Keywords
Last Name
Institution

Heather L Trantham-Davidson

Title
InstitutionMedical University of South Carolina
DepartmentPsychiatry and Behavioral Sciences
AddressP.O. Box MSC861
465 IOP
67 President St.
Phone843-792-1134
Fax843-792-7353
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    Dr. Davidson's research is focused on understanding the effects of adolescent alcohol exposure on development of the prefrontal cortex and how these changes impact cognitive function in adulthood. Recent work from her group has shown that exposure to alcohol during adolescence results in cognitive impairments that persist well into adulthood. Her current studies involve examining the effects of adolescent binge-like exposure to alcohol on prefrontal projections to specific subcortical structures. Early studies have shown an overall loss of D1 receptor modulation of prefrontal activity but dopamine may exert pathway specific effects on cortical circuits and current studies are aimed at elucidating the cellular pathways that are affected by adolescent exposure to alcohol and relating these changes to deficits in cognitive function that would impact decison making and risky behavior.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Trantham-Davidson H, Lavin A. Loss of dysbindin-1 affects GABAergic transmission in the PFC. Psychopharmacology (Berl). 2019 Nov; 236(11):3291-3300. PMID: 31201475.
      View in: PubMed
    2. Trantham-Davidson H, Centanni SW, Garr SC, New NN, Mulholland PJ, Gass JT, Glover EJ, Floresco SB, Crews FT, Krishnan HR, Pandey SC, Chandler LJ. Binge-Like Alcohol Exposure During Adolescence Disrupts Dopaminergic Neurotransmission in the Adult Prelimbic Cortex. Neuropsychopharmacology. 2017 Apr; 42(5):1024-1036. PMID: 27620551.
      View in: PubMed
    3. Rinker JA, Fulmer DB, Trantham-Davidson H, Smith ML, Williams RW, Lopez MF, Randall PK, Chandler LJ, Miles MF, Becker HC, Mulholland PJ. Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking. Alcohol. 2017 Feb; 58:33-45. PMID: 27432260.
      View in: PubMed
    4. Centanni SW, Burnett EJ, Trantham-Davidson H, Chandler LJ. Loss of d-GABAA receptor-mediated tonic currents in the adult prelimbic cortex following adolescent alcohol exposure. Addict Biol. 2017 May; 22(3):616-628. PMID: 26804056.
      View in: PubMed
    5. Trantham-Davidson H, Chandler LJ. Alcohol-induced alterations in dopamine modulation of prefrontal activity. Alcohol. 2015 Dec; 49(8):773-9. PMID: 26558348.
      View in: PubMed
    6. Burnett EJ, Chandler LJ, Trantham-Davidson H. Glutamatergic plasticity and alcohol dependence-induced alterations in reward, affect and cognition. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Feb 04; 65:309-20. PMID: 26341050.
      View in: PubMed
    7. Scofield MD, Trantham-Davidson H, Schwendt M, Leong KC, Peters J, See RE, Reichel CM. Failure to Recognize Novelty after Extended Methamphetamine Self-Administration Results from Loss of Long-Term Depression in the Perirhinal Cortex. Neuropsychopharmacology. 2015 Oct; 40(11):2526-35. PMID: 25865928.
      View in: PubMed
    8. Gass JT, Trantham-Davidson H, Kassab AS, Glen WB, Olive MF, Chandler LJ. Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex. J Neurosci. 2014 May 28; 34(22):7562-74. PMID: 24872560.
      View in: PubMed
    9. Gass JT, Glen WB, McGonigal JT, Trantham-Davidson H, Lopez MF, Randall PK, Yaxley R, Floresco SB, Chandler LJ. Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood. Neuropsychopharmacology. 2014 Oct; 39(11):2570-83. PMID: 24820536.
      View in: PubMed
    10. Trantham-Davidson H, Burnett EJ, Gass JT, Lopez MF, Mulholland PJ, Centanni SW, Floresco SB, Chandler LJ. Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex. J Neurosci. 2014 Mar 05; 34(10):3706-18. PMID: 24599469.
      View in: PubMed
    11. Knackstedt LA, Trantham-Davidson HL, Schwendt M. The role of ventral and dorsal striatum mGluR5 in relapse to cocaine-seeking and extinction learning. Addict Biol. 2014 Jan; 19(1):87-101. PMID: 23710649.
      View in: PubMed
    12. Badanich KA, Mulholland PJ, Beckley JT, Trantham-Davidson H, Woodward JJ. Ethanol reduces neuronal excitability of lateral orbitofrontal cortex neurons via a glycine receptor dependent mechanism. Neuropsychopharmacology. 2013 Jun; 38(7):1176-88. PMID: 23314219.
      View in: PubMed
    13. Trantham-Davidson H, LaLumiere RT, Reissner KJ, Kalivas PW, Knackstedt LA. Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training. J Neurosci. 2012 Sep 05; 32(36):12406-10. PMID: 22956831.
      View in: PubMed
    14. Karlsgodt KH, Robleto K, Trantham-Davidson H, Jairl C, Cannon TD, Lavin A, Jentsch JD. Reduced dysbindin expression mediates N-methyl-D-aspartate receptor hypofunction and impaired working memory performance. Biol Psychiatry. 2011 Jan 01; 69(1):28-34. PMID: 21035792.
      View in: PubMed
    15. Jentsch JD, Trantham-Davidson H, Jairl C, Tinsley M, Cannon TD, Lavin A. Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice. Neuropsychopharmacology. 2009 Nov; 34(12):2601-8. PMID: 19641486.
      View in: PubMed
    16. Trantham-Davidson H, Vazdarjanova A, Dai R, Terry A, Bergson C. Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice. Behav Brain Res. 2008 Jun 03; 189(2):244-9. PMID: 18295356.
      View in: PubMed
    17. Trantham-Davidson H, Kröner S, Seamans JK. Dopamine modulation of prefrontal cortex interneurons occurs independently of DARPP-32. Cereb Cortex. 2008 Apr; 18(4):951-8. PMID: 17693396.
      View in: PubMed
    18. Trantham-Davidson H, Neely LC, Lavin A, Seamans JK. Mechanisms underlying differential D1 versus D2 dopamine receptor regulation of inhibition in prefrontal cortex. J Neurosci. 2004 Nov 24; 24(47):10652-9. PMID: 15564581.
      View in: PubMed
    19. Trantham-Davidson H, Lavin A. Acute cocaine administration depresses cortical activity. Neuropsychopharmacology. 2004 Nov; 29(11):2046-51. PMID: 15138440.
      View in: PubMed
    20. Neve KA, Seamans JK, Trantham-Davidson H. Dopamine receptor signaling. J Recept Signal Transduct Res. 2004 Aug; 24(3):165-205. PMID: 15521361.
      View in: PubMed
    21. Trantham H, Szumlinski KK, McFarland K, Kalivas PW, Lavin A. Repeated cocaine administration alters the electrophysiological properties of prefrontal cortical neurons. Neuroscience. 2002; 113(4):749-53. PMID: 12182882.
      View in: PubMed
    Trantham-Davidson's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description