Keywords
Last Name
Institution

John J. Woodward

Title
InstitutionMedical University of South Carolina
DepartmentNeuroscience
AddressP.O. Box MSC 861
456 IOPN
67 President St.
Phone843-792-5225
Fax843-792-7353
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    Dr. Woodward's lab is focused on defining the neural sites of action of alcohol and abused inhalants such as toluene and TCE with an emphasis on cortical based brain circuitry. Alcohol and abused inhalants produce diverse effects on neuronal function by altering the function of different types of ion channels that regulate neuronal excitability. These include voltage dependent channels as well as those gated by neurotransmitters such as glutamate, Ach and ATP. Electrophysiological recording techniques are used to directly measure the function of both recombinant and native channels while site-directed mutagenesis is used to probe for discrete sites of action on the ion channel itself. These approaches are complemented by optogenetic and chemogenetic (DREADD) techniques that provide for more precise control over neuronal function.

    Collapse keywords
    neural basis of action of alcohol and abused inhalants, electrophysiology, ion channels, prefrontal cortex

    Collapse ORNG Applications 
    Collapse studies/trials

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Nimitvilai S, Lopez MF, Woodward JJ. Sex-dependent differences in ethanol inhibition of mouse lateral orbitofrontal cortex neurons. Addict Biol. 2018 Nov 23. PMID: 30468275.
      View in: PubMed
    2. Haun HL, Griffin WC, Lopez MF, Solomon MG, Mulholland PJ, Woodward JJ, McGinty JF, Ron D, Becker HC. Increasing Brain-Derived Neurotrophic Factor (BDNF) in medial prefrontal cortex selectively reduces excessive drinking in ethanol dependent mice. Neuropharmacology. 2018 09 15; 140:35-42. PMID: 30056122.
      View in: PubMed
    3. Harlan BA, Becker HC, Woodward JJ, Riegel AC. Opposing actions of CRF-R1 and CB1 receptors on VTA-GABAergic plasticity following chronic exposure to ethanol. Neuropsychopharmacology. 2018 09; 43(10):2064-2074. PMID: 29946104.
      View in: PubMed
    4. Nimitvilai S, Lopez MF, Woodward JJ. Effects of monoamines on the intrinsic excitability of lateral orbitofrontal cortex neurons in alcohol-dependent and non-dependent female mice. Neuropharmacology. 2018 07 15; 137:1-12. PMID: 29689260.
      View in: PubMed
    5. Gioia DA, Xu M, Wayman WN, Woodward JJ. Effects of drugs of abuse on channelrhodopsin-2 function. Neuropharmacology. 2018 06; 135:316-327. PMID: 29580953.
      View in: PubMed
    6. Zamudio-Bulcock PA, Homanics GE, Woodward JJ. Loss of Ethanol Inhibition of N-Methyl-D-Aspartate Receptor-Mediated Currents and Plasticity of Cerebellar Synapses in Mice Expressing the GluN1(F639A) Subunit. Alcohol Clin Exp Res. 2018 Apr; 42(4):698-705. PMID: 29323417.
      View in: PubMed
    7. Wayman WN, Woodward JJ. Chemogenetic Excitation of Accumbens-Projecting Infralimbic Cortical Neurons Blocks Toluene-Induced Conditioned Place Preference. J Neurosci. 2018 02 07; 38(6):1462-1471. PMID: 29317484.
      View in: PubMed
    8. Cannady R, Rinker JA, Nimitvilai S, Woodward JJ, Mulholland PJ. Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior. Handb Exp Pharmacol. 2018; 248:311-343. PMID: 29374839.
      View in: PubMed
    9. Cannady R, Rinker JA, Nimitvilai S, Woodward JJ, Mulholland PJ. Correction to: Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior. Handb Exp Pharmacol. 2018; 248:619. PMID: 30810861.
      View in: PubMed
    10. Braunscheidel KM, Gass JT, Mulholland PJ, Floresco SB, Woodward JJ. Persistent cognitive and morphological alterations induced by repeated exposure of adolescent rats to the abused inhalant toluene. Neurobiol Learn Mem. 2017 Oct; 144:136-146. PMID: 28720405.
      View in: PubMed
    11. Wayman WN, Woodward JJ. Exposure to the Abused Inhalant Toluene Alters Medial Prefrontal Cortex Physiology. Neuropsychopharmacology. 2018 03; 43(4):912-924. PMID: 28589963.
      View in: PubMed
    12. Cannady R, McGonigal JT, Newsom RJ, Woodward JJ, Mulholland PJ, Gass JT. Prefrontal Cortex KCa2 Channels Regulate mGlu5-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior. J Neurosci. 2017 04 19; 37(16):4359-4369. PMID: 28320841.
      View in: PubMed
    13. Nimitvilai S, Uys JD, Woodward JJ, Randall PK, Ball LE, Williams RW, Jones BC, Lu L, Grant KA, Mulholland PJ. Orbitofrontal Neuroadaptations and Cross-Species Synaptic Biomarkers in Heavy-Drinking Macaques. J Neurosci. 2017 03 29; 37(13):3646-3660. PMID: 28270566.
      View in: PubMed
    14. den Hartog CR, Gilstrap M, Eaton B, Lench DH, Mulholland PJ, Homanics GE, Woodward JJ. Effects of Repeated Ethanol Exposures on NMDA Receptor Expression and Locomotor Sensitization in Mice Expressing Ethanol Resistant NMDA Receptors. Front Neurosci. 2017; 11:84. PMID: 28270746.
      View in: PubMed
    15. Nimitvilai S, Lopez MF, Mulholland PJ, Woodward JJ. Ethanol Dependence Abolishes Monoamine and GIRK (Kir3) Channel Inhibition of Orbitofrontal Cortex Excitability. Neuropsychopharmacology. 2017 Aug; 42(9):1800-1812. PMID: 28139680.
      View in: PubMed
    16. Smothers CT, Woodward JJ. Differential effects of TM4 tryptophan mutations on inhibition of N-methyl-d-aspartate receptors by ethanol and toluene. Alcohol. 2016 11; 56:15-19. PMID: 27814790.
      View in: PubMed
    17. Nimitvilai S, You C, Arora DS, McElvain MA, Vandegrift BJ, Brodie MS, Woodward JJ. Differential Effects of Toluene and Ethanol on Dopaminergic Neurons of the Ventral Tegmental Area. Front Neurosci. 2016; 10:434. PMID: 27713687.
      View in: PubMed
    18. Tabakoff B, Ren W, Vanderlinden L, Snell LD, Matheson CJ, Wang ZJ, Levinson R, Smothers CT, Woodward JJ, Honse Y, Lovinger D, Rush AM, Sather WA, Gustafson DL, Hoffman PL. A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain. Eur J Pharmacol. 2016 Aug 05; 784:1-14. PMID: 27158117.
      View in: PubMed
    19. den Hartog C, Zamudio-Bulcock P, Nimitvilai S, Gilstrap M, Eaton B, Fedarovich H, Motts A, Woodward JJ. Inactivation of the lateral orbitofrontal cortex increases drinking in ethanol-dependent but not non-dependent mice. Neuropharmacology. 2016 08; 107:451-459. PMID: 27016020.
      View in: PubMed
    20. Tomko RL, Prisciandaro JJ, Falls SK, Magid V. The structure of the UPPS-R-Child impulsivity scale and its relations with substance use outcomes among treatment-seeking adolescents. Drug Alcohol Depend. 2016 Apr 01; 161:276-83. PMID: 26905208.
      View in: PubMed
    21. Lopez MF, Anderson RI, Becker HC. Effect of different stressors on voluntary ethanol intake in ethanol-dependent and nondependent C57BL/6J mice. Alcohol. 2016 Mar; 51:17-23. PMID: 26992696.
      View in: PubMed
    22. Hughes BA, Woodward JJ. Disruption of S2-M4 linker coupling reveals novel subunit-specific contributions to N-methyl-d-aspartate receptor function and ethanol sensitivity. Neuropharmacology. 2016 06; 105:96-105. PMID: 26577016.
      View in: PubMed
    23. Smothers CT, Szumlinski KK, Worley PF, Woodward JJ. Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene. Synapse. 2016 Jan; 70(1):33-9. PMID: 26426435.
      View in: PubMed
    24. Nimitvilai S, Lopez MF, Mulholland PJ, Woodward JJ. Chronic Intermittent Ethanol Exposure Enhances the Excitability and Synaptic Plasticity of Lateral Orbitofrontal Cortex Neurons and Induces a Tolerance to the Acute Inhibitory Actions of Ethanol. Neuropsychopharmacology. 2016 Mar; 41(4):1112-27. PMID: 26286839.
      View in: PubMed
    25. Beckley JT, Randall PK, Smith RJ, Hughes BA, Kalivas PW, Woodward JJ. Phenotype-dependent inhibition of glutamatergic transmission on nucleus accumbens medium spiny neurons by the abused inhalant toluene. Addict Biol. 2016 May; 21(3):530-46. PMID: 25752326.
      View in: PubMed
    26. Padula AE, Griffin WC, Lopez MF, Nimitvilai S, Cannady R, McGuier NS, Chesler EJ, Miles MF, Williams RW, Randall PK, Woodward JJ, Becker HC, Mulholland PJ. KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. Neuropsychopharmacology. 2015 Jul; 40(8):1928-39. PMID: 25662840.
      View in: PubMed
    27. Xu M, Smothers CT, Woodward JJ. Cysteine substitution of transmembrane domain amino acids alters the ethanol inhibition of GluN1/GluN2A N-methyl-D-aspartate receptors. J Pharmacol Exp Ther. 2015 Apr; 353(1):91-101. PMID: 25635140.
      View in: PubMed
    28. McGuier NS, Padula AE, Lopez MF, Woodward JJ, Mulholland PJ. Withdrawal from chronic intermittent alcohol exposure increases dendritic spine density in the lateral orbitofrontal cortex of mice. Alcohol. 2015 Feb; 49(1):21-7. PMID: 25468278.
      View in: PubMed
    29. Pava MJ, Woodward JJ. Chronic ethanol alters network activity and endocannabinoid signaling in the prefrontal cortex. Front Integr Neurosci. 2014; 8:58. PMID: 25100953.
      View in: PubMed
    30. Mahler SV, Vazey EM, Beckley JT, Keistler CR, McGlinchey EM, Kaufling J, Wilson SP, Deisseroth K, Woodward JJ, Aston-Jones G. Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking. Nat Neurosci. 2014 Apr; 17(4):577-85. PMID: 24584054.
      View in: PubMed
    31. Pava MJ, den Hartog CR, Blanco-Centurion C, Shiromani PJ, Woodward JJ. Endocannabinoid modulation of cortical up-states and NREM sleep. PLoS One. 2014; 9(2):e88672. PMID: 24520411.
      View in: PubMed
    32. Woodward JJ, Beckley J. Effects of the abused inhalant toluene on the mesolimbic dopamine system. J Drug Alcohol Res. 2014; 3. PMID: 25360326.
      View in: PubMed
    33. Cruz SL, Rivera-GarcĂ­a MT, Woodward JJ. Review of toluene action: clinical evidence, animal studies and molecular targets. J Drug Alcohol Res. 2014; 3. PMID: 25360325.
      View in: PubMed
    34. den Hartog CR, Beckley JT, Smothers TC, Lench DH, Holseberg ZL, Fedarovich H, Gilstrap MJ, Homanics GE, Woodward JJ. Alterations in ethanol-induced behaviors and consumption in knock-in mice expressing ethanol-resistant NMDA receptors. PLoS One. 2013; 8(11):e80541. PMID: 24244696.
      View in: PubMed
    35. Beckley JT, Woodward JJ. Volatile solvents as drugs of abuse: focus on the cortico-mesolimbic circuitry. Neuropsychopharmacology. 2013 Dec; 38(13):2555-67. PMID: 23954847.
      View in: PubMed
    36. Smothers CT, Jin C, Woodward JJ. Deletion of the N-terminal domain alters the ethanol inhibition of N-methyl-D-aspartate receptors in a subunit-dependent manner. Alcohol Clin Exp Res. 2013 Nov; 37(11):1882-90. PMID: 23905549.
      View in: PubMed
    37. Hughes BA, Smothers CT, Woodward JJ. Dephosphorylation of GluN2B C-terminal tyrosine residues does not contribute to acute ethanol inhibition of recombinant NMDA receptors. Alcohol. 2013 May; 47(3):181-6. PMID: 23357553.
      View in: PubMed
    38. Badanich KA, Mulholland PJ, Beckley JT, Trantham-Davidson H, Woodward JJ. Ethanol reduces neuronal excitability of lateral orbitofrontal cortex neurons via a glycine receptor dependent mechanism. Neuropsychopharmacology. 2013 Jun; 38(7):1176-88. PMID: 23314219.
      View in: PubMed
    39. Beckley JT, Evins CE, Fedarovich H, Gilstrap MJ, Woodward JJ. Medial prefrontal cortex inversely regulates toluene-induced changes in markers of synaptic plasticity of mesolimbic dopamine neurons. J Neurosci. 2013 Jan 09; 33(2):804-13. PMID: 23303956.
      View in: PubMed
    40. Pava MJ, Woodward JJ. A review of the interactions between alcohol and the endocannabinoid system: implications for alcohol dependence and future directions for research. Alcohol. 2012 May; 46(3):185-204. PMID: 22459871.
      View in: PubMed
    41. Diaz MR, Wadleigh A, Hughes BA, Woodward JJ, Valenzuela CF. Bestrophin1 Channels are Insensitive to Ethanol and Do not Mediate Tonic GABAergic Currents in Cerebellar Granule Cells. Front Neurosci. 2011; 5:148. PMID: 22275879.
      View in: PubMed
    42. Woodward JJ, Pava M. Ethanol inhibition of up-states in prefrontal cortical neurons expressing the genetically encoded calcium indicator GCaMP3. Alcohol Clin Exp Res. 2012 May; 36(5):780-7. PMID: 22141337.
      View in: PubMed
    43. Badanich KA, Becker HC, Woodward JJ. Effects of chronic intermittent ethanol exposure on orbitofrontal and medial prefrontal cortex-dependent behaviors in mice. Behav Neurosci. 2011 Dec; 125(6):879-91. PMID: 22122149.
      View in: PubMed
    44. Xu M, Smothers CT, Trudell J, Woodward JJ. Ethanol inhibition of constitutively open N-methyl-D-aspartate receptors. J Pharmacol Exp Ther. 2012 Jan; 340(1):218-26. PMID: 22005043.
      View in: PubMed
    45. Pava MJ, Blake EM, Green ST, Mizroch BJ, Mulholland PJ, Woodward JJ. Tolerance to cannabinoid-induced behaviors in mice treated chronically with ethanol. Psychopharmacology (Berl). 2012 Jan; 219(1):137-47. PMID: 21701813.
      View in: PubMed
    46. Beckley JT, Woodward JJ. The abused inhalant toluene differentially modulates excitatory and inhibitory synaptic transmission in deep-layer neurons of the medial prefrontal cortex. Neuropsychopharmacology. 2011 Jun; 36(7):1531-42. PMID: 21430649.
      View in: PubMed
    47. Xu M, Smothers CT, Woodward JJ. Effects of ethanol on phosphorylation site mutants of recombinant N-methyl-D-aspartate receptors. Alcohol. 2011 Jun; 45(4):373-80. PMID: 21163614.
      View in: PubMed
    48. Mulholland PJ, Becker HC, Woodward JJ, Chandler LJ. Small conductance calcium-activated potassium type 2 channels regulate alcohol-associated plasticity of glutamatergic synapses. Biol Psychiatry. 2011 Apr 01; 69(7):625-32. PMID: 21056409.
      View in: PubMed
    49. Das A, McDowell M, Pava MJ, Smith JA, Reiter RJ, Woodward JJ, Varma AK, Ray SK, Banik NL. The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-alpha toxicity involves membrane melatonin receptors. J Pineal Res. 2010 Mar; 48(2):157-69. PMID: 20082663.
      View in: PubMed
    50. Abernathy K, Chandler LJ, Woodward JJ. Alcohol and the prefrontal cortex. Int Rev Neurobiol. 2010; 91:289-320. PMID: 20813246.
      View in: PubMed
    51. Woodward JJ, Pava MJ. Effects of ethanol on persistent activity and up-States in excitatory and inhibitory neurons in prefrontal cortex. Alcohol Clin Exp Res. 2009 Dec; 33(12):2134-40. PMID: 19764936.
      View in: PubMed
    52. Smothers CT, Woodward JJ. Expression of glycine-activated diheteromeric NR1/NR3 receptors in human embryonic kidney 293 cells Is NR1 splice variant-dependent. J Pharmacol Exp Ther. 2009 Dec; 331(3):975-84. PMID: 19726695.
      View in: PubMed
    53. Sribnick EA, Del Re AM, Ray SK, Woodward JJ, Banik NL. Estrogen attenuates glutamate-induced cell death by inhibiting Ca2+ influx through L-type voltage-gated Ca2+ channels. Brain Res. 2009 Jun 18; 1276:159-70. PMID: 19389388.
      View in: PubMed
    54. Sas AR, Bimonte-Nelson H, Smothers CT, Woodward J, Tyor WR. Interferon-alpha causes neuronal dysfunction in encephalitis. J Neurosci. 2009 Mar 25; 29(12):3948-55. PMID: 19321791.
      View in: PubMed
    55. Mulholland PJ, Carpenter-Hyland EP, Woodward JJ, Chandler LJ. Ethanol disrupts NMDA receptor and astroglial EAAT2 modulation of Kv2.1 potassium channels in hippocampus. Alcohol. 2009 Feb; 43(1):45-50. PMID: 19185209.
      View in: PubMed
    56. Mulholland PJ, Carpenter-Hyland EP, Hearing MC, Becker HC, Woodward JJ, Chandler LJ. Glutamate transporters regulate extrasynaptic NMDA receptor modulation of Kv2.1 potassium channels. J Neurosci. 2008 Aug 27; 28(35):8801-9. PMID: 18753382.
      View in: PubMed
    57. Asatryan L, Popova M, Woodward JJ, King BF, Alkana RL, Davies DL. Roles of ectodomain and transmembrane regions in ethanol and agonist action in purinergic P2X2 and P2X3 receptors. Neuropharmacology. 2008 Oct; 55(5):835-43. PMID: 18639563.
      View in: PubMed
    58. Xu M, Chandler LJ, Woodward JJ. Ethanol inhibition of recombinant NMDA receptors is not altered by coexpression of CaMKII-alpha or CaMKII-beta. Alcohol. 2008 Aug; 42(5):425-32. PMID: 18562151.
      View in: PubMed
    59. Jin C, Smothers CT, Woodward JJ. Enhanced ethanol inhibition of recombinant N-methyl-D-aspartate receptors by magnesium: role of NR3A subunits. Alcohol Clin Exp Res. 2008 Jun; 32(6):1059-66. PMID: 18445116.
      View in: PubMed
    60. Weitlauf C, Woodward JJ. Ethanol selectively attenuates NMDAR-mediated synaptic transmission in the prefrontal cortex. Alcohol Clin Exp Res. 2008 Apr; 32(4):690-8. PMID: 18341645.
      View in: PubMed
    61. Woodward JJ. GABAA alpha 4 receptor subunits and ethanol: a knockout punch? Alcohol Clin Exp Res. 2008 Jan; 32(1):8-9. PMID: 18070251.
      View in: PubMed
    62. Mulholland PJ, Luong NT, Woodward JJ, Chandler LJ. Brain-derived neurotrophic factor activation of extracellular signal-regulated kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular signal-regulated kinase shutoff pathway. Neuroscience. 2008 Jan 24; 151(2):419-27. PMID: 18055129.
      View in: PubMed
    63. Smothers CT, Woodward JJ. Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits. J Pharmacol Exp Ther. 2007 Aug; 322(2):739-48. PMID: 17502428.
      View in: PubMed
    64. Tu Y, Kroener S, Abernathy K, Lapish C, Seamans J, Chandler LJ, Woodward JJ. Ethanol inhibits persistent activity in prefrontal cortical neurons. J Neurosci. 2007 Apr 25; 27(17):4765-75. PMID: 17460089.
      View in: PubMed
    65. Ogata J, Shiraishi M, Namba T, Smothers CT, Woodward JJ, Harris RA. Effects of anesthetics on mutant N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther. 2006 Jul; 318(1):434-43. PMID: 16622040.
      View in: PubMed
    66. Del Re AM, Dopico AM, Woodward JJ. Effects of the abused inhalant toluene on ethanol-sensitive potassium channels expressed in oocytes. Brain Res. 2006 May 04; 1087(1):75-82. PMID: 16626657.
      View in: PubMed
    67. Das A, Garner DP, Del Re AM, Woodward JJ, Kumar DM, Agarwal N, Banik NL, Ray SK. Calpeptin provides functional neuroprotection to rat retinal ganglion cells following Ca2+ influx. Brain Res. 2006 Apr 21; 1084(1):146-57. PMID: 16600192.
      View in: PubMed
    68. Jin C, Woodward JJ. Effects of 8 different NR1 splice variants on the ethanol inhibition of recombinant NMDA receptors. Alcohol Clin Exp Res. 2006 Apr; 30(4):673-9. PMID: 16573586.
      View in: PubMed
    69. Xu M, Woodward JJ. Ethanol inhibition of NMDA receptors under conditions of altered protein kinase A activity. J Neurochem. 2006 Mar; 96(6):1760-7. PMID: 16539691.
      View in: PubMed
    70. Smothers CT, Woodward JJ. Effects of amino acid substitutions in transmembrane domains of the NR1 subunit on the ethanol inhibition of recombinant N-methyl-D-aspartate receptors. Alcohol Clin Exp Res. 2006 Mar; 30(3):523-30. PMID: 16499494.
      View in: PubMed
    71. Woodward JJ, Ron D, Winder D, Roberto M. From blue states to up states: a regional view of NMDA-ethanol interactions. Alcohol Clin Exp Res. 2006 Feb; 30(2):359-67. PMID: 16441285.
      View in: PubMed
    72. Davies DL, Asatryan L, Kuo ST, Woodward JJ, King BF, Alkana RL, Xiao C, Ye JH, Sun H, Zhang L, Hu XQ, Hayrapetyan V, Lovinger DM, Machu TK. Effects of ethanol on adenosine 5'-triphosphate-gated purinergic and 5-hydroxytryptamine receptors. Alcohol Clin Exp Res. 2006 Feb; 30(2):349-58. PMID: 16441284.
      View in: PubMed
    73. Shafer TJ, Bushnell PJ, Benignus VA, Woodward JJ. Perturbation of voltage-sensitive Ca2+ channel function by volatile organic solvents. J Pharmacol Exp Ther. 2005 Dec; 315(3):1109-18. PMID: 16109744.
      View in: PubMed
    74. Das A, Sribnick EA, Wingrave JM, Del Re AM, Woodward JJ, Appel SH, Banik NL, Ray SK. Calpain activation in apoptosis of ventral spinal cord 4.1 (VSC4.1) motoneurons exposed to glutamate: calpain inhibition provides functional neuroprotection. J Neurosci Res. 2005 Aug 15; 81(4):551-62. PMID: 15968645.
      View in: PubMed
    75. Davies DL, Kochegarov AA, Kuo ST, Kulkarni AA, Woodward JJ, King BF, Alkana RL. Ethanol differentially affects ATP-gated P2X(3) and P2X(4) receptor subtypes expressed in Xenopus oocytes. Neuropharmacology. 2005 Aug; 49(2):243-53. PMID: 15993446.
      View in: PubMed
    76. Bale AS, Tu Y, Carpenter-Hyland EP, Chandler LJ, Woodward JJ. Alterations in glutamatergic and gabaergic ion channel activity in hippocampal neurons following exposure to the abused inhalant toluene. Neuroscience. 2005; 130(1):197-206. PMID: 15561435.
      View in: PubMed
    77. Del Re AM, Woodward JJ. Inhibition of gap junction currents by the abused solvent toluene. Drug Alcohol Depend. 2005 May 09; 78(2):221-4. PMID: 15845326.
      View in: PubMed
    78. Woodward JJ. Fyn kinase does not reduce ethanol inhibition of zinc-insensitive NR2A-containing N-methyl-D-aspartate receptors. Alcohol. 2004 Oct-Nov; 34(2-3):101-5. PMID: 15902902.
      View in: PubMed
    79. Carpenter-Hyland EP, Woodward JJ, Chandler LJ. Chronic ethanol induces synaptic but not extrasynaptic targeting of NMDA receptors. J Neurosci. 2004 Sep 08; 24(36):7859-68. PMID: 15356198.
      View in: PubMed
    80. Woodward JJ, Nowak M, Davies DL. Effects of the abused solvent toluene on recombinant P2X receptors expressed in HEK293 cells. Brain Res Mol Brain Res. 2004 Jun 18; 125(1-2):86-95. PMID: 15193425.
      View in: PubMed
    81. Smothers CT, Woodward JJ. Effect of the NR3 subunit on ethanol inhibition of recombinant NMDA receptors. Brain Res. 2003 Oct 10; 987(1):117-21. PMID: 14499953.
      View in: PubMed
    82. Woodward JJ, Smothers C. Ethanol inhibition of recombinant NR1/2A receptors: effects of heavy metal chelators and a zinc-insensitive NR2A mutant. Alcohol. 2003 Aug-Oct; 31(1-2):71-6. PMID: 14615013.
      View in: PubMed
    83. Tillar R, Shafer TJ, Woodward JJ. Toluene inhibits voltage-sensitive calcium channels expressed in pheochromocytoma cells. Neurochem Int. 2002 Dec; 41(6):391-7. PMID: 12213226.
      View in: PubMed
    84. Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S, Barron A, Brooks K, Buckee CO, Burrows C, Cherevach I, Chillingworth C, Chillingworth T, Christodoulou Z, Clark L, Clark R, Corton C, Cronin A, Davies R, Davis P, Dear P, Dearden F, Doggett J, Feltwell T, Goble A, Goodhead I, Gwilliam R, Hamlin N, Hance Z, Harper D, Hauser H, Hornsby T, Holroyd S, Horrocks P, Humphray S, Jagels K, James KD, Johnson D, Kerhornou A, Knights A, Konfortov B, Kyes S, Larke N, Lawson D, Lennard N, Line A, Maddison M, McLean J, Mooney P, Moule S, Murphy L, Oliver K, Ormond D, Price C, Quail MA, Rabbinowitsch E, Rajandream MA, Rutter S, Rutherford KM, Sanders M, Simmonds M, Seeger K, Sharp S, Smith R, Squares R, Squares S, Stevens K, Taylor K, Tivey A, Unwin L, Whitehead S, Woodward J, Sulston JE, Craig A, Newbold C, Barrell BG. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature. 2002 Oct 03; 419(6906):527-31. PMID: 12368867.
      View in: PubMed
    85. Bale AS, Smothers CT, Woodward JJ. Inhibition of neuronal nicotinic acetylcholine receptors by the abused solvent, toluene. Br J Pharmacol. 2002 Oct; 137(3):375-83. PMID: 12237258.
      View in: PubMed
    86. Khaldi A, Chiueh CC, Bullock MR, Woodward JJ. The significance of nitric oxide production in the brain after injury. Ann N Y Acad Sci. 2002 May; 962:53-9. PMID: 12076962.
      View in: PubMed
    87. Chu DM, Woodward J, Fritzinger A, Marciano-Cabral F. Calcium-dependent protection from complement lysis in Naegleria fowleri amebae. Cell Calcium. 2002 Mar; 31(3):105-14. PMID: 12027384.
      View in: PubMed
    88. Woodward JJ. Prostacyclin-induced rundown of N-methyl-D-aspartate receptor currents in HEK293 cells is protein kinase A-dependent and NR2 subunit-selective. J Neurochem. 2002 Feb; 80(4):598-604. PMID: 11841567.
      View in: PubMed
    89. Ronald KM, Mirshahi T, Woodward JJ. Ethanol inhibition of N-methyl-D-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue. J Biol Chem. 2001 Nov 30; 276(48):44729-35. PMID: 11572853.
      View in: PubMed
    90. Khaldi A, Zauner A, Reinert M, Woodward JJ, Bullock MR. Measurement of nitric oxide and brain tissue oxygen tension in patients after severe subarachnoid hemorrhage. Neurosurgery. 2001 Jul; 49(1):33-8; discussion 38-40. PMID: 11440457.
      View in: PubMed
    91. Smothers CT, Clayton R, Blevins T, Woodward JJ. Ethanol sensitivity of recombinant human N-methyl-D-aspartate receptors. Neurochem Int. 2001 Apr; 38(4):333-40. PMID: 11137628.
      View in: PubMed
    92. Sun H, Subbotin V, Woodward J, Valdivia L, Fung JJ, Rao AS. Role of MHC class I and CD8(+) T cells in the pathogenesis of chronic rejection. Transplant Proc. 2001 Feb-Mar; 33(1-2):319. PMID: 11266839.
      View in: PubMed
    93. Cruz SL, Balster RL, Woodward JJ. Effects of volatile solvents on recombinant N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Br J Pharmacol. 2000 Dec; 131(7):1303-8. PMID: 11090101.
      View in: PubMed
    94. Spector M, Nguyen VA, Sheng X, He L, Woodward J, Fan S, Baumgarten CM, Kunos G, Dent P, Gao B. Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells. Exp Cell Res. 2000 Jul 10; 258(1):109-20. PMID: 10912793.
      View in: PubMed
    95. Anders DL, Blevins T, Smothers CT, Woodward JJ. Reduced ethanol inhibition of N-methyl-D-aspartate receptors by deletion of the NR1 C0 domain or overexpression of alpha-actinin-2 proteins. J Biol Chem. 2000 May 19; 275(20):15019-24. PMID: 10809744.
      View in: PubMed
    96. Clayton R, Woodward JJ. Effects of ethanol on three endogenous membrane conductances present in Xenopus laevis oocytes. Neurochem Int. 2000 Jan; 36(1):67-74. PMID: 10566960.
      View in: PubMed
    97. Woodward JJ. Ethanol and NMDA receptor signaling. Crit Rev Neurobiol. 2000; 14(1):69-89. PMID: 11253956.
      View in: PubMed
    98. Woodward JJ. Overview of the effects of alcohol on the cerebral nervous system. Neurochem Int. 1999 Aug; 35(2):93-4. PMID: 10405991.
      View in: PubMed
    99. Woodward JJ. Ionotropic glutamate receptors as sites of action for ethanol in the brain. Neurochem Int. 1999 Aug; 35(2):107-13. PMID: 10405994.
      View in: PubMed
    100. Anders DL, Blevins T, Sutton G, Swope S, Chandler LJ, Woodward JJ. Fyn tyrosine kinase reduces the ethanol inhibition of recombinant NR1/NR2A but not NR1/NR2B NMDA receptors expressed in HEK 293 cells. J Neurochem. 1999 Apr; 72(4):1389-93. PMID: 10098840.
      View in: PubMed
    101. Anders DL, Blevins T, Sutton G, Chandler LJ, Woodward JJ. Effects of c-Src tyrosine kinase on ethanol sensitivity of recombinant NMDA receptors expressed in HEK 293 cells. Alcohol Clin Exp Res. 1999 Feb; 23(2):357-62. PMID: 10069568.
      View in: PubMed
    102. Alessandri B, Doppenberg E, Zauner A, Woodward J, Choi S, Bullock R. Evidence for time-dependent glutamate-mediated glycolysis in head-injured patients: a microdialysis study. Acta Neurochir Suppl. 1999; 75:25-8. PMID: 10635372.
      View in: PubMed
    103. Alessandri B, Doppenberg E, Bullock R, Woodward J, Choi S, Koura S, Young HF. Glucose and lactate metabolism after severe human head injury: influence of excitatory neurotransmitters and injury type. Acta Neurochir Suppl. 1999; 75:21-4. PMID: 10635371.
      View in: PubMed
    104. Bullock R, Zauner A, Woodward JJ, Myseros J, Choi SC, Ward JD, Marmarou A, Young HF. Factors affecting excitatory amino acid release following severe human head injury. J Neurosurg. 1998 Oct; 89(4):507-18. PMID: 9761042.
      View in: PubMed
    105. Mirshahi T, Anders DL, Ronald KM, Woodward JJ. Intracellular calcium enhances the ethanol sensitivity of NMDA receptors through an interaction with the C0 domain of the NR1 subunit. J Neurochem. 1998 Sep; 71(3):1095-107. PMID: 9721734.
      View in: PubMed
    106. Cruz SL, Mirshahi T, Thomas B, Balster RL, Woodward JJ. Effects of the abused solvent toluene on recombinant N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther. 1998 Jul; 286(1):334-40. PMID: 9655877.
      View in: PubMed
    107. Doppenberg EM, Rice MR, Di X, Young HF, Woodward JJ, Bullock R. Increased free radical production due to subdural hematoma in the rat: effect of increased inspired oxygen fraction. J Neurotrauma. 1998 May; 15(5):337-47. PMID: 9605348.
      View in: PubMed
    108. Blevins T, Mirshahi T, Chandler LJ, Woodward JJ. Effects of acute and chronic ethanol exposure on heteromeric N-methyl-D-aspartate receptors expressed in HEK 293 cells. J Neurochem. 1997 Dec; 69(6):2345-54. PMID: 9375665.
      View in: PubMed
    109. Zauner A, Doppenberg EM, Woodward JJ, Choi SC, Young HF, Bullock R. Continuous monitoring of cerebral substrate delivery and clearance: initial experience in 24 patients with severe acute brain injuries. Neurosurgery. 1997 Nov; 41(5):1082-91; discussion 1091-3. PMID: 9361062.
      View in: PubMed
    110. Zauner A, Doppenberg E, Woodward JJ, Allen C, Jebraili S, Young HF, Bullock R. Multiparametric continuous monitoring of brain metabolism and substrate delivery in neurosurgical patients. Neurol Res. 1997 Jun; 19(3):265-73. PMID: 9192379.
      View in: PubMed
    111. Grasing K, Bills D, Ghosh S, Schlussman SD, Patel AH, Woodward JJ. Opiate modulation of striatal dopamine and hippocampal norepinephrine release following morphine withdrawal. Neurochem Res. 1997 Mar; 22(3):239-48. PMID: 9051656.
      View in: PubMed
    112. Moore KA, Mirshahi T, Compton DR, Poklis A, Woodward JJ. Pharmacological characterization of BNMPA (alpha-benzyl-N-methylphenethylamine), an impurity of illicit methamphetamine synthesis. Eur J Pharmacol. 1996 Sep 12; 311(2-3):133-9. PMID: 8891593.
      View in: PubMed
    113. Tsuchida E, Harms JF, Woodward JJ, Bullock R. A use-dependent sodium channel antagonist, 619C89, in reduction of ischemic brain damage and glutamate release after acute subdural hematoma in the rat. J Neurosurg. 1996 Jul; 85(1):104-11. PMID: 8683258.
      View in: PubMed
    114. Zauner A, Bullock R, Kuta AJ, Woodward J, Young HF. Glutamate release and cerebral blood flow after severe human head injury. Acta Neurochir Suppl. 1996; 67:40-4. PMID: 8870800.
      View in: PubMed
    115. Blevins T, Mirshahi T, Woodward JJ. Increased agonist and antagonist sensitivity of N-methyl-D-aspartate stimulated calcium flux in cultured neurons following chronic ethanol exposure. Neurosci Lett. 1995 Nov 24; 200(3):214-8. PMID: 9064615.
      View in: PubMed
    116. Bullock R, Zauner A, Woodward J, Young HF. Massive persistent release of excitatory amino acids following human occlusive stroke. Stroke. 1995 Nov; 26(11):2187-9. PMID: 7482671.
      View in: PubMed
    117. Bullock R, Zauner A, Myseros JS, Marmarou A, Woodward JJ, Young HF. Evidence for prolonged release of excitatory amino acids in severe human head trauma. Relationship to clinical events. Ann N Y Acad Sci. 1995 Sep 15; 765:290-7; discussion 298. PMID: 7486616.
      View in: PubMed
    118. Stout AK, Woodward JJ. Mechanism for nitric oxide's enhancement of NMDA-stimulated [3H]norepinephrine release from rat hippocampal slices. Neuropharmacology. 1995 Jul; 34(7):723-9. PMID: 8532139.
      View in: PubMed
    119. Lin J, Yon RW, Chavin KD, Qin L, Woodward J, Ding Y, Yagita H, Bromberg JS. Anti-CD2 monoclonal antibody-induced receptor changes: down modulation of cell surface CD2. Transplantation. 1995 Apr 27; 59(8):1162-71. PMID: 7537394.
      View in: PubMed
    120. Woodward JJ, Compton DM, Balster RL, Martin BR. In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter. Eur J Pharmacol. 1995 Apr 13; 277(1):7-13. PMID: 7635175.
      View in: PubMed
    121. Mirshahi T, Woodward JJ. Ethanol sensitivity of heteromeric NMDA receptors: effects of subunit assembly, glycine and NMDAR1 Mg(2+)-insensitive mutants. Neuropharmacology. 1995 Mar; 34(3):347-55. PMID: 7630488.
      View in: PubMed
    122. Baliga P, Chavin KD, Qin L, Woodward J, Lin J, Linsley PS, Bromberg JS. CTLA4Ig prolongs allograft survival while suppressing cell-mediated immunity. Transplantation. 1994 Nov 27; 58(10):1082-90. PMID: 7526493.
      View in: PubMed
    123. Stout AK, Woodward JJ. Differential effects of nitric oxide gas and nitric oxide donors on depolarization-induced release of [3H]norepinephrine from rat hippocampal slices. Neuropharmacology. 1994 Nov; 33(11):1367-74. PMID: 7532819.
      View in: PubMed
    124. Chavin KD, Qin L, Lin J, Woodward J, Baliga P, Kato K, Yagita H, Bromberg JS. Anti-CD48 (murine CD2 ligand) mAbs suppress cell mediated immunity in vivo. Int Immunol. 1994 May; 6(5):701-9. PMID: 7521667.
      View in: PubMed
    125. Woodward JJ. The effects of thiol reduction and oxidation on the inhibition of NMDA-stimulated neurotransmitter release by ethanol. Neuropharmacology. 1994 May; 33(5):635-40. PMID: 7936098.
      View in: PubMed
    126. Woodward JJ. A comparison of the effects of ethanol and the competitive glycine antagonist 7-chlorokynurenic acid on N-methyl-D-aspartic acid-induced neurotransmitter release from rat hippocampal slices. J Neurochem. 1994 Mar; 62(3):987-91. PMID: 7906723.
      View in: PubMed
    127. Mandel RJ, Hartgraves SL, Severson JA, Woodward JJ, Wilcox RE, Randall PK. A quantitative estimate of the role of striatal D-2 receptor proliferation in dopaminergic behavioral supersensitivity: the contribution of mesolimbic dopamine to the magnitude of 6-OHDA lesion-induced agonist sensitivity in the rat. Behav Brain Res. 1993 Dec 31; 59(1-2):53-64. PMID: 8155293.
      View in: PubMed
    128. Woodward JJ, Cueto S. Effects of the putative polyamine antagonists diethylenetriamine and 1,10-diaminodecane on N-methyl-D-aspartic acid-stimulated [3H]norepinephrine release from rat hippocampal slices. J Pharmacol Exp Ther. 1993 Aug; 266(2):563-9. PMID: 8355191.
      View in: PubMed
    129. Woodward JJ, Harms J. Potentiation of N-methyl-D-aspartate-stimulated dopamine release from rat brain slices by aluminum fluoride and carbachol. J Neurochem. 1992 Apr; 58(4):1547-54. PMID: 1532197.
      View in: PubMed
    130. Woodward JJ, Harms J. The putative polyamine antagonists ifenprodil and SL 82.0715 enhance dopamine efflux from rat striatal slices independent of NMDA receptor activation. Eur J Pharmacol. 1992 Jan 21; 210(3):265-70. PMID: 1351843.
      View in: PubMed
    131. Woodward JJ, Blair R. Redox modulation of N-methyl-D-aspartate-stimulated neurotransmitter release from rat brain slices. J Neurochem. 1991 Dec; 57(6):2059-64. PMID: 1682419.
      View in: PubMed
    132. Woodward JJ, Mansbach R, Carroll FI, Balster RL. Cocaethylene inhibits dopamine uptake and produces cocaine-like actions in drug discrimination studies. Eur J Pharmacol. 1991 May 17; 197(2-3):235-6. PMID: 1915572.
      View in: PubMed
    133. Woodward JJ, Brown L, Gonzales RA. Modulation of ethanol-induced inhibition of N-methyl-D-aspartate-stimulated neurotransmitter release by glycine. Alcohol Alcohol Suppl. 1991; 1:177-80. PMID: 1845534.
      View in: PubMed
    134. Wilcox RE, Severson JA, Woodward JJ, Randall PK, Vaughn DM, Riffee WH. Behavioral sensitization following a single apomorphine pretreatment--selective effects on the dopamine release process. Brain Res. 1990 Sep 24; 528(1):109-13. PMID: 2147118.
      View in: PubMed
    135. Vaughn DM, Severson JA, Woodward JJ, Randall PK, Riffee WH, Leslie SW, Wilcox RE. Behavioral sensitization following subchronic apomorphine treatment--possible neurochemical basis. Brain Res. 1990 Aug 27; 526(1):37-44. PMID: 2150341.
      View in: PubMed
    136. Woodward JJ, Machu T, Leslie SW. Chronic ethanol treatment alters omega-conotoxin and Bay K 8644 sensitive calcium channels in rat striatal synaptosomes. Alcohol. 1990 Jul-Aug; 7(4):279-84. PMID: 1697172.
      View in: PubMed
    137. Gonzales RA, Woodward JJ. Ethanol inhibits N-methyl-D-aspartate-stimulated [3H]norepinephrine release from rat cortical slices. J Pharmacol Exp Ther. 1990 Jun; 253(3):1138-44. PMID: 2162947.
      View in: PubMed
    138. Woodward JJ, Gonzales RA. Ethanol inhibition of N-methyl-D-aspartate-stimulated endogenous dopamine release from rat striatal slices: reversal by glycine. J Neurochem. 1990 Feb; 54(2):712-5. PMID: 2405104.
      View in: PubMed
    139. Machu T, Woodward JJ, Leslie SW. Ethanol and inositol 1,4,5-trisphosphate mobilize calcium from rat brain microsomes. Alcohol. 1989 Nov-Dec; 6(6):431-6. PMID: 2597345.
      View in: PubMed
    140. Rezazadeh SM, Woodward JJ, Leslie SW. Fura-2 measurement of cytosolic free calcium in rat brain cortical synaptosomes and the influence of ethanol. Alcohol. 1989 Sep-Oct; 6(5):341-5. PMID: 2818835.
      View in: PubMed
    141. Woodward JJ, Leslie SW, Severson JA, Wilcox RE. Aging does not alter the voltage-dependent release of endogenous dopamine from mouse striatal synaptosomes. Neurosci Lett. 1989 Feb 13; 97(1-2):191-7. PMID: 2919003.
      View in: PubMed
    142. Woodward JJ, Rezazadeh SM, Leslie SW. Differential sensitivity of synaptosomal calcium entry and endogenous dopamine release to omega-conotoxin. Brain Res. 1988 Dec 13; 475(1):141-5. PMID: 3214720.
      View in: PubMed
    143. Woodward JJ, Chandler LJ, Leslie SW. Calcium-dependent and -independent release of endogenous dopamine from rat striatal synaptosomes. Brain Res. 1988 Nov 08; 473(1):91-8. PMID: 3208129.
      View in: PubMed
    144. Woodward JJ, Cook ME, Leslie SW. Characterization of dihydropyridine-sensitive calcium channels in rat brain synaptosomes. Proc Natl Acad Sci U S A. 1988 Oct; 85(19):7389-93. PMID: 2459704.
      View in: PubMed
    145. Giulian D, Woodward J, Young DG, Krebs JF, Lachman LB. Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization. J Neurosci. 1988 Jul; 8(7):2485-90. PMID: 2470873.
      View in: PubMed
    146. Woodward JJ, Wilcox RE, Leslie SW, Riffee WH. Dopamine uptake during fast-phase endogenous dopamine release from mouse striatal synaptosomes. Neurosci Lett. 1986 Oct 30; 71(1):106-12. PMID: 3785732.
      View in: PubMed
    147. Severson JA, Woodward JJ, Wilcox RE. Subdivision of mouse brain [3H]imipramine binding based on ion dependence and serotonin sensitivity. J Neurochem. 1986 Jun; 46(6):1743-54. PMID: 3701330.
      View in: PubMed
    148. Woodward JJ, Leslie SW. Bay K 8644 stimulation of calcium entry and endogenous dopamine release in rat striatal synaptosomes antagonized by nimodipine. Brain Res. 1986 Apr 09; 370(2):397-400. PMID: 2423182.
      View in: PubMed
    149. Leslie SW, Woodward JJ, Wilcox RE, Farrar RP. Chronic ethanol treatment uncouples striatal calcium entry and endogenous dopamine release. Brain Res. 1986 Mar 12; 368(1):174-7. PMID: 3955358.
      View in: PubMed
    150. Leslie SW, Woodward JJ, Wilcox RE. Correlation of rates of calcium entry and endogenous dopamine release in mouse striatal synaptosomes. Brain Res. 1985 Jan 28; 325(1-2):99-105. PMID: 2983836.
      View in: PubMed
    151. Casillas E, Smith LS, Woodward JJ, D'Aoust BG. Hematologic response of fish to changes in gas or hydrostatic pressure. Am J Physiol. 1980 Jul; 239(1):R161-7. PMID: 7396032.
      View in: PubMed
    Woodward's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _