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Igor Roninson

Title
InstitutionMedical University of South Carolina
DepartmentSCCP Pharmaceutical and Biomedical Sciences - USC Campus
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chen M, Li J, Liang J, Thompson ZS, Kathrein K, Broude EV, Roninson IB. Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition. Cells. 2019 Nov 09; 8(11). PMID: 31717492.
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    2. Li J, Ji H, Porter DC, Broude EV, Roninson IB, Chen M. Characterizing CDK8/19 Inhibitors through a NF?B-Dependent Cell-Based Assay. Cells. 2019 10 06; 8(10). PMID: 31590445.
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    3. Roninson IB, Gyorffy B, Mack ZT, Shtil AA, Shtutman MS, Chen M, Broude EV. Identifying Cancers Impacted by CDK8/19. Cells. 2019 08 03; 8(8). PMID: 31382571.
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    4. Alam A, Kowal J, Broude E, Roninson I, Locher KP. Structural insight into substrate and inhibitor discrimination by human P-glycoprotein. Science. 2019 02 15; 363(6428):753-756. PMID: 30765569.
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    5. Liang J, Chen M, Broude EV, Roninson IB. Role of transcription-regulating kinase CDK8 in colon cancer metastasis. Oncotarget. 2019 Jan 18; 10(6):622-623. PMID: 30774756.
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    6. Liang J, Chen M, Hughes D, Chumanevich AA, Altilia S, Kaza V, Lim CU, Kiaris H, Mythreye K, Pena MM, Broude EV, Roninson IB. CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases. Cancer Res. 2018 12 01; 78(23):6594-6606. PMID: 30185549.
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    7. Serrao A, Jenkins LM, Chumanevich AA, Horst B, Liang J, Gatza ML, Lee NY, Roninson IB, Broude EV, Mythreye K. Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer. Oncogene. 2018 08; 37(35):4792-4808. PMID: 29780169.
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    8. Alam A, Küng R, Kowal J, McLeod RA, Tremp N, Broude EV, Roninson IB, Stahlberg H, Locher KP. Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):E1973-E1982. PMID: 29440498.
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    9. Chen M, Liang J, Ji H, Yang Z, Altilia S, Hu B, Schronce A, McDermott MSJ, Schools GP, Lim CU, Oliver D, Shtutman MS, Lu T, Stark GR, Porter DC, Broude EV, Roninson IB. CDK8/19 Mediator kinases potentiate induction of transcription by NF?B. Proc Natl Acad Sci U S A. 2017 09 19; 114(38):10208-10213. PMID: 28855340.
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    10. McDermott MS, Chumanevich AA, Lim CU, Liang J, Chen M, Altilia S, Oliver D, Rae JM, Shtutman M, Kiaris H, Gyorffy B, Roninson IB, Broude EV. Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. Oncotarget. 2017 Feb 21; 8(8):12558-12575. PMID: 28147342.
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    11. Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen EJ, Kokkalis A, Roumelioti FM, Gagos S, Tzetis M, Canovas B, Igea A, Ahuja AK, Zellweger R, Havaki S, Kanavakis E, Kletsas D, Roninson IB, Garbis SD, Lopes M, Nebreda A, Thanos D, Blow JJ, Townsend P, Sørensen CS, Bartek J, Gorgoulis VG. Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing. Nat Cell Biol. 2016 07; 18(7):777-89. PMID: 27323328.
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    12. Levina E, Ji H, Chen M, Baig M, Oliver D, Ohouo P, Lim CU, Schools G, Carmack S, Ding Y, Broude EV, Roninson IB, Buttyan R, Shtutman M. Identification of novel genes that regulate androgen receptor signaling and growth of androgen-deprived prostate cancer cells. Oncotarget. 2015 May 30; 6(15):13088-104. PMID: 26036626.
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    13. Broude EV, Gyorffy B, Chumanevich AA, Chen M, McDermott MS, Shtutman M, Catroppo JF, Roninson IB. Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer. Curr Cancer Drug Targets. 2015; 15(8):739-49. PMID: 26452386.
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    14. Porter DC, Farmaki E, Altilia S, Schools GP, West DK, Chen M, Chang BD, Puzyrev AT, Lim CU, Rokow-Kittell R, Friedhoff LT, Papavassiliou AG, Kalurupalle S, Hurteau G, Shi J, Baran PS, Gyorffy B, Wentland MP, Broude EV, Kiaris H, Roninson IB. Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13799-804. PMID: 22869755.
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    15. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
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    16. Masgras I, Carrera S, de Verdier PJ, Brennan P, Majid A, Makhtar W, Tulchinsky E, Jones GD, Roninson IB, Macip S. Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21. J Biol Chem. 2012 Mar 23; 287(13):9845-54. PMID: 22311974.
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    17. Altilia S, Santoro A, Malagoli D, Lanzarini C, Ballesteros Álvarez JA, Galazzo G, Porter DC, Crocco P, Rose G, Passarino G, Roninson IB, Franceschi C, Salvioli S. TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells. Aging (Albany NY). 2012 Jan; 4(1):28-39. PMID: 22289634.
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    18. Shtutman M, Roninson IB. A subunit of coatomer protein complex offers a novel tumor-specific target through a surprising mechanism. Autophagy. 2011 Dec; 7(12):1551-2. PMID: 22024755.
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    19. Gonzalez RE, Lim CU, Cole K, Bianchini CH, Schools GP, Davis BE, Wada I, Roninson IB, Broude EV. Effects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells. Cell Cycle. 2011 Oct 15; 10(20):3505-14. PMID: 22067657.
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    20. Shtutman M, Baig M, Levina E, Hurteau G, Lim CU, Broude E, Nikiforov M, Harkins TT, Carmack CS, Ding Y, Wieland F, Buttyan R, Roninson IB. Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ? 2 renders tumor cells dependent on its paralogous gene COPZ1. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12449-54. PMID: 21746916.
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    21. Zironi I, Gaibani P, Remondini D, Salvioli S, Altilia S, Pierini M, Aicardi G, Verondini E, Milanesi L, Bersani F, Gravina S, Roninson IB, Franceschi C, Castellani G. Molecular remodeling of potassium channels in fibroblasts from centenarians: a marker of longevity? Mech Ageing Dev. 2010 Nov-Dec; 131(11-12):674-81. PMID: 20858515.
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    22. Shtutman M, Maliyekkel A, Shao Y, Carmack CS, Baig M, Warholic N, Cole K, Broude EV, Harkins TT, Ding Y, Roninson IB. Function-based gene identification using enzymatically generated normalized shRNA library and massive parallel sequencing. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7377-82. PMID: 20368428.
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    23. Prencipe M, Fitzpatrick P, Gorman S, Tosetto M, Mosetto M, Klinger R, Furlong F, Harrison M, O'Connor D, Roninson IB, O'Sullivan J, McCann A. Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro. Br J Cancer. 2009 Dec 01; 101(11):1900-8. PMID: 19935801.
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    24. Gravina S, Lescai F, Hurteau G, Brock GJ, Saramaki A, Salvioli S, Franceschi C, Roninson IB. Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population. Aging (Albany NY). 2009 May; 1(5):470-80. PMID: 20126416.
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    25. Chan CY, Carmack CS, Long DD, Maliyekkel A, Shao Y, Roninson IB, Ding Y. A structural interpretation of the effect of GC-content on efficiency of RNA interference. BMC Bioinformatics. 2009 Jan 30; 10 Suppl 1:S33. PMID: 19208134.
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    26. Tapias A, Ciudad CJ, Roninson IB, Noé V. Regulation of Sp1 by cell cycle related proteins. Cell Cycle. 2008 Sep 15; 7(18):2856-67. PMID: 18769160.
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    27. Yates KE, Korbel GA, Shtutman M, Roninson IB, DiMaio D. Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. Aging Cell. 2008 Oct; 7(5):609-21. PMID: 18616636.
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    28. Shao Y, Chan CY, Maliyekkel A, Lawrence CE, Roninson IB, Ding Y. Effect of target secondary structure on RNAi efficiency. RNA. 2007 Oct; 13(10):1631-40. PMID: 17684233.
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    29. Broude EV, Swift ME, Vivo C, Chang BD, Davis BM, Kalurupalle S, Blagosklonny MV, Roninson IB. p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation. Oncogene. 2007 Oct 18; 26(48):6954-8. PMID: 17486059.
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    30. Broude EV, Demidenko ZN, Vivo C, Swift ME, Davis BM, Blagosklonny MV, Roninson IB. p21 (CDKN1A) is a negative regulator of p53 stability. Cell Cycle. 2007 Jun 15; 6(12):1468-71. PMID: 17585201.
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    31. Shtutman M, Levina E, Ohouo P, Baig M, Roninson IB. Cell adhesion molecule L1 disrupts E-cadherin-containing adherens junctions and increases scattering and motility of MCF7 breast carcinoma cells. Cancer Res. 2006 Dec 01; 66(23):11370-80. PMID: 17145883.
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    32. Barré B, Vigneron A, Perkins N, Roninson IB, Gamelin E, Coqueret O. The STAT3 oncogene as a predictive marker of drug resistance. Trends Mol Med. 2007 Jan; 13(1):4-11. PMID: 17118707.
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    33. Maliyekkel A, Davis BM, Roninson IB. Cell cycle arrest drastically extends the duration of gene silencing after transient expression of short hairpin RNA. Cell Cycle. 2006 Oct; 5(20):2390-5. PMID: 17102616.
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    34. Chen Y, Dokmanovic M, Stein WD, Ardecky RJ, Roninson IB. Agonist and antagonist of retinoic acid receptors cause similar changes in gene expression and induce senescence-like growth arrest in MCF-7 breast carcinoma cells. Cancer Res. 2006 Sep 01; 66(17):8749-61. PMID: 16951191.
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    35. Currid CA, O'Connor DP, Chang BD, Gebus C, Harris N, Dawson KA, Dunn MJ, Pennington SR, Roninson IB, Gallagher WM. Proteomic analysis of factors released from p21-overexpressing tumour cells. Proteomics. 2006 Jul; 6(13):3739-53. PMID: 16739131.
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    36. Vigneron A, Roninson IB, Gamelin E, Coqueret O. Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1. Cancer Res. 2005 Oct 01; 65(19):8927-35. PMID: 16204065.
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    37. Roninson IB. Seeking favors from nature. Cancer Biol Ther. 2005 Jul; 4(7):794-9. PMID: 16082180.
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    38. Poole JC, Thain A, Perkins ND, Roninson IB. Induction of transcription by p21Waf1/Cip1/Sdi1: role of NFkappaB and effect of non-steroidal anti-inflammatory drugs. Cell Cycle. 2004 Jul; 3(7):931-40. PMID: 15190207.
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    39. Nickoloff BJ, Lingen MW, Chang BD, Shen M, Swift M, Curry J, Bacon P, Bodner B, Roninson IB. Tumor suppressor maspin is up-regulated during keratinocyte senescence, exerting a paracrine antiangiogenic activity. Cancer Res. 2004 May 01; 64(9):2956-61. PMID: 15126325.
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    40. Shay JW, Roninson IB. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene. 2004 Apr 12; 23(16):2919-33. PMID: 15077154.
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    41. Primiano T, Baig M, Maliyekkel A, Chang BD, Fellars S, Sadhu J, Axenovich SA, Holzmayer TA, Roninson IB. Identification of potential anticancer drug targets through the selection of growth-inhibitory genetic suppressor elements. Cancer Cell. 2003 Jul; 4(1):41-53. PMID: 12892712.
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    42. Roninson IB. Tumor cell senescence in cancer treatment. Cancer Res. 2003 Jun 01; 63(11):2705-15. PMID: 12782571.
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    43. Roninson IB, Dokmanovic M. Induction of senescence-associated growth inhibitors in the tumor-suppressive function of retinoids. J Cell Biochem. 2003 Jan 01; 88(1):83-94. PMID: 12461777.
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    44. Roninson IB, Gudkov AV. Genetic suppressor elements in the characterization and identification of tumor suppressor genes. Methods Mol Biol. 2003; 222:413-36. PMID: 12710702.
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    45. Roninson IB. Tumor senescence as a determinant of drug response in vivo. Drug Resist Updat. 2002 Oct; 5(5):204-8. PMID: 12450785.
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    46. Gregory DJ, Garcia-Wilson E, Poole JC, Snowden AW, Roninson IB, Perkins ND. Induction of transcription through the p300 CRD1 motif by p21WAF1/CIP1 is core promoter specific and cyclin dependent kinase independent. Cell Cycle. 2002 Sep-Oct; 1(5):343-50. PMID: 12461297.
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    47. Roninson IB. Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts. Cancer Lett. 2002 May 08; 179(1):1-14. PMID: 11880176.
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    48. Dokmanovic M, Chang BD, Fang J, Roninson IB. Retinoid-induced growth arrest of breast carcinoma cells involves co-activation of multiple growth-inhibitory genes. Cancer Biol Ther. 2002 Jan-Feb; 1(1):24-7. PMID: 12170760.
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    49. Zhu H, Chang BD, Uchiumi T, Roninson IB. Identification of promoter elements responsible for transcriptional inhibition of polo-like kinase 1 and topoisomerase IIalpha genes by p21(WAF1/CIP1/SDI1). Cell Cycle. 2002 Jan; 1(1):59-66. PMID: 12429910.
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    50. Chang BD, Swift ME, Shen M, Fang J, Broude EV, Roninson IB. Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):389-94. PMID: 11752408.
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    51. Kramer DL, Chang BD, Chen Y, Diegelman P, Alm K, Black AR, Roninson IB, Porter CW. Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype. Cancer Res. 2001 Nov 01; 61(21):7754-62. PMID: 11691789.
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    52. Roninson IB, Broude EV, Chang BD. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat. 2001 Oct; 4(5):303-13. PMID: 11991684.
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    53. Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, Shiyanova T, Roninson I, Weng W, Suzuki R, Tobe K, Kadowaki T, Hay N. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 2001 Sep 01; 15(17):2203-8. PMID: 11544177.
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    54. Druley TE, Stein WD, Roninson IB. Analysis of MDR1 P-glycoprotein conformational changes in permeabilized cells using differential immunoreactivity. Biochemistry. 2001 Apr 10; 40(14):4312-22. PMID: 11284687.
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    55. Druley TE, Stein WD, Ruth A, Roninson IB. P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation. Biochemistry. 2001 Apr 10; 40(14):4323-31. PMID: 11284688.
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    56. Ruth A, Stein WD, Rose E, Roninson IB. Coordinate changes in drug resistance and drug-induced conformational transitions in altered-function mutants of the multidrug transporter P-glycoprotein. Biochemistry. 2001 Apr 10; 40(14):4332-9. PMID: 11284689.
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    57. Levenson VV, Davidovich IA, Roninson IB. Pleiotropic resistance to DNA-interactive drugs is associated with increased expression of genes involved in DNA replication, repair, and stress response. Cancer Res. 2000 Sep 15; 60(18):5027-30. PMID: 11016623.
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    58. Watanabe T, Uchiyama N, Roninson IB, Cohen D, Atadja P. Altered activity of MDR-reversing agents on KB3-1 cells transfected with Gly(185)-->Val human P-glycoprotein. Int J Oncol. 2000 Sep; 17(3):579-86. PMID: 10938401.
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    59. Ruth AC, Roninson IB. Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation. Cancer Res. 2000 May 15; 60(10):2576-8. PMID: 10825123.
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    60. Chang BD, Broude EV, Fang J, Kalinichenko TV, Abdryashitov R, Poole JC, Roninson IB. p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene. 2000 Apr 20; 19(17):2165-70. PMID: 10815808.
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    61. Chang BD, Watanabe K, Broude EV, Fang J, Poole JC, Kalinichenko TV, Roninson IB. Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4291-6. PMID: 10760295.
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    62. Chang BD, Xuan Y, Broude EV, Zhu H, Schott B, Fang J, Roninson IB. Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene. 1999 Aug 26; 18(34):4808-18. PMID: 10490814.
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    63. Chang BD, Broude EV, Dokmanovic M, Zhu H, Ruth A, Xuan Y, Kandel ES, Lausch E, Christov K, Roninson IB. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res. 1999 Aug 01; 59(15):3761-7. PMID: 10446993.
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    64. Li LF, Chang BD, Roninson IB, Fiedler VC, Kumar R. Alteration of skin protein kinase C alpha protein and mRNA levels during induced mouse hair growth. J Dermatol. 1999 Apr; 26(4):203-9. PMID: 10343463.
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    65. Shtil AA, Mandlekar S, Yu R, Walter RJ, Hagen K, Tan TH, Roninson IB, Kong AN. Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells. Oncogene. 1999 Jan 14; 18(2):377-84. PMID: 9927194.
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    66. Dunn SJ, Park SW, Sharma V, Raghu G, Simone JM, Tavassoli R, Young LM, Ortega MA, Pan CH, Alegre GJ, Roninson IB, Lipkina G, Dayn A, Holzmayer TA. Isolation of efficient antivirals: genetic suppressor elements against HIV-1. Gene Ther. 1999 Jan; 6(1):130-7. PMID: 10341885.
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    67. Levenson VV, Lausch E, Kirschling DJ, Broude EV, Davidovich IA, Libants S, Fedosova V, Roninson IB. A combination of genetic suppressor elements produces resistance to drugs inhibiting DNA replication. Somat Cell Mol Genet. 1999 Jan; 25(1):9-26. PMID: 10925700.
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    68. Axenovich SA, Kazarov AR, Boiko AD, Armin G, Roninson IB, Gudkov AV. Altered expression of ubiquitous kinesin heavy chain results in resistance to etoposide and hypersensitivity to colchicine: mapping of the domain associated with drug response. Cancer Res. 1998 Aug 01; 58(15):3423-8. PMID: 9699675.
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    69. Levenson VV, Transue ED, Roninson IB. Internal ribosomal entry site-containing retroviral vectors with green fluorescent protein and drug resistance markers. Hum Gene Ther. 1998 May 20; 9(8):1233-6. PMID: 9625263.
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    70. Szabó K, Welker E, Müller M, Roninson I, Váradi A, Sarkadi B. Drug-stimulated nucleotide trapping in the human multidrug transporter MDR1. Cooperation of the nucleotide binding domains. J Biol Chem. 1998 Apr 24; 273(17):10132-8. PMID: 9553060.
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    71. Komarov PG, Shtil AA, Holian O, Tee L, Buckingham L, Mechetner EB, Roninson IB, Coon JS. Activation of the LRP (lung resistance-related protein) gene by short-term exposure of human leukemia cells to phorbol ester and cytarabine. Oncol Res. 1998; 10(4):185-92. PMID: 9778689.
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    72. Roninson IB, Zuhn D, Ruth A, de Graaf D. Isolation of altered-function mutants and genetic suppressor elements of multidrug transporter P-glycoprotein by expression selection from retroviral libraries. Methods Enzymol. 1998; 292:225-48. PMID: 9711557.
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    73. Mechetner EB, Schott B, Morse BS, Stein WD, Druley T, Davis KA, Tsuruo T, Roninson IB. P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):12908-13. PMID: 9371774.
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    74. Levine EA, Holzmayer T, Bacus S, Mechetner E, Mera R, Bolliger C, Roninson IB, Das Gupta TK. Evaluation of newer prognostic markers for adult soft tissue sarcomas. J Clin Oncol. 1997 Oct; 15(10):3249-57. PMID: 9336362.
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    75. Kolchinsky A, Roninson IB. Drug resistance conferred by MDR1 expression in spheroids formed by glioblastoma cell lines. Anticancer Res. 1997 Sep-Oct; 17(5A):3321-7. PMID: 9413166.
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    76. Kandel ES, Chang BD, Schott B, Shtil AA, Gudkov AV, Roninson IB. Applications of green fluorescent protein as a marker of retroviral vectors. Somat Cell Mol Genet. 1997 Sep; 23(5):325-40. PMID: 9546076.
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    77. Schott B, Kandel ES, Roninson IB. Efficient recovery and regeneration of integrated retroviruses. Nucleic Acids Res. 1997 Jul 15; 25(14):2940-2. PMID: 9207047.
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    78. Walter RJ, Shtil AA, Roninson IB, Holian O. 60-Hz electric fields inhibit protein kinase C activity and multidrug resistance gene (MDR1) up-regulation. Radiat Res. 1997 Mar; 147(3):369-75. PMID: 9052685.
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    79. Gallagher WM, Cairney M, Schott B, Roninson IB, Brown R. Identification of p53 genetic suppressor elements which confer resistance to cisplatin. Oncogene. 1997 Jan 16; 14(2):185-93. PMID: 9010220.
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    80. Gudkov AV, Roninson IB. Isolation of genetic suppressor elements (GSEs) from random fragment cDNA libraries in retroviral vectors. Methods Mol Biol. 1997; 69:221-40. PMID: 9116855.
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    81. Chang BD, Roninson IB. Inducible retroviral vectors regulated by lac repressor in mammalian cells. Gene. 1996 Dec 12; 183(1-2):137-42. PMID: 8996098.
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    82. Komarov PG, Shtil AA, Buckingham LE, Balasubramanian M, Piraner O, Emanuele RM, Roninson IB, Coon JS. Inhibition of cytarabine-induced MDR1 (P-glycoprotein) gene activation in human tumor cells by fatty acid-polyethylene glycol-fatty acid diesters, novel inhibitors of P-glycoprotein function. Int J Cancer. 1996 Oct 09; 68(2):245-50. PMID: 8900436.
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    83. Yu R, Shtil AA, Tan TH, Roninson IB, Kong AN. Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis. Cancer Lett. 1996 Oct 01; 107(1):73-81. PMID: 8913269.
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    84. Raghu G, Park SW, Roninson IB, Mechetner EB. Monoclonal antibodies against P-glycoprotein, an MDR1 gene product, inhibit interleukin-2 release from PHA-activated lymphocytes. Exp Hematol. 1996 Aug; 24(10):1258-64. PMID: 8765502.
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    85. Schott B, Iraj ES, Roninson IB. Effects of infection rate and selection pressure on gene expression from an internal promoter of a double gene retroviral vector. Somat Cell Mol Genet. 1996 Jul; 22(4):291-309. PMID: 9000173.
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    86. Norris MD, De Graaf D, Haber M, Kavallaris M, Madafiglio J, Gilbert J, Kwan E, Stewart BW, Mechetner EB, Gudkov AV, Roninson IB. Involvement of MDR1 P-glycoprotein in multifactorial resistance to methotrexate. Int J Cancer. 1996 Mar 01; 65(5):613-9. PMID: 8598312.
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    87. de Graaf D, Sharma RC, Mechetner EB, Schimke RT, Roninson IB. P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake. Proc Natl Acad Sci U S A. 1996 Feb 06; 93(3):1238-42. PMID: 8577747.
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    88. Müller M, Bakos E, Welker E, Váradi A, Germann UA, Gottesman MM, Morse BS, Roninson IB, Sarkadi B. Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein. J Biol Chem. 1996 Jan 26; 271(4):1877-83. PMID: 8567633.
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    89. Roninson IB, Gudkov AV, Holzmayer TA, Kirschling DJ, Kazarov AR, Zelnick CR, Mazo IA, Axenovich S, Thimmapaya R. Genetic suppressor elements: new tools for molecular oncology--thirteenth Cornelius P. Rhoads Memorial Award Lecture. Cancer Res. 1995 Sep 15; 55(18):4023-8. PMID: 7664275.
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    90. Hanania EG, Fu S, Roninson I, Zu Z, Deisseroth AB. Resistance to taxol chemotherapy produced in mouse marrow cells by safety-modified retroviruses containing a human MDR-1 transcription unit. Gene Ther. 1995 Jun; 2(4):279-84. PMID: 7552988.
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    91. Tang-Wai DF, Kajiji S, DiCapua F, de Graaf D, Roninson IB, Gros P. Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators. Biochemistry. 1995 Jan 10; 34(1):32-9. PMID: 7819214.
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    92. Gudkov AV, Kazarov AR, Thimmapaya R, Axenovich SA, Mazo IA, Roninson IB. Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3744-8. PMID: 8170981.
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    93. Schinkel AH, Arceci RJ, Smit JJ, Wagenaar E, Baas F, Dollé M, Tsuruo T, Mechetner EB, Roninson IB, Borst P. Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein. Int J Cancer. 1993 Sep 30; 55(3):478-84. PMID: 8104165.
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    94. Frommel TO, Coon JS, Tsuruo T, Roninson IB. Variable effects of sodium butyrate on the expression and function of the MDR1 (P-glycoprotein) gene in colon carcinoma cell lines. Int J Cancer. 1993 Sep 09; 55(2):297-302. PMID: 8103760.
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    95. Levine EA, Holzmayer TA, Roninson IB, Das Gupta TK. MDR-1 expression in metastatic malignant melanoma. J Surg Res. 1993 Jun; 54(6):621-4. PMID: 8105147.
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    96. Chaudhary PM, Roninson IB. Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J Natl Cancer Inst. 1993 Apr 21; 85(8):632-9. PMID: 8096875.
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    97. Gudkov AV, Zelnick CR, Kazarov AR, Thimmapaya R, Suttle DP, Beck WT, Roninson IB. Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3231-5. PMID: 8386368.
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    98. Chaudhary PM, Mechetner EB, Roninson IB. Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood. 1992 Dec 01; 80(11):2735-9. PMID: 1360267.
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    99. Holzmayer TA, Hilsenbeck S, Von Hoff DD, Roninson IB. Clinical correlates of MDR1 (P-glycoprotein) gene expression in ovarian and small-cell lung carcinomas. J Natl Cancer Inst. 1992 Oct 07; 84(19):1486-91. PMID: 1359152.
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    100. Mechetner EB, Roninson IB. Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):5824-8. PMID: 1352877.
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    101. Roninson IB. From amplification to function: the case of the MDR1 gene. Mutat Res. 1992 May; 276(3):151-61. PMID: 1374511.
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    102. Holzmayer TA, Pestov DG, Roninson IB. Isolation of dominant negative mutants and inhibitory antisense RNA sequences by expression selection of random DNA fragments. Nucleic Acids Res. 1992 Feb 25; 20(4):711-7. PMID: 1531871.
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    103. Roninson IB. The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo. Biochem Pharmacol. 1992 Jan 09; 43(1):95-102. PMID: 1346497.
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    104. Chaudhary PM, Roninson IB. Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists. Oncol Res. 1992; 4(7):281-90. PMID: 1360276.
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    105. Choi K, Frommel TO, Stern RK, Perez CF, Kriegler M, Tsuruo T, Roninson IB. Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7386-90. PMID: 1678523.
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    106. Chaudhary PM, Roninson IB. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell. 1991 Jul 12; 66(1):85-94. PMID: 1712673.
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    107. Weinstein RS, Jakate SM, Dominguez JM, Lebovitz MD, Koukoulis GK, Kuszak JR, Klusens LF, Grogan TM, Saclarides TJ, Roninson IB, et al. Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis. Cancer Res. 1991 May 15; 51(10):2720-6. PMID: 1673639.
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    108. Chumakov KM, Powers LB, Noonan KE, Roninson IB, Levenbook IS. Correlation between amount of virus with altered nucleotide sequence and the monkey test for acceptability of oral poliovirus vaccine. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):199-203. PMID: 1846038.
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    109. Safa AR, Stern RK, Choi K, Agresti M, Tamai I, Mehta ND, Roninson IB. Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein. Proc Natl Acad Sci U S A. 1990 Sep; 87(18):7225-9. PMID: 1976255.
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    110. Noonan KE, Beck C, Holzmayer TA, Chin JE, Wunder JS, Andrulis IL, Gazdar AF, Willman CL, Griffith B, Von Hoff DD, Roninson IB. Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction. Proc Natl Acad Sci U S A. 1990 09; 87(18):7160-4. PMID: 1976252.
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    111. Tan F, Weerasinghe DK, Skidgel RA, Tamei H, Kaul RK, Roninson IB, Schilling JW, Erdös EG. The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats. J Biol Chem. 1990 Jan 05; 265(1):13-9. PMID: 2378615.
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    112. Chen CJ, Clark D, Ueda K, Pastan I, Gottesman MM, Roninson IB. Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J Biol Chem. 1990 Jan 05; 265(1):506-14. PMID: 1967175.
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    113. Fukumoto M, Tashiro H, Roninson IB. Analysis of gene amplification in human tumor cells by in-gel DNA renaturation assay. Nihon Ketsueki Gakkai Zasshi. 1989 Dec; 52(8):1463-70. PMID: 2629466.
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    114. Chin JE, Soffir R, Noonan KE, Choi K, Roninson IB. Structure and expression of the human MDR (P-glycoprotein) gene family. Mol Cell Biol. 1989 Sep; 9(9):3808-20. PMID: 2571078.
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    115. Fukumoto M, Estensen RD, Sha L, Oakley GJ, Twiggs LB, Adcock LL, Carson LF, Roninson IB. Association of Ki-ras with amplified DNA sequences, detected in human ovarian carcinomas by a modified in-gel renaturation assay. Cancer Res. 1989 Apr 01; 49(7):1693-7. PMID: 2647292.
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    116. Ruiz JC, Choi KH, von Hoff DD, Roninson IB, Wahl GM. Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line. Mol Cell Biol. 1989 Jan; 9(1):109-15. PMID: 2648129.
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    117. Kere J, Ruutu T, Davies KA, Roninson IB, Watkins PC, Winqvist R, de la Chapelle A. Chromosome 7 long arm deletion in myeloid disorders: a narrow breakpoint region in 7q22 defined by molecular mapping. Blood. 1989 Jan; 73(1):230-4. PMID: 2562922.
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    118. Noonan KE, Roninson IB. mRNA phenotyping by enzymatic amplification of randomly primed cDNA. Nucleic Acids Res. 1988 Nov 11; 16(21):10366. PMID: 3194208.
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    119. Fukumoto M, Shevrin DH, Roninson IB. Analysis of gene amplification in human tumor cell lines. Proc Natl Acad Sci U S A. 1988 Sep; 85(18):6846-50. PMID: 3413126.
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    120. Choi KH, Chen CJ, Kriegler M, Roninson IB. An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene. Cell. 1988 May 20; 53(4):519-29. PMID: 2897240.
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    121. Tsuruo T, Sugimoto Y, Hamada H, Roninson I, Okumura M, Adachi K, Morishima Y, Ohno R. Detection of multidrug resistance markers, P-glycoprotein and mdr1 mRNA, in human leukemia cells. Jpn J Cancer Res. 1987 Dec; 78(12):1415-9. PMID: 2892823.
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    122. Sugimoto Y, Roninson IB, Tsuruo T. Decreased expression of the amplified mdr1 gene in revertants of multidrug-resistant human myelogenous leukemia K562 occurs without loss of amplified DNA. Mol Cell Biol. 1987 Dec; 7(12):4549-52. PMID: 3481435.
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    123. Callen DF, Baker E, Simmers RN, Seshadri R, Roninson IB. Localization of the human multiple drug resistance gene, MDR1, to 7q21.1. Hum Genet. 1987 Oct; 77(2):142-4. PMID: 3477522.
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    124. Choi K, Hake LE, Bowcock AM, Roninson IB, Cavalli-Sforza LL. RFLPs associated with MDR2, a member of the human multidrug resistance gene family mapped to chromosome 7. Nucleic Acids Res. 1987 Aug 11; 15(15):6305. PMID: 2888077.
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    125. Ueda K, Clark DP, Chen CJ, Roninson IB, Gottesman MM, Pastan I. The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation. J Biol Chem. 1987 Jan 15; 262(2):505-8. PMID: 3027054.
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    126. Roninson IB. Use of in-gel DNA renaturation for detection and cloning of amplified genes. Methods Enzymol. 1987; 151:332-71. PMID: 2828830.
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    127. Roninson IB. Molecular mechanism of multidrug resistance in tumor cells. Clin Physiol Biochem. 1987; 5(3-4):140-51. PMID: 2887329.
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    128. Ueda K, Cornwell MM, Gottesman MM, Pastan I, Roninson IB, Ling V, Riordan JR. The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochem Biophys Res Commun. 1986 Dec 30; 141(3):956-62. PMID: 2880583.
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    129. Chen CJ, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell. 1986 Nov 07; 47(3):381-9. PMID: 2876781.
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    130. Fukumoto M, Roninson IB. Detection of amplified sequences in mammalian DNA by in-gel renaturation and SINE hybridization. Somat Cell Mol Genet. 1986 Nov; 12(6):611-23. PMID: 3024334.
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    131. Shen DW, Fojo A, Roninson IB, Chin JE, Soffir R, Pastan I, Gottesman MM. Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene. Mol Cell Biol. 1986 Nov; 6(11):4039-45. PMID: 3796599.
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    132. Fojo A, Lebo R, Shimizu N, Chin JE, Roninson IB, Merlino GT, Gottesman MM, Pastan I. Localization of multidrug resistance-associated DNA sequences to human chromosome 7. Somat Cell Mol Genet. 1986 Jul; 12(4):415-20. PMID: 3016920.
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    133. Roninson IB, Chin JE, Choi KG, Gros P, Housman DE, Fojo A, Shen DW, Gottesman MM, Pastan I. Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4538-42. PMID: 3459187.
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    134. Shen DW, Fojo A, Chin JE, Roninson IB, Richert N, Pastan I, Gottesman MM. Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification. Science. 1986 May 02; 232(4750):643-5. PMID: 3457471.
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    135. Gros P, Croop J, Roninson I, Varshavsky A, Housman DE. Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc Natl Acad Sci U S A. 1986 Jan; 83(2):337-41. PMID: 3455770.
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    136. Roninson IB, Abelson HT, Housman DE, Howell N, Varshavsky A. Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells. Nature. 1984 Jun 14-20; 309(5969):626-8. PMID: 6728022.
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    137. Roninson IB. Detection and mapping of homologous, repeated and amplified DNA sequences by DNA renaturation in agarose gels. Nucleic Acids Res. 1983 Aug 25; 11(16):5413-31. PMID: 6310499.
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    138. Roninson IB, Ingram VM. Expression and partial DNA sequence of the chicken beta H-globin gene. J Biol Chem. 1983 Jan 25; 258(2):802-9. PMID: 6296082.
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    139. Varshavsky A, Barsoum J, Roninson I, Snapka R. Acquisition and loss of amplified genes: dramatic effects of hormones, tumor promoters and cytotoxic drugs. Princess Takamatsu Symp. 1983; 14:235-54. PMID: 6394591.
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    140. Garon CF, Parr RP, Padmanabhan R, Roninson I, Garrison JW, Rose JA. Structural characterization of the adenovirus 18 inverted terminal repetition. Virology. 1982 Sep; 121(2):230-9. PMID: 6289515.
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    141. Buescher MA, Roninson I, Padmanabhan R. Physical mapping of human adenovirus type 7 DNA using a simple and sensitive method of terminal labeling. Gene. 1982 May; 18(2):123-31. PMID: 6290317.
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    142. Roninson IB, Ingram VM. Gene evolution in the chicken beta-globin cluster. Cell. 1982 Mar; 28(3):515-21. PMID: 6896168.
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    143. Haigh LS, Hellewell S, Roninson IB, Owens BB, Ingram VM. Control of hemoglobin expression in chick embryonic development. Prog Clin Biol Res. 1982; 102 pt A:35-46. PMID: 6897746.
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    144. Roninson IB, Ingram VM. cDNA sequence of a new chicken embryonic rho-globin. Proc Natl Acad Sci U S A. 1981 Aug; 78(8):4782-5. PMID: 6170981.
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    145. Roninson I, Padmanabhan R. Studies on the nature of the linkage between the terminal protein and the adenovirus DNA. Biochem Biophys Res Commun. 1980 May 14; 94(1):398-405. PMID: 6992783.
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    146. Naroditskii BS, Roninson IB, Kislina OS, Zavizion BA, Tikhonenko TI. [Physical mapping of the genome of phage Cd]. Mol Biol (Mosk). 1979 Mar-Apr; 13(2):309-23. PMID: 440304.
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    147. Roninson IB, Naroditskii BS. [Functional organization of papova- and adenovirus DNA]. Vopr Med Khim. 1978 Sep-Oct; 24(5):579-91. PMID: 212867.
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    148. Roninson IB, Naroditskii BS. [Physical mapping of the genomes of DNA-containing oncogenic viruses]. Vopr Virusol. 1978 Jul-Aug; (4):394-8. PMID: 219614.
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