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Eric Daniel Hamlett

Title
InstitutionMedical University of South Carolina
DepartmentPathology and Laboratory Medicine
AddressP.O. Box MSC 908
RS403B
Walton Research Building - 39 Sabin Street
Phone843-792-2498
Fax843-792-0368
ORCID ORCID Icon0000-0002-2900-7949 Additional info
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    Collapse Biography 
    Collapse education and training
    Western Carolina University, Cullowhee, NC, USAB.S.06/2002Biological chemistry
    University of North Carolina at Chapel Hill, NC, USAPostbac06/2012Entrepreneurship
    Medical University of South Carolina, Charleston, SC, USAPh.D.05/2017Neurosciences
    University of Denver, Denver, CO, USAPostDoc03/2018Neurosciences
    Collapse awards and honors
    2016 - 2016SC Aging Research Award, MUSC Center on Aging
    2016 - 2016Travel Award, Bright Focus Foundation
    2017 - 2017 Neuroscience Discovery Award, MilliporeSigma
    2016 - 2017Innovation Excellence Award, NIH-Center for Advancing Innovation
    2018 - 2018Ethics in Translational Neuroscience Prize, Herrenhausen Conference
    2018 - 2018Travel Award, Caymen Chemical
    2018 - 2018Novel Neural Therapies Award, ASNTR
    2019 - 2019Annette Karmiloff-Smith Award, T21 Research Society
    2020 - 2020Simoa Success Grant Award, Quanterix

    Collapse Overview 
    Collapse overview
    I am a strong believer in community and aim to maximize inclusiveness of a variety of under-represented talent in Science and Research. My objectives are: to better understand Alzheimer's disease, to find novel therapeutic targets, and to enhance others through education.
    Collapse keywords
    Alzheimer's disease, Down syndrome, Neurodegeneration, Neuropathology, Aging, Clinical studies, Biomarkers, Comorbidity, Animal models, Proteomics

    Collapse ORNG Applications 
    Collapse Faculty Mentoring
    Collapse studies/trials
    Collapse Featured Presentations

    Collapse Research 
    Collapse research activities and funding
    3P50DC000422-31A1S1     (DUBNO, JUDY R)Jul 1, 1997 - Aug 31, 2024
    NIH
    Experimental and Clinical Studies of Presbyacusis
    Role: Co-Investigator
    R01AG055132     (JOSEPH, JANE E)Sep 30, 2017 - Jun 30, 2022
    NIH
    Using connectomics to characterize risk for Alzheimer's Disease
    Role: Co-Investigator
    R01HD096501     (YU, JEREMY YONGXIN)Aug 22, 2018 - May 31, 2023
    NIH
    Translational Research in Pediatric and Obstetric Pharmacology and Therapeutics
    Role: Co-Investigator
    R01AG061566     (GRANHOLM-BENTLEY, ANN-CHARLOTTE ESTHER)Feb 1, 2019 - Nov 30, 2023
    NIH
    Tau pathology in Down syndrome and Alzheimer's
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Hamlett ED, Hjorth E, Ledreux A, Gilmore A, Schultzberg M, Granholm AC. RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome. Glia. 2020 Jan 16. PMID: 31944407.
      View in: PubMed
    2. Hamlett ED, Ledreux A, Gilmore A, Vazey EM, Aston-Jones G, Boger HA, Paredes D, Granholm AE. Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome. Neurobiol Dis. 2020 Feb; 134:104616. PMID: 31678403.
      View in: PubMed
    3. Hamlett ED, LaRosa A, Mufson EJ, Fortea J, Ledreux A, Granholm AC. Exosome release and cargo in Down syndrome. Dev Neurobiol. 2019 07; 79(7):639-655. PMID: 31347291.
      View in: PubMed
    4. Watson LS, Hamlett ED, Stone TD, Sims-Robinson C. Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer's disease. Mol Neurodegener. 2019 06 10; 14(1):22. PMID: 31182115.
      View in: PubMed
    5. Hamlett ED, Ledreux A, Potter H, Chial HJ, Patterson D, Espinosa JM, Bettcher BM, Granholm AC. Exosomal biomarkers in Down syndrome and Alzheimer's disease. Free Radic Biol Med. 2018 01; 114:110-121. PMID: 28882786.
      View in: PubMed
    6. Hamlett ED, Goetzl EJ, Ledreux A, Vasilevko V, Boger HA, LaRosa A, Clark D, Carroll SL, Carmona-Iragui M, Fortea J, Mufson EJ, Sabbagh M, Mohammed AH, Hartley D, Doran E, Lott IT, Granholm AC. Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome. Alzheimers Dement. 2017 May; 13(5):541-549. PMID: 27755974.
      View in: PubMed
    7. Hamlett ED, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm AC. Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Curr Alzheimer Res. 2016; 13(1):35-52. PMID: 26391050.
      View in: PubMed
    8. Hiller S, DeKroon R, Hamlett ED, Xu L, Osorio C, Robinette J, Winnik W, Simington S, Maeda N, Alzate O, Yi X. Alpha-lipoic acid supplementation protects enzymes from damage by nitrosative and oxidative stress. Biochim Biophys Acta. 2016 Jan; 1860(1 Pt A):36-45. PMID: 26344063.
      View in: PubMed
    9. Fortress AM, Hamlett ED, Vazey EM, Aston-Jones G, Cass WA, Boger HA, Granholm AC. Designer receptors enhance memory in a mouse model of Down syndrome. J Neurosci. 2015 Jan 28; 35(4):1343-53. PMID: 25632113.
      View in: PubMed
    10. Nie X, Hamlett ED, Granholm AC, Hui ES, Helpern JA, Jensen JH, Boger HA, Collins HR, Falangola MF. Evidence of altered age-related brain cytoarchitecture in mouse models of down syndrome: a diffusional kurtosis imaging study. Magn Reson Imaging. 2015 May; 33(4):437-47. PMID: 25527393.
      View in: PubMed
    11. Rubel CE, Schisler JC, Hamlett ED, DeKroon RM, Gautel M, Alzate O, Patterson C. Diggin' on u(biquitin): a novel method for the identification of physiological E3 ubiquitin ligase substrates. Cell Biochem Biophys. 2013 Sep; 67(1):127-38. PMID: 23695782.
      View in: PubMed
    12. Londono C, DeKroon RM, Mocanu M, Booe J, Winnik WM, Swank A, Osorio C, Hamlett ED, Alzate O. Proteomic analysis of mice expressing human ApoE demonstrates no differences in global protein solubility between APOE 3 and APOE 4 young mice. Electrophoresis. 2012 Dec; 33(24):3745-55. PMID: 23161654.
      View in: PubMed
    13. Winnik WM, Dekroon RM, Jeong JS, Mocanu M, Robinette JB, Osorio C, Dicheva NN, Hamlett E, Alzate O. Analysis of proteins using DIGE and MALDI mass spectrometry. Methods Mol Biol. 2012; 854:47-66. PMID: 22311753.
      View in: PubMed
    14. DeKroon RM, Robinette JB, Osorio C, Jeong JS, Hamlett E, Mocanu M, Alzate O. Analysis of protein posttranslational modifications using DIGE-based proteomics. Methods Mol Biol. 2012; 854:129-43. PMID: 22311757.
      View in: PubMed
    15. Duan J, Gherghe C, Liu D, Hamlett E, Srikantha L, Rodgers L, Regan JN, Rojas M, Willis M, Leask A, Majesky M, Deb A. Wnt1/ßcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J. 2012 Jan 18; 31(2):429-42. PMID: 22085926.
      View in: PubMed
    16. Khatun J, Hamlett E, Giddings MC. Incorporating sequence information into the scoring function: a hidden Markov model for improved peptide identification. Bioinformatics. 2008 Mar 01; 24(5):674-81. PMID: 18187442.
      View in: PubMed
    17. Yang D, Ramkissoon K, Hamlett E, Giddings MC. High-accuracy peptide mass fingerprinting using peak intensity data with machine learning. J Proteome Res. 2008 Jan; 7(1):62-9. PMID: 17914788.
      View in: PubMed
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