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John J. Lemasters

Title
InstitutionMedical University of South Carolina
DepartmentCOP Drug Discovery and Biomedical Sciences - MUSC Campus
AddressP.O. Box MSC139
DD504
Drug Discovery Building - 70 President St.
Phone843-876-2360
Fax843-876-2353
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    Collapse Biography 
    Collapse awards and honors
    1969B.A., cum laude with Honors in Psychology, Yale University
    1970Achievement Rewards for College Scientists (ARCS) Foundation Scholarship, ARCS Foundation
    1970 - 1971Franklin Paine Mall Prize in Anatomy, Johns Hopkins University School of Medicine
    1982 - 1987Established Investigator of the American Heart Association, American Heart Association
    1987Visiting Professor, Division of Gastroenterology and Section of Transplantation Surgery, Mayo Graduate School of Medicine
    1998 - 2002Alcohol-Toxicology Study Section 4, National Institutes of Health
    2001 - 2006Associate Editor, Gastroenterology
    2003 - 2006Councillor-at-Large, American Association for the Study of Liver Diseases
    2006GlaxoSmithKline South Carolina Center of Economic Excellence Distinguished Endowed Chair in Advanced, Medical University of South Carolina
    2007Association of American Physicians
    2009Thurman Lectureship Award, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
    2009 - 2013Hepatobiliary Pathophysiology (HBPP) Study Section, National Institutes of Health
    2012Established Researcher of the Year Award,, South Carolina College of Pharmacy
    2013Distinguished Toxicology Scholar Award, Society of Toxicology
    2013Distinguished Toxicology Scholar Award, Society of Toxicology
    2014Inaugural Fellow, American Association for the Study of Liver Diseases

    Collapse Overview 
    Collapse overview
    I have a long-standing interest in hepatic ischemia-reperfusion (IR) injury, especially as it relates to organ preservation for transplantation. I and my colleagues were the first to show a prominent role for nonparenchymal cells in IR injury to cold-stored livers. Specifically, we showed that reperfusion after cold ischemic storage leads to killing of sinusoidal endothelial cells and activation of Kupffer cells. We were also pioneers in showing that onset of the mitochondrial permeability transition (MPT) then developed in hepatic parenchymal cells, leading to hepatic apoptosis, necrosis and graft failure, and we developed a variety of stratagems to ameliorate these injuries that are beginning to find clinical application. Overall, my laboratory has published over 350 papers in peer-reviewed journals plus more than 100 book chapters. Productive, long-term collaborations with both junior and senior colleagues contributed importantly to this success.

    My research interests continue to relate to mitochondrial and cellular bioenergetics, including studies of oxidative phosphorylation in isolated mitochondria, mitochondrial dysfunction in toxic, and hypoxic and reperfusion injury to liver and heart cells, and graft failure from preservation injury to livers stored for transplantation surgery. Our in vitro and in vivo studies of living cells and tissues have shown that mitochondrial calcium uptake, iron translocation from lysosomes to mitochondria, and oxidative stress promote the MPT. The MPT initially induces lysosomal degradation of mitochondria by autophagy, a selective process called mitophagy. However, excess MPT induction induces both necrotic cell death from ATP depletion and apoptosis due to cytochrome c release after mitochondrial swelling. For these projects, my laboratory extensively applies new techniques of quantitative laser scanning confocal and intravital multiphoton microscopy for physiological analysis of single cells and living organs. The lab also extensively employs Seahorse technology to measure respiration and glycolytic flux in cultured cells. Current projects are examining how iron mobilization from lysosomes to cytosol and then to mitochondria during cold ischemic liver storage sensitizes hepatocytes and nonparenchymal cells to adverse events after reperfusion, leading ultimately to injury and failure of liver grafts.

    Despite a detailed understanding of their metabolism, mitochondria often behave anomalously. In particular, global suppression of mitochondrial metabolism and metabolite exchange occurs in apoptosis, ischemia/hypoxia, alcoholic liver disease and aerobic glycolysis in cancer cells (Warburg effect). My lab is also examining and supporting the novel hypothesis that closure of voltage-dependent anion channels (VDAC) in the mitochondrial outer membrane accounts for global mitochondrial suppression consistent with a role for VDAC as a dynamic regulator, or governator, of global mitochondrial function both in health and disease. In cancer cells, we showed that free tubulin causes closure of VDAC.

    Collapse keywords
    mitochondrial and cellular bioenergetics, Mitochondrial physiology and pathophysiology, Cellular and molecular mechanisms of apoptosis and necrosis, Confocal and multiphoton microscopy

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jing R, Corbett JL, Cai J, Beeson GC, Beeson CC, Chan SS, Dimmock DP, Lazcares L, Geurts AM, Lemasters JJ, Duncan SA. A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for mtDNA Depletion Syndrome. Cell Rep. 2018 Nov 06; 25(6):1469-1484.e5. PMID: 30404003.
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    2. Lemasters JJ, Zhong Z. Mitophagy in hepatocytes: Types, initiators and role in adaptive ethanol metabolism?. Liver Res. 2018 Sep; 2(3):125-132. PMID: 31157120.
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    3. Zhong Z, Lemasters JJ. A Unifying Hypothesis Linking Hepatic Adaptations for Ethanol Metabolism to the Proinflammatory and Profibrotic Events of Alcoholic Liver Disease. Alcohol Clin Exp Res. 2018 Nov; 42(11):2072-2089. PMID: 30132924.
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    4. Mironova GD, Khrenov MO, Talanov EY, Glushkova OV, Parfenyuk SB, Novoselova TV, Lunin SM, Belosludtseva NV, Novoselova EG, Lemasters JJ. The role of mitochondrial KATP channel in anti-inflammatory effects of uridine in endotoxemic mice. Arch Biochem Biophys. 2018 09 15; 654:70-76. PMID: 30009781.
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    5. Liu Q, Rehman H, Krishnasamy Y, Lemasters JJ, Zhong Z. Ischemic preconditioning attenuates acute lung injury after partial liver transplantation. Int J Physiol Pathophysiol Pharmacol. 2018; 10(2):83-94. PMID: 29755641.
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    6. Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 03; 25(3):486-541. PMID: 29362479.
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    7. Ramshesh VK, Lemasters JJ. Imaging of Mitochondrial pH Using SNARF-1. Methods Mol Biol. 2018; 1782:351-356. PMID: 29851011.
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    8. DeHart DN, Fang D, Heslop K, Li L, Lemasters JJ, Maldonado EN. Opening of voltage dependent anion channels promotes reactive oxygen species generation, mitochondrial dysfunction and cell death in cancer cells. Biochem Pharmacol. 2018 02; 148:155-162. PMID: 29289511.
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    9. Novgorodov SA, Voltin JR, Gooz MA, Li L, Lemasters JJ, Gudz TI. Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis. J Lipid Res. 2018 02; 59(2):312-329. PMID: 29282302.
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    10. Shoshan-Barmatz V, Kmita H, Lemasters JJ. Editorial: Uncovering the Function of the Mitochondrial Protein VDAC in Health and Disease: From Structure-Function to Novel Therapeutic Strategies. Front Oncol. 2017; 7:320. PMID: 29312890.
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    11. Lemasters JJ. Evolution of Voltage-Dependent Anion Channel Function: From Molecular Sieve to Governator to Actuator of Ferroptosis. Front Oncol. 2017; 7:303. PMID: 29312883.
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    12. Herr DJ, Baarine M, Aune SE, Li X, Ball LE, Lemasters JJ, Beeson CC, Chou JC, Menick DR. HDAC1 localizes to the mitochondria of cardiac myocytes and contributes to early cardiac reperfusion injury. J Mol Cell Cardiol. 2018 01; 114:309-319. PMID: 29224834.
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    13. Maldonado EN, DeHart DN, Patnaik J, Klatt SC, Gooz MB, Lemasters JJ. ATP/ADP turnover and import of glycolytic ATP into mitochondria in cancer cells is independent of the adenine nucleotide translocator. J Biol Chem. 2017 10 13; 292(41):16969. PMID: 29030537.
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    14. DeHart DN, Lemasters JJ, Maldonado EN. Erastin-Like Anti-Warburg Agents Prevent Mitochondrial Depolarization Induced by Free Tubulin and Decrease Lactate Formation in Cancer Cells. SLAS Discov. 2018 01; 23(1):23-33. PMID: 29024608.
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    15. Liu Q, Rehman H, Krishnasamy Y, Lemasters JJ, Zhong Z. 8-pCPT-cGMP prevents mitochondrial depolarization and improves the outcome of steatotic partial liver transplantation. Int J Physiol Pathophysiol Pharmacol. 2017; 9(3):69-83. PMID: 28694919.
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    16. Teplova VV, Kruglov AG, Kovalyov LI, Nikiforova AB, Fedotcheva NI, Lemasters JJ. Glutamate contributes to alcohol hepatotoxicity by enhancing oxidative stress in mitochondria. J Bioenerg Biomembr. 2017 Jun; 49(3):253-264. PMID: 28478591.
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    17. Lemasters JJ, Ramshesh VK, Lovelace GL, Lim J, Wright GD, Harland D, Dawson TL. Compartmentation of Mitochondrial and Oxidative Metabolism in Growing Hair Follicles: A Ring of Fire. J Invest Dermatol. 2017 07; 137(7):1434-1444. PMID: 28344061.
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    18. Azarashvili T, Krestinina O, Baburina Y, Odinokova I, Akatov V, Beletsky I, Lemasters J, Papadopoulos V. Effect of the CRAC Peptide, VLNYYVW, on mPTP Opening in Rat Brain and Liver Mitochondria. Int J Mol Sci. 2016 Dec 13; 17(12). PMID: 27983605.
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    19. Baburina Y, Odinokova I, Azarashvili T, Akatov V, Lemasters JJ, Krestinina O. 2',3'-Cyclic nucleotide 3'-phosphodiesterase as a messenger of protection of the mitochondrial function during melatonin treatment in aging. Biochim Biophys Acta Biomembr. 2017 Jan; 1859(1):94-103. PMID: 27836641.
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    20. Krishnasamy Y, Ramshesh VK, Gooz M, Schnellmann RG, Lemasters JJ, Zhong Z. Ethanol and High Cholesterol Diet Causes Severe Steatohepatitis and Early Liver Fibrosis in Mice. PLoS One. 2016; 11(9):e0163342. PMID: 27676640.
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    21. Maldonado EN, DeHart DN, Patnaik J, Klatt SC, Gooz MB, Lemasters JJ. ATP/ADP Turnover and Import of Glycolytic ATP into Mitochondria in Cancer Cells Is Independent of the Adenine Nucleotide Translocator. J Biol Chem. 2016 09 09; 291(37):19642-50. PMID: 27458020.
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    22. Hu J, Kholmukhamedov A, Lindsey CC, Beeson CC, Jaeschke H, Lemasters JJ. Translocation of iron from lysosomes to mitochondria during acetaminophen-induced hepatocellular injury: Protection by starch-desferal and minocycline. Free Radic Biol Med. 2016 08; 97:418-426. PMID: 27345134.
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    23. Rehman H, Liu Q, Krishnasamy Y, Shi Z, Ramshesh VK, Haque K, Schnellmann RG, Murphy MP, Lemasters JJ, Rockey DC, Zhong Z. The mitochondria-targeted antioxidant MitoQ attenuates liver fibrosis in mice. Int J Physiol Pathophysiol Pharmacol. 2016; 8(1):14-27. PMID: 27186319.
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    24. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
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    25. Hu J, Ramshesh VK, McGill MR, Jaeschke H, Lemasters JJ. Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver. Toxicol Sci. 2016 Mar; 150(1):204-15. PMID: 26721299.
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    26. Azarashvili T, Krestinina O, Baburina Y, Odinokova I, Grachev D, Papadopoulos V, Akatov V, Lemasters JJ, Reiser G. Combined effect of G3139 and TSPO ligands on Ca(2+)-induced permeability transition in rat brain mitochondria. Arch Biochem Biophys. 2015 Dec 01; 587:70-7. PMID: 26498031.
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    27. Liu Q, Krishnasamy Y, Rehman H, Lemasters JJ, Schnellmann RG, Zhong Z. Disrupted Renal Mitochondrial Homeostasis after Liver Transplantation in Rats. PLoS One. 2015; 10(10):e0140906. PMID: 26480480.
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    28. Belosludtsev KN, Belosludtseva NV, Agafonov AV, Penkov NV, Samartsev VN, Lemasters JJ, Mironova GD. Effect of surface-potential modulators on the opening of lipid pores in liposomal and mitochondrial inner membranes induced by palmitate and calcium ions. Biochim Biophys Acta. 2015 Oct; 1848(10 Pt A):2200-5. PMID: 26014488.
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    29. Yuan H, Wang X, Hill K, Chen J, Lemasters J, Yang SM, Sha SH. Autophagy attenuates noise-induced hearing loss by reducing oxidative stress. Antioxid Redox Signal. 2015 May 20; 22(15):1308-24. PMID: 25694169.
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    30. Liu Q, Rehman H, Krishnasamy Y, Schnellmann RG, Lemasters JJ, Zhong Z. Improvement of liver injury and survival by JNK2 and iNOS deficiency in liver transplants from cardiac death mice. J Hepatol. 2015 Jul; 63(1):68-74. PMID: 25703084.
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    31. Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 2015 Jan; 22(1):58-73. PMID: 25236395.
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    32. Maldonado EN, Lemasters JJ. ATP/ADP ratio, the missed connection between mitochondria and the Warburg effect. Mitochondrion. 2014 Nov; 19 Pt A:78-84. PMID: 25229666.
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    33. Kholmukhamedov A, Czerny C, Hu J, Schwartz J, Zhong Z, Lemasters JJ. Minocycline and doxycycline, but not tetracycline, mitigate liver and kidney injury after hemorrhagic shock/resuscitation. Shock. 2014 Sep; 42(3):256-63. PMID: 24978888.
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    34. Qanungo S, Uys JD, Manevich Y, Distler AM, Shaner B, Hill EG, Mieyal JJ, Lemasters JJ, Townsend DM, Nieminen AL. N-acetyl-L-cysteine sensitizes pancreatic cancers to gemcitabine by targeting the NF?B pathway. Biomed Pharmacother. 2014 Sep; 68(7):855-64. PMID: 25257100.
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    35. Azarashvili T, Baburina Y, Grachev D, Krestinina O, Papadopoulos V, Lemasters JJ, Odinokova I, Reiser G. Carbenoxolone induces permeability transition pore opening in rat mitochondria via the translocator protein TSPO and connexin43. Arch Biochem Biophys. 2014 Sep 15; 558:87-94. PMID: 24995971.
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    36. Lemasters JJ. Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3). Redox Biol. 2014; 2:749-54. PMID: 25009776.
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    37. Beck Gooz M, Maldonado EN, Dang Y, Amria MY, Higashiyama S, Abboud HE, Lemasters JJ, Bell PD. ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease. Am J Physiol Renal Physiol. 2014 Sep 01; 307(5):F551-9. PMID: 24899059.
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    38. Zhong Z, Ramshesh VK, Rehman H, Liu Q, Theruvath TP, Krishnasamy Y, Lemasters JJ. Acute ethanol causes hepatic mitochondrial depolarization in mice: role of ethanol metabolism. PLoS One. 2014; 9(3):e91308. PMID: 24618581.
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    39. Kholmukhamedov A, Spinale FG, Mukherjee R, Lemasters JJ. Reply to "letter to the editor: 'cyclosporin A in left ventricular remodeling after myocardial infarction'". Am J Physiol Heart Circ Physiol. 2014 Mar 01; 306(5):H778-9. PMID: 24583826.
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    40. Kholmukhamedov A, Logdon C, Hu J, McKinney RA, Spinale FG, Lemasters JJ, Mukherjee R. Cyclosporin A in left ventricular remodeling after myocardial infarction. Am J Physiol Heart Circ Physiol. 2014 Jan 01; 306(1):H53-9. PMID: 24163074.
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    41. Schwartz J, Holmuhamedov E, Zhang X, Lovelace GL, Smith CD, Lemasters JJ. Minocycline and doxycycline, but not other tetracycline-derived compounds, protect liver cells from chemical hypoxia and ischemia/reperfusion injury by inhibition of the mitochondrial calcium uniporter. Toxicol Appl Pharmacol. 2013 Nov 15; 273(1):172-9. PMID: 24012766.
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    42. Rehman H, Krishnasamy Y, Haque K, Thurman RG, Lemasters JJ, Schnellmann RG, Zhong Z. Green tea polyphenols stimulate mitochondrial biogenesis and improve renal function after chronic cyclosporin a treatment in rats. PLoS One. 2014; 8(6):e65029. PMID: 23755172.
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    43. Kholmukhamedov A, Schwartz JM, Lemasters JJ. Isolated mitochondria infusion mitigates ischemia-reperfusion injury of the liver in rats: mitotracker probes and mitochondrial membrane potential. Shock. 2013 Jun; 39(6):543. PMID: 23680774.
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    44. Czaja MJ, Ding WX, Donohue TM, Friedman SL, Kim JS, Komatsu M, Lemasters JJ, Lemoine A, Lin JD, Ou JH, Perlmutter DH, Randall G, Ray RB, Tsung A, Yin XM. Functions of autophagy in normal and diseased liver. Autophagy. 2013 Aug; 9(8):1131-58. PMID: 23774882.
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    45. Zhang X, Lemasters JJ. Translocation of iron from lysosomes to mitochondria during ischemia predisposes to injury after reperfusion in rat hepatocytes. Free Radic Biol Med. 2013 Oct; 63:243-53. PMID: 23665427.
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    46. Maldonado EN, Sheldon KL, DeHart DN, Patnaik J, Manevich Y, Townsend DM, Bezrukov SM, Rostovtseva TK, Lemasters JJ. Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin. J Biol Chem. 2013 Apr 26; 288(17):11920-9. PMID: 23471966.
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    47. Schemmer P, Lemasters JJ, Clavien PA. Ischemia/Reperfusion injury in liver surgery and transplantation. HPB Surg. 2012; 2012:453295. PMID: 23345924.
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    48. He S, Rehman H, Shi Y, Krishnasamy Y, Lemasters JJ, Schnellmann RG, Zhong Z. Suramin decreases injury and improves regeneration of ethanol-induced steatotic partial liver grafts. J Pharmacol Exp Ther. 2013 Feb; 344(2):417-25. PMID: 23161217.
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    127. He L, Lemasters JJ. Dephosphorylation of the Rieske iron-sulfur protein after induction of the mitochondrial permeability transition. Biochem Biophys Res Commun. 2005 Sep 02; 334(3):829-37. PMID: 16023995.
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    128. Bustamante E, Pediaditakis P, He L, Lemasters JJ. Isolated mouse liver mitochondria are devoid of glucokinase. Biochem Biophys Res Commun. 2005 Sep 02; 334(3):907-10. PMID: 16036222.
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    129. Cover C, Mansouri A, Knight TR, Bajt ML, Lemasters JJ, Pessayre D, Jaeschke H. Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity. J Pharmacol Exp Ther. 2005 Nov; 315(2):879-87. PMID: 16081675.
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    130. Zhong Z, Connor HD, Froh M, Bunzendahl H, Lind H, Lehnert M, Mason RP, Thurman RG, Lemasters JJ. Free radical-dependent dysfunction of small-for-size rat liver grafts: prevention by plant polyphenols. Gastroenterology. 2005 Aug; 129(2):652-64. PMID: 16083719.
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    131. Lemasters JJ. Dying a thousand deaths: redundant pathways from different organelles to apoptosis and necrosis. Gastroenterology. 2005 Jul; 129(1):351-60. PMID: 16012960.
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    132. Lemasters JJ. Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res. 2005; 8(1):3-5. PMID: 15798367.
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    133. Kim JS, Ohshima S, Pediaditakis P, Lemasters JJ. Nitric oxide: a signaling molecule against mitochondrial permeability transition- and pH-dependent cell death after reperfusion. Free Radic Biol Med. 2004 Dec 15; 37(12):1943-50. PMID: 15544914.
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    134. Rodriguez-Enriquez S, He L, Lemasters JJ. Role of mitochondrial permeability transition pores in mitochondrial autophagy. Int J Biochem Cell Biol. 2004 Dec; 36(12):2463-72. PMID: 15325585.
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    135. Kon K, Kim JS, Jaeschke H, Lemasters JJ. Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology. 2004 Nov; 40(5):1170-9. PMID: 15486922.
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    136. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R, Brenner DA, Lemasters J. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation. 2004 Aug 15; 78(3):324-32. PMID: 15316358.
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    137. Zhong Z, Lemasters JJ. Role of free radicals in failure of fatty liver grafts caused by ethanol. Alcohol. 2004 Aug; 34(1):49-58. PMID: 15670666.
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    138. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ, Brenner DA, Rippe RA, Behrns KE. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J Hepatol. 2004 Jun; 40(6):942-51. PMID: 15158334.
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    139. Kim JS, Ohshima S, Pediaditakis P, Lemasters JJ. Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition. Hepatology. 2004 Jun; 39(6):1533-43. PMID: 15185294.
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    140. Zhong Z, Connor HD, Froh M, Lind H, Bunzendahl H, Mason RP, Thurman RG, Lemasters JJ. Polyphenols from Camellia sinenesis prevent primary graft failure after transplantation of ethanol-induced fatty livers from rats. Free Radic Biol Med. 2004 May 15; 36(10):1248-58. PMID: 15110390.
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    141. Lemasters JJ. Whither our libraries? Gastroenterology. 2004 May; 126(5):1234. PMID: 15131781.
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    142. Bajt ML, Knight TR, Lemasters JJ, Jaeschke H. Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine. Toxicol Sci. 2004 Aug; 80(2):343-9. PMID: 15115886.
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    143. Lemasters JJ. Rusty notions of cell injury. J Hepatol. 2004 Apr; 40(4):696-8. PMID: 15030988.
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    144. Takei Y, Maruyama A, Ferdous A, Nishimura Y, Kawano S, Ikejima K, Okumura S, Asayama S, Nogawa M, Hashimoto M, Makino Y, Kinoshita M, Watanabe S, Akaike T, Lemasters JJ, Sato N. Targeted gene delivery to sinusoidal endothelial cells: DNA nanoassociate bearing hyaluronan-glycocalyx. FASEB J. 2004 Apr; 18(6):699-701. PMID: 14977882.
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    145. Elmore SP, Nishimura Y, Qian T, Herman B, Lemasters JJ. Discrimination of depolarized from polarized mitochondria by confocal fluorescence resonance energy transfer. Arch Biochem Biophys. 2004 Feb 15; 422(2):145-52. PMID: 14759601.
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    146. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ, Brenner DA. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J. 2004 Apr; 18(6):720-2. PMID: 14766793.
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    147. Bataller R, Paik YH, Lindquist JN, Lemasters JJ, Brenner DA. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology. 2004 Feb; 126(2):529-40. PMID: 14762790.
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    148. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ, Brenner DA. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest. 2003 Nov; 112(9):1383-94. PMID: 14597764.
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    149. Jaeschke H, Lemasters JJ. Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. Gastroenterology. 2003 Oct; 125(4):1246-57. PMID: 14517806.
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    150. Zhao Y, Ding WX, Qian T, Watkins S, Lemasters JJ, Yin XM. Bid activates multiple mitochondrial apoptotic mechanisms in primary hepatocytes after death receptor engagement. Gastroenterology. 2003 Sep; 125(3):854-67. PMID: 12949730.
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    151. Kim JS, He L, Qian T, Lemasters JJ. Role of the mitochondrial permeability transition in apoptotic and necrotic death after ischemia/reperfusion injury to hepatocytes. Curr Mol Med. 2003 Sep; 3(6):527-35. PMID: 14527084.
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    152. Conzelmann LO, Zhong Z, Bunzendahl H, Wheeler MD, Lemasters JJ. Reduced-size liver transplantation in the mouse. Transplantation. 2003 Aug 15; 76(3):496-501. PMID: 12923434.
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    153. Waldmeier PC, Zimmermann K, Qian T, Tintelnot-Blomley M, Lemasters JJ. Cyclophilin D as a drug target. Curr Med Chem. 2003 Aug; 10(16):1485-506. PMID: 12871122.
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    154. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ, Brenner DA, Thurman RG. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Transplantation. 2003 Jul 15; 76(1):28-37. PMID: 12865782.
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    155. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ, Brenner DA. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. J Hepatol. 2003 Jul; 39(1):38-46. PMID: 12821042.
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    156. Zhong Z, Froh M, Lehnert M, Schoonhoven R, Yang L, Lind H, Lemasters JJ, Thurman RG. Polyphenols from Camellia sinenesis attenuate experimental cholestasis-induced liver fibrosis in rats. Am J Physiol Gastrointest Liver Physiol. 2003 Nov; 285(5):G1004-13. PMID: 12791596.
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    157. Kim JS, He L, Lemasters JJ. Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun. 2003 May 09; 304(3):463-70. PMID: 12729580.
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    158. Oh KW, Qian T, Brenner DA, Lemasters JJ. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Toxicol Sci. 2003 May; 73(1):44-52. PMID: 12700412.
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    159. Lehnert M, Arteel GE, Smutney OM, Conzelmann LO, Zhong Z, Thurman RG, Lemasters JJ. Dependence of liver injury after hemorrhage/resuscitation in mice on NADPH oxidase-derived superoxide. Shock. 2003 Apr; 19(4):345-51. PMID: 12688546.
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    160. Zhong Z, Wheeler MD, Li X, Froh M, Schemmer P, Yin M, Bunzendaul H, Bradford B, Lemasters JJ. L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Curr Opin Clin Nutr Metab Care. 2003 Mar; 6(2):229-40. PMID: 12589194.
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    161. He L, Lemasters JJ. Heat shock suppresses the permeability transition in rat liver mitochondria. J Biol Chem. 2003 May 09; 278(19):16755-60. PMID: 12611884.
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    162. Kim JS, Qian T, Lemasters JJ. Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes. Gastroenterology. 2003 Feb; 124(2):494-503. PMID: 12557154.
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    163. Lemasters JJ. Impact factors--a good thing? Gastroenterology. 2003 Feb; 124(2):286. PMID: 12557131.
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    164. Kim YS, Schwabe RF, Qian T, Lemasters JJ, Brenner DA. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Hepatology. 2002 Dec; 36(6):1498-508. PMID: 12447876.
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    165. Zhong Z, Froh M, Connor HD, Li X, Conzelmann LO, Mason RP, Lemasters JJ, Thurman RG. Prevention of hepatic ischemia-reperfusion injury by green tea extract. Am J Physiol Gastrointest Liver Physiol. 2002 Oct; 283(4):G957-64. PMID: 12223356.
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    166. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE, Brenner DA. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal. 2002 Oct; 4(5):769-81. PMID: 12470504.
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    167. Waldmeier PC, Feldtrauer JJ, Qian T, Lemasters JJ. Inhibition of the mitochondrial permeability transition by the nonimmunosuppressive cyclosporin derivative NIM811. Mol Pharmacol. 2002 Jul; 62(1):22-9. PMID: 12065751.
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    168. Yin M, Currin RT, Peng XX, Mekeel HE, Schoonhoven R, Lemasters JJ. Carolina rinse solution minimizes kidney injury and improves graft function and survival after prolonged cold ischemia. Transplantation. 2002 May 15; 73(9):1410-20. PMID: 12023618.
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    169. Yin M, Currin RT, Peng XX, Mekeel HE, Schoonhoven R, Lemasters JJ. Different patterns of renal cell killing after warm and cold ischemia. Ren Fail. 2002 Mar; 24(2):147-63. PMID: 12071589.
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    170. He L, Lemasters JJ. Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function? FEBS Lett. 2002 Feb 13; 512(1-3):1-7. PMID: 11852041.
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    171. Jaeschke H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D, Lemasters JJ. Mechanisms of hepatotoxicity. Toxicol Sci. 2002 Feb; 65(2):166-76. PMID: 11812920.
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    172. Cascio WE, Yang H, Johnson TA, Muller-Borer BJ, Lemasters JJ. Electrical properties and conduction in reperfused papillary muscle. Circ Res. 2001 Oct 26; 89(9):807-14. PMID: 11679411.
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    173. Lemasters JJ. Cytochrome c: which way out? Hepatology. 2001 Sep; 34(3):605-7. PMID: 11526550.
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    174. Elmore SP, Qian T, Grissom SF, Lemasters JJ. The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J. 2001 Oct; 15(12):2286-7. PMID: 11511528.
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    175. Blattner JR, He L, Lemasters JJ. Screening assays for the mitochondrial permeability transition using a fluorescence multiwell plate reader. Anal Biochem. 2001 Aug 15; 295(2):220-6. PMID: 11488625.
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    176. Nishimura Y, Lemasters JJ. Glycine blocks opening of a death channel in cultured hepatic sinusoidal endothelial cells during chemical hypoxia. Cell Death Differ. 2001 Aug; 8(8):850-8. PMID: 11526438.
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    177. Schemmer P, Enomoto N, Bradford BU, Bunzendahl H, Raleigh JA, Lemasters JJ, Thurman RG. Activated Kupffer cells cause a hypermetabolic state after gentle in situ manipulation of liver in rats. Am J Physiol Gastrointest Liver Physiol. 2001 Jun; 280(6):G1076-82. PMID: 11352799.
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    178. Hunt JP, Hunter CT, Brownstein MR, Ku J, Roberts L, Currin RT, Lemasters JJ, Baker CC. Alteration in Kupffer cell function after mild hemorrhagic shock. Shock. 2001 May; 15(5):403-7. PMID: 11336202.
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    179. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ, Brenner DA. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Gastroenterology. 2001 Apr; 120(5):1251-62. PMID: 11266388.
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    180. Arai M, Thurman RG, Lemasters JJ. Ischemic preconditioning of rat livers against cold storage-reperfusion injury: role of nonparenchymal cells and the phenomenon of heterologous preconditioning. Liver Transpl. 2001 Apr; 7(4):292-9. PMID: 11303287.
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    181. Rudolph JG, Lemasters JJ, Crews FT. Effects of NMDA and ferrous sulfate on oxidation and cell death in primary neuronal cultures. Neurochem Int. 2000 Nov-Dec; 37(5-6):497-507. PMID: 10871701.
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    182. Huynh T, Lemasters JJ, Bracey LW, Baker CC. Proinflammatory kupffer cell alterations after femur fracture trauma and sepsis in rats. Shock. 2000 Nov; 14(5):555-60. PMID: 11092689.
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    183. Nicholls D, Bernardi P, Brand M, Halestrap A, Lemasters J, Reynolds I. Apoptosis and the laws of thermodynamics. Nat Cell Biol. 2000 Oct; 2(10):E172-3. PMID: 11025673.
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    184. Oh KW, Currin RT, Lemasters JJ. Kupffer cells mediate increased anoxic hepatocellular killing from hyperosmolarity by an oxygen- and prostaglandin-independent mechanism. Toxicol Lett. 2000 Sep 30; 117(1-2):95-100. PMID: 11033238.
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    185. Arai M, Thurman RG, Lemasters JJ. Contribution of adenosine A(2) receptors and cyclic adenosine monophosphate to protective ischemic preconditioning of sinusoidal endothelial cells against Storage/Reperfusion injury in rat livers. Hepatology. 2000 Aug; 32(2):297-302. PMID: 10915736.
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    186. El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA. Molecular cloning and characterization of a human mitochondrial ceramidase. J Biol Chem. 2000 Jul 14; 275(28):21508-13. PMID: 10781606.
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    187. Trollinger DR, Cascio WE, Lemasters JJ. Mitochondrial calcium transients in adult rabbit cardiac myocytes: inhibition by ruthenium red and artifacts caused by lysosomal loading of Ca(2+)-indicating fluorophores. Biophys J. 2000 Jul; 79(1):39-50. PMID: 10866936.
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    188. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ, Brenner DA. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. J Biol Chem. 2000 Apr 21; 275(16):11814-23. PMID: 10766806.
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    189. Schemmer P, Bradford BU, Bunzendahl H, Lemasters JJ, Thurman RG. Gentle in situ liver manipulation during organ harvest increases oxygen consumption in liver. Transplant Proc. 2000 Feb; 32(1):112. PMID: 10700988.
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    190. Lemasters JJ. The mitochondrial permeability transition and the calcium, oxygen and pH paradoxes: one paradox after another. Cardiovasc Res. 1999 Dec; 44(3):470-3. PMID: 10690277.
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    191. Zhang Y, Lemasters J, Herman B. Secretory group IIA phospholipase A(2) generates anti-apoptotic survival signals in kidney fibroblasts. J Biol Chem. 1999 Sep 24; 274(39):27726-33. PMID: 10488115.
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    192. Lemasters JJ, Nieminen AL. Negative contrast imaging of mitochondria by confocal microscopy. Biophys J. 1999 Sep; 77(3):1747-50. PMID: 10523077.
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    193. Arai M, Peng XX, Currin RT, Thurman RG, Lemasters JJ. Protection of sinusoidal endothelial cells against storage/reperfusion injury by prostaglandin E2 derived from Kupffer cells. Transplantation. 1999 Aug 15; 68(3):440-5. PMID: 10459549.
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    194. Zhong Z, Arteel GE, Connor HD, Schemmer P, Chou SC, Raleigh JA, Mason RP, Lemasters JJ, Thurman RG. Binge drinking disturbs hepatic microcirculation after transplantation: prevention with free radical scavengers. J Pharmacol Exp Ther. 1999 Aug; 290(2):611-20. PMID: 10411569.
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    195. Lemasters JJ, Qian T, Bradham CA, Brenner DA, Cascio WE, Trost LC, Nishimura Y, Nieminen AL, Herman B. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. J Bioenerg Biomembr. 1999 Aug; 31(4):305-19. PMID: 10665521.
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    196. Liu X, LeCluyse EL, Brouwer KR, Gan LS, Lemasters JJ, Stieger B, Meier PJ, Brouwer KL. Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration. Am J Physiol. 1999 07; 277(1):G12-21. PMID: 10409146.
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    197. Byrne AM, Lemasters JJ, Nieminen AL. Contribution of increased mitochondrial free Ca2+ to the mitochondrial permeability transition induced by tert-butylhydroperoxide in rat hepatocytes. Hepatology. 1999 May; 29(5):1523-31. PMID: 10216138.
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    198. Schemmer P, Bradford BU, Rose ML, Bunzendahl H, Raleigh JA, Lemasters JJ, Thurman RG. Intravenous glycine improves survival in rat liver transplantation. Am J Physiol. 1999 04; 276(4):G924-32. PMID: 10198336.
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    199. Schemmer P, Bunzendahl H, Lemasters JJ, Thurman RG. Selective hepatic denervation prior to organ harvest improves survival after liver transplantation. Transplant Proc. 1999 Feb-Mar; 31(1-2):537. PMID: 10083225.
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    200. Takei Y, Maruyama A, Kawano S, Nishimura Y, Asayama S, Nogawa M, Ikejima K, Hori M, Akaike T, Lemasters JJ, Watanabe S, Sato N. Targeted gene transfer to sinusoidal endothelial cells and expression in vivo. Transplant Proc. 1999 Feb-Mar; 31(1-2):790-1. PMID: 10083339.
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    201. Arai M, Thurman RG, Lemasters JJ. Involvement of Kupffer cells and sinusoidal endothelial cells in ischemic preconditioning to rat livers stored for transplantation. Transplant Proc. 1999 Feb-Mar; 31(1-2):425-7. PMID: 10083172.
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    202. Qian T, Herman B, Lemasters JJ. The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187. Toxicol Appl Pharmacol. 1999 Jan 15; 154(2):117-25. PMID: 9925795.
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    203. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA, Brenner DA, Nieminen AL. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. Biochem Soc Symp. 1999; 66:205-22. PMID: 10989668.
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    204. v Frankenberg M, Stachlewitz RF, Forman DT, Frey W, Bunzendahl H, Lemasters JJ, Thurman RG. Amino acids in rinse effluents as a predictor of graft function after transplantation of fatty livers in rats. Transpl Int. 1999; 12(3):168-75. PMID: 10429953.
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    205. Lemasters JJ, Trollinger DR, Qian T, Cascio WE, Ohata H. Confocal imaging of Ca2+, pH, electrical potential, and membrane permeability in single living cells. Methods Enzymol. 1999; 302:341-58. PMID: 12876784.
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    206. Lemasters JJ. V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis. Am J Physiol. 1999 01; 276(1):G1-6. PMID: 9886971.
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    207. Schemmer P, Schoonhoven R, Swenberg JA, Bunzendahl H, Raleigh JA, Lemasters JJ, Thurman RG. Gentle organ manipulation during harvest as a key determinant of survival of fatty livers after transplantation in the rat. Transpl Int. 1999; 12(5):351-9. PMID: 10552001.
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    208. Lichtman SN, Lemasters JJ. Role of cytokines and cytokine-producing cells in reperfusion injury to the liver. Semin Liver Dis. 1999; 19(2):171-87. PMID: 10422199.
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    209. Zhong Z, Connor HD, Mason RP, Lemasters JJ, Thurman RG. Ethanol, not fat accumulation per se, increases free radical production in a low-flow, reflow liver perfusion model. Transplantation. 1998 Dec 15; 66(11):1431-8. PMID: 9869083.
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    210. Rudolph JG, Lemasters JJ, Crews FT. Effects of chronic ethanol exposure on oxidation and NMDA-stimulated neuronal death in primary cortical neuronal cultures. Alcohol Clin Exp Res. 1998 Dec; 22(9):2080-5. PMID: 9884154.
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    211. Muller-Borer BJ, Yang H, Marzouk SA, Lemasters JJ, Cascio WE. pHi and pHo at different depths in perfused myocardium measured by confocal fluorescence microscopy. Am J Physiol. 1998 12; 275(6):H1937-47. PMID: 9843791.
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    212. Bradham CA, Qian T, Streetz K, Trautwein C, Brenner DA, Lemasters JJ. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Mol Cell Biol. 1998 Nov; 18(11):6353-64. PMID: 9774651.
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    213. Lichtman SN, Wang J, Lemasters JJ. Lipopolysaccharide-stimulated TNF-alpha release from cultured rat Kupffer cells: sequence of intracellular signaling pathways. J Leukoc Biol. 1998 Sep; 64(3):368-72. PMID: 9738664.
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    214. Lemasters JJ. The mitochondrial permeability transition: from biochemical curiosity to pathophysiological mechanism. Gastroenterology. 1998 Sep; 115(3):783-6. PMID: 9742002.
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    215. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA, Brenner DA, Herman B. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta. 1998 Aug 10; 1366(1-2):177-96. PMID: 9714796.
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    216. Lichtman SN, Wang J, Lemasters JJ. LPS receptor CD14 participates in release of TNF-alpha in RAW 264.7 and peritoneal cells but not in kupffer cells. Am J Physiol. 1998 07; 275(1):G39-46. PMID: 9655682.
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    217. Hyatt CJ, Lemasters JJ, Muller-Borer BJ, Johnson TA, Cascio WE. A superfusion system to study border zones in confluent cultures of neonatal rat heart cells. Am J Physiol. 1998 06; 274(6):H2001-8. PMID: 9841526.
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    218. Ohata H, Chacon E, Tesfai SA, Harper IS, Herman B, Lemasters JJ. Mitochondrial Ca2+ transients in cardiac myocytes during the excitation-contraction cycle: effects of pacing and hormonal stimulation. J Bioenerg Biomembr. 1998 Jun; 30(3):207-22. PMID: 9733088.
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    219. Nishimura Y, Romer LH, Lemasters JJ. Mitochondrial dysfunction and cytoskeletal disruption during chemical hypoxia to cultured rat hepatic sinusoidal endothelial cells: the pH paradox and cytoprotection by glucose, acidotic pH, and glycine. Hepatology. 1998 Apr; 27(4):1039-49. PMID: 9537444.
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    220. Lemasters JJ, Qian T, Elmore SP, Trost LC, Nishimura Y, Herman B, Bradham CA, Brenner DA, Nieminen AL. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. Biofactors. 1998; 8(3-4):283-5. PMID: 9914830.
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    221. Thurman RG, Schemmer P, Zhong Z, Bunzendahl H, von Frankenberg M, Lemasters JJ. Kupffer cell-dependent reperfusion injury in liver transplantation: new clinically relevant use of glycine. Langenbecks Arch Chir Suppl Kongressbd. 1998; 115:185-90. PMID: 9931608.
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    222. Trost LC, Lemasters JJ. Role of the mitochondrial permeability transition in salicylate toxicity to cultured rat hepatocytes: implications for the pathogenesis of Reye's syndrome. Toxicol Appl Pharmacol. 1997 Dec; 147(2):431-41. PMID: 9439738.
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    223. Qian T, Nieminen AL, Herman B, Lemasters JJ. Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes. Am J Physiol. 1997 12; 273(6):C1783-92. PMID: 9435481.
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    224. Zhong Z, Connor H, Stachlewitz RF, Frankenberg M, Mason RP, Lemasters JJ, Thurman RG. Role of free radicals in primary nonfunction of marginal fatty grafts from rats treated acutely with ethanol. Mol Pharmacol. 1997 Nov; 52(5):912-9. PMID: 9351983.
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    225. D'Armini AM, Lemasters JJ, Egan TM, Viganó M. Effect of perfusion pH on rat lung viability of non-heart beating donors. Eur J Cardiothorac Surg. 1997 Nov; 12(5):787-91. PMID: 9458152.
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    226. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Herman B. The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury. Mol Cell Biochem. 1997 Sep; 174(1-2):159-65. PMID: 9309681.
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    227. Trollinger DR, Cascio WE, Lemasters JJ. Selective loading of Rhod 2 into mitochondria shows mitochondrial Ca2+ transients during the contractile cycle in adult rabbit cardiac myocytes. Biochem Biophys Res Commun. 1997 Jul 30; 236(3):738-42. PMID: 9245725.
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    228. Jones DR, Becker RM, Hoffmann SC, Lemasters JJ, Egan TM. When does the lung die? Kfc, cell viability, and adenine nucleotide changes in the circulation-arrested rat lung. J Appl Physiol (1985). 1997 Jul; 83(1):247-52. PMID: 9216970.
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    229. Huynh T, Baker CC, Bracey LW, Lemasters JJ. Adaptive Kupffer cell alterations after femur fracture trauma in rats. Am J Physiol. 1997 Jun; 272(6 Pt 1):G1457-62. PMID: 9227482.
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    230. Lemasters JJ, Nieminen AL. Mitochondrial oxygen radical formation during reductive and oxidative stress to intact hepatocytes. Biosci Rep. 1997 Jun; 17(3):281-91. PMID: 9337483.
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    231. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG, Brenner DA. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology. 1997 May; 25(5):1128-35. PMID: 9141429.
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    232. Nieminen AL, Byrne AM, Herman B, Lemasters JJ. Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species. Am J Physiol. 1997 Apr; 272(4 Pt 1):C1286-94. PMID: 9142854.
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    233. Harrison-Shostak DC, Lemasters JJ, Edgell CJ, Herman B. Role of ICE-like proteases in endothelial cell hypoxic and reperfusion injury. Biochem Biophys Res Commun. 1997 Feb 24; 231(3):844-7. PMID: 9070907.
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    234. Frankenberg MV, Forman DT, Frey W, Bunzendahl H, Lemasters JJ, Thurman RG. Amino acids in storage solution predict primary nonfunction in fatty liver grafts. Transplant Proc. 1997 Feb-Mar; 29(1-2):1331-2. PMID: 9123328.
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    235. Bachmann S, Bechstein WO, Keck H, Lemmens HP, Brandes N, John AK, Lemasters JJ, Neuhaus P. Pilot study: Carolina Rinse Solution improves graft function after orthotopic liver transplantation in humans. Transplant Proc. 1997 Feb-Mar; 29(1-2):390-2. PMID: 9123051.
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    236. Rudolph JG, Lemasters JJ, Crews FT. Use of a multiwell fluorescence scanner with propidium iodide to assess NMDA mediated excitotoxicity in rat cortical neuronal cultures. Neurosci Lett. 1997 Jan 17; 221(2-3):149-52. PMID: 9121686.
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    237. Lemasters JJ, Thurman RG. Reperfusion injury after liver preservation for transplantation. Annu Rev Pharmacol Toxicol. 1997; 37:327-38. PMID: 9131256.
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    238. Currin RT, Caldwell-Kenkel JC, Lichtman SN, Bachmann S, Takei Y, Kawano S, Thurman RG, Lemasters JJ. Protection by Carolina rinse solution, acidotic pH, and glycine against lethal reperfusion injury to sinusoidal endothelial cells of rat livers stored for transplantation. Transplantation. 1996 Dec 15; 62(11):1549-58. PMID: 8970606.
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    239. Nieminen AL, Petrie TG, Lemasters JJ, Selman WR. Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: evidence of the mitochondrial permeability transition. Neuroscience. 1996 Dec; 75(4):993-7. PMID: 8938735.
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    240. D'Armini AM, Lemasters JJ, Egan TM. Studies of rat lung viability and adenine nucleotide metabolism after death. Ann Thorac Surg. 1996 Nov; 62(5):1448-53. PMID: 8893582.
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    241. Lichtman SN, Wang J, Zhang C, Lemasters JJ. Endocytosis and Ca2+ are required for endotoxin-stimulated TNF-alpha release by rat Kupffer cells. Am J Physiol. 1996 Nov; 271(5 Pt 1):G920-8. PMID: 8944708.
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    242. Wang H, Harrison-Shostak DC, Lemasters JJ, Herman B. Contribution of pH-dependent group II phospholipase A2 to chemical hypoxic injury in rat hepatocytes. FASEB J. 1996 Sep; 10(11):1319-25. PMID: 8836046.
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    243. Trost LC, Lemasters JJ. The mitochondrial permeability transition: a new pathophysiological mechanism for Reye's syndrome and toxic liver injury. J Pharmacol Exp Ther. 1996 Sep; 278(3):1000-5. PMID: 8819478.
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    244. Zhong Z, Connor H, Mason RP, Qu W, Stachlewitz RF, Gao W, Lemasters JJ, Thurman RG. Destruction of Kupffer cells increases survival and reduces graft injury after transplantation of fatty livers from ethanol-treated rats. Liver Transpl Surg. 1996 Sep; 2(5):383-7. PMID: 9346680.
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    245. D'Armini AM, Roberts CS, Lemasters JJ, Egan TM. Lung retrieval from cadaver donors with nonbeating hearts: optimal preservation solution. J Heart Lung Transplant. 1996 May; 15(5):496-505. PMID: 8771505.
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    246. Hennington MH, D'Armini AM, Lemasters JJ, Egan TM. Cadaver lungs for transplantation. Effect of ventilation with alveolar gas. Transplantation. 1996 Apr 15; 61(7):1009-14. PMID: 8623177.
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    247. Chacon E, Ohata H, Harper IS, Trollinger DR, Herman B, Lemasters JJ. Mitochondrial free calcium transients during excitation-contraction coupling in rabbit cardiac myocytes. FEBS Lett. 1996 Mar 11; 382(1-2):31-6. PMID: 8612759.
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    248. Roberts CS, Hennington MH, D'Armini AM, Griffith PK, Lemasters JJ, Egan TM. Donor lungs from ventilated cadavers: impart of a free radical scavenger. J Heart Lung Transplant. 1996 Mar; 15(3):275-82. PMID: 8777211.
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    249. Wang H, Harrison-Shostak DC, Lemasters JJ, Herman B. Down-regulation of HCW9 mRNA in rat hepatocytes during chemical hypoxia involves both transcriptional and posttranscriptional mechanisms. Biochem Biophys Res Commun. 1996 Jan 05; 218(1):360-4. PMID: 8573162.
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    250. Lemasters JJ, Bond JM, Chacon E, Harper IS, Kaplan SH, Ohata H, Trollinger DR, Herman B, Cascio WE. The pH paradox in ischemia-reperfusion injury to cardiac myocytes. EXS. 1996; 76:99-114. PMID: 8805791.
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    251. Thurman RG, Gao W, Connor HD, Adachi Y, Stachlewitz RF, Zhong Z, Knecht KT, Bradford BU, Mason RP, Lemasters JJ. Role of free radicals in failure of fatty livers following liver transplantation and alcoholic liver injury. Adv Exp Med Biol. 1996; 387:231-41. PMID: 8794217.
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    252. Zhong Z, Connor HD, Mason RP, Qu W, Gao W, Lemasters JJ, Thurman RG. Role of Kupffer cells in reperfusion injury in fat-loaded livers from ethanol-treated rats. J Pharmacol Exp Ther. 1995 Dec; 275(3):1512-7. PMID: 8531123.
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    253. Wang H, Harrison-Shostak DC, Lemasters JJ, Herman B. Cloning of a rat cDNA encoding a novel LIM domain protein with high homology to rat RIL. Gene. 1995 Nov 20; 165(2):267-71. PMID: 8522188.
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    254. D'Armini AM, Tom EJ, Roberts CS, Henke DC, Lemasters JJ, Egan TM. When does the lung die? Time course of high energy phosphate depletion and relationship to lung viability after "death". J Surg Res. 1995 Oct; 59(4):468-74. PMID: 7564319.
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    255. Wang H, Lemasters JJ, Herman B. Cloning of a rat cDNA encoding a protein with high homology to mouse phospholipase A2-activating protein. Gene. 1995 Aug 19; 161(2):237-41. PMID: 7665086.
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    256. Peng XX, Currin RT, Thurman RG, Lemasters JJ. Protection by pentoxifylline against normothermic liver ischemia/reperfusion in rats. Transplantation. 1995 Jun 15; 59(11):1537-41. PMID: 7778168.
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    257. Zahrebelski G, Nieminen AL, al-Ghoul K, Qian T, Herman B, Lemasters JJ. Progression of subcellular changes during chemical hypoxia to cultured rat hepatocytes: a laser scanning confocal microscopic study. Hepatology. 1995 May; 21(5):1361-72. PMID: 7737643.
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    258. Nieminen AL, Saylor AK, Tesfai SA, Herman B, Lemasters JJ. Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide. Biochem J. 1995 Apr 01; 307 ( Pt 1):99-106. PMID: 7718000.
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    259. Lemasters JJ, Thurman RG. The many facets of reperfusion injury. Gastroenterology. 1995 Apr; 108(4):1317-20. PMID: 7698602.
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    260. Gao W, Connor HD, Lemasters JJ, Mason RP, Thurman RG. Primary nonfunction of fatty livers produced by alcohol is associated with a new, antioxidant-insensitive free radical species. Transplantation. 1995 Mar 15; 59(5):674-9. PMID: 7886790.
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    261. Lemasters JJ, Bunzendahl H, Thurman RG. Reperfusion injury to donor livers stored for transplantation. Liver Transpl Surg. 1995 Mar; 1(2):124-38. PMID: 9346554.
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    262. Wang XF, Florine-Casteel K, Lemasters JJ, Herman B. Video fluorescence microscopic techniques to monitor local lipid and phospholipid molecular order and organization in cell membranes during hypoxic injury. J Fluoresc. 1995 Mar; 5(1):71-84. PMID: 24226613.
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    263. Kaplan SH, Yang H, Gilliam DE, Shen J, Lemasters JJ, Cascio WE. Hypercapnic acidosis and dimethyl amiloride reduce reperfusion induced cell death in ischaemic ventricular myocardium. Cardiovasc Res. 1995 Feb; 29(2):231-8. PMID: 7736500.
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    264. Bachmann S, Peng XX, Currin RT, Thurman RG, Lemasters JJ. Glycine in Carolina rinse solution reduces reperfusion injury, improves graft function, and increases graft survival after rat liver transplantation. Transplant Proc. 1995 Feb; 27(1):741-2. PMID: 7879166.
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    265. Lemasters JJ, Chacon E, Ohata H, Harper IS, Nieminen AL, Tesfai SA, Herman B. Measurement of electrical potential, pH, and free calcium ion concentration in mitochondria of living cells by laser scanning confocal microscopy. Methods Enzymol. 1995; 260:428-44. PMID: 8592465.
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    266. Lemasters JJ, Peng XX, Bachmann S, Currin RT, Gao W, Thurman RG. Dual role of Kupffer cell activation and endothelial cell damage in reperfusion injury to livers stored for transplantation surgery. J Gastroenterol Hepatol. 1995; 10 Suppl 1:S84-7. PMID: 8589353.
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    267. Thurman RG, Gao W, Connor HD, Adachi Y, Stachlewitz RF, Zhong Z, Knecht KT, Bradford BU, Mason RP, Lemasters JJ. Role of Kupffer cells in failure of fatty livers following liver transplantation and alcoholic liver injury. J Gastroenterol Hepatol. 1995; 10 Suppl 1:S24-30. PMID: 8589336.
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    268. Caldwell-Kenkel JC, Currin RT, Coote A, Thurman RG, Lemasters JJ. Reperfusion injury to endothelial cells after cold storage of rat livers: protection by mildly acidic pH and lack of protection by antioxidants. Transpl Int. 1995; 8(2):77-85. PMID: 7766302.
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    269. Ohata H, Trollinger DR, Lemasters JJ. Changes in shape and viability of cultured adult rabbit cardiac myocytes during ischemia/reperfusion injury. Res Commun Mol Pathol Pharmacol. 1994 Dec; 86(3):259-71. PMID: 7712103.
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    270. Mehendale HM, Roth RA, Gandolfi AJ, Klaunig JE, Lemasters JJ, Curtis LR. Novel mechanisms in chemically induced hepatotoxicity. FASEB J. 1994 Dec; 8(15):1285-95. PMID: 8001741.
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    271. Huynh T, Currin RT, Tanaka Y, Lemasters JJ, Baker CC. Activation of Kupffer cells in vivo following femur fracture. Arch Surg. 1994 Dec; 129(12):1324-8; discussion 1328-9. PMID: 7986164.
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    272. Fusaoka T, Hunt KJ, Lemasters JJ, Thurman RG. Evidence that activation of Kupffer cells increases oxygen uptake after cold storage. Transplantation. 1994 Nov 27; 58(10):1067-71. PMID: 7974712.
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    273. D'Armini AM, Roberts CS, Griffith PK, Lemasters JJ, Egan TM. When does the lung die? I. Histochemical evidence of pulmonary viability after "death". J Heart Lung Transplant. 1994 Sep-Oct; 13(5):741-7. PMID: 7803413.
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    274. Trost LC, Lemasters JJ. A cytotoxicity assay for tumor necrosis factor employing a multiwell fluorescence scanner. Anal Biochem. 1994 Jul; 220(1):149-53. PMID: 7978238.
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    275. Nieminen AL, Saylor AK, Herman B, Lemasters JJ. ATP depletion rather than mitochondrial depolarization mediates hepatocyte killing after metabolic inhibition. Am J Physiol. 1994 Jul; 267(1 Pt 1):C67-74. PMID: 8048493.
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    276. Bond JM, Harper IS, Chacon E, Reece JM, Herman B, Lemasters JJ. The pH paradox in the pathophysiology of reperfusion injury to rat neonatal cardiac myocytes. Ann N Y Acad Sci. 1994 Jun 17; 723:25-37. PMID: 8030870.
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    277. Reinstein LJ, Lichtman SN, Currin RT, Wang J, Thurman RG, Lemasters JJ. Suppression of lipopolysaccharide-stimulated release of tumor necrosis factor by adenosine: evidence for A2 receptors on rat Kupffer cells. Hepatology. 1994 Jun; 19(6):1445-52. PMID: 8188175.
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    278. Chacon E, Reece JM, Nieminen AL, Zahrebelski G, Herman B, Lemasters JJ. Distribution of electrical potential, pH, free Ca2+, and volume inside cultured adult rabbit cardiac myocytes during chemical hypoxia: a multiparameter digitized confocal microscopic study. Biophys J. 1994 Apr; 66(4):942-52. PMID: 8038398.
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    279. Lichtman SN, Wang J, Schwab JH, Lemasters JJ. Comparison of peptidoglycan-polysaccharide and lipopolysaccharide stimulation of Kupffer cells to produce tumor necrosis factor and interleukin-1. Hepatology. 1994 Apr; 19(4):1013-22. PMID: 8138241.
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    280. Savier E, Lemasters JJ, Thurman RG. Kupffer cells participate in rejection following liver transplantation in the rat. Transpl Int. 1994; 7 Suppl 1:S183-6. PMID: 11271199.
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    281. Thurman RG, Gao W, Connor HD, Mason RP, Lemasters JJ, Bozigian H, Adams LM. SPC-100270, a protein kinase C inhibitor, reduced hypoxic injury due to reperfusion following orthotopic liver transplantation in the rat. Transpl Int. 1994; 7 Suppl 1:S167-70. PMID: 11271195.
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    282. Hunt KJ, Lemasters JJ, Thurman RG. High concentrations of adenosine are needed in Carolina rinse to prevent activation of Kupffer cells. Transpl Int. 1994; 7 Suppl 1:S493-5. PMID: 11271289.
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    283. Goto M, Lemasters JJ, Thurman RG. Activation of voltage-dependent calcium channels in Kupffer cells by chronic treatment with alcohol in the rat. J Pharmacol Exp Ther. 1993 Dec; 267(3):1264-8. PMID: 8263789.
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    284. Lichtman SN, Bachmann S, Munoz SR, Schwab JH, Bender DE, Sartor RB, Lemasters JJ. Bacterial cell wall polymers (peptidoglycan-polysaccharide) cause reactivation of arthritis. Infect Immun. 1993 Nov; 61(11):4645-53. PMID: 8406862.
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    285. Harper IS, Bond JM, Chacon E, Reece JM, Herman B, Lemasters JJ. Inhibition of Na+/H+ exchange preserves viability, restores mechanical function, and prevents the pH paradox in reperfusion injury to rat neonatal myocytes. Basic Res Cardiol. 1993 Sep-Oct; 88(5):430-42. PMID: 8117249.
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    286. Hijioka T, Goto M, Lemasters JJ, Thurman RG. Effect of short-term ethanol treatment on voltage-dependent calcium channels in Kupffer cells. Hepatology. 1993 Aug; 18(2):400-5. PMID: 7687982.
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    287. Gao W, Lemasters JJ, Thurman RG. Development of a new method for hepatic rearterialization in rat orthotopic liver transplantation. Reduction of liver injury and improvement of surgical outcome by arterialization. Transplantation. 1993 Jul; 56(1):19-24. PMID: 8333041.
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    288. Bond JM, Chacon E, Herman B, Lemasters JJ. Intracellular pH and Ca2+ homeostasis in the pH paradox of reperfusion injury to neonatal rat cardiac myocytes. Am J Physiol. 1993 Jul; 265(1 Pt 1):C129-37. PMID: 8338121.
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    289. Imberti R, Nieminen AL, Herman B, Lemasters JJ. Mitochondrial and glycolytic dysfunction in lethal injury to hepatocytes by t-butylhydroperoxide: protection by fructose, cyclosporin A and trifluoperazine. J Pharmacol Exp Ther. 1993 Apr; 265(1):392-400. PMID: 8474021.
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    290. Dawson TL, Gores GJ, Nieminen AL, Herman B, Lemasters JJ. Mitochondria as a source of reactive oxygen species during reductive stress in rat hepatocytes. Am J Physiol. 1993 Apr; 264(4 Pt 1):C961-7. PMID: 8386454.
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    291. Currin RT, Reinstein LJ, Lichtman SN, Thurman RG, Lemasters JJ. Inhibition of tumor necrosis factor release from cultured rat Kupffer cells by agents that reduce graft failure from storage injury. Transplant Proc. 1993 Feb; 25(1 Pt 2):1631-2. PMID: 8442217.
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    292. Sanchez-Urdazpal L, Gores GJ, Lemasters JJ, Thurman RG, Steers JL, Wahlstrom HE, Hay EI, Porayko MK, Wiesner RH, Krom RA. Carolina rinse solution decreases liver injury during clinical liver transplantation. Transplant Proc. 1993 Feb; 25(1 Pt 2):1574-5. PMID: 8442196.
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    293. Bachmann S, Caldwell-Kenkel JC, Currin RT, Tanaka Y, Takei Y, Marzi I, Thurman RG, Lemasters JJ. Ultrastructural correlates of liver graft failure from storage injury: studies of graft protection by Carolina rinse solution and pentoxifylline. Transplant Proc. 1993 Feb; 25(1 Pt 2):1620-4. PMID: 8442213.
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    294. Thurman RG, Bunzendahl H, Lemasters JJ. Role of sinusoidal lining cells in hepatic reperfusion injury following cold storage and transplantation. Semin Liver Dis. 1993 Feb; 13(1):93-100. PMID: 8446911.
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    295. Merrick P, Nieminen AL, Harper RA, Herman B, Lemasters JJ. Cytotoxicity screening of surfactant-based shampoos using a multiwell fluorescence scanner: Correlation with Draize eye scores. Toxicol In Vitro. 1992 Nov; 6(6):543-7. PMID: 20732156.
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    296. Imberti R, Nieminen AL, Herman B, Lemasters JJ. Synergism of cyclosporin A and phospholipase inhibitors in protection against lethal injury to rat hepatocytes from oxidant chemicals. Res Commun Chem Pathol Pharmacol. 1992 Oct; 78(1):27-38. PMID: 1462047.
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    297. Yamanaka H, Nukina S, Handler JA, Currin RT, Lemasters JJ, Thurman RG. Transient activation of hepatic glycogenolysis by thrombin in perfused rat livers. Eur J Biochem. 1992 Sep 15; 208(3):753-9. PMID: 1396679.
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    298. Connor HD, Gao W, Nukina S, Lemasters JJ, Mason RP, Thurman RG. Evidence that free radicals are involved in graft failure following orthotopic liver transplantation in the rat--an electron paramagnetic resonance spin trapping study. Transplantation. 1992 Aug; 54(2):199-204. PMID: 1323148.
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    299. Nieminen AL, Gores GJ, Bond JM, Imberti R, Herman B, Lemasters JJ. A novel cytotoxicity screening assay using a multiwell fluorescence scanner. Toxicol Appl Pharmacol. 1992 Aug; 115(2):147-55. PMID: 1641848.
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    300. Bachmann S, Caldwell-Kenkel JC, Oleksy I, Steffen R, Thurman RG, Lemasters JJ. Warm Carolina rinse solution prevents graft failure from storage injury after orthotopic rat liver transplantation with arterialization. Transpl Int. 1992 May; 5(2):108-14. PMID: 1627236.
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    301. Hijioka T, Rosenberg RL, Lemasters JJ, Thurman RG. Kupffer cells contain voltage-dependent calcium channels. Mol Pharmacol. 1992 Mar; 41(3):435-40. PMID: 1372081.
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    302. Lindert KA, Caldwell-Kenkel JC, Nukina S, Lemasters JJ, Thurman RG. Activation of Kupffer cells on reperfusion following hypoxia: particle phagocytosis in a low-flow, reflow model. Am J Physiol. 1992 Feb; 262(2 Pt 1):G345-50. PMID: 1539667.
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    303. Bachmann S, Caldwell-Kenkel JC, Currin RT, Lichtman SN, Steffen R, Thurman RG, Lemasters JJ. Protection by pentoxifylline against graft failure from storage injury after orthotopic rat liver transplantation with arterialization. Transpl Int. 1992; 5 Suppl 1:S345-50. PMID: 14621819.
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    304. Savier E, Shedlofsky SI, Swim AT, Lemasters JJ, Thurman RG. The calcium channel blocker nisoldipine minimizes the release of tumor necrosis factor and interleukin-6 following rat liver transplantation. Transpl Int. 1992; 5 Suppl 1:S398-402. PMID: 14621831.
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    305. Gao W, Lemasters JJ, Thurman RG. The second generation of Carolina Rinse, solution II, improves graft survival following orthotopic liver transplantation in the rat by preventing reperfusion injury. Transpl Int. 1992; 5 Suppl 1:S362-5. PMID: 14621822.
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    306. Gao W, Currin RJ, Lemasters JJ, Connor HD, Mason RP, Thurman RG. Reperfusion rather than storage injury predominates following long-term (48 h) cold storage of grafts in UW solution: studies with Carolina Rinse in transplanted rat liver. Transpl Int. 1992; 5 Suppl 1:S329-35. PMID: 14621815.
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    307. Marzi I, Cowper K, Takei Y, Lindert K, Lemasters JJ, Thurman RG. Methyl palmitate prevents Kupffer cell activation and improves survival after orthotopic liver transplantation in the rat. Transpl Int. 1991 Dec; 4(4):215-20. PMID: 1786059.
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    308. Gao WS, Hijioka T, Lindert KA, Caldwell-Kenkel JC, Lemasters JJ, Thurman RG. Evidence that adenosine is a key component in Carolina rinse responsible for reducing graft failure after orthotopic liver transplantation in the rat. Transplantation. 1991 Dec; 52(6):992-8. PMID: 1750086.
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    309. Lemasters JJ, Thurman RG. Reperfusion injury: a role for neutrophils. Hepatology. 1991 Nov; 14(5):954-5. PMID: 1937402.
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    310. Geeraerts MD, Ronveaux-Dupal MF, Lemasters JJ, Herman B. Cytosolic free Ca2+ and proteolysis in lethal oxidative injury in endothelial cells. Am J Physiol. 1991 Nov; 261(5 Pt 1):C889-96. PMID: 1951673.
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    311. Kawanishi T, Nieminen AL, Herman B, Lemasters JJ. Suppression of Ca2+ oscillations in cultured rat hepatocytes by chemical hypoxia. J Biol Chem. 1991 Oct 25; 266(30):20062-9. PMID: 1939069.
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    312. Bond JM, Herman B, Lemasters JJ. Protection by acidotic pH against anoxia/reoxygenation injury to rat neonatal cardiac myocytes. Biochem Biophys Res Commun. 1991 Sep 16; 179(2):798-803. PMID: 1898402.
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    313. Gao WS, Takei Y, Marzi I, Lindert KA, Caldwell-Kenkel JC, Currin RT, Tanaka Y, Lemasters JJ, Thurman RG. Carolina rinse solution--a new strategy to increase survival time after orthotopic liver transplantation in the rat. Transplantation. 1991 Sep; 52(3):417-24. PMID: 1897011.
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    314. te Koppele JM, Keller BJ, Caldwell-Kenkel JC, Lemasters JJ, Thurman RG. Effect of hepatotoxic chemicals and hypoxia on hepatic nonparenchymal cells: impairment of phagocytosis by Kupffer cells and disruption of the endothelium in rat livers perfused with colloidal carbon. Toxicol Appl Pharmacol. 1991 Aug; 110(1):20-30. PMID: 1871771.
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    315. Takei Y, Gao WS, Hijioka T, Savier E, Lindert KA, Lemasters JJ, Thurman RG. Increase in survival of liver grafts after rinsing with warm Ringer's solution due to improvement of hepatic microcirculation. Transplantation. 1991 Aug; 52(2):225-30. PMID: 1871793.
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    316. Takei Y, Marzi I, Gao WS, Gores GJ, Lemasters JJ, Thurman RG. Leukocyte adhesion and cell death following orthotopic liver transplantation in the rat. Transplantation. 1991 May; 51(5):959-65. PMID: 2031279.
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    317. Florine-Casteel K, Lemasters JJ, Herman B. Lipid order in hepatocyte plasma membrane blebs during ATP depletion measured by digitized video fluorescence polarization microscopy. FASEB J. 1991 Apr; 5(7):2078-84. PMID: 2010060.
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    318. Ganey PE, Keller B, Lichtman SN, Lemasters JJ, Thurman RG. A new method to monitor Kupffer cell phagocytosis continuously in perfused rat liver. Hepatology. 1991 Mar; 13(3):567-74. PMID: 1999326.
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    319. Gao W, Takei Y, Marzi I, Currin RT, Lemasters JJ, Thurman RG. Carolina rinse solution increases survival time dramatically after orthotopic liver transplantation in the rat. Transplant Proc. 1991 Feb; 23(1 Pt 1):648-50. PMID: 1990634.
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    320. Currin RT, Thurman RG, Lemasters JJ. Carolina rinse solution protects adenosine triphosphate-depleted hepatocytes against lethal cell injury. Transplant Proc. 1991 Feb; 23(1 Pt 1):645-7. PMID: 1990633.
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    321. Currin RT, Gores GJ, Thurman RG, Lemasters JJ. Protection by acidotic pH against anoxic cell killing in perfused rat liver: evidence for a pH paradox. FASEB J. 1991 Feb; 5(2):207-10. PMID: 2004664.
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    322. Bond JM, Herman B, Lemasters JJ. Recovery of cultured rat neonatal myocytes from hypercontracture after chemical hypoxia. Res Commun Chem Pathol Pharmacol. 1991 Feb; 71(2):195-208. PMID: 2047566.
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    323. Harrison DC, Lemasters JJ, Herman B. A pH-dependent phospholipase A2 contributes to loss of plasma membrane integrity during chemical hypoxia in rat hepatocytes. Biochem Biophys Res Commun. 1991 Jan 31; 174(2):654-9. PMID: 1899571.
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    324. Caldwell-Kenkel JC, Currin RT, Tanaka Y, Thurman RG, Lemasters JJ. Kupffer cell activation and endothelial cell damage after storage of rat livers: effects of reperfusion. Hepatology. 1991 Jan; 13(1):83-95. PMID: 1988348.
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    325. Currin RT, Toole JG, Thurman RG, Lemasters JJ. Evidence that Carolina rinse solution protects sinusoidal endothelial cells against reperfusion injury after cold ischemic storage of rat liver. Transplantation. 1990 Dec; 50(6):1076-8. PMID: 1701572.
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    326. Kehrer JP, Jones DP, Lemasters JJ, Farber JL, Jaeschke H. Mechanisms of hypoxic cell injury. Summary of the symposium presented at the 1990 annual meeting of the Society of Toxicology. Toxicol Appl Pharmacol. 1990 Nov; 106(2):165-78. PMID: 2256109.
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    327. Takei Y, Marzi I, Kauffman FC, Cowper K, Lemasters JJ, Thurman RG. Prevention of early graft failure by the calcium channel blocker nisoldipine: involvement of Kupffer cells. Transplant Proc. 1990 Oct; 22(5):2202-3. PMID: 2219344.
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    328. Kost LJ, Gores GJ, Sayles JM, Miller LJ, Lemasters JJ, Herman B, LaRusso NF. Lack of metabolic effects of cholecystokinin on hepatocytes. Hepatology. 1990 Aug; 12(2):301-5. PMID: 2391069.
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    329. Marzi I, Takei Y, Knee J, Menger M, Gores GJ, Bühren V, Trentz O, Lemasters JJ, Thurman RG. Assessment of reperfusion injury by intravital fluorescence microscopy following liver transplantation in the rat. Transplant Proc. 1990 Aug; 22(4):2004-5. PMID: 2389510.
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    330. Harman AW, Nieminen AL, Lemasters JJ, Herman B. Cytosolic free magnesium, ATP and blebbing during chemical hypoxia in cultured rat hepatocytes. Biochem Biophys Res Commun. 1990 Jul 31; 170(2):477-83. PMID: 2383254.
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    331. Takei Y, Marzi I, Kauffman FC, Currin RT, Lemasters JJ, Thurman RG. Increase in survival time of liver transplants by protease inhibitors and a calcium channel blocker, nisoldipine. Transplantation. 1990 Jul; 50(1):14-20. PMID: 2368133.
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    332. Lemasters JJ, Nieminen AL, Herman B. Is there release of mitochondrial calcium in toxic injury? Hepatology. 1990 May; 11(5):902-3. PMID: 2347564.
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    333. Gores GJ, Herman B, Lemasters JJ. Plasma membrane bleb formation and rupture: a common feature of hepatocellular injury. Hepatology. 1990 Apr; 11(4):690-8. PMID: 2184116.
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    334. Nieminen AL, Dawson TL, Gores GJ, Kawanishi T, Herman B, Lemasters JJ. Protection by acidotic pH and fructose against lethal injury to rat hepatocytes from mitochondrial inhibitors, ionophores and oxidant chemicals. Biochem Biophys Res Commun. 1990 Mar 16; 167(2):600-6. PMID: 2322245.
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    335. Lemasters JJ, Gores GJ, Nieminen AL, Dawson TL, Wray BE, Herman B. Multiparameter digitized video microscopy of toxic and hypoxic injury in single cells. Environ Health Perspect. 1990 Mar; 84:83-94. PMID: 2190822.
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    336. Cowper KB, Currin RT, Dawson TL, Lindert KA, Lemasters JJ, Thurman RG. A new method to monitor Kupffer-cell function continuously in the perfused rat liver. Dissociation of glycogenolysis from particle phagocytosis. Biochem J. 1990 Feb 15; 266(1):141-7. PMID: 2310369.
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    337. Nieminen AL, Gores GJ, Dawson TL, Herman B, Lemasters JJ. Toxic injury from mercuric chloride in rat hepatocytes. J Biol Chem. 1990 Feb 05; 265(4):2399-408. PMID: 2105322.
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    338. Roe MW, Lemasters JJ, Herman B. Assessment of Fura-2 for measurements of cytosolic free calcium. Cell Calcium. 1990 Feb-Mar; 11(2-3):63-73. PMID: 2191782.
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    339. Herman B, Gores GJ, Nieminen AL, Kawanishi T, Harman A, Lemasters JJ. Calcium and pH in anoxic and toxic injury. Crit Rev Toxicol. 1990; 21(2):127-48. PMID: 2083032.
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    340. Marzi I, Zhong Z, Lemasters JJ, Thurman RG. Evidence that graft survival is not related to parenchymal cell viability in rat liver transplantation. The importance of nonparenchymal cells. Transplantation. 1989 Sep; 48(3):463-8. PMID: 2675407.
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    341. Caldwell-Kenkel JC, Currin RT, Tanaka Y, Thurman RG, Lemasters JJ. Reperfusion injury to endothelial cells following cold ischemic storage of rat livers. Hepatology. 1989 Sep; 10(3):292-9. PMID: 2668147.
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    342. Gores GJ, Flarsheim CE, Dawson TL, Nieminen AL, Herman B, Lemasters JJ. Swelling, reductive stress, and cell death during chemical hypoxia in hepatocytes. Am J Physiol. 1989 Aug; 257(2 Pt 1):C347-54. PMID: 2764095.
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    343. Zhong Z, Lemasters JJ, Thurman RG. Role of purines and xanthine oxidase in reperfusion injury in perfused rat liver. J Pharmacol Exp Ther. 1989 Aug; 250(2):470-5. PMID: 2547932.
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    344. Gores GJ, Nieminen AL, Wray BE, Herman B, Lemasters JJ. Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death. J Clin Invest. 1989 Feb; 83(2):386-96. PMID: 2536397.
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    345. Marzi I, Zhi ZN, Zimmermann FA, Lemasters JJ, Thurman RG. Xanthine and hypoxanthine accumulation during storage may contribute to reperfusion injury following liver transplantation in the rat. Transplant Proc. 1989 Feb; 21(1 Pt 2):1319-20. PMID: 2652436.
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    346. Nieminen AL, Gores GJ, Wray BE, Tanaka Y, Herman B, Lemasters JJ. Calcium dependence of bleb formation and cell death in hepatocytes. Cell Calcium. 1988 Dec; 9(5-6):237-46. PMID: 3224370.
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    347. Thurman RG, Marzi I, Seitz G, Thies J, Lemasters JJ, Zimmerman F. Hepatic reperfusion injury following orthotopic liver transplantation in the rat. Transplantation. 1988 Oct; 46(4):502-6. PMID: 3051556.
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    348. Gores GJ, Nieminen AL, Fleishman KE, Dawson TL, Herman B, Lemasters JJ. Extracellular acidosis delays onset of cell death in ATP-depleted hepatocytes. Am J Physiol. 1988 Sep; 255(3 Pt 1):C315-22. PMID: 3421314.
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    349. Stine KE, Reiter LW, Lemasters JJ. Alkyltin inhibition of ATPase activities in tissue homogenates and subcellular fractions from adult and neonatal rats. Toxicol Appl Pharmacol. 1988 Jul; 94(3):394-406. PMID: 2969635.
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    350. Marotto ME, Thurman RG, Lemasters JJ. Early midzonal cell death during low-flow hypoxia in the isolated, perfused rat liver: protection by allopurinol. Hepatology. 1988 May-Jun; 8(3):585-90. PMID: 3371875.
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    351. Caldwell-Kenkel JC, Thurman RG, Lemasters JJ. Selective loss of nonparenchymal cell viability after cold ischemic storage of rat livers. Transplantation. 1988 Apr; 45(4):834-7. PMID: 3282369.
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    352. Herman B, Nieminen AL, Gores GJ, Lemasters JJ. Irreversible injury in anoxic hepatocytes precipitated by an abrupt increase in plasma membrane permeability. FASEB J. 1988 Feb; 2(2):146-51. PMID: 3342967.
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    353. Thurman RG, Lemasters JJ. New micro-optical methods to study metabolism in periportal and pericentral regions of the liver lobule. Drug Metab Rev. 1988; 19(3-4):263-81. PMID: 3068031.
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    354. Thurman RG, Apel ED, Lemasters JJ. Protective effect of nitrendipine against hypoxic injury in perfused livers from ethanol-treated rats. J Cardiovasc Pharmacol. 1988; 12 Suppl 4:S113-6. PMID: 2468851.
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    355. Anundi I, King J, Owen DA, Schneider H, Lemasters JJ, Thurman RG. Fructose prevents hypoxic cell death in liver. Am J Physiol. 1987 Sep; 253(3 Pt 1):G390-6. PMID: 3631273.
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    356. Lemasters JJ, Fleishman KE. An ATP/2e-stoichiometry of 1 1/2 is thermodynamically possible for site 3 of oxidative phosphorylation. Biochem Biophys Res Commun. 1987 Jan 15; 142(1):176-82. PMID: 3028400.
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    357. Anundi I, King J, Owens DA, Schneider H, Lemasters JJ, Thurman RG. Total protection from hypoxic liver damage by fructose. Res Commun Chem Pathol Pharmacol. 1987 Jan; 55(1):111-6. PMID: 3563102.
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    358. Lemasters JJ, DiGuiseppi J, Nieminen AL, Herman B. Blebbing, free Ca2+ and mitochondrial membrane potential preceding cell death in hepatocytes. Nature. 1987 Jan 1-7; 325(6099):78-81. PMID: 3099216.
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    359. Emaus RK, Grunwald R, Lemasters JJ. Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. Biochim Biophys Acta. 1986 Jul 23; 850(3):436-48. PMID: 2873836.
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    360. Bradford BU, Marotto M, Lemasters JJ, Thurman RG. New, simple models to evaluate zone-specific damage due to hypoxia in the perfused rat liver: time course and effect of nutritional state. J Pharmacol Exp Ther. 1986 Jan; 236(1):263-8. PMID: 3941397.
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    361. Freedman JA, Lemasters JJ. Thermodynamics of reverse electron transfer across site 1: ATP/2e- is greater than one. Biochem Biophys Res Commun. 1984 Nov 30; 125(1):8-13. PMID: 6508810.
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    362. Lemasters JJ. The ATP-to-oxygen stoichiometries of oxidative phosphorylation by rat liver mitochondria. An analysis of ADP-induced oxygen jumps by linear nonequilibrium thermodynamics. J Biol Chem. 1984 Nov 10; 259(21):13123-30. PMID: 6548475.
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    363. Thurman RG, Ji S, Matsumura T, Lemasters JJ. Is hypoxia involved in the mechanism of alcohol-induced liver injury? Fundam Appl Toxicol. 1984 Apr; 4(2 Pt 1):125-33. PMID: 6724187.
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    364. Lemasters JJ, Grunwald R, Emaus RK. Thermodynamic limits to the ATP/site stoichiometries of oxidative phosphorylation by rat liver mitochondria. J Biol Chem. 1984 Mar 10; 259(5):3058-63. PMID: 6321493.
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    365. Thurman RG, Ji S, Lemasters JJ. Alcohol-induced liver injury. The role of oxygen. Recent Dev Alcohol. 1984; 2:103-17. PMID: 6374778.
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    366. Belinsky SA, Kauffman FC, Ji S, Lemasters JJ, Thurman RG. Stimulation of mixed-function oxidation of 7-ethoxycoumarin in periportal and pericentral regions of the perfused rat liver by xylitol. Eur J Biochem. 1983 Dec 01; 137(1-2):1-6. PMID: 6606574.
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    367. Lemasters JJ, Stemkowski CJ, Ji S, Thurman RG. Cell surface changes and enzyme release during hypoxia and reoxygenation in the isolated, perfused rat liver. J Cell Biol. 1983 Sep; 97(3):778-86. PMID: 6684126.
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    368. Thurman RG, Kauffman FC, Ji S, Lemasters JJ, Conway JG, Belinsky SA, Kashiwagi T, Matsamura T. Metabolic heterogeneity in the perfused rat liver. Pharmacol Biochem Behav. 1983; 18 Suppl 1:415-9. PMID: 6356163.
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    369. Jacobs KS, Lemasters JJ, Reiter LW. Inhibition of ATPase activities of brain and liver homogenates by triethyltin (TET). Dev Toxicol Environ Sci. 1983; 11:517-20. PMID: 6234157.
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    370. Lemasters JJ, Ji S, Stemkowski CJ, Thurman RG. Hypoxic hepatocellular injury. Pharmacol Biochem Behav. 1983; 18 Suppl 1:455-9. PMID: 6634855.
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    371. Ji S, Lemasters JJ, Christenson V, Thurman RG. Selective increase in pericentral oxygen gradient in perfused rat liver following ethanol treatment. Pharmacol Biochem Behav. 1983; 18 Suppl 1:439-42. PMID: 6685302.
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    372. Schneider H, Lemasters JJ, Hackenbrock CR. Lateral diffusion of ubiquinone during electron transfer in phospholipid- and ubiquinone-enriched mitochondrial membranes. J Biol Chem. 1982 Sep 25; 257(18):10789-93. PMID: 6286674.
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    373. Ji S, Lemasters JJ, Christenson V, Thurman RG. Periportal and pericentral pyridine nucleotide fluorescence from the surface of the perfused liver: evaluation of the hypothesis that chronic treatment with ethanol produces pericentral hypoxia. Proc Natl Acad Sci U S A. 1982 Sep; 79(17):5415-9. PMID: 6957871.
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    374. Kashiwagi T, Ji S, Lemasters JJ, Thurman RG. Rates of alcohol dehydrogenase-dependent ethanol metabolism in periportal and pericentral regions of the perfused rat liver. Mol Pharmacol. 1982 Mar; 21(2):438-43. PMID: 7048061.
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    375. Lemasters JJ, Billica WH. Non-equilibrium thermodynamics of oxidative phosphorylation by inverted inner membrane vesicles of rat liver mitochondria. J Biol Chem. 1981 Dec 25; 256(24):12949-57. PMID: 7309743.
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    376. Lemasters JJ, Ji S, Thurman RG. Centrilobular injury following hypoxia in isolated, perfused rat liver. Science. 1981 Aug 07; 213(4508):661-3. PMID: 7256265.
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    377. Ji S, Lemasters JJ, Thurman RG. A fluorometric method to measure sublobular rates of mixed-function oxidation in the hemoglobin-free perfused rat liver. Mol Pharmacol. 1981 May; 19(3):513-6. PMID: 6973689.
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    378. Lemasters JJ, Hackenbrock CR. The energized state of rat liver mitochondria. ATP equivalence, uncoupler sensitivity, and decay kinetics. J Biol Chem. 1980 Jun 25; 255(12):5674-80. PMID: 7380830.
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    379. Schneider H, Lemasters JJ, Höchli M, Hackenbrock CR. Liposome-mitochondrial inner membrane fusion. Lateral diffusion of integral electron transfer components. J Biol Chem. 1980 Apr 25; 255(8):3748-56. PMID: 6245090.
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    380. Ji S, Lemasters JJ, Thurman RG. A non-invasive method to study metabolic events within sublobular regions of hemoglobin-free perfused liver. FEBS Lett. 1980 Apr 21; 113(1):37-42. PMID: 7380004.
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    381. Lemasters JJ. Near thermodynamic equilibrium of oxidative phosphorylation by inverted inner membrane vesicles of rat liver mitochondria. FEBS Lett. 1980 Jan 28; 110(1):96-100. PMID: 7353670.
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    382. Hackenbrock CR, Schneider H, Lemasters JJ, Höchli M. Relationships between bilayer lipid, motional freedom of oxidoreductase components, and electron transfer in the mitochondrial inner membrane. Adv Exp Med Biol. 1980; 132:245-63. PMID: 7424710.
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    383. Ji S, Lemasters JJ, Thurman RG. Ethanol-induced changes in the intralobular oxygen gradient of perfused rat liver. Pharmacol Biochem Behav. 1980; 13 Suppl 1:41-5. PMID: 7243833.
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    384. Schneider H, Lemasters JJ, Höchli M, Hackenbrock CR. Fusion of liposomes with mitochondrial inner membranes. Proc Natl Acad Sci U S A. 1980 Jan; 77(1):442-6. PMID: 6928637.
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    385. Lemasters JJ, Sowers AE. Phosphate dependence and atractyloside inhibition of mitochondrial oxidative phosphorylation. The ADP-ATP carrier is rate-limiting. J Biol Chem. 1979 Feb 25; 254(4):1248-51. PMID: 762127.
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    386. Lemasters JJ, Hackenbrock CR. Continuous measurement of adenosine triphosphate with firefly luciferase luminescence. Methods Enzymol. 1979; 56:530-44. PMID: 459883.
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    387. Lemasters JJ. Possible role of the mitochondrial outer membrane as an oncotic regulator of mitochondrial volume. FEBS Lett. 1978 Apr 01; 88(1):10-4. PMID: 639975.
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    388. Lemasters JJ, Hackenbrock CR. Kinetics of product inhibition during firefly luciferase luminescence. Biochemistry. 1977 Feb 08; 16(3):445-7. PMID: 836795.
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    389. Lemasters JJ, Hackenbrock CR. Continuous measurement and rapid kinetics of ATP synthesis in rat liver mitochondria, mitoplasts and inner membrane vesicles determined by firefly-luciferase luminescence. Eur J Biochem. 1976 Aug 01; 67(1):1-10. PMID: 964235.
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    390. Lemasters JJ, Hackenbrock CE. Adenosine triphosphate: continuous measurement in mitochondrial suspension by firefly luciferase luminescence. Biochem Biophys Res Commun. 1973 Dec 19; 55(4):1262-70. PMID: 4771996.
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    391. Hackenbrock CR, Rehn TG, Weinbach EC, Lemasters JJ. Oxidative phosphorylation and ultrastructural transformation in mitochondria in the intact ascites tumor cell. J Cell Biol. 1971 Oct; 51(1):123-37. PMID: 5111873.
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