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Inderjit Singh

TitleDirector, Division of Development Neurogenetics
InstitutionMedical University of South Carolina
DepartmentPediatrics
AddressP.O. Box MSC 515
CR 509
173 Ashley Ave.
Phone843-792-3545
Fax843-792-7130
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dasgupta S, Gomez JJ, Singh I, Khan M. S-Nitrosylation in regulation of inflammation and cell damage. Curr Drug Targets. 2018 Feb 12. PMID: 29437005.
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    2. Singh I, Samuvel DJ, Choi S, Saxena N, Singh AK, Won J. Combination therapy of lovastatin and AMP-activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model. Immunology. 2018 Jan 13. PMID: 29331024.
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    3. Al-Mufti F, Amuluru K, Smith B, Damodara N, El-Ghanem M, Singh IP, Dangayach N, Gandhi CD. Emerging Markers of Early Brain Injury and Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage. World Neurosurg. 2017 Nov; 107:148-159. PMID: 28755916.
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    4. Lowe DW, Fraser JL, Rollins LG, Bentzley J, Nie X, Martin R, Singh I, Jenkins D. Vitamin D improves functional outcomes in neonatal hypoxic ischemic male rats treated with N-acetylcysteine and hypothermia. Neuropharmacology. 2017 Sep 01; 123:186-200. PMID: 28599922.
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    5. Khan M, Khan H, Singh I, Singh AK. Hypoxia inducible factor-1 alpha stabilization for regenerative therapy in traumatic brain injury. Neural Regen Res. 2017 May; 12(5):696-701. PMID: 28616019.
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    6. Kim J, Choi S, Saxena N, Singh AK, Singh I, Won JS. Regulation of STAT3 and NF-?B activations by S-nitrosylation in multiple myeloma. Free Radic Biol Med. 2017 05; 106:245-253. PMID: 28232202.
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    7. Munagala R, Aqil F, Jeyabalan J, Agrawal AK, Mudd AM, Kyakulaga AH, Singh IP, Vadhanam MV, Gupta RC. Exosomal formulation of anthocyanidins against multiple cancer types. Cancer Lett. 2017 05 01; 393:94-102. PMID: 28202351.
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    8. Won JS, Singh AK, Singh I. Biochemical, cell biological, pathological, and therapeutic aspects of Krabbe's disease. J Neurosci Res. 2016 11; 94(11):990-1006. PMID: 27638584.
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    9. Khan M, Dhammu TS, Baarine M, Kim J, Paintlia MK, Singh I, Singh AK. GSNO promotes functional recovery in experimental TBI by stabilizing HIF-1a. Behav Brain Res. 2018 03 15; 340:63-70. PMID: 27780722.
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    10. Singh V, Kahol A, Singh IP, Saraf I, Shri R. Evaluation of anti-amnesic effect of extracts of selected Ocimum species using in-vitro and in-vivo models. J Ethnopharmacol. 2016 Dec 04; 193:490-499. PMID: 27725240.
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    11. Eckard AR, Meissner EG, Singh I, McComsey GA. Cardiovascular Disease, Statins, and HIV. J Infect Dis. 2016 Oct 01; 214 Suppl 2:S83-92. PMID: 27625435.
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    12. Samuvel DJ, Shunmugavel A, Singh AK, Singh I, Khan M. S-Nitrosoglutathione ameliorates acute renal dysfunction in a rat model of lipopolysaccharide-induced sepsis. J Pharm Pharmacol. 2016 Oct; 68(10):1310-9. PMID: 27484743.
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    13. Khan M, Singh I. Inhibition of the AMPK/nNOS pathway for neuroprotection in stroke. Neural Regen Res. 2016 Mar; 11(3):398-9. PMID: 27127467; PMCID: PMC4828993.
    14. Nie X, Lowe DW, Rollins LG, Bentzley J, Fraser JL, Martin R, Singh I, Jenkins D. Sex-specific effects of N-acetylcysteine in neonatal rats treated with hypothermia after severe hypoxia-ischemia. Neurosci Res. 2016 Jul; 108:24-33. PMID: 26851769; PMCID: PMC4903952 [Available on 07/01/17].
    15. Shah N, Singh I. MicroRNA Profiling Identifies miR-196a as Differentially Expressed in Childhood Adrenoleukodystrophy and Adult Adrenomyeloneuropathy. Mol Neurobiol. 2017 Mar; 54(2):1392-1403. PMID: 26843114.
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    16. Khan M, Dhammu TS, Dhaindsa TS, Khan H, Singh AK, Singh I. An NO/GSNO-based Neuroregeneration Strategy for Stroke Therapy. J Neurol Neurosci. 2015; 6(4). PMID: 27668143.
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    17. Singh I, Kim J, Singh AK, Sharma AK, Won JS. STAT3 Regulation By S-Nitrosylation: Implication In Cancer. Redox Biol. 2015 08; 5:416-417. PMID: 28162277.
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    18. Baarine M, Khan M, Singh A, Singh I. Functional Characterization of IPSC-Derived Brain Cells as a Model for X-Linked Adrenoleukodystrophy. PLoS One. 2015; 10(11):e0143238. PMID: 26581106; PMCID: PMC4651558.
    19. Khan M, Dhammu TS, Matsuda F, Annamalai B, Dhindsa TS, Singh I, Singh AK. Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI. Brain Res. 2016 Jan 01; 1630:159-70. PMID: 26596859; PMCID: PMC4684819 [Available on 01/01/17].
    20. Samuvel DJ, Saxena N, Dhindsa JS, Singh AK, Gill GS, Grobelny DW, Singh I. AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis. PLoS One. 2015; 10(10):e0141781. PMID: 26513477; PMCID: PMC4626178.
    21. Won JS, Annamalai B, Choi S, Singh I, Singh AK. S-nitrosoglutathione reduces tau hyper-phosphorylation and provides neuroprotection in rat model of chronic cerebral hypoperfusion. Brain Res. 2015 Oct 22; 1624:359-369. PMID: 26271717.
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    22. Khan M, Dhammu TS, Matsuda F, Singh AK, Singh I. Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy. BMC Neurosci. 2015 Jul 15; 16:42. PMID: 26174015; PMCID: PMC4502912.
    23. Kaliyaperumal K, Sharma AK, McDonald DG, Dhindsa JS, Yount C, Singh AK, Won JS, Singh I. S-Nitrosoglutathione-mediated STAT3 regulation in efficacy of radiotherapy and cisplatin therapy in head and neck squamous cell carcinoma. Redox Biol. 2015 Dec; 6:41-50. PMID: 26177470; PMCID: PMC4511642.
    24. Khan M, Shunmugavel A, Dhammu TS, Matsuda F, Singh AK, Singh I. Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats. J Neuroinflammation. 2015 May 15; 12:94. PMID: 25971887; PMCID: PMC4436116.
    25. Khan M, Dhammu TS, Matsuda F, Baarine M, Dhindsa TS, Singh I, Singh AK. Promoting endothelial function by S-nitrosoglutathione through the HIF-1a/VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats. Drug Des Devel Ther. 2015; 9:2233-47. PMID: 25945035; PMCID: PMC4408969.
    26. Annamalai B, Won JS, Choi S, Singh I, Singh AK. Role of S-nitrosoglutathione mediated mechanisms in tau hyper-phosphorylation. Biochem Biophys Res Commun. 2015 Feb 27; 458(1):214-9. PMID: 25640839; PMCID: PMC4346186.
    27. Baarine M, Beeson C, Singh A, Singh I. ABCD1 deletion-induced mitochondrial dysfunction is corrected by SAHA: implication for adrenoleukodystrophy. J Neurochem. 2015 May; 133(3):380-96. PMID: 25393703; PMCID: PMC4397157.
    28. Aggarwal A, Khera A, Singh I, Sandhir R. S-nitrosoglutathione prevents blood-brain barrier disruption associated with increased matrix metalloproteinase-9 activity in experimental diabetes. J Neurochem. 2015 Mar; 132(5):595-608. PMID: 25187090.
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    29. Paintlia MK, Singh I, Singh AK. Effect of vitamin D3 intake on the onset of disease in a murine model of human Krabbe disease. J Neurosci Res. 2015 Jan; 93(1):28-42. PMID: 25236689; PMCID: PMC4237655.
    30. Shunmugavel A, Khan M, Hughes FM, Purves JT, Singh A, Singh I. S-Nitrosoglutathione protects the spinal bladder: novel therapeutic approach to post-spinal cord injury bladder remodeling. Neurourol Urodyn. 2015 Aug; 34(6):519-26. PMID: 24853799; PMCID: PMC4285587.
    31. Kim J, Won JS, Singh AK, Sharma AK, Singh I. STAT3 regulation by S-nitrosylation: implication for inflammatory disease. Antioxid Redox Signal. 2014 Jun 01; 20(16):2514-27. PMID: 24063605; PMCID: PMC4026100.
    32. Contreras MA, Alzate O, Singh AK, Singh I. PPARa activation induces N(e)-Lys-acetylation of rat liver peroxisomal multifunctional enzyme type 1. Lipids. 2014 Feb; 49(2):119-31. PMID: 24092543.
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    33. Cheng G, Palanisamy AP, Evans ZP, Sutter AG, Jin L, Singh I, May H, Schmidt MG, Chavin KD. Cerulenin blockade of fatty acid synthase reverses hepatic steatosis in ob/ob mice. PLoS One. 2013; 8(9):e75980. PMID: 24086674; PMCID: PMC3785413.
    34. Singh J, Khan M, Pujol A, Baarine M, Singh I. Histone deacetylase inhibitor upregulates peroxisomal fatty acid oxidation and inhibits apoptotic cell death in abcd1-deficient glial cells. PLoS One. 2013; 8(7):e70712. PMID: 23923017; PMCID: PMC3724778.
    35. Paintlia AS, Paintlia MK, Singh AK, Singh I. Modulation of Rho-Rock signaling pathway protects oligodendrocytes against cytokine toxicity via PPAR-a-dependent mechanism. Glia. 2013 Sep; 61(9):1500-1517. PMID: 23839981; PMCID: PMC3919553.
    36. Paintlia AS, Mohan S, Singh I. Combinatorial Effect of Metformin and Lovastatin Impedes T-cell Autoimmunity and Neurodegeneration in Experimental Autoimmune Encephalomyelitis. J Clin Cell Immunol. 2013 Jun 30; 4. PMID: 24324917.
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    37. Paintlia AS, Paintlia MK, Mohan S, Singh AK, Singh I. AMP-activated protein kinase signaling protects oligodendrocytes that restore central nervous system functions in an experimental autoimmune encephalomyelitis model. Am J Pathol. 2013 Aug; 183(2):526-41. PMID: 23759513; PMCID: PMC3730772.
    38. Won JS, Kim J, Paintlia MK, Singh I, Singh AK. Role of endogenous psychosine accumulation in oligodendrocyte differentiation and survival: implication for Krabbe disease. Brain Res. 2013 May 01; 1508:44-52. PMID: 23438514; PMCID: PMC3996506.
    39. Singh J, Khan M, Singh I. Caffeic acid phenethyl ester induces adrenoleukodystrophy (Abcd2) gene in human X-ALD fibroblasts and inhibits the proinflammatory response in Abcd1/2 silenced mouse primary astrocytes. Biochim Biophys Acta. 2013 Apr; 1831(4):747-58. PMID: 23318275; PMCID: PMC3607212.
    40. Won JS, Kim J, Annamalai B, Shunmugavel A, Singh I, Singh AK. Protective role of S-nitrosoglutathione (GSNO) against cognitive impairment in rat model of chronic cerebral hypoperfusion. J Alzheimers Dis. 2013; 34(3):621-35. PMID: 23254638; PMCID: PMC4040220.
    41. Paintlia MK, Paintlia AS, Singh AK, Singh I. S-nitrosoglutathione induces ciliary neurotrophic factor expression in astrocytes, which has implications to protect the central nervous system under pathological conditions. J Biol Chem. 2013 Feb 08; 288(6):3831-43. PMID: 23264628; PMCID: PMC3567638.
    42. Shunmugavel A, Martin MM, Khan M, Copay AG, Subach BR, Schuler TC, Singh I. Simvastatin ameliorates cauda equina compression injury in a rat model of lumbar spinal stenosis. J Neuroimmune Pharmacol. 2013 Mar; 8(1):274-86. PMID: 23188522; PMCID: PMC3587651.
    43. Khan M, Dhammu TS, Sakakima H, Shunmugavel A, Gilg AG, Singh AK, Singh I. The inhibitory effect of S-nitrosoglutathione on blood-brain barrier disruption and peroxynitrite formation in a rat model of experimental stroke. J Neurochem. 2012 Nov; 123 Suppl 2:86-97. PMID: 23050646; PMCID: PMC3481195.
    44. Shunmugavel A, Khan M, Martin MM, Copay AG, Subach BR, Schuler TC, Singh I. S-Nitrosoglutathione administration ameliorates cauda equina compression injury in rats. Neurosci Med. 2012 Sep 25; 3(3):294-305. PMID: 23997981.
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    45. Paintlia AS, Paintlia MK, Hollis BW, Singh AK, Singh I. Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis. Am J Pathol. 2012 Sep; 181(3):993-1006. PMID: 22796435; PMCID: PMC3432427.
    46. Chang EY, Zhang J, Sullivan S, Newman R, Singh I. N-acetylcysteine prevents preterm birth by attenuating the LPS-induced expression of contractile associated proteins in an animal model. J Matern Fetal Neonatal Med. 2012 Nov; 25(11):2395-400. PMID: 22676250.
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    47. Kausar H, Jeyabalan J, Aqil F, Chabba D, Sidana J, Singh IP, Gupta RC. Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells. Cancer Lett. 2012 Dec 01; 325(1):54-62. PMID: 22659736.
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    48. Sakakima H, Khan M, Dhammu TS, Shunmugavel A, Yoshida Y, Singh I, Singh AK. Stimulation of functional recovery via the mechanisms of neurorepair by S-nitrosoglutathione and motor exercise in a rat model of transient cerebral ischemia and reperfusion. Restor Neurol Neurosci. 2012; 30(5):383-96. PMID: 22717646; PMCID: PMC3471563.
    49. Shunmugavel A, Khan M, Chou PC, Singh I. Spinal cord injury induced arrest in estrous cycle of rats is ameliorated by S-nitrosoglutathione: novel therapeutic agent to treat amenorrhea. J Sex Med. 2012 Jan; 9(1):148-58. PMID: 22024253; PMCID: PMC3809072.
    50. Singh J, Khan M, Singh I. HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes. J Lipid Res. 2011 Nov; 52(11):2056-69. PMID: 21891797; PMCID: PMC3196237.
    51. Khan M, Sakakima H, Dhammu TS, Shunmugavel A, Im YB, Gilg AG, Singh AK, Singh I. S-nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats. J Neuroinflammation. 2011 Jul 06; 8:78. PMID: 21733162; PMCID: PMC3158546.
    52. Huang J, Viswakarma N, Yu S, Jia Y, Bai L, Vluggens A, Cherkaoui-Malki M, Khan M, Singh I, Yang G, Rao MS, Borensztajn J, Reddy JK. Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice. Am J Pathol. 2011 Aug; 179(2):703-13. PMID: 21801867; PMCID: PMC3157234.
    53. Chou PC, Shunmugavel A, El Sayed H, Desouki MM, Nguyen SA, Khan M, Singh I, Bilgen M. Preclinical use of longitudinal MRI for screening the efficacy of S-nitrosoglutathione in treating spinal cord injury. J Magn Reson Imaging. 2011 Jun; 33(6):1301-11. PMID: 21590998.
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    54. Paintlia MK, Paintlia AS, Singh AK, Singh I. Synergistic activity of interleukin-17 and tumor necrosis factor-a enhances oxidative stress-mediated oligodendrocyte apoptosis. J Neurochem. 2011 Feb; 116(4):508-21. PMID: 21143599; PMCID: PMC3033460.
    55. Chang EY, Zhang J, Sullivan S, Newman R, Singh I. N-acetylcysteine attenuates the maternal and fetal proinflammatory response to intrauterine LPS injection in an animal model for preterm birth and brain injury. J Matern Fetal Neonatal Med. 2011 May; 24(5):732-40. PMID: 21219105.
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    56. Paintlia AS, Paintlia MK, Singh AK, Orak JK, Singh I. Activation of PPAR-? and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells. Glia. 2010 Nov 01; 58(14):1669-85. PMID: 20578043; PMCID: PMC2939308.
    57. Tatar CL, Appikatla S, Bessert DA, Paintlia AS, Singh I, Skoff RP. Increased Plp1 gene expression leads to massive microglial cell activation and inflammation throughout the brain. ASN Neuro. 2010 Sep 27; 2(4):e00043. PMID: 20885931; PMCID: PMC2946597.
    58. Won JS, Im YB, Kim J, Singh AK, Singh I. Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis. Biochem Biophys Res Commun. 2010 Sep 03; 399(4):487-91. PMID: 20659426; PMCID: PMC2977999.
    59. Singh I, Pujol A. Pathomechanisms underlying X-adrenoleukodystrophy: a three-hit hypothesis. Brain Pathol. 2010 Jul; 20(4):838-44. PMID: 20626745; PMCID: PMC3021280.
    60. Contreras MA, Ries WL, Shanmugarajan S, Arboleda G, Singh I, Singh AK. Factors that affect postnatal bone growth retardation in the twitcher murine model of Krabbe disease. Biochim Biophys Acta. 2010 Jul-Aug; 1802(7-8):601-8. PMID: 20441793; PMCID: PMC2950787.
    61. Shunmugavel A, Khan M, Te Chou PC, Dhindsa RK, Martin MM, Copay AG, Subach BR, Schuler TC, Bilgen M, Orak JK, Singh I. Simvastatin protects bladder and renal functions following spinal cord injury in rats. J Inflamm (Lond). 2010 Apr 19; 7:17. PMID: 20403180; PMCID: PMC2873501.
    62. Vluggens A, Andreoletti P, Viswakarma N, Jia Y, Matsumoto K, Kulik W, Khan M, Huang J, Guo D, Yu S, Sarkar J, Singh I, Rao MS, Wanders RJ, Reddy JK, Cherkaoui-Malki M. Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected]. Lab Invest. 2010 May; 90(5):696-708. PMID: 20195242.
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    63. Khan M, Singh J, Gilg AG, Uto T, Singh I. Very long-chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy. J Lipid Res. 2010 Jul; 51(7):1685-95. PMID: 20173212; PMCID: PMC2882744.
    64. Nath N, Morinaga O, Singh I. S-nitrosoglutathione a physiologic nitric oxide carrier attenuates experimental autoimmune encephalomyelitis. J Neuroimmune Pharmacol. 2010 Jun; 5(2):240-51. PMID: 20091246; PMCID: PMC2965418.
    65. Khan M, Im YB, Shunmugavel A, Gilg AG, Dhindsa RK, Singh AK, Singh I. Administration of S-nitrosoglutathione after traumatic brain injury protects the neurovascular unit and reduces secondary injury in a rat model of controlled cortical impact. J Neuroinflammation. 2009 Nov 04; 6:32. PMID: 19889224; PMCID: PMC2777134.
    66. Jenkins DD, Chang E, Singh I. Neuroprotective interventions: is it too late? J Child Neurol. 2009 Sep; 24(9):1212-9. PMID: 19745093; PMCID: PMC3674502.
    67. Hoda MN, Singh I, Singh AK, Khan M. Reduction of lipoxidative load by secretory phospholipase A2 inhibition protects against neurovascular injury following experimental stroke in rat. J Neuroinflammation. 2009 Aug 13; 6:21. PMID: 19678934; PMCID: PMC2739168.
    68. Singh I, Singh AK, Contreras MA. Peroxisomal dysfunction in inflammatory childhood white matter disorders: an unexpected contributor to neuropathology. J Child Neurol. 2009 Sep; 24(9):1147-57. PMID: 19605772; PMCID: PMC3077730.
    69. Nath N, Khan M, Paintlia MK, Singh I, Hoda MN, Giri S. Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis. J Immunol. 2009 Jun 15; 182(12):8005-14. PMID: 19494326; PMCID: PMC2965405.
    70. Nath N, Khan M, Rattan R, Mangalam A, Makkar RS, de Meester C, Bertrand L, Singh I, Chen Y, Viollet B, Giri S. Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity. Biochem Biophys Res Commun. 2009 Aug 14; 386(1):16-20. PMID: 19486896; PMCID: PMC2976596.
    71. Paintlia AS, Paintlia MK, Singh I, Skoff RB, Singh AK. Combination therapy of lovastatin and rolipram provides neuroprotection and promotes neurorepair in inflammatory demyelination model of multiple sclerosis. Glia. 2009 Jan 15; 57(2):182-93. PMID: 18720408; PMCID: PMC2660597.
    72. Uto T, Contreras MA, Gilg AG, Singh I. Oxidative imbalance in nonstimulated X-adrenoleukodystrophy-derived lymphoblasts. Dev Neurosci. 2008; 30(6):410-8. PMID: 19127062; PMCID: PMC2744110.
    73. Paintlia MK, Paintlia AS, Singh AK, Singh I. Attenuation of lipopolysaccharide-induced inflammatory response and phospholipids metabolism at the feto-maternal interface by N-acetyl cysteine. Pediatr Res. 2008 Oct; 64(4):334-9. PMID: 18552708; PMCID: PMC2967178.
    74. Singh J, Khan M, Singh I. Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy. J Lipid Res. 2009 Jan; 50(1):135-47. PMID: 18723473; PMCID: PMC2602866.
    75. Prasad R, Giri S, Singh AK, Singh I. 15-deoxy-delta12,14-prostaglandin J2 attenuates endothelial-monocyte interaction: implication for inflammatory diseases. J Inflamm (Lond). 2008 Aug 08; 5:14. PMID: 18691416; PMCID: PMC2531100.
    76. Paintlia AS, Paintlia MK, Singh I, Singh AK. Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis. Exp Neurol. 2008 Dec; 214(2):168-80. PMID: 18775426; PMCID: PMC2636204.
    77. Contreras MA, Haq E, Uto T, Singh I, Singh AK. Psychosine-induced alterations in peroxisomes of twitcher mouse liver. Arch Biochem Biophys. 2008 Sep 15; 477(2):211-8. PMID: 18602885; PMCID: PMC2654593.
    78. Khan M, Singh J, Singh I. Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin. J Neurochem. 2008 Aug; 106(4):1766-79. PMID: 18540993; PMCID: PMC2575097.
    79. Lee JK, Won JS, Singh AK, Singh I. Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death. Neurosci Lett. 2008 Aug 08; 440(3):260-4. PMID: 18583044; PMCID: PMC2702849.
    80. Markovic-Plese S, Singh AK, Singh I. Therapeutic potential of statins in multiple sclerosis: immune modulation, neuroprotection and neurorepair. Future Neurol. 2008 Mar 01; 3(2):153. PMID: 20107624.
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    81. Won JS, Im YB, Khan M, Contreras M, Singh AK, Singh I. Lovastatin inhibits amyloid precursor protein (APP) beta-cleavage through reduction of APP distribution in Lubrol WX extractable low density lipid rafts. J Neurochem. 2008 May; 105(4):1536-49. PMID: 18266936; PMCID: PMC2707757.
    82. Giri S, Khan M, Nath N, Singh I, Singh AK. The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: implication for Krabbe disease. J Neurochem. 2008 Jun; 105(5):1820-33. PMID: 18248608; PMCID: PMC2673995.
    83. Paintlia AS, Paintlia MK, Singh AK, Singh I. Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis. Mol Pharmacol. 2008 May; 73(5):1381-93. PMID: 18239032; PMCID: PMC2706586.
    84. Paintlia MK, Paintlia AS, Khan M, Singh I, Singh AK. Modulation of peroxisome proliferator-activated receptor-alpha activity by N-acetyl cysteine attenuates inhibition of oligodendrocyte development in lipopolysaccharide stimulated mixed glial cultures. J Neurochem. 2008 May; 105(3):956-70. PMID: 18205750; PMCID: PMC2659629.
    85. Paintlia MK, Paintlia AS, Contreras MA, Singh I, Singh AK. Lipopolysaccharide-induced peroxisomal dysfunction exacerbates cerebral white matter injury: attenuation by N-acetyl cysteine. Exp Neurol. 2008 Apr; 210(2):560-76. PMID: 18291369; PMCID: PMC2673813.
    86. Won JS, Singh AK, Singh I. Lactosylceramide: a lipid second messenger in neuroinflammatory disease. J Neurochem. 2007 Nov; 103 Suppl 1:180-91. PMID: 17986153.
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    87. Sengupta TK, Leclerc GM, Hsieh-Kinser TT, Leclerc GJ, Singh I, Barredo JC. Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy. Mol Cancer. 2007 Jul 10; 6:46. PMID: 17623090; PMCID: PMC1948012.
    88. Haq E, Rohrer B, Nath N, Crosson CE, Singh I. S-nitrosoglutathione prevents interphotoreceptor retinoid-binding protein (IRBP(161-180))-induced experimental autoimmune uveitis. J Ocul Pharmacol Ther. 2007 Jun; 23(3):221-31. PMID: 17593005.
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    89. Khan M, Elango C, Ansari MA, Singh I, Singh AK. Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia. J Neurochem. 2007 Jul; 102(2):365-77. PMID: 17437550.
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    90. Pannu R, Christie DK, Barbosa E, Singh I, Singh AK. Post-trauma Lipitor treatment prevents endothelial dysfunction, facilitates neuroprotection, and promotes locomotor recovery following spinal cord injury. J Neurochem. 2007 Apr; 101(1):182-200. PMID: 17217414.
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    91. Prasad R, Giri S, Nath N, Singh I, Singh AK. GSNO attenuates EAE disease by S-nitrosylation-mediated modulation of endothelial-monocyte interactions. Glia. 2007 Jan 01; 55(1):65-77. PMID: 17019693.
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    92. Qiao F, Atkinson C, Song H, Pannu R, Singh I, Tomlinson S. Complement plays an important role in spinal cord injury and represents a therapeutic target for improving recovery following trauma. Am J Pathol. 2006 Sep; 169(3):1039-47. PMID: 16936276; PMCID: PMC1698827.
    93. Paintlia AS, Paintlia MK, Singh I, Singh AK. Immunomodulatory effect of combination therapy with lovastatin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside alleviates neurodegeneration in experimental autoimmune encephalomyelitis. Am J Pathol. 2006 Sep; 169(3):1012-25. PMID: 16936274; PMCID: PMC1698815.
    94. Prasad R, Giri S, Nath N, Singh I, Singh AK. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction. J Neurosci Res. 2006 Aug 15; 84(3):614-25. PMID: 16770773.
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    95. Giri S, Rattan R, Haq E, Khan M, Yasmin R, Won JS, Key L, Singh AK, Singh I. AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model. Nutr Metab (Lond). 2006 Aug 10; 3:31. PMID: 16901342; PMCID: PMC1564022.
    96. Peng X, Jin J, Giri S, Montes M, Sujkowski D, Tang Y, Smrtka J, Vollmer T, Singh I, Markovic-Plese S. Immunomodulatory effects of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors, potential therapy for relapsing remitting multiple sclerosis. J Neuroimmunol. 2006 Sep; 178(1-2):130-9. PMID: 16870268.
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    97. Nath N, Prasad R, Giri S, Singh AK, Singh I. T-bet is essential for the progression of experimental autoimmune encephalomyelitis. Immunology. 2006 Jul; 118(3):384-91. PMID: 16827899; PMCID: PMC1782298.
    98. Pannu R, Singh I. Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms. Neurochem Int. 2006 Jul; 49(2):170-82. PMID: 16765486.
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    99. Makkar RS, Contreras MA, Paintlia AS, Smith BT, Haq E, Singh I. Molecular organization of peroxisomal enzymes: protein-protein interactions in the membrane and in the matrix. Arch Biochem Biophys. 2006 Jul 15; 451(2):128-40. PMID: 16781659.
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    100. Jatana M, Giri S, Ansari MA, Elango C, Singh AK, Singh I, Khan M. Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia. J Neuroinflammation. 2006 May 11; 3:12. PMID: 16689995; PMCID: PMC1526713.
    101. Jatana M, Singh I, Singh AK, Jenkins D. Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatr Res. 2006 May; 59(5):684-9. PMID: 16627882.
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    102. Giri S, Khan M, Rattan R, Singh I, Singh AK. Krabbe disease: psychosine-mediated activation of phospholipase A2 in oligodendrocyte cell death. J Lipid Res. 2006 Jul; 47(7):1478-92. PMID: 16645197.
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    103. Paintlia AS, Paintlia MK, Singh I, Singh AK. IL-4-induced peroxisome proliferator-activated receptor gamma activation inhibits NF-kappaB trans activation in central nervous system (CNS) glial cells and protects oligodendrocyte progenitors under neuroinflammatory disease conditions: implication for CNS-demyelinating diseases. J Immunol. 2006 Apr 01; 176(7):4385-98. PMID: 16547277.
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    104. Khan M, Jatana M, Elango C, Paintlia AS, Singh AK, Singh I. Cerebrovascular protection by various nitric oxide donors in rats after experimental stroke. Nitric Oxide. 2006 Sep; 15(2):114-24. PMID: 16524750.
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    105. Haq E, Contreras MA, Giri S, Singh I, Singh AK. Dysfunction of peroxisomes in twitcher mice brain: a possible mechanism of psychosine-induced disease. Biochem Biophys Res Commun. 2006 Apr 28; 343(1):229-38. PMID: 16530726.
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    106. Won JS, Singh I. Sphingolipid signaling and redox regulation. Free Radic Biol Med. 2006 Jun 01; 40(11):1875-88. PMID: 16716889.
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    107. Rattan R, Giri S, Singh AK, Singh I. Rho/ROCK pathway as a target of tumor therapy. J Neurosci Res. 2006 Feb 01; 83(2):243-55. PMID: 16385577.
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    108. Rattan R, Giri S, Singh AK, Singh I. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J Biol Chem. 2005 Nov 25; 280(47):39582-93. PMID: 16176927.
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    109. Ayasolla KR, Singh AK, Singh I. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Abeta peptide-induced inflammatory mediators in astroglia. J Neuroinflammation. 2005 Sep 20; 2:21. PMID: 16174294; PMCID: PMC1262754.
    110. Paintlia AS, Paintlia MK, Khan M, Vollmer T, Singh AK, Singh I. HMG-CoA reductase inhibitor augments survival and differentiation of oligodendrocyte progenitors in animal model of multiple sclerosis. FASEB J. 2005 Sep; 19(11):1407-21. PMID: 16126908.
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    111. Chang EY, Barbosa E, Paintlia MK, Singh A, Singh I. The use of N-acetylcysteine for the prevention of hypertension in the reduced uterine perfusion pressure model for preeclampsia in Sprague-Dawley rats. Am J Obstet Gynecol. 2005 Sep; 193(3 Pt 2):952-6. PMID: 16157093.
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    112. Prasad R, Giri S, Nath N, Singh I, Singh AK. Inhibition of phosphoinositide 3 kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interaction. J Neurochem. 2005 Jul; 94(1):204-14. PMID: 15953363.
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    113. Won JS, Im YB, Khan M, Singh AK, Singh I. Involvement of phospholipase A2 and lipoxygenase in lipopolysaccharide-induced inducible nitric oxide synthase expression in glial cells. Glia. 2005 Jul; 51(1):13-21. PMID: 15779087.
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    114. Nath N, Giri S, Prasad R, Salem ML, Singh AK, Singh I. 5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis. J Immunol. 2005 Jul 01; 175(1):566-74. PMID: 15972693.
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    115. Khan M, Haq E, Giri S, Singh I, Singh AK. Peroxisomal participation in psychosine-mediated toxicity: implications for Krabbe's disease. J Neurosci Res. 2005 Jun 15; 80(6):845-54. PMID: 15898099.
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    116. Stanislaus R, Gilg AG, Singh AK, Singh I. N-acetyl-L-cysteine ameliorates the inflammatory disease process in experimental autoimmune encephalomyelitis in Lewis rats. J Autoimmune Dis. 2005 May 03; 2(1):4. PMID: 15869713.
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    117. Khan M, Sekhon B, Giri S, Jatana M, Gilg AG, Ayasolla K, Elango C, Singh AK, Singh I. S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke. J Cereb Blood Flow Metab. 2005 Feb; 25(2):177-92. PMID: 15647746.
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    118. Pannu R, Barbosa E, Singh AK, Singh I. Attenuation of acute inflammatory response by atorvastatin after spinal cord injury in rats. J Neurosci Res. 2005 Feb 01; 79(3):340-50. PMID: 15605375.
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    119. Pannu R, Singh AK, Singh I. A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha-mediated proliferation of rat primary astrocytes. Implications for astrogliosis following neurotrauma. J Biol Chem. 2005 Apr 08; 280(14):13742-51. PMID: 15668227.
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    120. Lee JK, Won JS, Singh AK, Singh I. Adenosine kinase inhibitor attenuates the expression of inducible nitric oxide synthase in glial cells. Neuropharmacology. 2005 Jan; 48(1):151-60. PMID: 15617735.
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    121. Kawada Y, Khan M, Sharma AK, Ratnayake DB, Dobashi K, Asayama K, Moser HW, Contreras MA, Singh I. Inhibition of peroxisomal functions due to oxidative imbalance induced by mistargeting of catalase to cytoplasm is restored by vitamin E treatment in skin fibroblasts from Zellweger syndrome-like patients. Mol Genet Metab. 2004 Dec; 83(4):297-305. PMID: 15589116.
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    122. Won JS, Im YB, Singh AK, Singh I. Dual role of cAMP in iNOS expression in glial cells and macrophages is mediated by differential regulation of p38-MAPK/ATF-2 activation and iNOS stability. Free Radic Biol Med. 2004 Dec 01; 37(11):1834-44. PMID: 15528042.
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    123. Paintlia MK, Paintlia AS, Barbosa E, Singh I, Singh AK. N-acetylcysteine prevents endotoxin-induced degeneration of oligodendrocyte progenitors and hypomyelination in developing rat brain. J Neurosci Res. 2004 Nov 01; 78(3):347-61. PMID: 15389835.
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    124. Giri S, Rattan R, Singh AK, Singh I. The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. J Immunol. 2004 Oct 15; 173(8):5196-208. PMID: 15470065.
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    125. Singh I, Paintlia AS, Khan M, Stanislaus R, Paintlia MK, Haq E, Singh AK, Contreras MA. Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment. Brain Res. 2004 Oct 01; 1022(1-2):1-11. PMID: 15353207.
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    126. Lin A, Sekhon C, Sekhon B, Smith A, Chavin K, Orak J, Singh I, Singh A. Attenuation of ischemia-reperfusion injury in a canine model of autologous renal transplantation. Transplantation. 2004 Sep 15; 78(5):654-9. PMID: 15371664.
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    127. Ayasolla K, Khan M, Singh AK, Singh I. Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E. Free Radic Biol Med. 2004 Aug 01; 37(3):325-38. PMID: 15223066.
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    128. Paintlia AS, Paintlia MK, Singh AK, Stanislaus R, Gilg AG, Barbosa E, Singh I. Regulation of gene expression associated with acute experimental autoimmune encephalomyelitis by Lovastatin. J Neurosci Res. 2004 Jul 01; 77(1):63-81. PMID: 15197739.
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    129. Pannu R, Won JS, Khan M, Singh AK, Singh I. A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-gamma-mediated inducible nitric oxide synthase gene expression: implications for neuroinflammatory diseases. J Neurosci. 2004 Jun 30; 24(26):5942-54. PMID: 15229242.
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    130. Vollmer T, Key L, Durkalski V, Tyor W, Corboy J, Markovic-Plese S, Preiningerova J, Rizzo M, Singh I. Oral simvastatin treatment in relapsing-remitting multiple sclerosis. Lancet. 2004 May 15; 363(9421):1607-8. PMID: 15145635.
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    131. Khan M, Sekhon B, Jatana M, Giri S, Gilg AG, Sekhon C, Singh I, Singh AK. Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke. J Neurosci Res. 2004 May 15; 76(4):519-27. PMID: 15114624.
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    132. Won JS, Im YB, Khan M, Singh AK, Singh I. The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase. J Neurochem. 2004 Feb; 88(3):583-93. PMID: 14720208.
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    133. Nath N, Giri S, Prasad R, Singh AK, Singh I. Potential targets of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for multiple sclerosis therapy. J Immunol. 2004 Jan 15; 172(2):1273-86. PMID: 14707106.
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    134. Giri S, Nath N, Smith B, Viollet B, Singh AK, Singh I. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J Neurosci. 2004 Jan 14; 24(2):479-87. PMID: 14724246.
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    135. Paintlia AS, Gilg AG, Khan M, Singh AK, Barbosa E, Singh I. Correlation of very long chain fatty acid accumulation and inflammatory disease progression in childhood X-ALD: implications for potential therapies. Neurobiol Dis. 2003 Dec; 14(3):425-39. PMID: 14678759.
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    136. Rattan R, Giri S, Singh AK, Singh I. Rho A negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: negative regulation of IKKalpha. Free Radic Biol Med. 2003 Nov 01; 35(9):1037-50. PMID: 14572607.
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    137. Haq E, Giri S, Singh I, Singh AK. Molecular mechanism of psychosine-induced cell death in human oligodendrocyte cell line. J Neurochem. 2003 Sep; 86(6):1428-40. PMID: 12950451.
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    138. Won JS, Im YB, Key L, Singh I, Singh AK. The involvement of glucose metabolism in the regulation of inducible nitric oxide synthase gene expression in glial cells: possible role of glucose-6-phosphate dehydrogenase and CCAAT/enhancing binding protein. J Neurosci. 2003 Aug 20; 23(20):7470-8. PMID: 12930785.
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    139. Sekhon B, Sekhon C, Khan M, Patel SJ, Singh I, Singh AK. N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemia. Brain Res. 2003 May 02; 971(1):1-8. PMID: 12691831.
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    140. Sekhon CS, Sekhon BK, Singh I, Orak JK, Singh AK. Attenuation of renal ischemia/reperfusion injury by a triple drug combination therapy. J Nephrol. 2003 Jan-Feb; 16(1):63-74. PMID: 12649537.
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    141. Stanislaus R, Gilg AG, Singh AK, Singh I. Immunomodulation of experimental autoimmune encephalomyelitis in the Lewis rats by Lovastatin. Neurosci Lett. 2002 Nov 29; 333(3):167-70. PMID: 12429374.
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    142. Dobashi K, Singh I, Orak JK, Asayama K, Singh AK. Combination therapy of N-acetylcysteine, sodium nitroprusside and phosphoramidon attenuates ischemia-reperfusion injury in rat kidney. Mol Cell Biochem. 2002 Nov; 240(1-2):9-17. PMID: 12487367.
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    143. Kaul P, Singh I, Turner RB. Effect of rhinovirus challenge on antioxidant enzymes in respiratory epithelial cells. Free Radic Res. 2002 Oct; 36(10):1085-9. PMID: 12516880.
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    144. Giri S, Jatana M, Rattan R, Won JS, Singh I, Singh AK. Galactosylsphingosine (psychosine)-induced expression of cytokine-mediated inducible nitric oxide synthases via AP-1 and C/EBP: implications for Krabbe disease. FASEB J. 2002 May; 16(7):661-72. PMID: 11978730.
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    145. Singh I. Peroxisomal fatty acid oxidation and cellular redox. Methods Enzymol. 2002; 352:361-72. PMID: 12125363.
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    146. Stanislaus R, Singh AK, Singh I. Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitis. J Neurosci Res. 2001 Oct 15; 66(2):155-62. PMID: 11592110.
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    147. Gilg AG, Singh AK, Singh I. Inducible nitric oxide synthase in the central nervous system of patients with X-adrenoleukodystrophy. J Neuropathol Exp Neurol. 2000 Dec; 59(12):1063-9. PMID: 11138926.
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    148. Sandhir R, Khan M, Singh I. Identification of the pathway of alpha-oxidation of cerebronic acid in peroxisomes. Lipids. 2000 Oct; 35(10):1127-33. PMID: 11104019.
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    149. Kaul P, Biagioli MC, Singh I, Turner RB. Rhinovirus-induced oxidative stress and interleukin-8 elaboration involves p47-phox but is independent of attachment to intercellular adhesion molecule-1 and viral replication. J Infect Dis. 2000 Jun; 181(6):1885-90. PMID: 10837166.
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    150. Ghosh B, Barbosa E, Singh I. Characterization of fibroblast cytoplasmic proteins that bind to the 3' UTR of human catalase mRNA. Mol Cell Biochem. 2000 Jun; 209(1-2):9-15. PMID: 10942196.
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    151. Pai GS, Khan M, Barbosa E, Key LL, Craver JR, Curé JK, Betros R, Singh I. Lovastatin therapy for X-linked adrenoleukodystrophy: clinical and biochemical observations on 12 patients. Mol Genet Metab. 2000 Apr; 69(4):312-22. PMID: 10870849.
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    152. Singh I, Carillo O, Namboodiri A. Isolation and biochemical characterization of peroxisomes from cultured rat glial cells. Neurochem Res. 2000 Feb; 25(2):197-203. PMID: 10786702.
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    153. Contreras MA, Khan M, Smith BT, Cimini AM, Gilg AG, Orak J, Singh I, Singh AK. Endotoxin induces structure-function alterations of rat liver peroxisomes: Kupffer cells released factors as possible modulators. Hepatology. 2000 Feb; 31(2):446-55. PMID: 10655269.
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    154. Smith BT, Sengupta TK, Singh I. Intraperoxisomal localization of very-long-chain fatty acyl-CoA synthetase: implication in X-adrenoleukodystrophy. Exp Cell Res. 2000 Feb 01; 254(2):309-20. PMID: 10640429.
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    155. Dobashi K, Ghosh B, Orak JK, Singh I, Singh AK. Kidney ischemia-reperfusion: modulation of antioxidant defenses. Mol Cell Biochem. 2000 Feb; 205(1-2):1-11. PMID: 10821417.
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    156. Khan M, Contreras M, Singh I. Endotoxin-induced alterations of lipid and fatty acid compositions in rat liver peroxisomes. J Endotoxin Res. 2000; 6(1):41-50. PMID: 11061031.
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    157. Pahan K, Dobashi K, Ghosh B, Singh I. Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide. J Neurochem. 1999 Aug; 73(2):513-20. PMID: 10428046.
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    158. Stanislaus R, Pahan K, Singh AK, Singh I. Amelioration of experimental allergic encephalomyelitis in Lewis rats by lovastatin. Neurosci Lett. 1999 Jul 09; 269(2):71-4. PMID: 10430507.
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    159. Kaul P, Singh I, Turner RB. Effect of nitric oxide on rhinovirus replication and virus-induced interleukin-8 elaboration. Am J Respir Crit Care Med. 1999 Apr; 159(4 Pt 1):1193-8. PMID: 10194165.
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    160. Pahan K, Raymond JR, Singh I. Inhibition of phosphatidylinositol 3-kinase induces nitric-oxide synthase in lipopolysaccharide- or cytokine-stimulated C6 glial cells. J Biol Chem. 1999 Mar 12; 274(11):7528-36. PMID: 10066820.
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    161. Biagioli MC, Kaul P, Singh I, Turner RB. The role of oxidative stress in rhinovirus induced elaboration of IL-8 by respiratory epithelial cells. Free Radic Biol Med. 1999 Feb; 26(3-4):454-62. PMID: 9895238.
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    162. Sandhir R, Khan M, Chahal A, Singh I. Localization of nervonic acid beta-oxidation in human and rodent peroxisomes: impaired oxidation in Zellweger syndrome and X-linked adrenoleukodystrophy. J Lipid Res. 1998 Nov; 39(11):2161-71. PMID: 9799802.
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    163. Singh I, Pahan K, Khan M, Singh AK. Cytokine-mediated induction of ceramide production is redox-sensitive. Implications to proinflammatory cytokine-mediated apoptosis in demyelinating diseases. J Biol Chem. 1998 Aug 07; 273(32):20354-62. PMID: 9685387.
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    164. Khan M, Pahan K, Singh AK, Singh I. Cytokine-induced accumulation of very long-chain fatty acids in rat C6 glial cells: implication for X-adrenoleukodystrophy. J Neurochem. 1998 Jul; 71(1):78-87. PMID: 9648853.
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    165. Chahal A, Khan M, Pai SG, Barbosa E, Singh I. Restoration of phytanic acid oxidation in Refsum disease fibroblasts from patients with mutations in the phytanoyl-CoA hydroxylase gene. FEBS Lett. 1998 Jun 05; 429(1):119-22. PMID: 9657395.
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    166. Pahan K, Sheikh FG, Namboodiri AM, Singh I. Inhibitors of protein phosphatase 1 and 2A differentially regulate the expression of inducible nitric-oxide synthase in rat astrocytes and macrophages. J Biol Chem. 1998 May 15; 273(20):12219-26. PMID: 9575170.
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    167. Pahan K, Khan M, Singh I. Therapy for X-adrenoleukodystrophy: normalization of very long chain fatty acids and inhibition of induction of cytokines by cAMP. J Lipid Res. 1998 May; 39(5):1091-100. PMID: 9610777.
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    168. Singh I, Pahan K, Khan M. Lovastatin and sodium phenylacetate normalize the levels of very long chain fatty acids in skin fibroblasts of X- adrenoleukodystrophy. FEBS Lett. 1998 Apr 24; 426(3):342-6. PMID: 9600263.
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    169. Sheikh FG, Pahan K, Khan M, Barbosa E, Singh I. Abnormality in catalase import into peroxisomes leads to severe neurological disorder. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):2961-6. PMID: 9501198; PMCID: PMC19677.
    170. Pahan K, Sheikh FG, Khan M, Namboodiri AM, Singh I. Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes. J Biol Chem. 1998 Jan 30; 273(5):2591-600. PMID: 9446561.
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    171. Pahan K, Sheikh FG, Namboodiri AM, Singh I. N-acetyl cysteine inhibits induction of no production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes. Free Radic Biol Med. 1998 Jan 01; 24(1):39-48. PMID: 9436612.
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    172. Pahan K, Sheikh FG, Namboodiri AM, Singh I. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. J Clin Invest. 1997 Dec 01; 100(11):2671-9. PMID: 9389730; PMCID: PMC508470.
    173. Gupta M, Dobashi K, Greene EL, Orak JK, Singh I. Studies on hepatic injury and antioxidant enzyme activities in rat subcellular organelles following in vivo ischemia and reperfusion. Mol Cell Biochem. 1997 Nov; 176(1-2):337-47. PMID: 9406179.
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    174. Singh I, Voigt RG, Sheikh FG, Kremser K, Brown FR. Biochemical features of a patient with Zellweger-like syndrome with normal PTS-1 and PTS-2 peroxisomal protein import systems: a new peroxisomal disease. Biochem Mol Med. 1997 Aug; 61(2):198-207. PMID: 9259985.
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    175. Dobashi K, Pahan K, Chahal A, Singh I. Modulation of endogenous antioxidant enzymes by nitric oxide in rat C6 glial cells. J Neurochem. 1997 May; 68(5):1896-903. PMID: 9109515.
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    176. Pahan K, Namboodiri AM, Sheikh FG, Smith BT, Singh I. Increasing cAMP attenuates induction of inducible nitric-oxide synthase in rat primary astrocytes. J Biol Chem. 1997 Mar 21; 272(12):7786-91. PMID: 9065441.
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    177. Singh I. Biochemistry of peroxisomes in health and disease. Mol Cell Biochem. 1997 Feb; 167(1-2):1-29. PMID: 9059978.
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    178. Singh I. Mammalian peroxisomes: metabolism of oxygen and reactive oxygen species. Ann N Y Acad Sci. 1996 Dec 27; 804:612-27. PMID: 8993576.
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    179. Singh I, Kremser K, Ghosh B, Singh AK, Pai S. Abnormality in translational regulation of catalase expression in disorders of peroxisomal biogenesis. J Neurochem. 1996 Dec; 67(6):2373-8. PMID: 8931469.
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    180. Contreras M, Sengupta TK, Sheikh F, Aubourg P, Singh I. Topology of ATP-binding domain of adrenoleukodystrophy gene product in peroxisomes. Arch Biochem Biophys. 1996 Oct 15; 334(2):369-79. PMID: 8900413.
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    181. Pahan K, Khan M, Singh I. Phytanic acid oxidation: normal activation and transport yet defective alpha-hydroxylation of phytanic acid in peroxisomes from Refsum disease and rhizomelic chondrodysplasia punctata. J Lipid Res. 1996 May; 37(5):1137-43. PMID: 8725164.
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    182. Pahan K, Smith BT, Singh I. Epoxide hydrolase in human and rat peroxisomes: implication for disorders of peroxisomal biogenesis. J Lipid Res. 1996 Jan; 37(1):159-67. PMID: 8820111.
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    183. Ghosh B, Hanevold CD, Dobashi K, Orak JK, Singh I. Tissue differences in antioxidant enzyme gene expression in response to endotoxin. Free Radic Biol Med. 1996; 21(4):533-40. PMID: 8886805.
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    184. Pahan K, Khan M, Smith BT, Singh I. Ketoconazole and other imidazole derivatives are potent inhibitors of peroxisomal phytanic acid alpha-oxidation. FEBS Lett. 1995 Dec 18; 377(2):213-6. PMID: 8543053.
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    185. Ghosh B, Barbosa E, Singh I. Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression. Mol Cell Biochem. 1995 Oct 04; 151(1):77-81. PMID: 8584017.
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    186. CantĂș ES, Sprinkle TJ, Ghosh B, Singh I. The human palmitoyl-CoA ligase (FACL2) gene maps to the chromosome 4q34-q35 region by fluorescence in situ hybridization (FISH) and somatic cell hybrid panels. Genomics. 1995 Aug 10; 28(3):600-2. PMID: 7490105.
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    187. Pahan K, Singh I. Phytanic acid oxidation: topographical localization of phytanoyl-CoA ligase and transport of phytanic acid into human peroxisomes. J Lipid Res. 1995 May; 36(5):986-97. PMID: 7544821.
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    188. Kremser K, Kremser-Jezik M, Singh I. Effect of hypoxia-reoxygenation on peroxisomal functions in cultured human skin fibroblasts from control and Zellweger syndrome patients. Free Radic Res. 1995 Jan; 22(1):39-46. PMID: 7889146.
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    189. Pahan K, Gulati S, Singh I. Phytanic acid alpha-oxidation in rat liver mitochondria. Biochim Biophys Acta. 1994 Dec 15; 1201(3):491-7. PMID: 7803482.
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    190. Dhaunsi GS, Singh I, Orak JK, Singh AK. Antioxidant enzymes in ciprofibrate-induced oxidative stress. Carcinogenesis. 1994 Sep; 15(9):1923-30. PMID: 7923586.
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    191. Dhaunsi GS, Hanevold CD, Singh I. Impairment of peroxisomal beta-oxidation system by endotoxin treatment. Mol Cell Biochem. 1994 Jun 29; 135(2):187-93. PMID: 7838145.
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    192. Singh I, Dhaunsi GS, Orak JK, Rajagopalan PR, Singh AK. CuZn superoxide dismutase: intraorganellar distribution in peroxisomes. Ann N Y Acad Sci. 1994 Jun 17; 723:406-8. PMID: 8030898.
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    193. Singh I, Dhaunsi GS, Orak JK, Rajagopalan PR, Singh AK. CuZn Superoxide Dismutase: Intraorganellar Distribution in Peroxisomes a. Ann N Y Acad Sci. 1994 Jun; 723(1):406-408. PMID: 28984938.
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    194. Contreras M, Mosser J, Mandel JL, Aubourg P, Singh I. The protein coded by the X-adrenoleukodystrophy gene is a peroxisomal integral membrane protein. FEBS Lett. 1994 May 16; 344(2-3):211-5. PMID: 8187886.
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    195. Orak JK, Singh AK, Rajagopalan PR, Singh I. Morphological analysis of mitochondrial integrity in prolonged cold renal ischemia utilizing Euro-Collins versus University of Wisconsin preservation solution in a whole organ model. Transplant Proc. 1994 Feb; 26(1):122-5. PMID: 8108903.
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    196. Pahan K, Singh I. Intraorganellar localization of CoASH-independent phytanic acid oxidation in human liver peroxisomes. FEBS Lett. 1993 Oct 25; 333(1-2):154-8. PMID: 8224157.
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    197. Gulati S, Ainol L, Orak J, Singh AK, Singh I. Alterations of peroxisomal function in ischemia-reperfusion injury of rat kidney. Biochim Biophys Acta. 1993 Oct 20; 1182(3):291-8. PMID: 8399363.
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    198. Singh I, Pahan K, Singh AK, Barbosa E. Refsum disease: a defect in the alpha-oxidation of phytanic acid in peroxisomes. J Lipid Res. 1993 Oct; 34(10):1755-64. PMID: 7504046.
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    199. Singh I, Lazo O, Kremser K. Purification of peroxisomes and subcellular distribution of enzyme activities for activation and oxidation of very-long-chain fatty acids in rat brain. Biochim Biophys Acta. 1993 Sep 29; 1170(1):44-52. PMID: 8399326.
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    200. Dhaunsi GS, Singh I, Hanevold CD. Peroxisomal participation in the cellular response to the oxidative stress of endotoxin. Mol Cell Biochem. 1993 Sep 08; 126(1):25-35. PMID: 8107687.
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    201. Singh I, Gulati S, Orak JK, Singh AK. Expression of antioxidant enzymes in rat kidney during ischemia-reperfusion injury. Mol Cell Biochem. 1993 Aug 25; 125(2):97-104. PMID: 8283974.
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    202. Lanier SM, Ivkovic B, Singh I, Neumeyer JL, Bakthavachalam V. Visualization of multiple imidazoline/guanidinium-receptive sites. J Biol Chem. 1993 Jul 25; 268(21):16047-51. PMID: 8340426.
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    203. Singh I, Pahan K, Dhaunsi GS, Lazo O, Ozand P. Phytanic acid alpha-oxidation. Differential subcellular localization in rat and human tissues and its inhibition by nycodenz. J Biol Chem. 1993 May 15; 268(14):9972-9. PMID: 8486724.
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    204. Pahan K, Cofer J, Baliga P, Singh I. Identification of phytanoyl-CoA ligase as a distinct acyl-CoA ligase in peroxisomes from cultured human skin fibroblasts. FEBS Lett. 1993 May 10; 322(2):101-4. PMID: 8482375.
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    205. Dhaunsi GS, Singh B, Singh AK, Kirschner DA, Singh I. Thioridazine induces lipid peroxidation in myelin of rat brain. Neuropharmacology. 1993 Feb; 32(2):157-67. PMID: 8383815.
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    206. Singh I, Lazo O, Kalipada P, Singh AK. Phytanic acid alpha-oxidation in human cultured skin fibroblasts. Biochim Biophys Acta. 1992 Dec 10; 1180(2):221-4. PMID: 1463774.
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    207. Singh I, Lazo O, Dhaunsi GS, Contreras M. Transport of fatty acids into human and rat peroxisomes. Differential transport of palmitic and lignoceric acids and its implication to X-adrenoleukodystrophy. J Biol Chem. 1992 Jul 05; 267(19):13306-13. PMID: 1618832.
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    208. Gulati S, Singh AK, Irazu C, Orak J, Rajagopalan PR, Fitts CT, Singh I. Ischemia-reperfusion injury: biochemical alterations in peroxisomes of rat kidney. Arch Biochem Biophys. 1992 May 15; 295(1):90-100. PMID: 1575521.
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    209. Singh I, Lazo O. Peroxisomal enzyme activities in brain and liver of pups of lactating mothers treated with ciprofibrate. Neurosci Lett. 1992 Apr 27; 138(2):283-6. PMID: 1608540.
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    210. Dhaunsi GS, Gulati S, Singh AK, Orak JK, Asayama K, Singh I. Demonstration of Cu-Zn superoxide dismutase in rat liver peroxisomes. Biochemical and immunochemical evidence. J Biol Chem. 1992 Apr 05; 267(10):6870-3. PMID: 1551895.
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    211. Yoshida Y, Singh I, Darby CP. Effect of salicylic acid and calcium on mitochondrial functions. Acta Neurol Scand. 1992 Mar; 85(3):191-6. PMID: 1575002.
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    212. Singh I. Peroxisomal activation, transport and oxidation of fatty acids: implications to peroxisomal disorders. Prog Clin Biol Res. 1992; 375:211-22. PMID: 1438366.
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    213. Stanczak H, Stanczak JJ, Singh I. Chromosomal localization of the human gene for palmitoyl-CoA ligase (FACL1). Cytogenet Cell Genet. 1992; 59(1):17-9. PMID: 1531127.
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    214. Stanczak H, Kremser K, Singh AK, Ashcraft J, Stanley W, Singh I. Complementation in Zellweger syndrome: biochemical analysis of newly generated peroxisomes. Hum Hered. 1992; 42(3):172-8. PMID: 1511996.
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    215. Lazo O, Singh AK, Singh I. Postnatal development and isolation of peroxisomes from brain. J Neurochem. 1991 Apr; 56(4):1343-53. PMID: 2002347.
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    216. Singh I, Lazo O, Contreras M, Stanley W, Hashimoto T. Rhizomelic chondrodysplasia punctata: biochemical studies of peroxisomes isolated from cultured skin fibroblasts. Arch Biochem Biophys. 1991 Apr; 286(1):277-83. PMID: 1680308.
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    217. Lazo O, Contreras M, Singh I. Effect of ciprofibrate on the activation and oxidation of very long chain fatty acids. Mol Cell Biochem. 1991 Feb 02; 100(2):159-67. PMID: 2008177.
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    218. Lazo O, Contreras M, Singh I. Topographical localization of peroxisomal acyl-CoA ligases: differential localization of palmitoyl-CoA and lignoceroyl-CoA ligases. Biochemistry. 1990 Apr 24; 29(16):3981-6. PMID: 2354170.
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    219. Lazo O, Contreras M, Yoshida Y, Singh AK, Stanley W, Weise M, Singh I. Cellular oxidation of lignoceric acid is regulated by the subcellular localization of lignoceroyl-CoA ligases. J Lipid Res. 1990 Apr; 31(4):583-95. PMID: 2141053.
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    220. Yoshida Y, Singh I. Effect of clofibrate on peroxisomal lignoceroyl-CoA ligase activity. Biochem Med Metab Biol. 1990 Feb; 43(1):22-9. PMID: 2310609.
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    221. Irazu CE, Rajagopalan PR, Orak JK, Fitts CT, Singh I. Mitochondrial membrane fluidity changes in renal ischemia. J Exp Pathol. 1990; 5(1):1-6. PMID: 2398421.
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    222. Bright GM, Singh I. Adrenal autoantibodies bind to adrenal subcellular fractions enriched in cytochrome-c reductase and 5'-nucleotidase. J Clin Endocrinol Metab. 1990 Jan; 70(1):95-9. PMID: 2294142.
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    223. Dhaunsi GS, Singh AK, Orak J, Singh I. Lipid peroxidation and oxidation of lignoceric acid in kidneys from thioridazine treated rats. J Exp Pathol. 1990; 5(4):177-86. PMID: 2101135.
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    224. Brown FR, Karthigasan J, Singh I, Kirschner DA. X-ray diffraction analysis of myelin lipid/proteolipid protein multilayers. J Neurosci Res. 1989 Oct; 24(2):192-200. PMID: 2585547.
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    225. Lazo O, Contreras M, Bhushan A, Stanley W, Singh I. Adrenoleukodystrophy: impaired oxidation of fatty acids due to peroxisomal lignoceroyl-CoA ligase deficiency. Arch Biochem Biophys. 1989 May 01; 270(2):722-8. PMID: 2705786.
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    226. Singh AK, Yoshida Y, Garvin AJ, Singh I. Effect of fatty acids and their derivatives on mitochondrial structures. J Exp Pathol. 1989; 4(1):9-15. PMID: 2778551.
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    227. Singh AK, Kulvatunyou N, Singh I, Stanley WS. In situ genetic complementation analysis of cells with generalized peroxisomal dysfunction. Hum Hered. 1989; 39(5):298-301. PMID: 2482247.
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    228. Irazu CE, Ruidera E, Singh I, Orak JK, Fitts CT, Rajagopalan PR. Effect of ischemia and 24 hour reperfusion on ATP synthesis in the rat kidney. J Exp Pathol. 1989; 4(1):29-36. PMID: 2778550.
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    229. Yoshida Y, Singh I, Singh AK, Tecklenberg FW, Brown FR, Darby CP. Reye syndrome: rate of oxidation of fatty acids in leukocytes and serum levels of lipid peroxides. J Exp Pathol. 1989; 4(3):133-9. PMID: 2769452.
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    230. Singh I, Bhushan A, Relan NK, Hashimoto T. Acyl-CoA ligases from rat brain microsomes: an immunochemical study. Biochim Biophys Acta. 1988 Dec 16; 963(3):509-14. PMID: 2973813.
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    231. Singh I, Johnson GH, Brown FR. Peroxisomal disorders. Biochemical and clinical diagnostic considerations. Am J Dis Child. 1988 Dec; 142(12):1297-301. PMID: 3057865.
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    232. Lazo O, Contreras M, Hashmi M, Stanley W, Irazu C, Singh I. Peroxisomal lignoceroyl-CoA ligase deficiency in childhood adrenoleukodystrophy and adrenomyeloneuropathy. Proc Natl Acad Sci U S A. 1988 Oct; 85(20):7647-51. PMID: 3174658; PMCID: PMC282249.
    233. Ruidera E, Irazu CE, Rajagopalan PR, Orak JK, Fitts CT, Singh I. Fatty acid metabolism in renal ischemia. Lipids. 1988 Sep; 23(9):882-4. PMID: 3185124.
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    234. Chakrabarti AK, Yoshida Y, Powers JM, Singh I, Hogan EL, Banik NL. Calcium-activated neutral proteinase in rat brain myelin and subcellular fractions. J Neurosci Res. 1988 Jul; 20(3):351-8. PMID: 2852261.
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    235. Yoshida Y, Fujii M, Brown FR, Singh I. Effect of salicylic acid on mitochondrial-peroxisomal fatty acid catabolism. Pediatr Res. 1988 Mar; 23(3):338-41. PMID: 3353181.
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    236. Konat G, Hogan EL, Leskawa KC, Gantt G, Singh I. Abnormal glycosylation of myelin-associated glycoprotein in quaking mouse brain. Neurochem Int. 1987; 10(4):555-8. PMID: 20501130.
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    237. Konat G, Gantt G, Singh I, Hogan EL. Synthesis and acylation of myelin proteolipid protein in quaking mouse brain. Metab Brain Dis. 1986 Dec; 1(4):241-7. PMID: 3508244.
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