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Donald R. Menick

Title
InstitutionMedical University of South Carolina
DepartmentCardiology
AddressP.O. Box MSC 773
326 C GCRI/STB
Thurmond Gazes - 30 Courtenay Drive
Phone843-876-5045
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    Collapse Overview 
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    My laboratory is focused on the analysis of signaling and gene regulatory pathways, which play a role in cardiac failure. Recently, others and we have demonstrated that protein acetylation, regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), plays a significant role in modulating gene expression in cardiac pathologies. Importantly, treatment with HDAC inhibitors preserves ventricular remodeling and cardiac function in models of cardiac hypertrophy, myocardial infarction (MI) and heart failure. We have demonstrated that the acetylation state of specific transcription factors affects their interaction with co-activators and co-repressors. Therefore, HDACs can facilitate gene activation via the direct deacetylation of transcription factors allowing for recruitment of co-activators to the promoter. We utilize both isolated adult cardiac myocytes as well as animal models of hypertrophy, MI and heart failure to determine the signals that regulate HDACs and HATs and how the resulting changes in protein acetylation modulate cardiomyocyte and ventricular function. Our goal is to translate our basic and pre-clinical discoveries into important new therapies for patients with heart disease.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kimbrough D, Wang SH, Wright LH, Mani SK, Kasiganesan H, LaRue AC, Cheng Q, Nadig SN, Atkinson C, Menick DR. HDAC inhibition helps post-MI healing by modulating macrophage polarization. J Mol Cell Cardiol. 2018 06; 119:51-63. PMID: 29680681.
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    2. Wright LH, Herr DJ, Brown SS, Kasiganesan H, Menick DR. Angiokine Wisp-1 is increased in myocardial infarction and regulates cardiac endothelial signaling. JCI Insight. 2018 Feb 22; 3(4). PMID: 29467324.
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    3. Herr DJ, Baarine M, Aune SE, Li X, Ball LE, Lemasters JJ, Beeson CC, Chou JC, Menick DR. HDAC1 localizes to the mitochondria of cardiac myocytes and contributes to early cardiac reperfusion injury. J Mol Cell Cardiol. 2018 01; 114:309-319. PMID: 29224834.
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    4. Richards DJ, Coyle RC, Tan Y, Jia J, Wong K, Toomer K, Menick DR, Mei Y. Inspiration from heart development: Biomimetic development of functional human cardiac organoids. Biomaterials. 2017 Oct; 142:112-123. PMID: 28732246.
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    5. Tan Y, Richards D, Coyle RC, Yao J, Xu R, Gou W, Wang H, Menick DR, Tian B, Mei Y. Cell number per spheroid and electrical conductivity of nanowires influence the function of silicon nanowired human cardiac spheroids. Acta Biomater. 2017 03 15; 51:495-504. PMID: 28087483.
      View in: PubMed
    6. Richards DJ, Tan Y, Coyle R, Li Y, Xu R, Yeung N, Parker A, Menick DR, Tian B, Mei Y. Nanowires and Electrical Stimulation Synergistically Improve Functions of hiPSC Cardiac Spheroids. Nano Lett. 2016 07 13; 16(7):4670-8. PMID: 27328393.
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    7. Wright LH, Menick DR. A class of their own: exploring the nondeacetylase roles of class IIa HDACs in cardiovascular disease. Am J Physiol Heart Circ Physiol. 2016 07 01; 311(1):H199-206. PMID: 27208161.
      View in: PubMed
    8. Harris LG, Wang SH, Mani SK, Kasiganesan H, Chou CJ, Menick DR. Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes. Nucleic Acids Res. 2016 05 05; 44(8):3610-7. PMID: 26704971.
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    9. Renaud L, Harris LG, Mani SK, Kasiganesan H, Chou JC, Baicu CF, Van Laer A, Akerman AW, Stroud RE, Jones JA, Zile MR, Menick DR. HDACs Regulate miR-133a Expression in Pressure Overload-Induced Cardiac Fibrosis. Circ Heart Fail. 2015 Nov; 8(6):1094-104. PMID: 26371176.
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    10. Durst R, Sauls K, Peal DS, deVlaming A, Toomer K, Leyne M, Salani M, Talkowski ME, Brand H, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, Le Tourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott JJ, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome AM, Williams K, Johnson A, Markwald RR, Jeunemaitre X, Hagege A, Levine RA, Milan DJ, Norris RA, Slaugenhaupt SA. Mutations in DCHS1 cause mitral valve prolapse. Nature. 2015 Sep 03; 525(7567):109-13. PMID: 26258302.
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    11. Herr DJ, Aune SE, Menick DR. Induction and Assessment of Ischemia-reperfusion Injury in Langendorff-perfused Rat Hearts. J Vis Exp. 2015 Jul 27; (101):e52908. PMID: 26274877.
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    12. Aune SE, Herr DJ, Kutz CJ, Menick DR. Histone Deacetylases Exert Class-Specific Roles in Conditioning the Brain and Heart Against Acute Ischemic Injury. Front Neurol. 2015; 6:145. PMID: 26175715.
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    13. Tan Y, Richards D, Xu R, Stewart-Clark S, Mani SK, Borg TK, Menick DR, Tian B, Mei Y. Silicon nanowire-induced maturation of cardiomyocytes derived from human induced pluripotent stem cells. Nano Lett. 2015 May 13; 15(5):2765-72. PMID: 25826336.
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    14. Mani SK, Kern CB, Kimbrough D, Addy B, Kasiganesan H, Rivers WT, Patel RK, Chou JC, Spinale FG, Mukherjee R, Menick DR. Inhibition of class I histone deacetylase activity represses matrix metalloproteinase-2 and -9 expression and preserves LV function postmyocardial infarction. Am J Physiol Heart Circ Physiol. 2015 Jun 01; 308(11):H1391-401. PMID: 25795711.
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    15. Alsarraf O, Fan J, Dahrouj M, Chou CJ, Menick DR, Crosson CE. Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration. Exp Eye Res. 2014 Oct; 127:124-31. PMID: 25064603.
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    16. Aune SE, Herr DJ, Mani SK, Menick DR. Selective inhibition of class I but not class IIb histone deacetylases exerts cardiac protection from ischemia reperfusion. J Mol Cell Cardiol. 2014 Jul; 72:138-45. PMID: 24632412.
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    17. Menick DR, Li MS, Chernysh O, Renaud L, Kimbrough D, Kasiganesan H, Mani SK. Transcriptional pathways and potential therapeutic targets in the regulation of Ncx1 expression in cardiac hypertrophy and failure. Adv Exp Med Biol. 2013; 961:125-35. PMID: 23224875.
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    18. Ounzain S, Kobayashi S, Peterson RE, He A, Motterle A, Samani NJ, Menick DR, Pu WT, Liang Q, Chong NW. Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4. Mol Cell Biol. 2012 May; 32(10):1830-43. PMID: 22431517.
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    19. Dai B, Huang W, Xu M, Millard RW, Gao MH, Hammond HK, Menick DR, Ashraf M, Wang Y. Reduced collagen deposition in infarcted myocardium facilitates induced pluripotent stem cell engraftment and angiomyogenesis for improvement of left ventricular function. J Am Coll Cardiol. 2011 Nov 08; 58(20):2118-27. PMID: 22051336.
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    20. Morad M, Cleemann L, Menick DR. NCX1 phosphorylation dilemma: a little closer to resolution. Focus on "Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase A". Am J Physiol Cell Physiol. 2011 May; 300(5):C970-3. PMID: 21389274.
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    21. Cheng G, Takahashi M, Shunmugavel A, Wallenborn JG, DePaoli-Roach AA, Gergs U, Neumann J, Kuppuswamy D, Menick DR, Cooper G. Basis for MAP4 dephosphorylation-related microtubule network densification in pressure overload cardiac hypertrophy. J Biol Chem. 2010 Dec 03; 285(49):38125-40. PMID: 20889984.
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    22. Kammili RK, Taylor DG, Xia J, Osuala K, Thompson K, Menick DR, Ebert SN. Generation of novel reporter stem cells and their application for molecular imaging of cardiac-differentiated stem cells in vivo. Stem Cells Dev. 2010 Sep; 19(9):1437-48. PMID: 20109065.
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    23. Chinnakkannu P, Samanna V, Cheng G, Ablonczy Z, Baicu CF, Bethard JR, Menick DR, Kuppuswamy D, Cooper G. Site-specific microtubule-associated protein 4 dephosphorylation causes microtubule network densification in pressure overload cardiac hypertrophy. J Biol Chem. 2010 Jul 09; 285(28):21837-48. PMID: 20436166.
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    24. Crosson CE, Mani SK, Husain S, Alsarraf O, Menick DR. Inhibition of histone deacetylase protects the retina from ischemic injury. Invest Ophthalmol Vis Sci. 2010 Jul; 51(7):3639-45. PMID: 20164449.
      View in: PubMed
    25. Kern CB, Wessels A, McGarity J, Dixon LJ, Alston E, Argraves WS, Geeting D, Nelson CM, Menick DR, Apte SS. Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies. Matrix Biol. 2010 May; 29(4):304-16. PMID: 20096780.
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    26. Mani SK, Egan EA, Addy BK, Grimm M, Kasiganesan H, Thiyagarajan T, Renaud L, Brown JH, Kern CB, Menick DR. beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes. J Mol Cell Cardiol. 2010 Feb; 48(2):342-51. PMID: 19945464.
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    27. Xu L, Kappler CS, Mani SK, Shepherd NR, Renaud L, Snider P, Conway SJ, Menick DR. Chronic administration of KB-R7943 induces up-regulation of cardiac NCX1. J Biol Chem. 2009 Oct 02; 284(40):27265-72. PMID: 19661061.
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    28. Chandrasekaran S, Peterson RE, Mani SK, Addy B, Buchholz AL, Xu L, Thiyagarajan T, Kasiganesan H, Kern CB, Menick DR. Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes. FASEB J. 2009 Nov; 23(11):3851-64. PMID: 19638401.
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    29. Cheng G, Zile MR, Takahashi M, Baicu CF, Bonnema DD, Cabral F, Menick DR, Cooper G. A direct test of the hypothesis that increased microtubule network density contributes to contractile dysfunction of the hypertrophied heart. Am J Physiol Heart Circ Physiol. 2008 May; 294(5):H2231-41. PMID: 18344371.
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    30. Snider P, Hinton RB, Moreno-Rodriguez RA, Wang J, Rogers R, Lindsley A, Li F, Ingram DA, Menick D, Field L, Firulli AB, Molkentin JD, Markwald R, Conway SJ. Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circ Res. 2008 Apr 11; 102(7):752-60. PMID: 18296617.
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    31. Scholz D, Baicu CF, Tuxworth WJ, Xu L, Kasiganesan H, Menick DR, Cooper G. Microtubule-dependent distribution of mRNA in adult cardiocytes. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1135-44. PMID: 18178719.
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    32. Menick DR, Renaud L, Buchholz A, Müller JG, Zhou H, Kappler CS, Kubalak SW, Conway SJ, Xu L. Regulation of Ncx1 gene expression in the normal and hypertrophic heart. Ann N Y Acad Sci. 2007 Mar; 1099:195-203. PMID: 17446459.
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    33. Xu L, Renaud L, Müller JG, Baicu CF, Bonnema DD, Zhou H, Kappler CS, Kubalak SW, Zile MR, Conway SJ, Menick DR. Regulation of Ncx1 expression. Identification of regulatory elements mediating cardiac-specific expression and up-regulation. J Biol Chem. 2006 Nov 10; 281(45):34430-40. PMID: 16966329.
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    34. Wang Y, Yin S, Blade K, Cooper G, Menick DR, Cabral F. Mutations at leucine 215 of beta-tubulin affect paclitaxel sensitivity by two distinct mechanisms. Biochemistry. 2006 Jan 10; 45(1):185-94. PMID: 16388594.
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    35. Xu L, Kappler CS, Menick DR. The role of p38 in the regulation of Na+-Ca2+ exchanger expression in adult cardiomyocytes. J Mol Cell Cardiol. 2005 May; 38(5):735-43. PMID: 15850567.
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    36. Tuxworth WJ, Saghir AN, Spruill LS, Menick DR, McDermott PJ. Regulation of protein synthesis by eIF4E phosphorylation in adult cardiocytes: the consequence of secondary structure in the 5'-untranslated region of mRNA. Biochem J. 2004 Feb 15; 378(Pt 1):73-82. PMID: 14629199.
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    37. Takahashi M, Shiraishi H, Ishibashi Y, Blade KL, McDermott PJ, Menick DR, Kuppuswamy D, Cooper G. Phenotypic consequences of beta1-tubulin expression and MAP4 decoration of microtubules in adult cardiocytes. Am J Physiol Heart Circ Physiol. 2003 Nov; 285(5):H2072-83. PMID: 12855424.
      View in: PubMed
    38. Conway SJ, Kruzynska-Frejtag A, Wang J, Rogers R, Kneer PL, Chen H, Creazzo T, Menick DR, Koushik SV. Role of sodium-calcium exchanger (Ncx1) in embryonic heart development: a transgenic rescue? Ann N Y Acad Sci. 2002 Nov; 976:268-81. PMID: 12502569.
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    39. Xu L, Muller JG, Withers PR, Kappler C, Jiang W, Menick DR. Role of MAP kinases in the Na+/Ca2+ exchanger gene expression in feline adult cardiocytes. Ann N Y Acad Sci. 2002 Nov; 976:285-7. PMID: 12502571.
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    40. Menick DR, Xu L, Kappler C, Jiang W, Withers P, Shepherd N, Conway SJ, Müller JG. Pathways regulating Na+/Ca2+ exchanger expression in the heart. Ann N Y Acad Sci. 2002 Nov; 976:237-47. PMID: 12502566.
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    41. Müller JG, Thompson JT, Edmonson AM, Rackley MS, Kasahara H, Izumo S, McQuinn TC, Menick DR, O'Brien TX. Differential regulation of the cardiac sodium calcium exchanger promoter in adult and neonatal cardiomyocytes by Nkx2.5 and serum response factor. J Mol Cell Cardiol. 2002 Jul; 34(7):807-21. PMID: 12099720.
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    42. Müller JG, Isomatsu Y, Koushik SV, O'Quinn M, Xu L, Kappler CS, Hapke E, Zile MR, Conway SJ, Menick DR. Cardiac-specific expression and hypertrophic upregulation of the feline Na(+)-Ca(2+) exchanger gene H1-promoter in a transgenic mouse model. Circ Res. 2002 Feb 08; 90(2):158-64. PMID: 11834708.
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    43. Imasheva ES, Lu M, Balashov SP, Ebrey TG, Chen Y, Ablonczy Z, Menick DR, Crouch RK. Exploring the function of Tyr83 in bacteriorhodopsin: features of the Y83F and Y83N mutants. Biochemistry. 2001 Nov 06; 40(44):13320-30. PMID: 11683642.
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    44. Laser M, Willey CD, Jiang W, Cooper G, Menick DR, Zile MR, Kuppuswamy D. Integrin activation and focal complex formation in cardiac hypertrophy. J Biol Chem. 2000 Nov 10; 275(45):35624-30. PMID: 10958798.
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    45. Lu M, Balashov SP, Ebrey TG, Chen N, Chen Y, Menick DR, Crouch RK. Evidence for the rate of the final step in the bacteriorhodopsin photocycle being controlled by the proton release group: R134H mutant. Biochemistry. 2000 Mar 07; 39(9):2325-31. PMID: 10694399.
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    46. Imasheva ES, Balashov SP, Ebrey TG, Chen N, Crouch RK, Menick DR. Two groups control light-induced Schiff base deprotonation and the proton affinity of Asp85 in the Arg82 his mutant of bacteriorhodopsin. Biophys J. 1999 Nov; 77(5):2750-63. PMID: 10545374.
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    47. Gonzalez-Garay ML, Chang L, Blade K, Menick DR, Cabral F. A beta-tubulin leucine cluster involved in microtubule assembly and paclitaxel resistance. J Biol Chem. 1999 Aug 20; 274(34):23875-82. PMID: 10446152.
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    48. Blade K, Menick DR, Cabral F. Overexpression of class I, II or IVb beta-tubulin isotypes in CHO cells is insufficient to confer resistance to paclitaxel. J Cell Sci. 1999 Jul; 112 ( Pt 13):2213-21. PMID: 10362551.
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    49. Cheng G, Hagen TP, Dawson ML, Barnes KV, Menick DR. The role of GATA, CArG, E-box, and a novel element in the regulation of cardiac expression of the Na+-Ca2+ exchanger gene. J Biol Chem. 1999 Apr 30; 274(18):12819-26. PMID: 10212268.
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    50. Narishige T, Blade KL, Ishibashi Y, Nagai T, Hamawaki M, Menick DR, Kuppuswamy D, Cooper G. Cardiac hypertrophic and developmental regulation of the beta-tubulin multigene family. J Biol Chem. 1999 Apr 02; 274(14):9692-7. PMID: 10092657.
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    51. Balashov SP, Lu M, Imasheva ES, Govindjee R, Ebrey TG, Othersen B, Chen Y, Crouch RK, Menick DR. The proton release group of bacteriorhodopsin controls the rate of the final step of its photocycle at low pH. Biochemistry. 1999 Feb 16; 38(7):2026-39. PMID: 10026285.
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    52. Misra S, Martin C, Kwon OH, Ebrey TG, Chen N, Crouch RK, Menick DR. Mutation of arginine 134 to lysine alters the pK(a)s of key groups involved in proton pumping by bacteriorhodopsin. Photochem Photobiol. 1997 Dec; 66(6):774-83. PMID: 9421964.
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    53. Sato H, Nagai T, Kuppuswamy D, Narishige T, Koide M, Menick DR, Cooper G. Microtubule stabilization in pressure overload cardiac hypertrophy. J Cell Biol. 1997 Nov 17; 139(4):963-73. PMID: 9362514.
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    54. Balashov SP, Imasheva ES, Ebrey TG, Chen N, Menick DR, Crouch RK. Glutamate-194 to cysteine mutation inhibits fast light-induced proton release in bacteriorhodopsin. Biochemistry. 1997 Jul 22; 36(29):8671-6. PMID: 9289012.
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    55. Misra S, Ebrey TG, Crouch RK, Menick DR. Charge movements in the 13-cis photocycles of the bacteriorhodopsin mutants R82K and R82Q. Photochem Photobiol. 1997 Jun; 65(6):1039-44. PMID: 9188284.
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    56. Barnes KV, Cheng G, Dawson MM, Menick DR. Cloning of cardiac, kidney, and brain promoters of the feline ncx1 gene. J Biol Chem. 1997 Apr 25; 272(17):11510-7. PMID: 9111065.
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    57. Kuppuswamy D, Kerr C, Narishige T, Kasi VS, Menick DR, Cooper G. Association of tyrosine-phosphorylated c-Src with the cytoskeleton of hypertrophying myocardium. J Biol Chem. 1997 Feb 14; 272(7):4500-8. PMID: 9020175.
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    58. Govindjee R, Imasheva ES, Misra S, Balashov SP, Ebrey TG, Chen N, Menick DR, Crouch RK. Mutation of a surface residue, lysine-129, reverses the order of proton release and uptake in bacteriorhodopsin; guanidine hydrochloride restores it. Biophys J. 1997 Feb; 72(2 Pt 1):886-98. PMID: 9017214.
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    59. Menick DR, Barnes KV, Dawson MM, Kent RL, Cooper G. Gene expression of the Na-Ca exchanger in cardiac hypertrophy. J Card Fail. 1996 Dec; 2(4 Suppl):S69-76. PMID: 8951563.
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    60. Govindjee R, Misra S, Balashov SP, Ebrey TG, Crouch RK, Menick DR. Arginine-82 regulates the pKa of the group responsible for the light-driven proton release in bacteriorhodopsin. Biophys J. 1996 Aug; 71(2):1011-23. PMID: 8842238.
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    61. Barnes KV, Dawson MM, Menick DR. Initial characterization of the feline sodium-calcium exchanger gene. Ann N Y Acad Sci. 1996 Apr 15; 779:121-5. PMID: 8659819.
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    62. Menick DR, Barnes KV, Thacker UF, Dawson MM, McDermott DE, Rozich JD, Kent RL, Cooper G. The exchanger and cardiac hypertrophy. Ann N Y Acad Sci. 1996 Apr 15; 779:489-501. PMID: 8659865.
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    63. Peiffer WE, Desrosiers MG, Menick DR. Cloning and expression of the unique Ca2+-ATPase from Flavobacterium odoratum. J Biol Chem. 1996 Mar 01; 271(9):5095-100. PMID: 8617788.
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    64. Desrosiers MG, Gately LJ, Gambel AM, Menick DR. Purification and characterization of the Ca2+-ATPase of Flavobacterium odoratum. J Biol Chem. 1996 Feb 16; 271(7):3945-51. PMID: 8632017.
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    65. Balashov SP, Govindjee R, Imasheva ES, Misra S, Ebrey TG, Feng Y, Crouch RK, Menick DR. The two pKa's of aspartate-85 and control of thermal isomerization and proton release in the arginine-82 to lysine mutant of bacteriorhodopsin. Biochemistry. 1995 Jul 11; 34(27):8820-34. PMID: 7612623.
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    66. Didyk RB, Anton EE, Robinson KA, Menick DR, Buse MG. Effect of immobilization on glucose transporter expression in rat hindlimb muscles. Metabolism. 1994 Nov; 43(11):1389-94. PMID: 7968595.
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    67. Feng Y, Menick DR, Katz BM, Beischel CJ, Hazard ES, Misra S, Ebrey TG, Crouch RK. Probing of the retinal binding site of bacteriorhodopsin by affinity labeling. Biochemistry. 1994 Sep 27; 33(38):11624-30. PMID: 7918376.
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    68. Balashov SP, Govindjee R, Kono M, Imasheva E, Lukashev E, Ebrey TG, Crouch RK, Menick DR, Feng Y. Effect of the arginine-82 to alanine mutation in bacteriorhodopsin on dark adaptation, proton release, and the photochemical cycle. Biochemistry. 1993 Oct 05; 32(39):10331-43. PMID: 8399176.
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    69. Gambel AM, Menick DR. Phosphorylation and reaction intermediates of the prokaryotic Ca(2+)-ATPase. J Biol Chem. 1993 Sep 25; 268(27):20590-7. PMID: 8376412.
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    70. Kent RL, Rozich JD, McCollam PL, McDermott DE, Thacker UF, Menick DR, McDermott PJ, Cooper G. Rapid expression of the Na(+)-Ca2+ exchanger in response to cardiac pressure overload. Am J Physiol. 1993 Sep; 265(3 Pt 2):H1024-9. PMID: 8214109.
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    71. Menick DR, Desrosiers MG, Gambel AM. Transport, hydrolysis, and phosphoenzyme formation of a prokaryotic Ca(2+)-ATPase. Ann N Y Acad Sci. 1992 Nov 30; 671:427-9. PMID: 1288341.
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    72. Gambel AM, Desrosiers MG, Menick DR. Characterization of a P-type Ca(2+)-ATPase from Flavobacterium odoratum. J Biol Chem. 1992 Aug 05; 267(22):15923-31. PMID: 1386366.
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    73. Gambel AM, Gallien TN, Dantzler-Whitworth T, Bowes M, Menick DR. Sequence of the feline cardiac sarcoplasmic reticulum Ca(2+)-ATPase. Biochim Biophys Acta. 1992 Jun 15; 1131(2):203-6. PMID: 1535224.
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    74. Block NE, Menick DR, Robinson KA, Buse MG. Effect of denervation on the expression of two glucose transporter isoforms in rat hindlimb muscle. J Clin Invest. 1991 Nov; 88(5):1546-52. PMID: 1939643.
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    75. van Iwaarden PR, Driessen AJ, Menick DR, Kaback HR, Konings WN. Characterization of purified, reconstituted site-directed cysteine mutants of the lactose permease of Escherichia coli. J Biol Chem. 1991 Aug 25; 266(24):15688-92. PMID: 1874727.
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    76. Costello MJ, Escaig J, Matsushita K, Viitanen PV, Menick DR, Kaback HR. Purified lac permease and cytochrome o oxidase are functional as monomers. J Biol Chem. 1987 Dec 15; 262(35):17072-82. PMID: 2824513.
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    77. Menick DR, Carrasco N, Antes L, Patel L, Kaback HR. lac permease of Escherichia coli: arginine-302 as a component of the postulated proton relay. Biochemistry. 1987 Oct 20; 26(21):6638-44. PMID: 2827732.
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    78. Menick DR, Lee JA, Brooker RJ, Wilson TH, Kaback HR. Role of cysteine residues in the lac permease of Escherichia coli. Biochemistry. 1987 Feb 24; 26(4):1132-6. PMID: 3552042.
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    79. Sarkar HK, Menick DR, Viitanen PV, Poonian MS, Kaback HR. Site-specific mutagenesis of cysteine 148 to serine in the lac permease of Escherichia coli. J Biol Chem. 1986 Jul 05; 261(19):8914-8. PMID: 3087982.
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    80. Viitanen PV, Menick DR, Sarkar HK, Trumble WR, Kaback HR. Site-directed mutagenesis of cysteine-148 in the lac permease of Escherichia coli: effect on transport, binding, and sulfhydryl inactivation. Biochemistry. 1985 Dec 17; 24(26):7628-35. PMID: 3912006.
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    81. Menick DR, Sarkar HK, Poonian MS, Kaback HR. cys154 Is important for lac permease activity in Escherichia coli. Biochem Biophys Res Commun. 1985 Oct 15; 132(1):162-70. PMID: 2998353.
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    82. Viitanen PV, Sarkar HK, Menick D, Trumble WR, Padan E, McComas W, Poonian M, Kaback HR. Site-directed mutagenesis of the lacY gene of Escherichia coli. Ann N Y Acad Sci. 1985; 456:307-8. PMID: 3911840.
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