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Last Name
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John Wyatt Gnann

Title
InstitutionMedical University of South Carolina
DepartmentInfectious Diseases
AddressP.O. Box MSC 752
135 Rutledge Ave.
Phone843-792-4541
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    Collapse Overview 
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    John W. Gnann, Jr., MD joined the MUSC DOM, Division of Infectious Diseases, in 2013. Dr. Gnann was born in Walterboro, SC and grew up in Savannah, GA. Following graduation from Davidson College and Duke University School of Medicine, Dr. Gnann completed his internal medicine residency and Infectious Diseases fellowship at the University of Alabama at Birmingham. At UAB, Dr. Gnann began to develop his career-long interest in clinical virology and antiviral chemotherapy. Fellowship was followed by a tour of duty in the US Army where Dr. Gnann served as the Chief of the Infectious Diseases Service at Madigan Army Medical Center in Tacoma, WA. Dr. Gnann then re-located to Southern California where he completed a 3 year postdoctoral research fellowship in virology and immunology at the Scripps Institute in La Jolla, CA.

    At the completion of his postdoctoral fellowship, Dr. Gnann was recruited to return to UAB to join the infectious diseases faculty. During his 25 years at UAB, Dr. Gnann rose through the ranks to become a Professor of Medicine, Pediatrics, and Microbiology. His research interests continued to focus on the diagnosis and treatment of viral infections, especially those caused by herpesviruses. He led numerous clinical trials related to development of antiviral therapy for infections caused by HSV and VZV. He also became interested in opportunistic viral infections occurring in immunocompromised patients and led clinical investigations of hepatitis C in liver transplant recipients, RSV infections in bone marrow transplant patients, and BK virus disease in renal transplant recipients. In addition, Dr. Gnann developed expertise in vaccine research and was a principal investigator for studies related to VZV and anthrax vaccines. At UAB, he also served as the medical director of the 1917 (HIV) Clinic.

    In 2013, Dr. Gnann was recruited to move to Charleston and joined MUSC. At MUSC, Dr. Gnann continues to provide specialized care for persons living with HIV and for organ transplant recipients who experience infectious complications. He is also the medical director for the MUSC Antimicrobial Stewardship program.
    Collapse keywords
    HIV / AIDS, Infectious Diseases, Drug Studies, Clinical virology, Antiviral drugs, Organ transplant

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gnann JW, Agrawal A, Hart J, Buitrago M, Carson P, Hanfelt-Goade D, Tyler K, Spotkov J, Freifeld A, Moore T, Reyno J, Masur H, Jester P, Dale I, Li Y, Aban I, Lakeman FD, Whitley RJ. Lack of Efficacy of High-Titered Immunoglobulin in Patients with West Nile Virus Central Nervous System Disease. Emerg Infect Dis. 2019 11; 25(11):2064-2073. PMID: 31625835.
      View in: PubMed
    2. Bosshardt CR, Gnann J, Lodhia N. Histoplasma meets Crohn's disease: a rare case of new-onset ascites. BMJ Case Rep. 2018 Apr 17; 2018. PMID: 29666076.
      View in: PubMed
    3. Gnann JW, Whitley RJ. Herpes Simplex Encephalitis: an Update. Curr Infect Dis Rep. 2017 Mar; 19(3):13. PMID: 28251511.
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    4. Gnann JW, Whitley RJ. Genital Herpes. N Engl J Med. 2016 11 10; 375(19):1906. PMID: 27959656.
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    5. Gnann JW, Whitley RJ. CLINICAL PRACTICE. Genital Herpes. N Engl J Med. 2016 Aug 18; 375(7):666-74. PMID: 27532832.
      View in: PubMed
    6. MacVane SH, Hurst JM, Boger MS, Gnann JW. Impact of a rapid multiplex polymerase chain reaction blood culture identification technology on outcomes in patients with vancomycin-resistant Enterococcal bacteremia. Infect Dis (Lond). 2016 Oct; 48(10):732-7. PMID: 27196015.
      View in: PubMed
    7. Gnann JW, Sk├Âldenberg B, Hart J. Gnann JW et al (Clin Infect Dis 2015; 61:683-91). Herpes Simplex Encephalitis: Lack of Clinical Benefit of Long-term Valacyclovir Therapy. Clin Infect Dis. 2016 Feb 15; 62(4):530. PMID: 26703861.
      View in: PubMed
    8. Rimawi BH, Meserve J, Rimawi RH, Min Z, Gnann JW. Disseminated Herpes Simplex Virus with Fulminant Hepatitis. Case Reports Hepatol. 2015; 2015:463825. PMID: 26290760.
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    9. Gnann JW, Sk├Âldenberg B, Hart J, Aurelius E, Schliamser S, Studahl M, Eriksson BM, Hanley D, Aoki F, Jackson AC, Griffiths P, Miedzinski L, Hanfelt-Goade D, Hinthorn D, Ahlm C, Aksamit A, Cruz-Flores S, Dale I, Cloud G, Jester P, Whitley RJ. Herpes Simplex Encephalitis: Lack of Clinical Benefit of Long-term Valacyclovir Therapy. Clin Infect Dis. 2015 Sep 01; 61(5):683-91. PMID: 25956891.
      View in: PubMed
    10. Hart J, Tillman G, Kraut MA, Chiang HS, Strain JF, Li Y, Agrawal AG, Jester P, Gnann JW, Whitley RJ. West Nile virus neuroinvasive disease: neurological manifestations and prospective longitudinal outcomes. BMC Infect Dis. 2014 May 09; 14:248. PMID: 24884681.
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    11. Min Z, Gnann JW. Reversible posterior leukoencephalopathy syndrome. Intern Emerg Med. 2014 Apr; 9(3):341-2. PMID: 24132656.
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    12. Min Z, Gnann JW. Kaposi's varicelliform eruption. Intern Emerg Med. 2014 Feb; 9(1):101-2. PMID: 24036906.
      View in: PubMed
    13. Min Z, Gnann JW. Mosquito bites and eastern equine encephalitis. QJM. 2014 May; 107(5):397-8. PMID: 23970186.
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    14. Levin MJ, Schmader KE, Gnann JW, McNeil SA, Vesikari T, Betts RF, Keay S, Stek JE, Bundick ND, Su SC, Zhao Y, Li X, Chan IS, Annunziato PW, Parrino J. Varicella-zoster virus-specific antibody responses in 50-59-year-old recipients of zoster vaccine. J Infect Dis. 2013 Nov 01; 208(9):1386-90. PMID: 23908486.
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    15. Morrison VA, Oxman MN, Levin MJ, Schmader KE, Guatelli JC, Betts RF, Gelb LD, Pachucki CT, Keay SK, Menzies B, Griffin MR, Kauffman CA, Marques AR, Toney JF, Simberkoff MS, Serrao R, Arbeit RD, Gnann JW, Greenberg RN, Holodniy M, Keitel WA, Yeh SS, Davis LE, Crawford GE, Neuzil KM, Johnson GR, Zhang JH, Harbecke R, Chan IS, Keller PM, Williams HM, Boardman KD, Silber JL, Annunziato PW. Safety of zoster vaccine in elderly adults following documented herpes zoster. J Infect Dis. 2013 Aug 15; 208(4):559-63. PMID: 23633406.
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    16. Gnann JW. Varicella-zoster virus: Prevention through vaccination. Clin Obstet Gynecol. 2012 Jun; 55(2):560-70. PMID: 22510639.
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    17. Schmader KE, Levin MJ, Gnann JW, McNeil SA, Vesikari T, Betts RF, Keay S, Stek JE, Bundick ND, Su SC, Zhao Y, Li X, Chan IS, Annunziato PW, Parrino J. Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 years. Clin Infect Dis. 2012 Apr; 54(7):922-8. PMID: 22291101.
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    18. Bradford RD, Pettit AC, Wright PW, Mulligan MJ, Moreland LW, McLain DA, Gnann JW, Bloch KC. Herpes simplex encephalitis during treatment with tumor necrosis factor-alpha inhibitors. Clin Infect Dis. 2009 Sep 15; 49(6):924-7. PMID: 19681709.
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    19. Whitley RJ, Gnann JW. Herpes zoster in the age of focused immunosuppressive therapy. JAMA. 2009 Feb 18; 301(7):774-5. PMID: 19224757.
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    20. Dworkin RH, Barbano RL, Tyring SK, Betts RF, McDermott MP, Pennella-Vaughan J, Bennett GJ, Berber E, Gnann JW, Irvine C, Kamp C, Kieburtz K, Max MB, Schmader KE. A randomized, placebo-controlled trial of oxycodone and of gabapentin for acute pain in herpes zoster. Pain. 2009 Apr; 142(3):209-17. PMID: 19195785.
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    21. Bartlett BL, Tyring SK, Fife K, Gnann JW, Hadala JT, Kianifard F, Berber E. Famciclovir treatment options for patients with frequent outbreaks of recurrent genital herpes: the RELIEF trial. J Clin Virol. 2008 Oct; 43(2):190-5. PMID: 18621575.
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    22. Schmader K, Gnann JW, Watson CP. The epidemiological, clinical, and pathological rationale for the herpes zoster vaccine. J Infect Dis. 2008 Mar 01; 197 Suppl 2:S207-15. PMID: 18419399.
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    23. Gnann JW. Vaccination to prevent herpes zoster in older adults. J Pain. 2008 Jan; 9(1 Suppl 1):S31-6. PMID: 18166463.
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    24. Dworkin RH, Gnann JW, Oaklander AL, Raja SN, Schmader KE, Whitley RJ. Diagnosis and assessment of pain associated with herpes zoster and postherpetic neuralgia. J Pain. 2008 Jan; 9(1 Suppl 1):S37-44. PMID: 18166464.
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    25. Whitley RJ, Gnann JW. The incidence and severity of herpes simplex encephalitis in Sweden, 1990-2001. Clin Infect Dis. 2007 Oct 01; 45(7):881-2. PMID: 17806054.
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    26. Dworkin RH, Johnson RW, Breuer J, Gnann JW, Levin MJ, Backonja M, Betts RF, Gershon AA, Haanpaa ML, McKendrick MW, Nurmikko TJ, Oaklander AL, Oxman MN, Pavan-Langston D, Petersen KL, Rowbotham MC, Schmader KE, Stacey BR, Tyring SK, van Wijck AJ, Wallace MS, Wassilew SW, Whitley RJ. Recommendations for the management of herpes zoster. Clin Infect Dis. 2007 Jan 01; 44 Suppl 1:S1-26. PMID: 17143845.
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    27. Boeckh M, Englund J, Li Y, Miller C, Cross A, Fernandez H, Kuypers J, Kim H, Gnann J, Whitley R. Randomized controlled multicenter trial of aerosolized ribavirin for respiratory syncytial virus upper respiratory tract infection in hematopoietic cell transplant recipients. Clin Infect Dis. 2007 Jan 15; 44(2):245-9. PMID: 17173225.
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    28. Davis GL, Nelson DR, Terrault N, Pruett TL, Schiano TD, Fletcher CV, Sapan CV, Riser LN, Li Y, Whitley RJ, Gnann JW. A randomized, open-label study to evaluate the safety and pharmacokinetics of human hepatitis C immune globulin (Civacir) in liver transplant recipients. Liver Transpl. 2005 Aug; 11(8):941-9. PMID: 16035063.
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    29. Oxman MN, Levin MJ, Johnson GR, Schmader KE, Straus SE, Gelb LD, Arbeit RD, Simberkoff MS, Gershon AA, Davis LE, Weinberg A, Boardman KD, Williams HM, Zhang JH, Peduzzi PN, Beisel CE, Morrison VA, Guatelli JC, Brooks PA, Kauffman CA, Pachucki CT, Neuzil KM, Betts RF, Wright PF, Griffin MR, Brunell P, Soto NE, Marques AR, Keay SK, Goodman RP, Cotton DJ, Gnann JW, Loutit J, Holodniy M, Keitel WA, Crawford GE, Yeh SS, Lobo Z, Toney JF, Greenberg RN, Keller PM, Harbecke R, Hayward AR, Irwin MR, Kyriakides TC, Chan CY, Chan IS, Wang WW, Annunziato PW, Silber JL. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med. 2005 Jun 02; 352(22):2271-84. PMID: 15930418.
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    30. Borucki MJ, Spritzler J, Asmuth DM, Gnann J, Hirsch MS, Nokta M, Aweeka F, Nadler PI, Sattler F, Alston B, Nevin TT, Owens S, Waterman K, Hubbard L, Caliendo A, Pollard RB. A phase II, double-masked, randomized, placebo-controlled evaluation of a human monoclonal anti-Cytomegalovirus antibody (MSL-109) in combination with standard therapy versus standard therapy alone in the treatment of AIDS patients with Cytomegalovirus retinitis. Antiviral Res. 2004 Nov; 64(2):103-11. PMID: 15498605.
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    31. Ison MG, Gnann JW, Nagy-Agren S, Treannor J, Paya C, Steigbigel R, Elliott M, Weiss HL, Hayden FG. Safety and efficacy of nebulized zanamivir in hospitalized patients with serious influenza. Antivir Ther. 2003 Jun; 8(3):183-90. PMID: 12924534.
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    32. Wright PW, Hoesley CJ, Squires KE, Croom-Rivers A, Weiss HL, Gnann JW. A prospective study of genital herpes simplex virus type 2 infection in human immunodeficiency virus type 1 (HIV-1)-seropositive women: correlations with CD4 cell count and plasma HIV-1 RNA level. Clin Infect Dis. 2003 Jan 15; 36(2):207-11. PMID: 12522754.
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    33. Gnann JW. Varicella-zoster virus: atypical presentations and unusual complications. J Infect Dis. 2002 Oct 15; 186 Suppl 1:S91-8. PMID: 12353193.
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    34. Gnann JW, Whitley RJ. Clinical practice. Herpes zoster. N Engl J Med. 2002 Aug 01; 347(5):340-6. PMID: 12151472.
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    35. Desmond RA, Weiss HL, Arani RB, Soong SJ, Wood MJ, Fiddian PA, Gnann JW, Whitley RJ. Clinical applications for change-point analysis of herpes zoster pain. J Pain Symptom Manage. 2002 Jun; 23(6):510-6. PMID: 12067775.
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    36. Whitley RJ, Gnann JW. Viral encephalitis: familiar infections and emerging pathogens. Lancet. 2002 Feb 09; 359(9305):507-13. PMID: 11853816.
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    37. Arani RB, Soong SJ, Weiss HL, Wood MJ, Fiddian PA, Gnann JW, Whitley R. Phase specific analysis of herpes zoster associated pain data: a new statistical approach. Stat Med. 2001 Aug 30; 20(16):2429-39. PMID: 11512133.
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    38. Kilby JM, Goepfert PA, Miller AP, Gnann JW, Sillers M, Saag MS, Bucy RP. Recurrence of the acute HIV syndrome after interruption of antiretroviral therapy in a patient with chronic HIV infection: A case report. Ann Intern Med. 2000 Sep 19; 133(6):435-8. PMID: 10975961.
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    39. Gnann JW, Pellett PE, Jaffe HW. Human herpesvirus 8 and Kaposi's sarcoma in persons infected with human immunodeficiency virus. Clin Infect Dis. 2000 Apr; 30 Suppl 1:S72-6. PMID: 10770915.
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    40. Whitley RJ, Gnann JW. Herpes zoster: focus on treatment in older adults. Antiviral Res. 1999 Dec 31; 44(3):145-54. PMID: 10651066.
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    41. Harrison RA, Soong S, Weiss HL, Gnann JW, Whitley RJ. A mixed model for factors predictive of pain in AIDS patients with herpes zoster. J Pain Symptom Manage. 1999 Jun; 17(6):410-7. PMID: 10388246.
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    42. Whitley RJ, Weiss HL, Soong SJ, Gnann JW. Herpes zoster: risk categories for persistent pain. J Infect Dis. 1999 Jan; 179(1):9-15. PMID: 9841816.
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    43. Whitley RJ, Gnann JW. Therapeutic approaches to the management of herpes zoster. Adv Exp Med Biol. 1999; 458:159-65. PMID: 10549388.
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    44. Gnann JW, Crumpacker CS, Lalezari JP, Smith JA, Tyring SK, Baum KF, Borucki MJ, Joseph WP, Mertz GJ, Steigbigel RT, Cloud GA, Soong SJ, Sherrill LC, DeHertogh DA, Whitley RJ. Sorivudine versus acyclovir for treatment of dermatomal herpes zoster in human immunodeficiency virus-infected patients: results from a randomized, controlled clinical trial. Collaborative Antiviral Study Group/AIDS Clinical Trials Group, Herpes Zoster Study Group. Antimicrob Agents Chemother. 1998 May; 42(5):1139-45. PMID: 9593141.
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    45. Whitley RJ, Weiss H, Gnann JW, Tyring S, Mertz GJ, Pappas PG, Schleupner CJ, Hayden F, Wolf J, Soong SJ. Acyclovir with and without prednisone for the treatment of herpes zoster. A randomized, placebo-controlled trial. The National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. Ann Intern Med. 1996 Sep 01; 125(5):376-83. PMID: 8702088.
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    46. Whitley RJ, Gnann JW, Weiss HL, Soong SJ. Unique clinical trial design: combination acyclovir plus prednisone therapy of localized zoster in the normal host. Antiviral Res. 1996 Jan; 29(1):67-8. PMID: 8721549.
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    47. Whitley RJ, Gnann JW. Herpes zoster in patients with human immunodeficiency virus infection--an ever-expanding spectrum of disease. Clin Infect Dis. 1995 Oct; 21(4):989-90. PMID: 8645853.
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    48. Gnann JW. New antivirals with activity against varicella-zoster virus. Ann Neurol. 1994; 35 Suppl:S69-72. PMID: 8185303.
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    49. Whitley RJ, Gnann JW. Acyclovir: a decade later. N Engl J Med. 1992 Sep 10; 327(11):782-9. PMID: 1288525.
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    50. Whitley RJ, Gnann JW, Hinthorn D, Liu C, Pollard RB, Hayden F, Mertz GJ, Oxman M, Soong SJ. Disseminated herpes zoster in the immunocompromised host: a comparative trial of acyclovir and vidarabine. The NIAID Collaborative Antiviral Study Group. J Infect Dis. 1992 Mar; 165(3):450-5. PMID: 1538151.
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    51. Gnann JW, Whitley RJ. Natural history and treatment of varicella-zoster in high-risk populations. J Hosp Infect. 1991 Jun; 18 Suppl A:317-29. PMID: 1679798.
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    52. Johnson JR, Lyons MF, Pearce W, Gorman P, Roberts PL, White N, Brust P, Olsen R, Gnann JW, Stamm WE. Therapy for women hospitalized with acute pyelonephritis: a randomized trial of ampicillin versus trimethoprim-sulfamethoxazole for 14 days. J Infect Dis. 1991 Feb; 163(2):325-30. PMID: 1988516.
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    53. Whitley RJ, Middlebrooks M, Gnann JW. Acyclovir: the past ten years. Adv Exp Med Biol. 1990; 278:243-53. PMID: 1963040.
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    54. Schrier RD, Gnann JW, Landes R, Lockshin C, Richman D, McCutchan A, Kennedy C, Oldstone MB, Nelson JA. T cell recognition of HIV synthetic peptides in a natural infection. J Immunol. 1989 Feb 15; 142(4):1166-76. PMID: 2783706.
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    55. Gnann JW, Smith LL, Oldstone MB. Custom-designed synthetic peptide immunoassays for distinguishing HIV type 1 and type 2 infections. Methods Enzymol. 1989; 178:693-714. PMID: 2481220.
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    56. Peacock JE, Kaplowitz LG, Sparling PF, Durack DT, Gnann JW, Whitley RJ, Lovett M, Bryson YJ, Klein RJ, Friedman-Kien AE, et al. Intravenous acyclovir therapy of first episodes of genital herpes: a multicenter double-blind, placebo-controlled trial. Am J Med. 1988 Sep; 85(3):301-6. PMID: 3046350.
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    57. Gnann JW, McCormick JB, Mitchell S, Nelson JA, Oldstone MB. Synthetic peptide immunoassay distinguishes HIV type 1 and HIV type 2 infections. Science. 1987 Sep 11; 237(4820):1346-9. PMID: 2888192.
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    58. Gnann JW, Gray BM, Griffin FM, Dismukes WE. Acute glomerulonephritis following group G streptococcal infection. J Infect Dis. 1987 Aug; 156(2):411-2. PMID: 3598242.
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    59. Gnann JW, Schwimmbeck PL, Nelson JA, Truax AB, Oldstone MB. Diagnosis of AIDS by using a 12-amino acid peptide representing an immunodominant epitope of the human immunodeficiency virus. J Infect Dis. 1987 Aug; 156(2):261-7. PMID: 2439614.
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    60. Luby JP, Gnann JW, Alexander WJ, Hatcher VA, Friedman-Kien AE, Klein RJ, Keyserling H, Nahmias A, Mills J, Schachter J, et al. A collaborative study of patient-initiated treatment of recurrent genital herpes with topical acyclovir or placebo. J Infect Dis. 1984 Jul; 150(1):1-6. PMID: 6086765.
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    61. Gnann JW, Barton NH, Whitley RJ. Acyclovir: mechanism of action, pharmacokinetics, safety and clinical applications. Pharmacotherapy. 1983 Sep-Oct; 3(5):275-83. PMID: 6359082.
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