Keywords
Last Name
Institution

Joe B Blumer

Title
InstitutionMedical University of South Carolina
DepartmentCell and Molecular Pharmacology and Experimental Therapeutics
AddressP.O. Box MSC 509
BSB 313D
173 Ashley Ave.
Phone843-792-3552
Fax843-792-2475
vCardDownload vCard

    Collapse Biography 
    Collapse awards and honors
    2009 - 2014R01 GM086510 "AGS4 in G-protein Signal Processing", Medical University of South Carolina

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Vural A, Nabar NR, Hwang IY, Sohn S, Park C, Karlsson MCI, Blumer JB, Kehrl JH. Gai2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination. J Immunol. 2019 Mar 01; 202(5):1510-1520. PMID: 30683698.
      View in: PubMed
    2. Robichaux WG, Branham-O'Connor M, Hwang IY, Vural A, Kehrl JH, Blumer JB. Regulation of Chemokine Signal Integration by Activator of G-Protein Signaling 4 (AGS4). J Pharmacol Exp Ther. 2017 03; 360(3):424-433. PMID: 28062526.
      View in: PubMed
    3. Vural A, Al-Khodor S, Cheung GY, Shi CS, Srinivasan L, McQuiston TJ, Hwang IY, Yeh AJ, Blumer JB, Briken V, Williamson PR, Otto M, Fraser ID, Kehrl JH. Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection. J Immunol. 2016 Jan 15; 196(2):846-56. PMID: 26667172.
      View in: PubMed
    4. Rasmussen SA, Kwon M, Pressly JD, Blumer JB, Regner KR, Park F. Activator of G-protein Signaling 3 Controls Renal Epithelial Cell Survival and ERK5 Activation. J Mol Signal. 2015 Nov 27; 10:6. PMID: 27096004.
      View in: PubMed
    5. Robichaux WG, Oner SS, Lanier SM, Blumer JB. Direct Coupling of a Seven-Transmembrane-Span Receptor to a Gai G-Protein Regulatory Motif Complex. Mol Pharmacol. 2015 Aug; 88(2):231-7. PMID: 25972449.
      View in: PubMed
    6. Brown NE, Blumer JB, Hepler JR. Bioluminescence resonance energy transfer to detect protein-protein interactions in live cells. Methods Mol Biol. 2015; 1278:457-65. PMID: 25859969.
      View in: PubMed
    7. Zhang J, Ye ZW, Gao P, Reyes L, Jones EE, Branham-O'Connor M, Blumer JB, Drake RR, Manevich Y, Townsend DM, Tew KD. Glutathione S-transferase P influences redox and migration pathways in bone marrow. PLoS One. 2014; 9(9):e107478. PMID: 25216273.
      View in: PubMed
    8. Branham-O'Connor M, Robichaux WG, Zhang XK, Cho H, Kehrl JH, Lanier SM, Blumer JB. Defective chemokine signal integration in leukocytes lacking activator of G protein signaling 3 (AGS3). J Biol Chem. 2014 Apr 11; 289(15):10738-47. PMID: 24573680.
      View in: PubMed
    9. Bradley A, Zheng H, Ziebarth A, Sakati W, Branham-O'Connor M, Blumer JB, Liu Y, Kistner-Griffin E, Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK, Landen CN, Eblen ST. EDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer. Carcinogenesis. 2014 May; 35(5):1100-9. PMID: 24379240.
      View in: PubMed
    10. Blumer JB, Lanier SM. Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad. Mol Pharmacol. 2014 Mar; 85(3):388-96. PMID: 24302560.
      View in: PubMed
    11. Vural A, McQuiston TJ, Blumer JB, Park C, Hwang IY, Williams-Bey Y, Shi CS, Ma DZ, Kehrl JH. Normal autophagic activity in macrophages from mice lacking Gai3, AGS3, or RGS19. PLoS One. 2013; 8(11):e81886. PMID: 24312373.
      View in: PubMed
    12. Oner SS, Blumer JB, Lanier SM. Group II activators of G-protein signaling: monitoring the interaction of Ga with the G-protein regulatory motif in the intact cell. Methods Enzymol. 2013; 522:153-67. PMID: 23374185.
      View in: PubMed
    13. Vellano CP, Brown NE, Blumer JB, Hepler JR. Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gai1 and Gai-linked G protein-coupled receptors. J Biol Chem. 2013 Feb 01; 288(5):3620-31. PMID: 23250758.
      View in: PubMed
    14. Kwon M, Pavlov TS, Nozu K, Rasmussen SA, Ilatovskaya DV, Lerch-Gaggl A, North LM, Kim H, Qian F, Sweeney WE, Avner ED, Blumer JB, Staruschenko A, Park F. G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):21462-7. PMID: 23236168.
      View in: PubMed
    15. Oner SS, Maher EM, Gabay M, Tall GG, Blumer JB, Lanier SM. Regulation of the G-protein regulatory-Gai signaling complex by nonreceptor guanine nucleotide exchange factors. J Biol Chem. 2013 Feb 01; 288(5):3003-15. PMID: 23212907.
      View in: PubMed
    16. Vellano CP, Maher EM, Hepler JR, Blumer JB. G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gai1 complex in live cells. J Biol Chem. 2011 Nov 04; 286(44):38659-69. PMID: 21880739.
      View in: PubMed
    17. Blumer JB, Oner SS, Lanier SM. Group II activators of G-protein signalling and proteins containing a G-protein regulatory motif. Acta Physiol (Oxf). 2012 Feb; 204(2):202-18. PMID: 21615707.
      View in: PubMed
    18. Reissner KJ, Uys JD, Schwacke JH, Comte-Walters S, Rutherford-Bethard JL, Dunn TE, Blumer JB, Schey KL, Kalivas PW. AKAP signaling in reinstated cocaine seeking revealed by iTRAQ proteomic analysis. J Neurosci. 2011 Apr 13; 31(15):5648-58. PMID: 21490206.
      View in: PubMed
    19. Regner KR, Nozu K, Lanier SM, Blumer JB, Avner ED, Sweeney WE, Park F. Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents. FASEB J. 2011 Jun; 25(6):1844-55. PMID: 21343176.
      View in: PubMed
    20. Chan P, Gabay M, Wright FA, Kan W, Oner SS, Lanier SM, Smrcka AV, Blumer JB, Tall GG. Purification of heterotrimeric G protein alpha subunits by GST-Ric-8 association: primary characterization of purified G alpha(olf). J Biol Chem. 2011 Jan 28; 286(4):2625-35. PMID: 21115479.
      View in: PubMed
    21. Oner SS, An N, Vural A, Breton B, Bouvier M, Blumer JB, Lanier SM. Regulation of the AGS3·G{alpha}i signaling complex by a seven-transmembrane span receptor. J Biol Chem. 2010 Oct 29; 285(44):33949-58. PMID: 20716524.
      View in: PubMed
    22. Nadella R, Blumer JB, Jia G, Kwon M, Akbulut T, Qian F, Sedlic F, Wakatsuki T, Sweeney WE, Wilson PD, Lanier SM, Park F. Activator of G protein signaling 3 promotes epithelial cell proliferation in PKD. J Am Soc Nephrol. 2010 Aug; 21(8):1275-80. PMID: 20488951.
      View in: PubMed
    23. Oner SS, Maher EM, Breton B, Bouvier M, Blumer JB. Receptor-regulated interaction of activator of G-protein signaling-4 and Galphai. J Biol Chem. 2010 Jul 02; 285(27):20588-94. PMID: 20452976.
      View in: PubMed
    24. Vural A, Oner S, An N, Simon V, Ma D, Blumer JB, Lanier SM. Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable. Mol Cell Biol. 2010 Mar; 30(6):1528-40. PMID: 20065032.
      View in: PubMed
    25. Raji B, Dansault A, Vieira V, de la Houssaye G, Lacassagne E, Kobetz A, Arbogast L, Dufier JL, Blumer JB, Menasche M, Abitbol M. Analysis of partner of inscuteable (mPins) expression in the developing mouse eye. Mol Vis. 2008; 14:2575-96. PMID: 19122831.
      View in: PubMed
    26. An N, Blumer JB, Bernard ML, Lanier SM. The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins. J Biol Chem. 2008 Sep 05; 283(36):24718-28. PMID: 18566450.
      View in: PubMed
    27. Blumer JB, Lord K, Saunders TL, Pacchioni A, Black C, Lazartigues E, Varner KJ, Gettys TW, Lanier SM. Activator of G protein signaling 3 null mice: I. Unexpected alterations in metabolic and cardiovascular function. Endocrinology. 2008 Aug; 149(8):3842-9. PMID: 18450958.
      View in: PubMed
    28. Blumer JB, Smrcka AV, Lanier SM. Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling. Pharmacol Ther. 2007 Mar; 113(3):488-506. PMID: 17240454.
      View in: PubMed
    29. Blumer JB, Kuriyama R, Gettys TW, Lanier SM. The G-protein regulatory (GPR) motif-containing Leu-Gly-Asn-enriched protein (LGN) and Gialpha3 influence cortical positioning of the mitotic spindle poles at metaphase in symmetrically dividing mammalian cells. Eur J Cell Biol. 2006 Dec; 85(12):1233-40. PMID: 17000024.
      View in: PubMed
    30. Song KS, Peterson YK, Freidman A, Blumer JB, Sato M, Lanier SM. Identification and characterization of a G-protein regulatory motif in WAVE1. FEBS Lett. 2006 Apr 03; 580(8):1993-8. PMID: 16530190.
      View in: PubMed
    31. Sato M, Blumer JB, Simon V, Lanier SM. Accessory proteins for G proteins: partners in signaling. Annu Rev Pharmacol Toxicol. 2006; 46:151-87. PMID: 16402902.
      View in: PubMed
    32. Sans N, Wang PY, Du Q, Petralia RS, Wang YX, Nakka S, Blumer JB, Macara IG, Wenthold RJ. mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression. Nat Cell Biol. 2005 Dec; 7(12):1179-90. PMID: 16299499.
      View in: PubMed
    33. Blumer JB, Cismowski MJ, Sato M, Lanier SM. AGS proteins: receptor-independent activators of G-protein signaling. Trends Pharmacol Sci. 2005 Sep; 26(9):470-6. PMID: 16084602.
      View in: PubMed
    34. Nair KS, Mendez A, Blumer JB, Rosenzweig DH, Slepak VZ. The presence of a Leu-Gly-Asn repeat-enriched protein (LGN), a putative binding partner of transducin, in ROD photoreceptors. Invest Ophthalmol Vis Sci. 2005 Jan; 46(1):383-9. PMID: 15623799.
      View in: PubMed
    35. Cao X, Cismowski MJ, Sato M, Blumer JB, Lanier SM. Identification and characterization of AGS4: a protein containing three G-protein regulatory motifs that regulate the activation state of Gialpha. J Biol Chem. 2004 Jun 25; 279(26):27567-74. PMID: 15096500.
      View in: PubMed
    36. Blumer JB, Bernard ML, Peterson YK, Nezu J, Chung P, Dunican DJ, Knoblich JA, Lanier SM. Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha. J Biol Chem. 2003 Jun 27; 278(26):23217-20. PMID: 12719437.
      View in: PubMed
    37. Blumer JB, Lanier SM. Accessory proteins for G protein-signaling systems: activators of G protein signaling and other nonreceptor proteins influencing the activation state of G proteins. Receptors Channels. 2003; 9(3):195-204. PMID: 12775339.
      View in: PubMed
    38. Blumer JB, Chandler LJ, Lanier SM. Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis. J Biol Chem. 2002 May 03; 277(18):15897-903. PMID: 11832491.
      View in: PubMed
    Blumer's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _