Eric Daniel Hamlett
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Institution | Medical University of South Carolina |
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Department | Pathology and Laboratory Medicine |
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Address | P.O. Box MSC 908 RS403B Walton Research Building - 39 Sabin Street
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Phone | 843-792-2498 |
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Fax | 843-792-0368 |
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ORCID
.gif) | 0000-0002-2900-7949  |
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vCard | Download vCard |
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Biography Western Carolina University, Cullowhee, NC, USA | B.S. | 06/2002 | Biological chemistry | University of North Carolina at Chapel Hill, NC, USA | Postbac | 06/2012 | Entrepreneurship | Medical University of South Carolina, Charleston, SC, USA | Ph.D. | 05/2017 | Neurosciences | University of Denver, Denver, CO, USA | PostDoc | 03/2018 | Neurosciences |
2016 - 2016 | SC Aging Research Award, MUSC Center on Aging | 2016 - 2016 | Travel Award, Bright Focus Foundation | 2017 - 2017 | Neuroscience Discovery Award, MilliporeSigma | 2016 - 2017 | Innovation Excellence Award, NIH-Center for Advancing Innovation | 2018 - 2018 | Ethics in Translational Neuroscience Prize, Herrenhausen Conference | 2018 - 2018 | Travel Award, Caymen Chemical | 2018 - 2018 | Novel Neural Therapies Award, ASNTR | 2019 - 2019 | Annette Karmiloff-Smith Award, T21 Research Society | 2020 - 2020 | Simoa Success Grant Award, Quanterix |
Overview I am a strong believer in community and aim to maximize inclusiveness of a variety of under-represented talent in Science and Research. My objectives are: to better understand Alzheimer's disease, to find novel therapeutic targets, and to enhance others through education.
Alzheimer's disease, Down syndrome, Neurodegeneration, Neuropathology, Aging, Clinical studies, Biomarkers, Comorbidity, Animal models, Proteomics
ORNG Applications Research 3P50DC000422-31A1S1 (DUBNO, JUDY R)Jul 1, 1997 - Aug 31, 2024 NIH Experimental and Clinical Studies of Presbyacusis Role: Co-Investigator |
| R01AG055132 (JOSEPH, JANE E)Sep 30, 2017 - Jun 30, 2022 NIH Using connectomics to characterize risk for Alzheimer's Disease Role: Co-Investigator |
| R01HD096501 (YU, JEREMY YONGXIN)Aug 22, 2018 - May 31, 2023 NIH Translational Research in Pediatric and Obstetric Pharmacology and Therapeutics Role: Co-Investigator |
| R01AG061566 (GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER)Feb 1, 2019 - Nov 30, 2023 NIH Tau pathology in Down syndrome and Alzheimer's Role: Co-Investigator |
Bibliographic
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Hamlett ED, Hjorth E, Ledreux A, Gilmore A, Schultzberg M, Granholm AC. RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome. Glia. 2020 Jan 16. PMID: 31944407.
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Hamlett ED, Ledreux A, Gilmore A, Vazey EM, Aston-Jones G, Boger HA, Paredes D, Granholm AE. Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome. Neurobiol Dis. 2020 Feb; 134:104616. PMID: 31678403.
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Hamlett ED, LaRosa A, Mufson EJ, Fortea J, Ledreux A, Granholm AC. Exosome release and cargo in Down syndrome. Dev Neurobiol. 2019 07; 79(7):639-655. PMID: 31347291.
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Watson LS, Hamlett ED, Stone TD, Sims-Robinson C. Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer's disease. Mol Neurodegener. 2019 06 10; 14(1):22. PMID: 31182115.
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Hamlett ED, Ledreux A, Potter H, Chial HJ, Patterson D, Espinosa JM, Bettcher BM, Granholm AC. Exosomal biomarkers in Down syndrome and Alzheimer's disease. Free Radic Biol Med. 2018 01; 114:110-121. PMID: 28882786.
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Hamlett ED, Goetzl EJ, Ledreux A, Vasilevko V, Boger HA, LaRosa A, Clark D, Carroll SL, Carmona-Iragui M, Fortea J, Mufson EJ, Sabbagh M, Mohammed AH, Hartley D, Doran E, Lott IT, Granholm AC. Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome. Alzheimers Dement. 2017 May; 13(5):541-549. PMID: 27755974.
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Hamlett ED, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm AC. Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Curr Alzheimer Res. 2016; 13(1):35-52. PMID: 26391050.
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Hiller S, DeKroon R, Hamlett ED, Xu L, Osorio C, Robinette J, Winnik W, Simington S, Maeda N, Alzate O, Yi X. Alpha-lipoic acid supplementation protects enzymes from damage by nitrosative and oxidative stress. Biochim Biophys Acta. 2016 Jan; 1860(1 Pt A):36-45. PMID: 26344063.
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Fortress AM, Hamlett ED, Vazey EM, Aston-Jones G, Cass WA, Boger HA, Granholm AC. Designer receptors enhance memory in a mouse model of Down syndrome. J Neurosci. 2015 Jan 28; 35(4):1343-53. PMID: 25632113.
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Nie X, Hamlett ED, Granholm AC, Hui ES, Helpern JA, Jensen JH, Boger HA, Collins HR, Falangola MF. Evidence of altered age-related brain cytoarchitecture in mouse models of down syndrome: a diffusional kurtosis imaging study. Magn Reson Imaging. 2015 May; 33(4):437-47. PMID: 25527393.
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Rubel CE, Schisler JC, Hamlett ED, DeKroon RM, Gautel M, Alzate O, Patterson C. Diggin' on u(biquitin): a novel method for the identification of physiological E3 ubiquitin ligase substrates. Cell Biochem Biophys. 2013 Sep; 67(1):127-38. PMID: 23695782.
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Londono C, DeKroon RM, Mocanu M, Booe J, Winnik WM, Swank A, Osorio C, Hamlett ED, Alzate O. Proteomic analysis of mice expressing human ApoE demonstrates no differences in global protein solubility between APOE 3 and APOE 4 young mice. Electrophoresis. 2012 Dec; 33(24):3745-55. PMID: 23161654.
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Winnik WM, Dekroon RM, Jeong JS, Mocanu M, Robinette JB, Osorio C, Dicheva NN, Hamlett E, Alzate O. Analysis of proteins using DIGE and MALDI mass spectrometry. Methods Mol Biol. 2012; 854:47-66. PMID: 22311753.
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DeKroon RM, Robinette JB, Osorio C, Jeong JS, Hamlett E, Mocanu M, Alzate O. Analysis of protein posttranslational modifications using DIGE-based proteomics. Methods Mol Biol. 2012; 854:129-43. PMID: 22311757.
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Duan J, Gherghe C, Liu D, Hamlett E, Srikantha L, Rodgers L, Regan JN, Rojas M, Willis M, Leask A, Majesky M, Deb A. Wnt1/ßcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J. 2012 Jan 18; 31(2):429-42. PMID: 22085926.
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Khatun J, Hamlett E, Giddings MC. Incorporating sequence information into the scoring function: a hidden Markov model for improved peptide identification. Bioinformatics. 2008 Mar 01; 24(5):674-81. PMID: 18187442.
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Yang D, Ramkissoon K, Hamlett E, Giddings MC. High-accuracy peptide mass fingerprinting using peak intensity data with machine learning. J Proteome Res. 2008 Jan; 7(1):62-9. PMID: 17914788.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2007 | 1 | 2008 | 1 | 2011 | 1 | 2012 | 3 | 2013 | 1 | 2014 | 1 | 2015 | 2 | 2016 | 2 | 2017 | 1 | 2019 | 3 | 2020 | 1 |
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