool in the radiologist’s toolbox.

    “The research we’ve been doing and the development of technology that we’re translating into the clinic is really exciting because it’s showing that we have exquisite sensitivity into imaging biomarkers early on into diseases such as Alzheimer’s Disease, epilepsy, attention deficit hyperactivity disorder, stroke and many others.”

    Helpern, who is director of MUSC’s Center for Biomedical Imaging, said the center has a strong team of scientists skilled in the art of imaging who work well together. He’s excited where the group is in advancing medicine across many fields. “I’m a strong believer in hallway conversations as a way of progressing science. It’s a physical center for scientists to get together to have impromptu talks on the chalkboard and get their ideas together. “

    Imaging technology is critical in medicine now and used for the advancement in every specialty. “A dollar spent in advancing imaging technology is spread quite nicely in investing across the entire enterprise of medicine. Ask yourself, how much is it worth to look inside someone’s body without opening it? There was a time, a day, when we used to cut inside people’s bodies just to see what the problem was and we don’t do that much anymore.”

    Before coming to MUSC in 2010, Helpern was the founding director of the Center for Biomedical Imaging at New York University School of Medicine. Helpern holds several patents in the field of MRI and has authored over 125 papers. He also hold’s a master’s degree in chemistry from the University of North Carolina, Chapel Hill, and a doctorate in medical physics from Oakland University in Rochester, Michigan. Helpern is the recipient of the Excellence in Research Award from the New York State Office of Mental Health, is an elected Fellow of the International Society for Magnetic Resonance in Medicine, and last year received the Distinguished Investigator Award by the Academy of Radiology Research.

    Collapse keywords
    ADD/ADHD, Women-s Health, Brain, Healthy Volunteer Studies, Substance Use, Adolescents

    Collapse ORNG Applications 
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    Collapse studies/trials

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Nie X, Falangola MF, Ward R, McKinnon ET, Helpern JA, Nietert PJ, Jensen JH. Diffusion MRI detects longitudinal white matter changes in the 3xTg-AD mouse model of Alzheimer's disease. Magn Reson Imaging. 2019 04; 57:235-242. PMID: 30543850.
      View in: PubMed
    2. Adisetiyo V, McGill CE, DeVries WH, Jensen JH, Hanlon CA, Helpern JA. Elevated Brain Iron in Cocaine Use Disorder as Indexed by Magnetic Field Correlation Imaging. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Jun; 4(6):579-588. PMID: 30581153.
      View in: PubMed
    3. McKinnon ET, Fridriksson J, Basilakos A, Hickok G, Hillis AE, Spampinato MV, Gleichgerrcht E, Rorden C, Jensen JH, Helpern JA, Bonilha L. Types of naming errors in chronic post-stroke aphasia are dissociated by dual stream axonal loss. Sci Rep. 2018 Sep 25; 8(1):14352. PMID: 30254222.
      View in: PubMed
    4. Benitez A, Jensen JH, Falangola MF, Nietert PJ, Helpern JA. Modeling white matter tract integrity in aging with diffusional kurtosis imaging. Neurobiol Aging. 2018 10; 70:265-275. PMID: 30055412.
      View in: PubMed
    5. Jensen JH, Helpern JA. Characterizing intra-axonal water diffusion with direction-averaged triple diffusion encoding MRI. NMR Biomed. 2018 07; 31(7):e3930. PMID: 29727508.
      View in: PubMed
    6. McKinnon ET, Helpern JA, Jensen JH. Modeling white matter microstructure with fiber ball imaging. Neuroimage. 2018 08 01; 176:11-21. PMID: 29660512.
      View in: PubMed
    7. Mohanty V, McKinnon ET, Helpern JA, Jensen JH. Comparison of cumulant expansion and q-space imaging estimates for diffusional kurtosis in brain. Magn Reson Imaging. 2018 05; 48:80-88. PMID: 29306048.
      View in: PubMed
    8. Del Gaizo J, Mofrad N, Jensen JH, Clark D, Glenn R, Helpern J, Bonilha L. Using machine learning to classify temporal lobe epilepsy based on diffusion MRI. Brain Behav. 2017 10; 7(10):e00801. PMID: 29075561.
      View in: PubMed
    9. McKinnon ET, Fridriksson J, Glenn GR, Jensen JH, Helpern JA, Basilakos A, Rorden C, Shih AY, Spampinato MV, Bonilha L. Structural plasticity of the ventral stream and aphasia recovery. Ann Neurol. 2017 Jul; 82(1):147-151. PMID: 28628946.
      View in: PubMed
    10. Spampinato MV, Kocher MR, Jensen JH, Helpern JA, Collins HR, Hatch NU. Diffusional Kurtosis Imaging of the Corticospinal Tract in Multiple Sclerosis: Association with Neurologic Disability. AJNR Am J Neuroradiol. 2017 Aug; 38(8):1494-1500. PMID: 28572153.
      View in: PubMed
    11. Spampinato MV, Chan C, Jensen JH, Helpern JA, Bonilha L, Kautz SA, Nietert PJ, Feng W. Diffusional Kurtosis Imaging and Motor Outcome in Acute Ischemic Stroke. AJNR Am J Neuroradiol. 2017 Jul; 38(7):1328-1334. PMID: 28473339.
      View in: PubMed
    12. Shaw CB, Hui ES, Helpern JA, Jensen JH. Tensor estimation for double-pulsed diffusional kurtosis imaging. NMR Biomed. 2017 Jul; 30(7). PMID: 28328072.
      View in: PubMed
    13. Summers PM, Hartmann DA, Hui ES, Nie X, Deardorff RL, McKinnon ET, Helpern JA, Jensen JH, Shih AY. Functional deficits induced by cortical microinfarcts. J Cereb Blood Flow Metab. 2017 Nov; 37(11):3599-3614. PMID: 28090802.
      View in: PubMed
    14. Jensen JH, McKinnon ET, Glenn GR, Helpern JA. Evaluating kurtosis-based diffusion MRI tissue models for white matter with fiber ball imaging. NMR Biomed. 2017 May; 30(5). PMID: 28085211.
      View in: PubMed
    15. Keller SS, Glenn GR, Weber B, Kreilkamp BA, Jensen JH, Helpern JA, Wagner J, Barker GJ, Richardson MP, Bonilha L. Preoperative automated fibre quantification predicts postoperative seizure outcome in temporal lobe epilepsy. Brain. 2017 01; 140(1):68-82. PMID: 28031219.
      View in: PubMed
    16. McKinnon ET, Jensen JH, Glenn GR, Helpern JA. Dependence on b-value of the direction-averaged diffusion-weighted imaging signal in brain. Magn Reson Imaging. 2017 Feb; 36:121-127. PMID: 27989904.
      View in: PubMed
    17. Shaw CB, Jensen JH, Deardorff RL, Spampinato MV, Helpern JA. Comparison of Diffusion Metrics Obtained at 1.5T and 3T in Human Brain With Diffusional Kurtosis Imaging. J Magn Reson Imaging. 2017 03; 45(3):673-680. PMID: 27402163.
      View in: PubMed
    18. Glenn GR, Jensen JH, Helpern JA, Spampinato MV, Kuzniecky R, Keller SS, Bonilha L. Epilepsy-related cytoarchitectonic abnormalities along white matter pathways. J Neurol Neurosurg Psychiatry. 2016 Sep; 87(9):930-6. PMID: 27076491.
      View in: PubMed
    19. Glenn GR, Kuo LW, Chao YP, Lee CY, Helpern JA, Jensen JH. Mapping the Orientation of White Matter Fiber Bundles: A Comparative Study of Diffusion Tensor Imaging, Diffusional Kurtosis Imaging, and Diffusion Spectrum Imaging. AJNR Am J Neuroradiol. 2016 Jul; 37(7):1216-22. PMID: 26939628.
      View in: PubMed
    20. Taylor ZJ, Hui ES, Watson AN, Nie X, Deardorff RL, Jensen JH, Helpern JA, Shih AY. Microvascular basis for growth of small infarcts following occlusion of single penetrating arterioles in mouse cortex. J Cereb Blood Flow Metab. 2016 08; 36(8):1357-73. PMID: 26661182.
      View in: PubMed
    21. Jensen JH, Helpern JA. Resolving power for the diffusion orientation distribution function. Magn Reson Med. 2016 08; 76(2):679-88. PMID: 26444579.
      View in: PubMed
    22. Jensen JH, Russell Glenn G, Helpern JA. Fiber ball imaging. Neuroimage. 2016 Jan 01; 124(Pt A):824-833. PMID: 26432187.
      View in: PubMed
    23. Glenn GR, Helpern JA, Tabesh A, Jensen JH. Optimization of white matter fiber tractography with diffusional kurtosis imaging. NMR Biomed. 2015 Oct; 28(10):1245-56. PMID: 26275886.
      View in: PubMed
    24. Glenn GR, Helpern JA, Tabesh A, Jensen JH. Quantitative assessment of diffusional kurtosis anisotropy. NMR Biomed. 2015 Apr; 28(4):448-59. PMID: 25728763.
      View in: PubMed
    25. Wintermark M, Coombs L, Druzgal TJ, Field AS, Filippi CG, Hicks R, Horton R, Lui YW, Law M, Mukherjee P, Norbash A, Riedy G, Sanelli PC, Stone JR, Sze G, Tilkin M, Whitlow CT, Wilde EA, York G, Provenzale JM. Traumatic brain injury imaging research roadmap. AJNR Am J Neuroradiol. 2015 Mar; 36(3):E12-23. PMID: 25655872.
      View in: PubMed
    26. Weber RA, Hui ES, Jensen JH, Nie X, Falangola MF, Helpern JA, Adkins DL. Diffusional kurtosis and diffusion tensor imaging reveal different time-sensitive stroke-induced microstructural changes. Stroke. 2015 Feb; 46(2):545-50. PMID: 25563646.
      View in: PubMed
    27. Amrhein TJ, Tabesh A, Collins HR, Gordon LL, Helpern JA, Jensen JH. Instituting a radiology residency scholarly activity program. Educ Health (Abingdon). 2015 Jan-Apr; 28(1):68-73. PMID: 26261118.
      View in: PubMed
    28. Adisetiyo V, Helpern JA. Brain iron: a promising noninvasive biomarker of attention-deficit/hyperactivity disorder that warrants further investigation. Biomark Med. 2015; 9(5):403-6. PMID: 25985171.
      View in: PubMed
    29. Nie X, Hamlett ED, Granholm AC, Hui ES, Helpern JA, Jensen JH, Boger HA, Collins HR, Falangola MF. Evidence of altered age-related brain cytoarchitecture in mouse models of down syndrome: a diffusional kurtosis imaging study. Magn Reson Imaging. 2015 May; 33(4):437-47. PMID: 25527393.
      View in: PubMed
    30. Bonilha L, Lee CY, Jensen JH, Tabesh A, Spampinato MV, Edwards JC, Breedlove J, Helpern JA. Altered microstructure in temporal lobe epilepsy: a diffusional kurtosis imaging study. AJNR Am J Neuroradiol. 2015 Apr; 36(4):719-24. PMID: 25500311.
      View in: PubMed
    31. Hui ES, Russell Glenn G, Helpern JA, Jensen JH. Kurtosis analysis of neural diffusion organization. Neuroimage. 2015 Feb 01; 106:391-403. PMID: 25463453.
      View in: PubMed
    32. Lee CY, Tabesh A, Nesland T, Jensen JH, Helpern JA, Spampinato MV, Bonilha L. Human brain asymmetry in microstructural connectivity demonstrated by diffusional kurtosis imaging. Brain Res. 2014 Nov 07; 1588:73-80. PMID: 25239477.
      View in: PubMed
    33. Adisetiyo V, Jensen JH, Tabesh A, Deardorff RL, Fieremans E, Di Martino A, Gray KM, Castellanos FX, Helpern JA. Multimodal MR imaging of brain iron in attention deficit hyperactivity disorder: a noninvasive biomarker that responds to psychostimulant treatment? Radiology. 2014 Aug; 272(2):524-32. PMID: 24937545.
      View in: PubMed
    34. Falangola MF, Guilfoyle DN, Tabesh A, Hui ES, Nie X, Jensen JH, Gerum SV, Hu C, LaFrancois J, Collins HR, Helpern JA. Histological correlation of diffusional kurtosis and white matter modeling metrics in cuprizone-induced corpus callosum demyelination. NMR Biomed. 2014 Aug; 27(8):948-57. PMID: 24890981.
      View in: PubMed
    35. Lee CY, Tabesh A, Spampinato MV, Helpern JA, Jensen JH, Bonilha L. Diffusional kurtosis imaging reveals a distinctive pattern of microstructural alternations in idiopathic generalized epilepsy. Acta Neurol Scand. 2014 Sep; 130(3):148-55. PMID: 24796428.
      View in: PubMed
    36. Jensen JH, Helpern JA. In vivo characterization of brain iron with magnetic field correlation imaging. Future Neurol. 2014 May 01; 9(3):247-250. PMID: 25379027.
      View in: PubMed
    37. Jensen JH, Hui ES, Helpern JA. Double-pulsed diffusional kurtosis imaging. NMR Biomed. 2014 Apr; 27(4):363-70. PMID: 24623712.
      View in: PubMed
    38. Novikov DS, Jensen JH, Helpern JA, Fieremans E. Revealing mesoscopic structural universality with diffusion. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):5088-93. PMID: 24706873.
      View in: PubMed
    39. Jensen JH, Hui ES, Helpern JA. Double-pulsed diffusional kurtosis imaging. NMR Biomed. 2014 Feb 20. PMID: 24677661.
      View in: PubMed
    40. Jensen JH, Helpern JA, Tabesh A. Leading non-Gaussian corrections for diffusion orientation distribution function. NMR Biomed. 2014 Feb; 27(2):202-11. PMID: 24738143.
      View in: PubMed
    41. Paydar A, Fieremans E, Nwankwo JI, Lazar M, Sheth HD, Adisetiyo V, Helpern JA, Jensen JH, Milla SS. Diffusional kurtosis imaging of the developing brain. AJNR Am J Neuroradiol. 2014 Apr; 35(4):808-14. PMID: 24231848.
      View in: PubMed
    42. Benitez A, Fieremans E, Jensen JH, Falangola MF, Tabesh A, Ferris SH, Helpern JA. White matter tract integrity metrics reflect the vulnerability of late-myelinating tracts in Alzheimer's disease. Neuroimage Clin. 2014; 4:64-71. PMID: 24319654.
      View in: PubMed
    43. Faro SH, Mohamed FB, Helpern JA, Jensen JH, Thulborn KR, Atkinson IC, Sair HI, Mikulis DJ. Hot topics in functional neuroradiology. AJNR Am J Neuroradiol. 2013 Dec; 34(12):2241-9. PMID: 24136644.
      View in: PubMed
    44. Bonilha L, Helpern JA, Sainju R, Nesland T, Edwards JC, Glazier SS, Tabesh A. Presurgical connectome and postsurgical seizure control in temporal lobe epilepsy. Neurology. 2013 Nov 05; 81(19):1704-10. PMID: 24107863.
      View in: PubMed
    45. Lee CY, Tabesh A, Benitez A, Helpern JA, Jensen JH, Bonilha L. Microstructural integrity of early- versus late-myelinating white matter tracts in medial temporal lobe epilepsy. Epilepsia. 2013 Oct; 54(10):1801-9. PMID: 24032670.
      View in: PubMed
    46. Adisetiyo V, Tabesh A, Di Martino A, Falangola MF, Castellanos FX, Jensen JH, Helpern JA. Attention-deficit/hyperactivity disorder without comorbidity is associated with distinct atypical patterns of cerebral microstructural development. Hum Brain Mapp. 2014 May; 35(5):2148-62. PMID: 23907808.
      View in: PubMed
    47. Fieremans E, Benitez A, Jensen JH, Falangola MF, Tabesh A, Deardorff RL, Spampinato MV, Babb JS, Novikov DS, Ferris SH, Helpern JA. Novel white matter tract integrity metrics sensitive to Alzheimer disease progression. AJNR Am J Neuroradiol. 2013 Nov-Dec; 34(11):2105-12. PMID: 23764722.
      View in: PubMed
    48. Falangola MF, Jensen JH, Tabesh A, Hu C, Deardorff RL, Babb JS, Ferris S, Helpern JA. Non-Gaussian diffusion MRI assessment of brain microstructure in mild cognitive impairment and Alzheimer's disease. Magn Reson Imaging. 2013 Jul; 31(6):840-6. PMID: 23602730.
      View in: PubMed
    49. Raz E, Bester M, Sigmund EE, Tabesh A, Babb JS, Jaggi H, Helpern J, Mitnick RJ, Inglese M. A better characterization of spinal cord damage in multiple sclerosis: a diffusional kurtosis imaging study. AJNR Am J Neuroradiol. 2013 Sep; 34(9):1846-52. PMID: 23578677.
      View in: PubMed
    50. Yang AW, Jensen JH, Hu CC, Tabesh A, Falangola MF, Helpern JA. Effect of cerebral spinal fluid suppression for diffusional kurtosis imaging. J Magn Reson Imaging. 2013 Feb; 37(2):365-71. PMID: 23034866.
      View in: PubMed
    51. Hui ES, Fieremans E, Jensen JH, Tabesh A, Feng W, Bonilha L, Spampinato MV, Adams R, Helpern JA. Stroke assessment with diffusional kurtosis imaging. Stroke. 2012 Nov; 43(11):2968-73. PMID: 22933581.
      View in: PubMed
    52. Adisetiyo V, Jensen JH, Ramani A, Tabesh A, Di Martino A, Fieremans E, Castellanos FX, Helpern JA. In vivo assessment of age-related brain iron differences by magnetic field correlation imaging. J Magn Reson Imaging. 2012 Aug; 36(2):322-31. PMID: 22392846.
      View in: PubMed
    53. Sigmund EE, Suero GA, Hu C, McGorty K, Sodickson DK, Wiggins GC, Helpern JA. High-resolution human cervical spinal cord imaging at 7?T. NMR Biomed. 2012 Jul; 25(7):891-9. PMID: 22183956.
      View in: PubMed
    54. Fieremans E, Jensen JH, Helpern JA. White matter characterization with diffusional kurtosis imaging. Neuroimage. 2011 Sep 01; 58(1):177-88. PMID: 21699989.
      View in: PubMed
    55. Novikov DS, Fieremans E, Jensen JH, Helpern JA. Random walk with barriers. Nat Phys. 2011 Jun 01; 7(6):508-514. PMID: 21686083.
      View in: PubMed
    56. Jiang Q, Qu C, Chopp M, Ding GL, Davarani SP, Helpern JA, Jensen JH, Zhang ZG, Li L, Lu M, Kaplan D, Hu J, Shen Y, Kou Z, Li Q, Wang S, Mahmood A. MRI evaluation of axonal reorganization after bone marrow stromal cell treatment of traumatic brain injury. NMR Biomed. 2011 Nov; 24(9):1119-28. PMID: 21432927.
      View in: PubMed
    57. Jensen JH, Helpern JA. Effect of gradient pulse duration on MRI estimation of the diffusional kurtosis for a two-compartment exchange model. J Magn Reson. 2011 Jun; 210(2):233-7. PMID: 21459638.
      View in: PubMed
    58. Helpern JA, Adisetiyo V, Falangola MF, Hu C, Di Martino A, Williams K, Castellanos FX, Jensen JH. Preliminary evidence of altered gray and white matter microstructural development in the frontal lobe of adolescents with attention-deficit hyperactivity disorder: a diffusional kurtosis imaging study. J Magn Reson Imaging. 2011 Jan; 33(1):17-23. PMID: 21182116.
      View in: PubMed
    59. Tabesh A, Jensen JH, Ardekani BA, Helpern JA. Estimation of tensors and tensor-derived measures in diffusional kurtosis imaging. Magn Reson Med. 2011 Mar; 65(3):823-36. PMID: 21337412.
      View in: PubMed
    60. Jensen JH, Falangola MF, Hu C, Tabesh A, Rapalino O, Lo C, Helpern JA. Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction. NMR Biomed. 2011 Jun; 24(5):452-7. PMID: 20960579.
      View in: PubMed
    61. Jensen JH, Helpern JA. Progress in diffusion-weighted imaging: concepts, techniques and applications to the central nervous system. NMR Biomed. 2010 Aug; 23(7):659-60. PMID: 20886561.
      View in: PubMed
    62. Fieremans E, Novikov DS, Jensen JH, Helpern JA. Monte Carlo study of a two-compartment exchange model of diffusion. NMR Biomed. 2010 Aug; 23(7):711-24. PMID: 20882537.
      View in: PubMed
    63. Jensen JH, Helpern JA. MRI quantification of non-Gaussian water diffusion by kurtosis analysis. NMR Biomed. 2010 Aug; 23(7):698-710. PMID: 20632416.
      View in: PubMed
    64. Jensen JH, Szulc K, Hu C, Ramani A, Lu H, Xuan L, Falangola MF, Chandra R, Knopp EA, Schenck J, Zimmerman EA, Helpern JA. Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain. Magn Reson Med. 2009 Feb; 61(2):481-5. PMID: 19161168.
      View in: PubMed
    65. Cheung MM, Hui ES, Chan KC, Helpern JA, Qi L, Wu EX. Does diffusion kurtosis imaging lead to better neural tissue characterization? A rodent brain maturation study. Neuroimage. 2009 Apr 01; 45(2):386-92. PMID: 19150655.
      View in: PubMed
    66. Falangola MF, Jensen JH, Babb JS, Hu C, Castellanos FX, Di Martino A, Ferris SH, Helpern JA. Age-related non-Gaussian diffusion patterns in the prefrontal brain. J Magn Reson Imaging. 2008 Dec; 28(6):1345-50. PMID: 19025941.
      View in: PubMed
    67. Lazar M, Jensen JH, Xuan L, Helpern JA. Estimation of the orientation distribution function from diffusional kurtosis imaging. Magn Reson Med. 2008 Oct; 60(4):774-81. PMID: 18816827.
      View in: PubMed
    68. Lu H, Law M, Ge Y, Hesseltine SM, Rapalino O, Jensen JH, Helpern JA. Quantitative measurement of spinal cord blood volume in humans using vascular-space-occupancy MRI. NMR Biomed. 2008 Mar; 21(3):226-32. PMID: 17557363.
      View in: PubMed
    69. Lu H, Pollack E, Young R, Babb JS, Johnson G, Zagzag D, Carson R, Jensen JH, Helpern JA, Law M. Predicting grade of cerebral glioma using vascular-space occupancy MR imaging. AJNR Am J Neuroradiol. 2008 Feb; 29(2):373-8. PMID: 17974612.
      View in: PubMed
    70. Ge Y, Jensen JH, Lu H, Helpern JA, Miles L, Inglese M, Babb JS, Herbert J, Grossman RI. Quantitative assessment of iron accumulation in the deep gray matter of multiple sclerosis by magnetic field correlation imaging. AJNR Am J Neuroradiol. 2007 Oct; 28(9):1639-44. PMID: 17893225.
      View in: PubMed
    71. Falangola MF, Dyakin VV, Lee SP, Bogart A, Babb JS, Duff K, Nixon R, Helpern JA. Quantitative MRI reveals aging-associated T2 changes in mouse models of Alzheimer's disease. NMR Biomed. 2007 May; 20(3):343-51. PMID: 17451178.
      View in: PubMed
    72. Ramani A, Jensen JH, Helpern JA. Quantitative MR imaging in Alzheimer disease. Radiology. 2006 Oct; 241(1):26-44. PMID: 16990669.
      View in: PubMed
    73. Jensen JH, Chandra R, Ramani A, Lu H, Johnson G, Lee SP, Kaczynski K, Helpern JA. Magnetic field correlation imaging. Magn Reson Med. 2006 Jun; 55(6):1350-61. PMID: 16700026.
      View in: PubMed
    74. Lu H, Jensen JH, Ramani A, Helpern JA. Three-dimensional characterization of non-gaussian water diffusion in humans using diffusion kurtosis imaging. NMR Biomed. 2006 Apr; 19(2):236-47. PMID: 16521095.
      View in: PubMed
    75. Lu H, Law M, Johnson G, Ge Y, van Zijl PC, Helpern JA. Novel approach to the measurement of absolute cerebral blood volume using vascular-space-occupancy magnetic resonance imaging. Magn Reson Med. 2005 Dec; 54(6):1403-11. PMID: 16254955.
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    76. Jensen JH, Helpern JA, Ramani A, Lu H, Kaczynski K. Diffusional kurtosis imaging: the quantification of non-gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med. 2005 Jun; 53(6):1432-40. PMID: 15906300.
      View in: PubMed
    77. Falangola MF, Lee SP, Nixon RA, Duff K, Helpern JA. Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice. Neurochem Res. 2005 Feb; 30(2):201-5. PMID: 15895823.
      View in: PubMed
    78. Falangola MF, Ardekani BA, Lee SP, Babb JS, Bogart A, Dyakin VV, Nixon R, Duff K, Helpern JA. Application of a non-linear image registration algorithm to quantitative analysis of T2 relaxation time in transgenic mouse models of AD pathology. J Neurosci Methods. 2005 May 15; 144(1):91-7. PMID: 15848243.
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    79. Jensen JH, Helpern JA. Iron-fortified MRI: effects and applications of iron-induced NMR relaxation in biological tissues. NMR Biomed. 2004 Nov; 17(7):425-6. PMID: 15523700.
      View in: PubMed
    80. Lee SP, Falangola MF, Nixon RA, Duff K, Helpern JA. Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents. Magn Reson Med. 2004 Sep; 52(3):538-44. PMID: 15334572.
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    81. Helpern JA, Lee SP, Falangola MF, Dyakin VV, Bogart A, Ardekani B, Duff K, Branch C, Wisniewski T, de Leon MJ, Wolf O, O'Shea J, Nixon RA. MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease. Magn Reson Med. 2004 Apr; 51(4):794-8. PMID: 15065253.
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    82. Helpern JA, Jensen J, Lee SP, Falangola MF. Quantitative MRI assessment of Alzheimer's disease. J Mol Neurosci. 2004; 24(1):45-8. PMID: 15314248.
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    83. Helpern JA. The promise of high-field-strength MR imaging. AJNR Am J Neuroradiol. 2003 Oct; 24(9):1738-9. PMID: 14561593.
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    84. Choi IY, Lee SP, Guilfoyle DN, Helpern JA. In vivo NMR studies of neurodegenerative diseases in transgenic and rodent models. Neurochem Res. 2003 Jul; 28(7):987-1001. PMID: 12737523.
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    85. Guilfoyle DN, Helpern JA, Lim KO. Diffusion tensor imaging in fixed brain tissue at 7.0 T. NMR Biomed. 2003 Apr; 16(2):77-81. PMID: 12730948.
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    86. Guilfoyle DN, Dyakin VV, O'Shea J, Pell GS, Helpern JA. Quantitative measurements of proton spin-lattice (T1) and spin-spin (T2) relaxation times in the mouse brain at 7.0 T. Magn Reson Med. 2003 Mar; 49(3):576-80. PMID: 12594763.
      View in: PubMed
    87. Peshkovsky A, Knuth KH, Helpern JA. Motion correction in MRI using an apparatus for dynamic angular position tracking (ADAPT). Magn Reson Med. 2003 Jan; 49(1):138-43. PMID: 12509829.
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    88. Ardekani BA, Choi SJ, Hossein-Zadeh GA, Porjesz B, Tanabe JL, Lim KO, Bilder R, Helpern JA, Begleiter H. Functional magnetic resonance imaging of brain activity in the visual oddball task. Brain Res Cogn Brain Res. 2002 Nov; 14(3):347-56. PMID: 12421658.
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    89. Lim KO, Helpern JA. Neuropsychiatric applications of DTI - a review. NMR Biomed. 2002 Nov-Dec; 15(7-8):587-93. PMID: 12489105.
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    90. Ardekani BA, Bachman AH, Helpern JA. A quantitative comparison of motion detection algorithms in fMRI. Magn Reson Imaging. 2001 Sep; 19(7):959-63. PMID: 11595367.
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    91. Helpern JA. The missing element. AJNR Am J Neuroradiol. 2001 Aug; 22(7):1235-6. PMID: 11498408.
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    92. Lipton ML, Branch CA, Hrabe J, Lewis DP, Helpern JA. RF excitation profiles with FAIR: impact of truncation of the arterial input function on quantitative perfusion. J Magn Reson Imaging. 2001 Feb; 13(2):207-14. PMID: 11169826.
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    93. Tanabe JL, Yongbi M, Branch C, Hrabe J, Johnson G, Helpern JA. MR perfusion imaging in human brain using the UNFAIR technique. Un-inverted flow-sensitive alternating inversion recovery. J Magn Reson Imaging. 1999 Jun; 9(6):761-7. PMID: 10373023.
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    94. Branch CA, Hernandez L, Yongbi M, Huang NC, Helpern JA. Rapid and continuous monitoring of cerebral perfusion by magnetic resonance line scan assessment with arterial spin tagging. NMR Biomed. 1999 Feb; 12(1):15-25. PMID: 10195325.
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    95. Yongbi MN, Branch CA, Helpern JA. Perfusion imaging using FOCI RF pulses. Magn Reson Med. 1998 Dec; 40(6):938-43. PMID: 9840841.
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    96. Huang NC, Yongbi MN, Helpern JA. The influence of preischemic hyperglycemia on acute changes in brain water ADCw following focal ischemia in rats. Brain Res. 1998 Mar 30; 788(1-2):137-43. PMID: 9554986.
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    97. Huang NC, Yongbi MN, Helpern JA. The influence of preischemic hyperglycemia on acute changes in the apparent diffusion coefficient of brain water following global ischemia in rats. Brain Res. 1997 May 16; 757(1):139-45. PMID: 9200508.
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    98. Yongbi MN, Huang NC, Branch CA, Helpern JA. The application of diffusion-weighted line-scanning for the rapid assessment of water ADC changes in stroke at high magnetic fields. NMR Biomed. 1997 Apr; 10(2):79-86. PMID: 9267865.
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    99. Helpern JA, Branch CA, Yongbi MN, Huang NC. Perfusion imaging by un-inverted flow-sensitive alternating inversion recovery (UNFAIR). Magn Reson Imaging. 1997; 15(2):135-9. PMID: 9106140.
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    100. Kao W, Helpern JA, Goldstein S, Gheorghiade M, Levine B. Abnormalities of skeletal muscle metabolism during nerve stimulation determined by 31P nuclear magnetic resonance spectroscopy in severe congestive heart failure. Am J Cardiol. 1995 Sep 15; 76(8):606-9. PMID: 7677088.
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    101. Gorell JM, Ordidge RJ, Brown GG, Deniau JC, Buderer NM, Helpern JA. Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease. Neurology. 1995 Jun; 45(6):1138-43. PMID: 7783878.
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    102. Helpern JA, Ordidge RJ, Gorell JM, Deniau JC, Welch KM. Preliminary observations of transverse relaxation rates obtained at 3 tesla from the substantia nigra of adult normal human brain. NMR Biomed. 1995 Feb; 8(1):25-7. PMID: 7547180.
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    103. Helpern JA, Huang N. Diffusion-weighted imaging in epilepsy. Magn Reson Imaging. 1995; 13(8):1227-31. PMID: 8750340.
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    104. Ordidge RJ, Gorell JM, Deniau JC, Knight RA, Helpern JA. Assessment of relative brain iron concentrations using T2-weighted and T2*-weighted MRI at 3 Tesla. Magn Reson Med. 1994 Sep; 32(3):335-41. PMID: 7984066.
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    105. Jiang Q, Chopp M, Zhang ZG, Helpern JA, Ordidge RJ, Ewing J, Jiang P, Marchese BA. The effect of hypothermia on transient focal ischemia in rat brain evaluated by diffusion- and perfusion-weighted NMR imaging. J Cereb Blood Flow Metab. 1994 Sep; 14(5):732-41. PMID: 8063869.
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    106. Knight RA, Dereski MO, Helpern JA, Ordidge RJ, Chopp M. Magnetic resonance imaging assessment of evolving focal cerebral ischemia. Comparison with histopathology in rats. Stroke. 1994 Jun; 25(6):1252-61; discussion 1261-2. PMID: 8202989.
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    107. Ordidge RJ, Helpern JA, Qing ZX, Knight RA, Nagesh V. Correction of motional artifacts in diffusion-weighted MR images using navigator echoes. Magn Reson Imaging. 1994; 12(3):455-60. PMID: 8007775.
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    108. Ordidge RJ, Knight RA, Helpern JA, Hugg JW. A low flip angle spin-echo technique for producing rapid diffusion weighted MR images. Magn Reson Imaging. 1994; 12(5):727-31. PMID: 7934659.
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    109. Jiang Q, Zhang ZG, Chopp M, Helpern JA, Ordidge RJ, Garcia JH, Marchese BA, Qing ZX, Knight RA. Temporal evolution and spatial distribution of the diffusion constant of water in rat brain after transient middle cerebral artery occlusion. J Neurol Sci. 1993 Dec 15; 120(2):123-30. PMID: 8138799.
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    110. Helpern JA, Vande Linde AM, Welch KM, Levine SR, Schultz LR, Ordidge RJ, Halvorson HR, Hugg JW. Acute elevation and recovery of intracellular [Mg2+] following human focal cerebral ischemia. Neurology. 1993 Aug; 43(8):1577-81. PMID: 8351015.
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    111. Brown GG, Garcia JH, Gdowski JW, Levine SR, Helpern JA. Altered brain energy metabolism in demented patients with multiple subcortical ischemic lesions. Working hypotheses. Arch Neurol. 1993 Apr; 50(4):384-8. PMID: 8460960.
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    112. Ewing JR, Warner R, Helpern JA. A cylindrically symmetric magnetic shield for a large-bore 3.0 Tesla magnet. Magn Reson Med. 1993 Mar; 29(3):398-401. PMID: 8450750.
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    113. Helpern JA, Dereski MO, Knight RA, Ordidge RJ, Chopp M, Qing ZX. Histopathological correlations of nuclear magnetic resonance imaging parameters in experimental cerebral ischemia. Magn Reson Imaging. 1993; 11(2):241-6. PMID: 8455433.
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    114. Branch CA, Ewing JR, Helpern JA, Ordidge RJ, Butt S, Welch KM. Atraumatic quantitation of cerebral perfusion in cats by 19F magnetic resonance imaging. Magn Reson Med. 1992 Nov; 28(1):39-53. PMID: 1435220.
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    115. Levine SR, Helpern JA, Welch KM, Vande Linde AM, Sawaya KL, Brown EE, Ramadan NM, Deveshwar RK, Ordidge RJ. Human focal cerebral ischemia: evaluation of brain pH and energy metabolism with P-31 NMR spectroscopy. Radiology. 1992 Nov; 185(2):537-44. PMID: 1410369.
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    116. Halvorson HR, Vande Linde AM, Helpern JA, Welch KM. Assessment of magnesium concentrations by 31P NMR in vivo. NMR Biomed. 1992 Mar-Apr; 5(2):53-8. PMID: 1622765.
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    117. Welch KM, Levine SR, Martin G, Ordidge R, Vande Linde AM, Helpern JA. Magnetic resonance spectroscopy in cerebral ischemia. Neurol Clin. 1992 Feb; 10(1):1-29. PMID: 1556996.
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    118. Vande Linde AM, Chopp M, Chen H, Helpern JA, Knight R, Schultz L, Welch KM. Chronic changes in the brain Mg2+ concentration after forebrain ischemia in the rat. Metab Brain Dis. 1991 Dec; 6(4):199-206. PMID: 1812393.
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    119. Jiang Q, Knight RA, Chopp M, Helpern JA, Ordidge RJ, Qing ZX, Hetzel FW. 1H magnetic resonance imaging of normal brain tissue response to photodynamic therapy. Neurosurgery. 1991 Oct; 29(4):538-46. PMID: 1834959.
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    120. Branch CA, Helpern JA, Ewing JR, Welch KM. 19F NMR imaging of cerebral blood flow. Magn Reson Med. 1991 Jul; 20(1):151-7. PMID: 1943655.
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    121. Knight RA, Ordidge RJ, Helpern JA, Chopp M, Rodolosi LC, Peck D. Temporal evolution of ischemic damage in rat brain measured by proton nuclear magnetic resonance imaging. Stroke. 1991 Jun; 22(6):802-8. PMID: 2057981.
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    122. Martin GB, Paradis NA, Helpern JA, Nowak RM, Welch KM. Nuclear magnetic resonance spectroscopy study of human brain after cardiac resuscitation. Stroke. 1991 Apr; 22(4):462-8. PMID: 2024276.
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    123. Ordidge RJ, Knight RA, Helpern JA. Magnetization transfer contrast (MTC) in flash MR imaging. Magn Reson Imaging. 1991; 9(6):889-93. PMID: 1766312.
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    124. Ordidge RJ, Helpern JA, Knight RA, Qing ZX, Welch KM. Investigation of cerebral ischemia using magnetization transfer contrast (MTC) MR imaging. Magn Reson Imaging. 1991; 9(6):895-902. PMID: 1766313.
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    125. Chopp M, Vande Linde AM, Chen H, Knight R, Helpern JA, Welch KM. Chronic cerebral intracellular alkalosis following forebrain ischemic insult in rats. Stroke. 1990 Mar; 21(3):463-6. PMID: 2309271.
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    126. Welch KM, Levine SR, Helpern JA. Pathophysiological correlates of cerebral ischemia the significance of cellular acid base shifts. Funct Neurol. 1990 Jan-Mar; 5(1):21-31. PMID: 2401427.
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    127. Ewing JR, Branch CA, Fagan SC, Helpern JA, Simkins RT, Butt SM, Welch KM. Fluorocarbon-23 measure of cat cerebral blood flow by nuclear magnetic resonance. Stroke. 1990 Jan; 21(1):100-6. PMID: 2300975.
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    128. Brown GG, Levine SR, Gorell JM, Pettegrew JW, Gdowski JW, Bueri JA, Helpern JA, Welch KM. In vivo 31P NMR profiles of Alzheimer's disease and multiple subcortical infarct dementia. Neurology. 1989 Nov; 39(11):1423-7. PMID: 2812317.
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    129. Ramadan NM, Halvorson H, Vande-Linde A, Levine SR, Helpern JA, Welch KM. Low brain magnesium in migraine. Headache. 1989 Oct; 29(9):590-3. PMID: 2584000.
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    130. Chopp M, Tidwell CD, Lee YJ, Knight R, Helpern JA, Welch KM. Reduction of hyperthermic ischemic acidosis by a conditioning event in cats. Stroke. 1989 Oct; 20(10):1357-60. PMID: 2799866.
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    131. Helpern JA, Welch KM, Halvorson HR. Rubidium transport in human erythrocyte suspensions monitored by 87Rb NMR with aqueous chemical shift reagents. NMR Biomed. 1989 Jul; 2(2):47-54. PMID: 2518154.
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    132. Ramadan NM, Halvorson H, Vande-Linde A, Levine SR, Helpern JA, Welch KM. Low brain magnesium in migraine. Headache. 1989 Jul; 29(7):416-9. PMID: 2759849.
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    133. Welch KM, Levine SR, D'Andrea G, Schultz LR, Helpern JA. Preliminary observations on brain energy metabolism in migraine studied by in vivo phosphorus 31 NMR spectroscopy. Neurology. 1989 Apr; 39(4):538-41. PMID: 2927679.
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    134. Helpern JA, Kao W, Gross B, Kensora TG, Welch KM. Interleaved 31P NMR with transcutaneous nerve stimulation (TNS): a method of monitoring compliance-independent skeletal muscle metabolic response to exercise. Magn Reson Med. 1989 Apr; 10(1):50-6. PMID: 2755333.
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    135. Chopp M, Knight R, Tidwell CD, Helpern JA, Brown E, Welch KM. The metabolic effects of mild hypothermia on global cerebral ischemia and recirculation in the cat: comparison to normothermia and hyperthermia. J Cereb Blood Flow Metab. 1989 Apr; 9(2):141-8. PMID: 2921288.
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    136. Ewing JR, Branch CA, Helpern JA, Smith MB, Butt SM, Welch KM. Cerebral blood flow measured by NMR indicator dilution in cats. Stroke. 1989 Feb; 20(2):259-67. PMID: 2645693.
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    137. Chopp M, Welch KM, Tidwell CD, Knight R, Helpern JA. Effect of mild hyperthermia on recovery of metabolic function after global cerebral ischemia in cats. Stroke. 1988 Dec; 19(12):1521-5. PMID: 3201511.
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    138. Welch KM, Levine SR, D'Andrea G, Helpern JA. Brain pH in migraine: an in vivo phosphorus-31 magnetic resonance spectroscopy study. Cephalalgia. 1988 Dec; 8(4):273-7. PMID: 3219729.
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    139. Chopp M, Welch KM, Tidwell CD, Helpern JA. Global cerebral ischemia and intracellular pH during hyperglycemia and hypoglycemia in cats. Stroke. 1988 Nov; 19(11):1383-7. PMID: 3188123.
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    140. Levine SR, Welch KM, Helpern JA, Chopp M, Bruce R, Selwa J, Smith MB. Prolonged deterioration of ischemic brain energy metabolism and acidosis associated with hyperglycemia: human cerebral infarction studied by serial 31P NMR spectroscopy. Ann Neurol. 1988 Apr; 23(4):416-8. PMID: 3382181.
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    141. Helpern JA, Curtis JC, Hearshen D, Smith MB, Welch KM. The development of a pH-sensitive contrast agent for NMR 1H imaging. Magn Reson Med. 1987 Sep; 5(3):302-5. PMID: 3431400.
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    142. Stein PD, Goldstein S, Sabbah HN, Liu ZQ, Helpern JA, Ewing JR, Lakier JB, Chopp M, LaPenna WF, Welch KM. In vivo evaluation of intracellular pH and high-energy phosphate metabolites during regional myocardial ischemia in cats using 31P nuclear magnetic resonance. Magn Reson Med. 1986 Apr; 3(2):262-9. PMID: 3713490.
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    143. Welch KM, Helpern JA, Ewing JR, Robertson WM, D'Andrea G. Biochemical effects of cerebral ischemia: relevance to migraine. Cephalalgia. 1985 May; 5 Suppl 2:35-42. PMID: 2861908.
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    144. Chopp M, Helpern JA, Frinak S, Hetzel FW, Ewing JR, Welch KM. In vivo 31-P NMR of photoactivated hematoporphyrin derivative in cat brain. Med Phys. 1985 Mar-Apr; 12(2):256-8. PMID: 4000089.
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    145. Chopp M, Helpern JA, Ewing JR, Welch KM. Anoxia followed by hyperoxia: in vivo 31-P NMR of cat brain. Magn Reson Imaging. 1984; 2(4):329-33. PMID: 6530935.
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    146. Helpern JA, McGee SJ, Riddle JM. Observations suggesting a possible link between gammacarboxyglutamic acid and porcine bioprosthetic valve calcification. Henry Ford Hosp Med J. 1982; 30(3):152-5. PMID: 7161130.
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