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Last Name
Institution

Denis C Guttridge

TitleDirector, Division of Darby Children?s Research Institute
InstitutionMedical University of South Carolina
DepartmentPediatrics
AddressP.O. Box MSC 514
DD 305
Drug Discovery Building - 70 President St.
Phone843-876-2166
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ramsey ML, Talbert E, Ahn D, Bekaii-Saab T, Badi N, Bloomston PM, Conwell DL, Cruz-Monserrate Z, Dillhoff M, Farren MR, Hinton A, Krishna SG, Lesinski GB, Mace T, Manilchuk A, Noonan A, Pawlik TM, Rajasekera PV, Schmidt C, Guttridge D, Hart PA. Circulating interleukin-6 is associated with disease progression, but not cachexia in pancreatic cancer. Pancreatology. 2019 Jan; 19(1):80-87. PMID: 30497874.
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    2. Pitarresi JR, Liu X, Avendano A, Thies KA, Sizemore GM, Hammer AM, Hildreth BE, Wang DJ, Steck SA, Donohue S, Cuitiño MC, Kladney RD, Mace TA, Chang JJ, Ennis CS, Li H, Reeves RH, Blackshaw S, Zhang J, Yu L, Fernandez SA, Frankel WL, Bloomston M, Rosol TJ, Lesinski GB, Konieczny SF, Guttridge DC, Rustgi AK, Leone G, Song JW, Wu J, Ostrowski MC. Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth. Life Sci Alliance. 2018 Oct; 1(5):e201800190. PMID: 30456390.
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    3. Hong HK, Maury E, Ramsey KM, Perelis M, Marcheva B, Omura C, Kobayashi Y, Guttridge DC, Barish GD, Bass J. Requirement for NF-?B in maintenance of molecular and behavioral circadian rhythms in mice. Genes Dev. 2018 11 01; 32(21-22):1367-1379. PMID: 30366905.
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    4. Calore F, Londhe P, Fadda P, Nigita G, Casadei L, Marceca GP, Fassan M, Lovat F, Gasparini P, Rizzotto L, Zanesi N, Jackson D, Mehta S, Nana-Sinkam P, Sampath D, Pollock RE, Guttridge DC, Croce CM. The TLR7/8/9 Antagonist IMO-8503 Inhibits Cancer-Induced Cachexia. Cancer Res. 2018 Dec 01; 78(23):6680-6690. PMID: 30209066.
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    5. Peterson JM, Wang DJ, Shettigar V, Roof SR, Canan BD, Bakkar N, Shintaku J, Gu JM, Little SC, Ratnam NM, Londhe P, Lu L, Gaw CE, Petrosino JM, Liyanarachchi S, Wang H, Janssen PML, Davis JP, Ziolo MT, Sharma SM, Guttridge DC. NF-?B inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model. Nat Commun. 2018 08 24; 9(1):3431. PMID: 30143619.
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    6. Yu PY, Lopez G, Braggio D, Koller D, Bill KLJ, Prudner BC, Zewdu A, Chen JL, Iwenofu OH, Lev D, Strohecker AM, Fenger JM, Pollock RE, Guttridge DC. miR-133a function in the pathogenesis of dedifferentiated liposarcoma. Cancer Cell Int. 2018; 18:89. PMID: 29983640.
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    7. Damrauer JS, Stadler ME, Acharyya S, Baldwin AS, Couch ME, Guttridge DC. Chemotherapy-induced muscle wasting: association with NF-?B and cancer cachexia. Eur J Transl Myol. 2018 Apr 24; 28(2):7590. PMID: 29991992.
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    8. Londhe P, Yu PY, Ijiri Y, Ladner KJ, Fenger JM, London C, Houghton PJ, Guttridge DC. Classical NF-?B Metabolically Reprograms Sarcoma Cells Through Regulation of Hexokinase 2. Front Oncol. 2018; 8:104. PMID: 29696133.
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    9. Chen S, Bonifati S, Qin Z, St Gelais C, Kodigepalli KM, Barrett BS, Kim SH, Antonucci JM, Ladner KJ, Buzovetsky O, Knecht KM, Xiong Y, Yount JS, Guttridge DC, Santiago ML, Wu L. SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-?B and interferon pathways. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3798-E3807. PMID: 29610295.
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    10. Baracos VE, Martin L, Korc M, Guttridge DC, Fearon KCH. Cancer-associated cachexia. Nat Rev Dis Primers. 2018 01 18; 4:17105. PMID: 29345251.
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    11. Talbert EE, Lewis HL, Farren MR, Ramsey ML, Chakedis JM, Rajasekera P, Haverick E, Sarna A, Bloomston M, Pawlik TM, Zimmers TA, Lesinski GB, Hart PA, Dillhoff ME, Schmidt CR, Guttridge DC. Circulating monocyte chemoattractant protein-1 (MCP-1) is associated with cachexia in treatment-naïve pancreatic cancer patients. J Cachexia Sarcopenia Muscle. 2018 04; 9(2):358-368. PMID: 29316343.
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    12. Lewis HL, Chakedis JM, Talbert E, Haverick E, Rajasekera P, Hart P, Bloomston M, Dillhoff M, Pawlik TM, Guttridge D, Schmidt CR. Perioperative cytokine levels portend early death after pancreatectomy for ductal adenocarcinoma. J Surg Oncol. 2018 May; 117(6):1260-1266. PMID: 29205349.
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    13. Yu PY, Guttridge DC. Dysregulated Myogenesis in Rhabdomyosarcoma. Curr Top Dev Biol. 2018; 126:285-297. PMID: 29305002.
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    14. Bandyopadhyay A, Favours E, Phelps DA, Pozo VD, Ghilu S, Kurmashev D, Michalek J, Trevino A, Guttridge D, London C, Hirotani K, Zhang L, Kurmasheva RT, Houghton PJ. Evaluation of patritumab with or without erlotinib in combination with standard cytotoxic agents against pediatric sarcoma xenograft models. Pediatr Blood Cancer. 2018 Feb; 65(2). PMID: 29080385.
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    15. Nemer L, Krishna SG, Shah ZK, Conwell DL, Cruz-Monserrate Z, Dillhoff M, Guttridge DC, Hinton A, Manilchuk A, Pawlik TM, Schmidt CR, Talbert EE, Bekaii-Saab T, Hart PA. Predictors of Pancreatic Cancer-Associated Weight Loss and Nutritional Interventions. Pancreas. 2017 10; 46(9):1152-1157. PMID: 28902785.
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    16. Ratnam NM, Peterson JM, Talbert EE, Ladner KJ, Rajasekera PV, Schmidt CR, Dillhoff ME, Swanson BJ, Haverick E, Kladney RD, Williams TM, Leone GW, Wang DJ, Guttridge DC. NF-?B regulates GDF-15 to suppress macrophage surveillance during early tumor development. J Clin Invest. 2017 Oct 02; 127(10):3796-3809. PMID: 28891811.
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    17. Cleary MM, Mansoor A, Settelmeyer T, Ijiri Y, Ladner KJ, Svalina MN, Rubin BP, Guttridge DC, Keller C. NF?B signaling in alveolar rhabdomyosarcoma. Dis Model Mech. 2017 09 01; 10(9):1109-1115. PMID: 28883017.
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    18. Yu PY, Gardner HL, Roberts R, Cam H, Hariharan S, Ren L, LeBlanc AK, Xiao H, Lin J, Guttridge DC, Mo X, Bennett CE, Coss CC, Ling Y, Phelps MA, Houghton P, London CA. Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma. PLoS One. 2017; 12(7):e0181885. PMID: 28750090.
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    19. Frakes AE, Braun L, Ferraiuolo L, Guttridge DC, Kaspar BK. Additive amelioration of ALS by co-targeting independent pathogenic mechanisms. Ann Clin Transl Neurol. 2017 02; 4(2):76-86. PMID: 28168207.
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    20. Qian Z, Rhodes CA, McCroskey LC, Wen J, Appiah-Kubi G, Wang DJ, Guttridge DC, Pei D. Enhancing the Cell Permeability and Metabolic Stability of Peptidyl Drugs by Reversible Bicyclization. Angew Chem Int Ed Engl. 2017 02 01; 56(6):1525-1529. PMID: 28035784.
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    21. Skipworth RJ, Stephens NA, Johns N, Guttridge DC, Tisdale MJ, Baracos VE, Glass DJ. Ken Fearon. Cell Metab. 2016 12 13; 24(6):765-766. PMID: 28034417.
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    22. Talbert EE, Yang J, Mace TA, Farren MR, Farris AB, Young GS, Elnaggar O, Che Z, Timmers CD, Rajasekera P, Maskarinec JM, Bloomston M, Bekaii-Saab T, Guttridge DC, Lesinski GB. Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities. Mol Cancer Ther. 2017 02; 16(2):344-356. PMID: 27811010.
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    23. Shintaku J, Peterson JM, Talbert EE, Gu JM, Ladner KJ, Williams DR, Mousavi K, Wang R, Sartorelli V, Guttridge DC. MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-?B. Cell Rep. 2016 10 04; 17(2):514-526. PMID: 27705798.
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    24. Cam M, Gardner HL, Roberts RD, Fenger JM, Guttridge DC, London CA, Cam H. ?Np63 mediates cellular survival and metastasis in canine osteosarcoma. Oncotarget. 2016 Jul 26; 7(30):48533-48546. PMID: 27391430.
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    25. Maharry SE, Walker CJ, Liyanarachchi S, Mehta S, Patel M, Bainazar MA, Huang X, Lankenau MA, Hoag KW, Ranganathan P, Garzon R, Blachly JS, Guttridge DC, Bloomfield CD, de la Chapelle A, Eisfeld AK. Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia. Cancer Discov. 2016 09; 6(9):1036-51. PMID: 27354268.
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    26. Corpeno Kalamgi R, Salah H, Gastaldello S, Martinez-Redondo V, Ruas JL, Fury W, Bai Y, Gromada J, Sartori R, Guttridge DC, Sandri M, Larsson L. Mechano-signalling pathways in an experimental intensive critical illness myopathy model. J Physiol. 2016 08 01; 594(15):4371-88. PMID: 26990577.
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    27. Cardenas H, Arango D, Nicholas C, Duarte S, Nuovo GJ, He W, Voss OH, Gonzalez-Mejia ME, Guttridge DC, Grotewold E, Doseff AI. Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-?B Activity, Halting Leukocyte Infiltration and Restoring Normal Metabolic Function. Int J Mol Sci. 2016 Mar 01; 17(3):323. PMID: 26938530.
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    28. Bid HK, Phelps DA, Xaio L, Guttridge DC, Lin J, London C, Baker LH, Mo X, Houghton PJ. The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma. Mol Cancer Ther. 2016 05; 15(5):1018-28. PMID: 26908627.
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    29. Yu PY, Balkhi MY, Ladner KJ, Alder H, Yu L, Mo X, Kraybill WG, Guttridge DC, Iwenofu OH. A selective screening platform reveals unique global expression patterns of microRNAs in a cohort of human soft-tissue sarcomas. Lab Invest. 2016 Apr; 96(4):481-91. PMID: 26878133.
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    30. Kim SH, Ezhilarasan R, Phillips E, Gallego-Perez D, Sparks A, Taylor D, Ladner K, Furuta T, Sabit H, Chhipa R, Cho JH, Mohyeldin A, Beck S, Kurozumi K, Kuroiwa T, Iwata R, Asai A, Kim J, Sulman EP, Cheng SY, Lee LJ, Nakada M, Guttridge D, DasGupta B, Goidts V, Bhat KP, Nakano I. Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-?B-dependent Manner. Cancer Cell. 2016 Feb 08; 29(2):201-13. PMID: 26859459.
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    31. Gu JM, Wang DJ, Peterson JM, Shintaku J, Liyanarachchi S, Coppola V, Frakes AE, Kaspar BK, Cornelison DD, Guttridge DC. An NF-?B--EphrinA5-Dependent Communication between NG2(+) Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates. Dev Cell. 2016 Jan 25; 36(2):215-24. PMID: 26777211.
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    32. Shintaku J, Guttridge DC. Analysis of Aerobic Respiration in Intact Skeletal Muscle Tissue by Microplate-Based Respirometry. Methods Mol Biol. 2016; 1460:337-43. PMID: 27492183.
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    33. Londhe P, Guttridge DC. Inflammation induced loss of skeletal muscle. Bone. 2015 Nov; 80:131-142. PMID: 26453502.
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    34. Guttridge DC. A TGF-ß pathway associated with cancer cachexia. Nat Med. 2015 Nov; 21(11):1248-9. PMID: 26540384.
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    35. Tseng YC, Kulp SK, Lai IL, Hsu EC, He WA, Frankhouser DE, Yan PS, Mo X, Bloomston M, Lesinski GB, Marcucci G, Guttridge DC, Bekaii-Saab T, Chen CS. Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia. J Natl Cancer Inst. 2015 Dec; 107(12):djv274. PMID: 26464423.
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    36. Talbert EE, Guttridge DC. Impaired regeneration: A role for the muscle microenvironment in cancer cachexia. Semin Cell Dev Biol. 2016 06; 54:82-91. PMID: 26385617.
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    37. Chadwick JA, Hauck JS, Lowe J, Shaw JJ, Guttridge DC, Gomez-Sanchez CE, Gomez-Sanchez EP, Rafael-Fortney JA. Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target. FASEB J. 2015 Nov; 29(11):4544-54. PMID: 26178166.
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    38. Couch ME, Dittus K, Toth MJ, Willis MS, Guttridge DC, George JR, Chang EY, Gourin CG, Der-Torossian H. Cancer cachexia update in head and neck cancer: Pathophysiology and treatment. Head Neck. 2015 Jul; 37(7):1057-72. PMID: 24634283.
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    39. Stephens NA, Skipworth RJ, Gallagher IJ, Greig CA, Guttridge DC, Ross JA, Fearon KC. Evaluating potential biomarkers of cachexia and survival in skeletal muscle of upper gastrointestinal cancer patients. J Cachexia Sarcopenia Muscle. 2015 Mar; 6(1):53-61. PMID: 26136412.
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    40. Hettmer S, Li Z, Billin AN, Barr FG, Cornelison DD, Ehrlich AR, Guttridge DC, Hayes-Jordan A, Helman LJ, Houghton PJ, Khan J, Langenau DM, Linardic CM, Pal R, Partridge TA, Pavlath GK, Rota R, Schäfer BW, Shipley J, Stillman B, Wexler LH, Wagers AJ, Keller C. Rhabdomyosarcoma: current challenges and their implications for developing therapies. Cold Spring Harb Perspect Med. 2014 Nov 03; 4(11):a025650. PMID: 25368019.
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    41. Kornegay JN, Peterson JM, Bogan DJ, Kline W, Bogan JR, Dow JL, Fan Z, Wang J, Ahn M, Zhu H, Styner M, Guttridge DC. NBD delivery improves the disease phenotype of the golden retriever model of Duchenne muscular dystrophy. Skelet Muscle. 2014; 4:18. PMID: 25789154.
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    42. Wang DJ, Ratnam NM, Byrd JC, Guttridge DC. NF-?B functions in tumor initiation by suppressing the surveillance of both innate and adaptive immune cells. Cell Rep. 2014 Oct 09; 9(1):90-103. PMID: 25263557.
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    43. Guttridge D, Couch M, Di Marco S, Gallouzi IE, Zitzmann ND, Baracos V, Rudnicki M, Tremblay M, Zimmers T. An invitation to the 2nd Cancer Cachexia Conference, Montréal, Canada. J Cachexia Sarcopenia Muscle. 2014 Sep; 5(3):181. PMID: 24965540.
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    44. Onesti JK, Guttridge DC. Inflammation based regulation of cancer cachexia. Biomed Res Int. 2014; 2014:168407. PMID: 24877061.
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    45. Talbert EE, Metzger GA, He WA, Guttridge DC. Modeling human cancer cachexia in colon 26 tumor-bearing adult mice. J Cachexia Sarcopenia Muscle. 2014 Dec; 5(4):321-8. PMID: 24668658.
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    46. Couch ME, Dittus K, Toth MJ, Willis MS, Guttridge DC, George JR, Barnes CA, Gourin CG, Der-Torossian H. Cancer cachexia update in head and neck cancer: Definitions and diagnostic features. Head Neck. 2015 Apr; 37(4):594-604. PMID: 24415363.
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    47. Garvey SM, Dugle JE, Kennedy AD, McDunn JE, Kline W, Guo L, Guttridge DC, Pereira SL, Edens NK. Metabolomic profiling reveals severe skeletal muscle group-specific perturbations of metabolism in aged FBN rats. Biogerontology. 2014 Jun; 15(3):217-32. PMID: 24652515.
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    48. He WA, Calore F, Londhe P, Canella A, Guttridge DC, Croce CM. Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7. Proc Natl Acad Sci U S A. 2014 Mar 25; 111(12):4525-9. PMID: 24616506.
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    49. Frakes AE, Ferraiuolo L, Haidet-Phillips AM, Schmelzer L, Braun L, Miranda CJ, Ladner KJ, Bevan AK, Foust KD, Godbout JP, Popovich PG, Guttridge DC, Kaspar BK. Microglia induce motor neuron death via the classical NF-?B pathway in amyotrophic lateral sclerosis. Neuron. 2014 Mar 05; 81(5):1009-1023. PMID: 24607225.
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    50. Hemminger JA, Toland AE, Scharschmidt TJ, Mayerson JL, Guttridge DC, Iwenofu OH. Expression of cancer-testis antigens MAGEA1, MAGEA3, ACRBP, PRAME, SSX2, and CTAG2 in myxoid and round cell liposarcoma. Mod Pathol. 2014 Sep; 27(9):1238-45. PMID: 24457462.
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    51. He WA, Berardi E, Cardillo VM, Acharyya S, Aulino P, Thomas-Ahner J, Wang J, Bloomston M, Muscarella P, Nau P, Shah N, Butchbach ME, Ladner K, Adamo S, Rudnicki MA, Keller C, Coletti D, Montanaro F, Guttridge DC. NF-?B-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia. J Clin Invest. 2013 Nov; 123(11):4821-35. PMID: 24084740.
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    52. Keller C, Guttridge DC. Mechanisms of impaired differentiation in rhabdomyosarcoma. FEBS J. 2013 Sep; 280(17):4323-34. PMID: 23822136.
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    53. Balkhi MY, Balkhi MY, Iwenofu OH, Bakkar N, Ladner KJ, Chandler DS, Houghton PJ, London CA, Kraybill W, Perrotti D, Croce CM, Keller C, Guttridge DC. miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR. Sci Signal. 2013 Jul 30; 6(286):ra63. PMID: 23901138.
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    54. Parker MH, von Maltzahn J, Bakkar N, Al-Joubori B, Ishibashi J, Guttridge D, Rudnicki MA. Retraction: MyoD-dependent regulation of NF-?B activity couples cell-cycle withdrawal to myogenic differentiation. Skelet Muscle. 2013 Jul 18; 3(1):15. PMID: 23870549.
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    55. Wu C, Fernandez SA, Criswell T, Chidiac TA, Guttridge D, Villalona-Calero M, Bekaii-Saab TS. Disrupting cytokine signaling in pancreatic cancer: a phase I/II study of etanercept in combination with gemcitabine in patients with advanced disease. Pancreas. 2013 Jul; 42(5):813-8. PMID: 23429495.
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    56. Shintaku J, Guttridge DC. Reining in nuclear factor-kappaB in skeletal muscle disorders. Curr Opin Clin Nutr Metab Care. 2013 May; 16(3):251-7. PMID: 23493016.
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    57. Remels AH, Gosker HR, Bakker J, Guttridge DC, Schols AM, Langen RC. Regulation of skeletal muscle oxidative phenotype by classical NF-?B signalling. Biochim Biophys Acta. 2013 Aug; 1832(8):1313-25. PMID: 23563317.
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    58. Banerjee A, Guttridge DC. Mechanisms for maintaining muscle. Curr Opin Support Palliat Care. 2012 Dec; 6(4):451-6. PMID: 23108340.
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    59. Hemminger JA, Ewart Toland A, Scharschmidt TJ, Mayerson JL, Kraybill WG, Guttridge DC, Iwenofu OH. The cancer-testis antigen NY-ESO-1 is highly expressed in myxoid and round cell subset of liposarcomas. Mod Pathol. 2013 Feb; 26(2):282-8. PMID: 22936067.
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    60. Rutkowski A, Bönnemann C, Brown S, Thorsteinsdóttir S, Dominov J, Ruegg MA, Matter ML, Guttridge D, Crosbie-Watson RH, Kardon G, Nagaraju K, Girgenrath M, Burkin DJ. Report on the Myomatrix Conference April 22-24, 2012, University of Nevada, Reno, Nevada, USA. Neuromuscul Disord. 2013 Feb; 23(2):188-91. PMID: 22800409.
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    61. Fearon KC, Glass DJ, Guttridge DC. Cancer cachexia: mediators, signaling, and metabolic pathways. Cell Metab. 2012 Aug 08; 16(2):153-66. PMID: 22795476.
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    62. Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N, Huard J, Clemens PR, Stolz DB, Guttridge DC, Watkins SC, Garinis GA, Wang Y, Niedernhofer LJ, Robbins PD. NF-?B inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest. 2012 Jul; 122(7):2601-12. PMID: 22706308.
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    63. Parker MH, von Maltzahn J, Bakkar N, Al-Joubori B, Ishibashi J, Guttridge D, Rudnicki MA. MyoD-dependent regulation of NF-?B activity couples cell-cycle withdrawal to myogenic differentiation. Skelet Muscle. 2012 05 19; 2(1):6. PMID: 22541644.
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    64. Balkhi MY, Willette-Brown J, Zhu F, Chen Z, Liu S, Guttridge DC, Karin M, Hu Y. IKKa-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis. Blood. 2012 Jun 07; 119(23):5467-77. PMID: 22544702.
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    65. Wang L, Zhou L, Jiang P, Lu L, Chen X, Lan H, Guttridge DC, Sun H, Wang H. Loss of miR-29 in myoblasts contributes to dystrophic muscle pathogenesis. Mol Ther. 2012 Jun; 20(6):1222-33. PMID: 22434133.
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    66. Bakkar N, Ladner K, Canan BD, Liyanarachchi S, Bal NC, Pant M, Periasamy M, Li Q, Janssen PM, Guttridge DC. IKKa and alternative NF-?B regulate PGC-1ß to promote oxidative muscle metabolism. J Cell Biol. 2012 Feb 20; 196(4):497-511. PMID: 22351927.
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    67. Dahlman JM, Guttridge DC. Detection of NF-?B activity in skeletal muscle cells by electrophoretic mobility shift analysis. Methods Mol Biol. 2012; 798:505-16. PMID: 22130857.
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    68. Wang Y, Mo X, Piper MG, Wang H, Parinandi NL, Guttridge D, Marsh CB. M-CSF induces monocyte survival by activating NF-?B p65 phosphorylation at Ser276 via protein kinase C. PLoS One. 2011; 6(12):e28081. PMID: 22216091.
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    69. Lu A, Proto JD, Guo L, Tang Y, Lavasani M, Tilstra JS, Niedernhofer LJ, Wang B, Guttridge DC, Robbins PD, Huard J. NF-?B negatively impacts the myogenic potential of muscle-derived stem cells. Mol Ther. 2012 Mar; 20(3):661-8. PMID: 22158056.
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    70. Guttridge DC. Making muscles grow by g protein-coupled receptor signaling. Sci Signal. 2011 Nov 29; 4(201):pe45. PMID: 22126962.
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    71. Bonetto A, Aydogdu T, Kunzevitzky N, Guttridge DC, Khuri S, Koniaris LG, Zimmers TA. STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia. PLoS One. 2011; 6(7):e22538. PMID: 21799891.
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    72. Mundy-Bosse BL, Lesinski GB, Jaime-Ramirez AC, Benninger K, Khan M, Kuppusamy P, Guenterberg K, Kondadasula SV, Chaudhury AR, La Perle KM, Kreiner M, Young G, Guttridge DC, Carson WE. Myeloid-derived suppressor cell inhibition of the IFN response in tumor-bearing mice. Cancer Res. 2011 Aug 01; 71(15):5101-10. PMID: 21680779.
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    73. Shadfar S, Couch ME, McKinney KA, Weinstein LJ, Yin X, Rodríguez JE, Guttridge DC, Willis M. Oral resveratrol therapy inhibits cancer-induced skeletal muscle and cardiac atrophy in vivo. Nutr Cancer. 2011; 63(5):749-62. PMID: 21660860.
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    74. Reay DP, Yang M, Watchko JF, Daood M, O'Day TL, Rehman KK, Guttridge DC, Robbins PD, Clemens PR. Systemic delivery of NEMO binding domain/IKK? inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology. Neurobiol Dis. 2011 Sep; 43(3):598-608. PMID: 21624467.
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    75. Delfín DA, Xu Y, Peterson JM, Guttridge DC, Rafael-Fortney JA, Janssen PM. Improvement of cardiac contractile function by peptide-based inhibition of NF-?B in the utrophin/dystrophin-deficient murine model of muscular dystrophy. J Transl Med. 2011 May 17; 9:68. PMID: 21586145.
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    76. Hosoyama T, Aslam MI, Abraham J, Prajapati SI, Nishijo K, Michalek JE, Zarzabal LA, Nelon LD, Guttridge DC, Rubin BP, Keller C. IL-4R drives dedifferentiation, mitogenesis, and metastasis in rhabdomyosarcoma. Clin Cancer Res. 2011 May 01; 17(9):2757-66. PMID: 21536546.
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    77. Peterson JM, Kline W, Canan BD, Ricca DJ, Kaspar B, Delfín DA, DiRienzo K, Clemens PR, Robbins PD, Baldwin AS, Flood P, Kaumaya P, Freitas M, Kornegay JN, Mendell JR, Rafael-Fortney JA, Guttridge DC, Janssen PM. Peptide-based inhibition of NF-?B rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy. Mol Med. 2011 May-Jun; 17(5-6):508-15. PMID: 21267511.
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    78. Peterson JM, Bakkar N, Guttridge DC. NF-?B signaling in skeletal muscle health and disease. Curr Top Dev Biol. 2011; 96:85-119. PMID: 21621068.
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    79. Wallace LM, Garwick SE, Mei W, Belayew A, Coppee F, Ladner KJ, Guttridge D, Yang J, Harper SQ. DUX4, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53-dependent myopathy in vivo. Ann Neurol. 2011 Mar; 69(3):540-52. PMID: 21446026.
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    80. Acharyya S, Sharma SM, Cheng AS, Ladner KJ, He W, Kline W, Wang H, Ostrowski MC, Huang TH, Guttridge DC. TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy. PLoS One. 2010 Aug 30; 5(8):e12479. PMID: 20814569.
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    81. Tang Y, Reay DP, Salay MN, Mi MY, Clemens PR, Guttridge DC, Robbins PD, Huard J, Wang B. Inhibition of the IKK/NF-?B pathway by AAV gene transfer improves muscle regeneration in older mdx mice. Gene Ther. 2010 Dec; 17(12):1476-83. PMID: 20720575.
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    82. Bakkar N, Guttridge DC. NF-kappaB signaling: a tale of two pathways in skeletal myogenesis. Physiol Rev. 2010 Apr; 90(2):495-511. PMID: 20393192.
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    83. Skipworth RJ, Stewart GD, Bhana M, Christie J, Sturgeon CM, Guttridge DC, Cronshaw AD, Fearon KC, Ross JA. Mass spectrometric detection of candidate protein biomarkers of cancer cachexia in human urine. Int J Oncol. 2010 Apr; 36(4):973-82. PMID: 20198343.
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    84. Bao S, Liu MJ, Lee B, Besecker B, Lai JP, Guttridge DC, Knoell DL. Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaB. Am J Physiol Lung Cell Mol Physiol. 2010 Jun; 298(6):L744-54. PMID: 20207754.
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    85. Stephens NA, Gallagher IJ, Rooyackers O, Skipworth RJ, Tan BH, Marstrand T, Ross JA, Guttridge DC, Lundell L, Fearon KC, Timmons JA. Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia. Genome Med. 2010 Jan 15; 2(1):1. PMID: 20193046.
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    86. Dahlman JM, Bakkar N, He W, Guttridge DC. NF-kappaB functions in stromal fibroblasts to regulate early postnatal muscle development. J Biol Chem. 2010 Feb 19; 285(8):5479-87. PMID: 20018862.
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    87. Wang J, Jacob NK, Ladner KJ, Beg A, Perko JD, Tanner SM, Liyanarachchi S, Fishel R, Guttridge DC. RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair. EMBO Rep. 2009 Nov; 10(11):1272-8. PMID: 19779484.
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    88. Raices RM, Kannan Y, Bellamkonda-Athmaram V, Seshadri S, Wang H, Guttridge DC, Wewers MD. A novel role for IkappaBzeta in the regulation of IFNgamma production. PLoS One. 2009 Aug 26; 4(8):e6776. PMID: 19707556.
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    89. Taniguchi E, Cho MJ, Arenkiel BR, Hansen MS, Rivera OJ, McCleish AT, Qualman SJ, Guttridge DC, Scott MP, Capecchi MR, Keller C. Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. Pediatr Blood Cancer. 2009 Aug; 53(2):136-44. PMID: 19213072.
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    90. Chen SS, Raval A, Johnson AJ, Hertlein E, Liu TH, Jin VX, Sherman MH, Liu SJ, Dawson DW, Williams KE, Lanasa M, Liyanarachchi S, Lin TS, Marcucci G, Pekarsky Y, Davuluri R, Croce CM, Guttridge DC, Teitell MA, Byrd JC, Plass C. Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13433-8. PMID: 19666576.
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    91. Wang H, Sun H, Guttridge DC. microRNAs: novel components in a muscle gene regulatory network. Cell Cycle. 2009 Jun 15; 8(12):1833-7. PMID: 19448406.
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    92. Dahlman JM, Wang J, Bakkar N, Guttridge DC. The RelA/p65 subunit of NF-kappaB specifically regulates cyclin D1 protein stability: implications for cell cycle withdrawal and skeletal myogenesis. J Cell Biochem. 2009 Jan 01; 106(1):42-51. PMID: 19016262.
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    93. Wang H, Garzon R, Sun H, Ladner KJ, Singh R, Dahlman J, Cheng A, Hall BM, Qualman SJ, Chandler DS, Croce CM, Guttridge DC. NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell. 2008 Nov 04; 14(5):369-81. PMID: 18977326.
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    94. Lesinski GB, Raig ET, Guenterberg K, Brown L, Go MR, Shah NN, Lewis A, Quimper M, Hade E, Young G, Chaudhury AR, Ladner KJ, Guttridge DC, Bouchard P, Carson WE. IFN-alpha and bortezomib overcome Bcl-2 and Mcl-1 overexpression in melanoma cells by stimulating the extrinsic pathway of apoptosis. Cancer Res. 2008 Oct 15; 68(20):8351-60. PMID: 18922907.
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    95. Evans WJ, Morley JE, Argilés J, Bales C, Baracos V, Guttridge D, Jatoi A, Kalantar-Zadeh K, Lochs H, Mantovani G, Marks D, Mitch WE, Muscaritoli M, Najand A, Ponikowski P, Rossi Fanelli F, Schambelan M, Schols A, Schuster M, Thomas D, Wolfe R, Anker SD. Cachexia: a new definition. Clin Nutr. 2008 Dec; 27(6):793-9. PMID: 18718696.
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    96. Cannon T, Shores C, Yin X, Dahlman J, Guttridge D, Lai V, George J, Buzkova P, Couch M. Immunocompetent murine model of cancer cachexia for head and neck squamous cell carcinoma. Head Neck. 2008 Mar; 30(3):320-6. PMID: 17657796.
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    97. Fong LY, Jiang Y, Riley M, Liu X, Smalley KJ, Guttridge DC, Farber JL. Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2. Int J Cancer. 2008 Mar 01; 122(5):978-89. PMID: 17985342.
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    98. Bakkar N, Wang J, Ladner KJ, Wang H, Dahlman JM, Carathers M, Acharyya S, Rudnicki MA, Hollenbach AD, Guttridge DC. IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis. J Cell Biol. 2008 Feb 25; 180(4):787-802. PMID: 18299349.
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    99. Peterson JM, Guttridge DC. Skeletal muscle diseases, inflammation, and NF-kappaB signaling: insights and opportunities for therapeutic intervention. Int Rev Immunol. 2008; 27(5):375-87. PMID: 18853344.
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    100. Cannon TY, Guttridge D, Dahlman J, George JR, Lai V, Shores C, Buzková P, Couch ME. The effect of altered Toll-like receptor 4 signaling on cancer cachexia. Arch Otolaryngol Head Neck Surg. 2007 Dec; 133(12):1263-9. PMID: 18086970.
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    101. Cannon T, Couch M, Yin X, Guttridge D, Lai V, Shores C. Comparison of animal models for head and neck cancer cachexia. Laryngoscope. 2007 Dec; 117(12):2152-8. PMID: 17921906.
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    102. Nicholas C, Batra S, Vargo MA, Voss OH, Gavrilin MA, Wewers MD, Guttridge DC, Grotewold E, Doseff AI. Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation. J Immunol. 2007 Nov 15; 179(10):7121-7. PMID: 17982104.
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    103. Madhavan S, Anghelina M, Sjostrom D, Dossumbekova A, Guttridge DC, Agarwal S. Biomechanical signals suppress TAK1 activation to inhibit NF-kappaB transcriptional activation in fibrochondrocytes. J Immunol. 2007 Nov 01; 179(9):6246-54. PMID: 17947700.
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    104. Waldman WJ, Williams MV, Lemeshow S, Binkley P, Guttridge D, Kiecolt-Glaser JK, Knight DA, Ladner KJ, Glaser R. Epstein-Barr virus-encoded dUTPase enhances proinflammatory cytokine production by macrophages in contact with endothelial cells: evidence for depression-induced atherosclerotic risk. Brain Behav Immun. 2008 Feb; 22(2):215-23. PMID: 17845840.
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    105. Nadella MV, Dirksen WP, Nadella KS, Shu S, Cheng AS, Morgenstern JA, Richard V, Fernandez SA, Huang TH, Guttridge D, Rosol TJ. Transcriptional regulation of parathyroid hormone-related protein promoter P2 by NF-kappaB in adult T-cell leukemia/lymphoma. Leukemia. 2007 Aug; 21(8):1752-62. PMID: 17554373.
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    106. George J, Cannon T, Lai V, Richey L, Zanation A, Hayes DN, Shores C, Guttridge D, Couch M. Cancer cachexia syndrome in head and neck cancer patients: Part II. Pathophysiology. Head Neck. 2007 May; 29(5):497-507. PMID: 17390378.
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    107. Wang H, Hertlein E, Bakkar N, Sun H, Acharyya S, Wang J, Carathers M, Davuluri R, Guttridge DC. NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes. Mol Cell Biol. 2007 Jun; 27(12):4374-87. PMID: 17438126.
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    108. Couch M, Lai V, Cannon T, Guttridge D, Zanation A, George J, Hayes DN, Zeisel S, Shores C. Cancer cachexia syndrome in head and neck cancer patients: part I. Diagnosis, impact on quality of life and survival, and treatment. Head Neck. 2007 Apr; 29(4):401-11. PMID: 17285641.
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    109. Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PM, Carathers M, Li ZW, Beg AA, Ghosh S, Sahenk Z, Weinstein M, Gardner KL, Rafael-Fortney JA, Karin M, Tidball JG, Baldwin AS, Guttridge DC. Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest. 2007 Apr; 117(4):889-901. PMID: 17380205.
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    110. Acharyya S, Guttridge DC. Cancer cachexia signaling pathways continue to emerge yet much still points to the proteasome. Clin Cancer Res. 2007 Mar 01; 13(5):1356-61. PMID: 17332276.
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    111. Skipworth RJ, Stewart GD, Ross JA, Guttridge DC, Fearon KC. The molecular mechanisms of skeletal muscle wasting: implications for therapy. Surgeon. 2006 Oct; 4(5):273-83. PMID: 17009546.
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    112. Monk JP, Phillips G, Waite R, Kuhn J, Schaaf LJ, Otterson GA, Guttridge D, Rhoades C, Shah M, Criswell T, Caligiuri MA, Villalona-Calero MA. Assessment of tumor necrosis factor alpha blockade as an intervention to improve tolerability of dose-intensive chemotherapy in cancer patients. J Clin Oncol. 2006 Apr 20; 24(12):1852-9. PMID: 16622259.
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    113. Sarkar A, Duncan M, Hart J, Hertlein E, Guttridge DC, Wewers MD. ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. J Immunol. 2006 Apr 15; 176(8):4979-86. PMID: 16585594.
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    114. Acharyya S, Butchbach ME, Sahenk Z, Wang H, Saji M, Carathers M, Ringel MD, Skipworth RJ, Fearon KC, Hollingsworth MA, Muscarella P, Burghes AH, Rafael-Fortney JA, Guttridge DC. Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia. Cancer Cell. 2005 Nov; 8(5):421-32. PMID: 16286249.
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    115. Hertlein E, Wang J, Ladner KJ, Bakkar N, Guttridge DC. RelA/p65 regulation of IkappaBbeta. Mol Cell Biol. 2005 Jun; 25(12):4956-68. PMID: 15923614.
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    116. Acharyya S, Ladner KJ, Nelsen LL, Damrauer J, Reiser PJ, Swoap S, Guttridge DC. Cancer cachexia is regulated by selective targeting of skeletal muscle gene products. J Clin Invest. 2004 Aug; 114(3):370-8. PMID: 15286803.
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    117. Guttridge DC. Signaling pathways weigh in on decisions to make or break skeletal muscle. Curr Opin Clin Nutr Metab Care. 2004 Jul; 7(4):443-50. PMID: 15192448.
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    118. Hartman MG, Lu D, Kim ML, Kociba GJ, Shukri T, Buteau J, Wang X, Frankel WL, Guttridge D, Prentki M, Grey ST, Ron D, Hai T. Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol Cell Biol. 2004 Jul; 24(13):5721-32. PMID: 15199129.
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    119. Cogswell PC, Kashatus DF, Keifer JA, Guttridge DC, Reuther JY, Bristow C, Roy S, Nicholson DW, Baldwin AS. NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B. J Biol Chem. 2003 Jan 31; 278(5):2963-8. PMID: 12433922.
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    120. Ladner KJ, Caligiuri MA, Guttridge DC. Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products. J Biol Chem. 2003 Jan 24; 278(4):2294-303. PMID: 12431991.
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    121. You Z, Saims D, Chen S, Zhang Z, Guttridge DC, Guan KL, MacDougald OA, Brown AM, Evan G, Kitajewski J, Wang CY. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol. 2002 Apr 29; 157(3):429-40. PMID: 11980918.
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    122. Chen S, Guttridge DC, Tang E, Shi S, Guan K, Wang CY. Suppression of tumor necrosis factor-mediated apoptosis by nuclear factor kappaB-independent bone morphogenetic protein/Smad signaling. J Biol Chem. 2001 Oct 19; 276(42):39259-63. PMID: 11500509.
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    123. Keifer JA, Guttridge DC, Ashburner BP, Baldwin AS. Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity. J Biol Chem. 2001 Jun 22; 276(25):22382-7. PMID: 11297551.
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    124. Chen S, Guttridge DC, You Z, Zhang Z, Fribley A, Mayo MW, Kitajewski J, Wang CY. Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. J Cell Biol. 2001 Jan 08; 152(1):87-96. PMID: 11149923.
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    125. Guttridge DC, Mayo MW, Madrid LV, Wang CY, Baldwin AS. NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. Science. 2000 Sep 29; 289(5488):2363-6. PMID: 11009425.
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    126. Madrid LV, Wang CY, Guttridge DC, Schottelius AJ, Baldwin AS, Mayo MW. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Mol Cell Biol. 2000 Mar; 20(5):1626-38. PMID: 10669740.
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    127. Cogswell PC, Guttridge DC, Funkhouser WK, Baldwin AS. Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3. Oncogene. 2000 Feb 24; 19(9):1123-31. PMID: 10713699.
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    128. Wang CY, Guttridge DC, Mayo MW, Baldwin AS. NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol. 1999 Sep; 19(9):5923-9. PMID: 10454539.
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    129. Batra RK, Guttridge DC, Brenner DA, Dubinett SM, Baldwin AS, Boucher RC. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. Am J Respir Cell Mol Biol. 1999 Aug; 21(2):238-45. PMID: 10423407.
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    130. Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS. NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol. 1999 Aug; 19(8):5785-99. PMID: 10409765.
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    131. Guttridge DC, Lau A, Tran L, Cunningham DD. Thrombin causes a marked delay in skeletal myogenesis that correlates with the delayed expression of myogenin and p21CIP1/WAF1. J Biol Chem. 1997 Sep 26; 272(39):24117-20. PMID: 9305855.
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    132. Guttridge DC, Cunningham DD. Characterization of the human protease nexin-1 promoter and its regulation by Sp1 through a G/C-rich activation domain. J Neurochem. 1996 Aug; 67(2):498-507. PMID: 8764573.
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    133. Guttridge DC, Lau AL, Cunningham DD. Protease nexin-1, a thrombin inhibitor, is regulated by interleukin-1 and dexamethasone in normal human fibroblasts. J Biol Chem. 1993 Sep 05; 268(25):18966-74. PMID: 8360185.
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    134. Guttridge D. Levodopa-carbidopa. Aust Nurses J. 1980 May; 9(10):28-9. PMID: 6901482.
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