Hugh L. Myrick

Title
InstitutionMedical University of South Carolina
DepartmentPsychiatry and Behavioral Sciences
AddressP.O. Box MSC 861
67 President St.
Phone843-789-7316
Fax843-792-7353
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    Donald L. "Hugh" Myrick, MD, is an Associate Professor of Psychiatry in the Addiction Sciences Division at the Medical University of South Carolina. Dr. Myrick currently serves as the Medical Director of the Center for Drug and Alcohol Programs. In addition, he is the Associate Chief of Staff of the Mental Health Service Line at the Veterans Administration Medical Center in Charleston.

    Dr. Myrick’s research interests include the pharmacological treatment of addictive disorders. Specifically, he has completed trials using anticonvulsant agents in the treatment of alcohol withdrawal, alcoholism, and cocaine dependence. In addition, Dr. Myrick was awarded a K Award by NIAAA to use neuroimaging to determine the neuronal networks associated with craving.

    Dr. Myrick has written manuscripts and book chapters on the pharmacotherapy of substance abuse and dual diagnosis, and he speaks frequently on these topics at major association meetings. He is actively involved in intramural committees and mentoring activities as well professional organizations such as the American Psychiatric Association, the Research Society on Alcoholism, and the American Academy of Addiction Psychiatry.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Schacht JP, Randall PK, Latham PK, Voronin KE, Book SW, Myrick H, Anton RF. Predictors of Naltrexone Response in a Randomized Trial: Reward-Related Brain Activation, OPRM1 Genotype, and Smoking Status. Neuropsychopharmacology. 2017 12; 42(13):2654. PMID: 29123234.
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    2. Trivedi MH, Greer TL, Rethorst CD, Carmody T, Grannemann BD, Walker R, Warden D, Shores-Wilson K, Stoutenberg M, Oden N, Silverstein M, Hodgkins C, Love L, Seamans C, Stotts A, Causey T, Szucs-Reed RP, Rinaldi P, Myrick H, Straus M, Liu D, Lindblad R, Church T, Blair SN, Nunes EV. Randomized Controlled Trial Comparing Exercise to Health Education for Stimulant Use Disorder: Results From the CTN-0037 STimulant Reduction Intervention Using Dosed Exercise (STRIDE) Study. J Clin Psychiatry. 2017 Sep/Oct; 78(8):1075-1082. PMID: 28199070.
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    3. Schacht JP, Randall PK, Latham PK, Voronin KE, Book SW, Myrick H, Anton RF. Predictors of Naltrexone Response in a Randomized Trial: Reward-Related Brain Activation, OPRM1 Genotype, and Smoking Status. Neuropsychopharmacology. 2017 Dec; 42(13):2640-2653. PMID: 28409564.
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    4. Malcolm R, Myrick H, Li X, Henderson S, Brady KT, George MS, See RE. Regional Brain Activity in Abstinent Methamphetamine Dependent Males Following Cue Exposure. J Drug Abuse. 2016; 2(1). PMID: 27314105.
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    5. De Santis ML, Myrick H, Lamis DA, Pelic CP, Rhue C, Rhue C, York J. Suicide-specific Safety in the Inpatient Psychiatric Unit. Issues Ment Health Nurs. 2015 Mar; 36(3):190-9. PMID: 25898018.
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    6. Harris AH, Bowe T, Del Re AC, Finlay AK, Oliva E, Myrick HL, Rubinsky AD. Extended release naltrexone for alcohol use disorders: quasi-experimental effects on mortality and subsequent detoxification episodes. Alcohol Clin Exp Res. 2015 Jan; 39(1):79-83. PMID: 25623408.
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    7. Zhang J, Sheerin C, Mandel H, Banducci AN, Myrick H, Acierno R, Amstadter AB, Wang Z. Variation in SLC1A1 is related to combat-related posttraumatic stress disorder. J Anxiety Disord. 2014 Dec; 28(8):902-7. PMID: 25445080.
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    8. Prisciandaro JJ, Joseph JE, Myrick H, McRae-Clark AL, Henderson S, Pfeifer J, Brady KT. The relationship between years of cocaine use and brain activation to cocaine and response inhibition cues. Addiction. 2014 Dec; 109(12):2062-70. PMID: 24938849.
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    9. Schacht JP, Anton RF, Randall PK, Li X, Henderson S, Myrick H. Varenicline effects on drinking, craving and neural reward processing among non-treatment-seeking alcohol-dependent individuals. Psychopharmacology (Berl). 2014 Sep; 231(18):3799-807. PMID: 24647921.
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    10. Prisciandaro JJ, Myrick H, Henderson S, McRae-Clark AL, Brady KT. Prospective associations between brain activation to cocaine and no-go cues and cocaine relapse. Drug Alcohol Depend. 2013 Jul 01; 131(1-2):44-9. PMID: 23683790.
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    11. Prisciandaro JJ, Myrick H, Henderson S, McRae-Clark AL, Santa Ana EJ, Saladin ME, Brady KT. Impact of DCS-facilitated cue exposure therapy on brain activation to cocaine cues in cocaine dependence. Drug Alcohol Depend. 2013 Sep 01; 132(1-2):195-201. PMID: 23497788.
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    12. Schacht JP, Anton RF, Randall PK, Li X, Henderson S, Myrick H. Effects of a GABA-ergic medication combination and initial alcohol withdrawal severity on cue-elicited brain activation among treatment-seeking alcoholics. Psychopharmacology (Berl). 2013 Jun; 227(4):627-37. PMID: 23389755.
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    13. Tuerk PW, Wangelin B, Rauch SA, Dismuke CE, Yoder M, Myrick H, Eftekhari A, Acierno R. Health service utilization before and after evidence-based treatment for PTSD. Psychol Serv. 2013 Nov; 10(4):401-9. PMID: 23148769.
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    14. Turner TH, Horner MD, Vankirk KK, Myrick H, Tuerk PW. A pilot trial of neuropsychological evaluations conducted via telemedicine in the Veterans Health Administration. Telemed J E Health. 2012 Nov; 18(9):662-7. PMID: 23050802.
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    15. Schacht JP, Anton RF, Voronin KE, Randall PK, Li X, Henderson S, Myrick H. Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues. Neuropsychopharmacology. 2013 Feb; 38(3):414-22. PMID: 23032071.
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    16. Verduin ML, LaRowe SD, Myrick H, Cannon-Bowers J, Bowers C. Computer simulation games as an adjunct for treatment in male veterans with alcohol use disorder. J Subst Abuse Treat. 2013 Mar; 44(3):316-22. PMID: 23009800.
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    17. Schacht JP, Anton RF, Myrick H. Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review. Addict Biol. 2013 Jan; 18(1):121-33. PMID: 22574861.
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    18. Anton RF, Voronin KK, Randall PK, Myrick H, Tiffany A. Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm: influence of OPRM1 and dopamine transporter (SLC6A3) genes. Alcohol Clin Exp Res. 2012 Nov; 36(11):2000-7. PMID: 22551036.
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    19. Ditre JW, Oliver JA, Myrick H, Henderson S, Saladin ME, Drobes DJ. Effects of divalproex on smoking cue reactivity and cessation outcomes among smokers achieving initial abstinence. Exp Clin Psychopharmacol. 2012 Aug; 20(4):293-301. PMID: 22468897.
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    20. Prisciandaro JJ, McRae-Clark AL, Myrick H, Henderson S, Brady KT. Brain activation to cocaine cues and motivation/treatment status. Addict Biol. 2014 Mar; 19(2):240-9. PMID: 22458561.
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    21. Yoder M, Tuerk PW, Price M, Grubaugh AL, Strachan M, Myrick H, Acierno R. Prolonged exposure therapy for combat-related posttraumatic stress disorder: comparing outcomes for veterans of different wars. Psychol Serv. 2012 Feb; 9(1):16-25. PMID: 22449084.
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    22. Hartwell KJ, Johnson KA, Li X, Myrick H, LeMatty T, George MS, Brady KT. Neural correlates of craving and resisting craving for tobacco in nicotine dependent smokers. Addict Biol. 2011 Oct; 16(4):654-66. PMID: 21790899.
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    23. Schacht JP, Randall PK, Waid LR, Baros AM, Latham PK, Wright TM, Myrick H, Anton RF. Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence. Alcohol Clin Exp Res. 2011 Nov; 35(11):2030-8. PMID: 21631542.
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    24. Anton RF, Myrick H, Wright TM, Latham PK, Baros AM, Waid LR, Randall PK. Gabapentin combined with naltrexone for the treatment of alcohol dependence. Am J Psychiatry. 2011 Jul; 168(7):709-17. PMID: 21454917.
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    25. Schacht JP, Anton RF, Randall PK, Li X, Henderson S, Myrick H. Stability of fMRI striatal response to alcohol cues: a hierarchical linear modeling approach. Neuroimage. 2011 May 01; 56(1):61-8. PMID: 21316465.
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    26. Tuerk PW, Yoder M, Grubaugh A, Myrick H, Hamner M, Acierno R. Prolonged exposure therapy for combat-related posttraumatic stress disorder: an examination of treatment effectiveness for veterans of the wars in Afghanistan and Iraq. J Anxiety Disord. 2011 Apr; 25(3):397-403. PMID: 21131170.
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    27. Myrick H, Li X, Randall PK, Henderson S, Voronin K, Anton RF. The effect of aripiprazole on cue-induced brain activation and drinking parameters in alcoholics. J Clin Psychopharmacol. 2010 Aug; 30(4):365-72. PMID: 20571434.
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    28. Brady KT, Tuerk P, Back SE, Saladin ME, Waldrop AE, Myrick H. Combat posttraumatic stress disorder, substance use disorders, and traumatic brain injury. J Addict Med. 2009 Dec; 3(4):179-88. PMID: 21769015.
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    29. Anton RF, Myrick H, Baros AM, Latham PK, Randall PK, Wright TM, Stewart SH, Waid R, Malcolm R. Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms. J Clin Psychopharmacol. 2009 Aug; 29(4):334-42. PMID: 19593171.
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    30. Myrick H, Malcolm R, Randall PK, Boyle E, Anton RF, Becker HC, Randall CL. A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal. Alcohol Clin Exp Res. 2009 Sep; 33(9):1582-8. PMID: 19485969.
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    31. Voronin K, Randall P, Myrick H, Anton R. Aripiprazole effects on alcohol consumption and subjective reports in a clinical laboratory paradigm--possible influence of self-control. Alcohol Clin Exp Res. 2008 Nov; 32(11):1954-61. PMID: 18782344.
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    32. Myrick H, Anton RF, Li X, Henderson S, Randall PK, Voronin K. Effect of naltrexone and ondansetron on alcohol cue-induced activation of the ventral striatum in alcohol-dependent people. Arch Gen Psychiatry. 2008 Apr; 65(4):466-75. PMID: 18391135.
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    33. LaRowe SD, Myrick H, Hedden S, Mardikian P, Saladin M, McRae A, Brady K, Kalivas PW, Malcolm R. Is cocaine desire reduced by N-acetylcysteine? Am J Psychiatry. 2007 Jul; 164(7):1115-7. PMID: 17606664.
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    34. Book SW, Myrick H, Malcolm R, Strain EC. Buprenorphine for postoperative pain following general surgery in a buprenorphine-maintained patient. Am J Psychiatry. 2007 Jun; 164(6):979. PMID: 17541066.
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    35. Wright TM, Myrick H, Malcolm R, Randall P, Boyle E, Henderson S, Anton R. Impact of lifetime alcohol quit attempts and medicated detoxifications on time to relapse during an index alcohol detoxification. J Addict Med. 2007 Mar; 1(1):15-20. PMID: 21768927.
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    36. Myrick H, Anton R, Voronin K, Wang W, Henderson S. A double-blind evaluation of gabapentin on alcohol effects and drinking in a clinical laboratory paradigm. Alcohol Clin Exp Res. 2007 Feb; 31(2):221-7. PMID: 17250613.
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    37. Wright TM, Myrick H. Acamprosate: a new tool in the battle against alcohol dependence. Neuropsychiatr Dis Treat. 2006 Dec; 2(4):445-53. PMID: 19412493.
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    38. Wright T, Myrick H, Henderson S, Peters H, Malcolm R. Risk factors for delirium tremens: a retrospective chart review. Am J Addict. 2006 May-Jun; 15(3):213-9. PMID: 16923667.
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    39. Becker HC, Myrick H, Veatch LM. Pregabalin is effective against behavioral and electrographic seizures during alcohol withdrawal. Alcohol Alcohol. 2006 Jul-Aug; 41(4):399-406. PMID: 16636010.
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    40. LaRowe SD, Mardikian P, Malcolm R, Myrick H, Kalivas P, McFarland K, Saladin M, McRae A, Brady K. Safety and tolerability of N-acetylcysteine in cocaine-dependent individuals. Am J Addict. 2006 Jan-Feb; 15(1):105-10. PMID: 16449100.
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    41. Myrick H, Taylor B, LaRowe S, Nguyen S, Boyle E, Cochran K, Malcolm R. A retrospective chart review comparing tiagabine and benzodiazepines for the treatment of alcohol withdrawal. J Psychoactive Drugs. 2005 Dec; 37(4):409-14. PMID: 16480168.
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    42. Turkcapar H, Kose S, Ince A, Myrick H. Beliefs as a predictor of relapse in alcohol-dependent Turkish men. J Stud Alcohol. 2005 Nov; 66(6):848-51. PMID: 16459947.
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    43. Anton RF, Moak DH, Latham P, Waid LR, Myrick H, Voronin K, Thevos A, Wang W, Woolson R. Naltrexone combined with either cognitive behavioral or motivational enhancement therapy for alcohol dependence. J Clin Psychopharmacol. 2005 Aug; 25(4):349-57. PMID: 16012278.
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    44. Bedwell JS, Horner MD, Yamanaka K, Li X, Myrick H, Nahas Z, George MS. Functional neuroanatomy of subcomponent cognitive processes involved in verbal working memory. Int J Neurosci. 2005 Jul; 115(7):1017-32. PMID: 16051547.
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    45. Lee YK, Park SW, Kim YK, Kim DJ, Jeong J, Myrick H, Kim YH. Effects of naltrexone on the ethanol-induced changes in the rat central dopaminergic system. Alcohol Alcohol. 2005 Jul-Aug; 40(4):297-301. PMID: 15897221.
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    46. Verduin ML, Carter RE, Brady KT, Myrick H, Timmerman MA. Health service use among persons with comorbid bipolar and substance use disorders. Psychiatr Serv. 2005 Apr; 56(4):475-80. PMID: 15812100.
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    47. Book SW, Myrick H. Novel anticonvulsants in the treatment of alcoholism. Expert Opin Investig Drugs. 2005 Apr; 14(4):371-6. PMID: 15882114.
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    48. Johnson BA, Swift RM, Addolorato G, Ciraulo DA, Myrick H. Safety and efficacy of GABAergic medications for treating alcoholism. Alcohol Clin Exp Res. 2005 Feb; 29(2):248-54. PMID: 15714047.
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    49. Frueh BC, Henderson S, Myrick H. Telehealth service delivery for persons with alcoholism. J Telemed Telecare. 2005; 11(7):372-5. PMID: 16238840.
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    50. Myrick H, Cluver J, Swavely S, Peters H. Diagnosis and treatment of co-occurring affective disorders and substance use disorders. Psychiatr Clin North Am. 2004 Dec; 27(4):649-59. PMID: 15550285.
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    51. Kim DJ, Yoon SJ, Choi B, Kim TS, Woo YS, Kim W, Myrick H, Peterson BS, Choi YB, Kim YK, Jeong J. Increased fasting plasma ghrelin levels during alcohol abstinence. Alcohol Alcohol. 2005 Jan-Feb; 40(1):76-9. PMID: 15520048.
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    52. Myrick H, Anton R. Recent advances in the pharmacotherapy of alcoholism. Curr Psychiatry Rep. 2004 Oct; 6(5):332-8. PMID: 15355755.
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    53. Mishory A, Molnar C, Koola J, Li X, Kozel FA, Myrick H, Stroud Z, Nahas Z, George MS. The maximum-likelihood strategy for determining transcranial magnetic stimulation motor threshold, using parameter estimation by sequential testing is faster than conventional methods with similar precision. J ECT. 2004 Sep; 20(3):160-5. PMID: 15343000.
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    54. Myrick H, Malcolm R, Taylor B, LaRowe S. Modafinil: preclinical, clinical, and post-marketing surveillance--a review of abuse liability issues. Ann Clin Psychiatry. 2004 Apr-Jun; 16(2):101-9. PMID: 15328903.
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    55. Myrick H, Anton RF, Li X, Henderson S, Drobes D, Voronin K, George MS. Differential brain activity in alcoholics and social drinkers to alcohol cues: relationship to craving. Neuropsychopharmacology. 2004 Feb; 29(2):393-402. PMID: 14679386.
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    56. Kim DJ, Jeong J, Kim KS, Chae JH, Jin SH, Ahn KJ, Myrick H, Yoon SJ, Kim HR, Kim SY. Complexity changes of the EEG induced by alcohol cue exposure in alcoholics and social drinkers. Alcohol Clin Exp Res. 2003 Dec; 27(12):1955-61. PMID: 14691383.
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    57. Lanford W, Myrick H, O'Bryan E, Gorman JM. A severe case of clonidine dependence and withdrawal. J Psychiatr Pract. 2003 Mar; 9(2):167-70. PMID: 15985928.
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    58. Myrick H, Brady KT. The use of divalproex in the treatment of addictive disorders. Psychopharmacol Bull. 2003; 37 Suppl 2:89-97. PMID: 15021864.
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    59. Brady KT, Myrick H, Henderson S, Coffey SF. The use of divalproex in alcohol relapse prevention: a pilot study. Drug Alcohol Depend. 2002 Aug 01; 67(3):323-30. PMID: 12127203.
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    60. Malcolm R, Myrick H, Roberts J, Wang W, Anton RF, Ballenger JC. The effects of carbamazepine and lorazepam on single versus multiple previous alcohol withdrawals in an outpatient randomized trial. J Gen Intern Med. 2002 May; 17(5):349-55. PMID: 12047731.
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    61. Malcolm R, Myrick H, Roberts J, Wang W, Anton RF. The differential effects of medication on mood, sleep disturbance, and work ability in outpatient alcohol detoxification. Am J Addict. 2002; 11(2):141-50. PMID: 12028744.
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    62. Myrick H, Henderson S, Dansky B, Pelic C, Brady KT. Clinical characteristics of under-reporters on urine drug screens in a cocaine treatment study. Am J Addict. 2002; 11(4):255-61. PMID: 12584868.
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    63. Myrick H, Henderson S, Anton RF. Utility of a new assay for carbohydrate-deficient transferrin (Biorad %CDT TIA) to monitor abstinence during a treatment outcome study. Alcohol Clin Exp Res. 2001 Sep; 25(9):1330-4. PMID: 11584153.
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    64. Myrick H, Henderson S, Brady KT, Malcom R, Measom M. Divalproex loading in the treatment of cocaine dependence. J Psychoactive Drugs. 2001 Jul-Sep; 33(3):283-7. PMID: 11718321.
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    65. Myrick H, Malcolm R, Henderson S, McCormick K. Gabapentin for misuse of homemade nicotine nasal spray. Am J Psychiatry. 2001 Mar; 158(3):498. PMID: 11230002.
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    66. Malcolm R, Myrick H, Brady KT, Ballenger JC. Update on anticonvulsants for the treatment of alcohol withdrawal. Am J Addict. 2001; 10(s1):s16-s23. PMID: 11268817.
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    67. Myrick H, Henderson S, Brady KT, Malcolm R. Gabapentin in the treatment of cocaine dependence: a case series. J Clin Psychiatry. 2001 Jan; 62(1):19-23. PMID: 11235923.
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    68. Myrick H, Brady KT, Malcolm R. New developments in the pharmacotherapy of alcohol dependence. Am J Addict. 2001; 10(s1):s3-s15. PMID: 11268820.
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    69. Malcolm R, Roberts JS, Wang W, Myrick H, Anton RF. Multiple previous detoxifications are associated with less responsive treatment and heavier drinking during an index outpatient detoxification. Alcohol. 2000 Nov; 22(3):159-64. PMID: 11163123.
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    70. Myrick H, Brady KT, Malcolm R. Divalproex in the treatment of alcohol withdrawal. Am J Drug Alcohol Abuse. 2000 Feb; 26(1):155-60. PMID: 10718170.
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    71. Myrick H, Anton RF. Clinical management of alcohol withdrawal. CNS Spectr. 2000 Feb; 5(2):22-32. PMID: 18296996.
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    72. Myrick H, Malcolm R, Brady KT. Gabapentin treatment of alcohol withdrawal. Am J Psychiatry. 1998 Nov; 155(11):1632. PMID: 9812141.
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    73. Myrick H, Markowitz JS, Henderson S. Priapism following trazodone overdose with cocaine use. Ann Clin Psychiatry. 1998 Jun; 10(2):81-3. PMID: 9669540.
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    74. Brady KT, Myrick H, McElroy S. The relationship between substance use disorders, impulse control disorders, and pathological aggression. Am J Addict. 1998; 7(3):221-30. PMID: 9702290.
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    75. Myrick H, Anton RF. Treatment of alcohol withdrawal. Alcohol Health Res World. 1998; 22(1):38-43. PMID: 15706731.
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    76. Markowitz JS, Finkenbine R, Myrick H, King L, Carson WH. Gabapentin abuse in a cocaine user: implications for treatment? J Clin Psychopharmacol. 1997 Oct; 17(5):423-4. PMID: 9315994.
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    77. Markowitz JS, Myrick H, Hiott W. Clonidine dependence. J Clin Psychopharmacol. 1997 Apr; 17(2):137-8. PMID: 10950490.
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    78. Myrick H, Brady KT. Social phobia in cocaine-dependent individuals. Am J Addict. 1997; 6(2):99-104. PMID: 9134071.
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