Keywords
Last Name
Institution

Deirdre K Luttrell

Title
InstitutionMedical University of South Carolina
DepartmentMedicine
AddressP.O. Box MSC 624
Clinical Science Bldg. - 96 Jonathan Lucas St.
Phone843-792-2529
Fax843-792-4114
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    Deirdre K. Luttrell, Ph.D. is an Assistant Professor in the Divison of Nephrology at the Medical University of South Carolina in Charleston, S.C. Dr. Luttrell earned her Bachelor of Arts degree in Zoology from Pomona College in 1979 and her AM in Zoology from Duke University in 1982. Her doctorate in Microbiology was awarded in 1989 for work done on the role of the c-src proto-oncogene in signal transduction in the laboratory of Dr. Sarah Parsons at the University of Virginia. She worked in drug discovery at GlaxoSmithKline from 1989-2004, where she served as project leader on the discovery of Votrient, A VEGFR2 tyrosine kinase inhibitor. Dr. Luttrell joined MUSC in 2004, where her research focuses on GPCR transactivation of receptor tyrosine kinases.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Jaffa MA, Bebu I, Luttrell D, Braffett BH, Lachin JM, Hunt K, Lopes-Virella M, Luttrell L, Lyons TJ, Jaffa AA. Longitudinal Plasma Kallikrein Levels and Their Association With the Risk of Cardiovascular Disease Outcomes in Type 1 Diabetes in DCCT/EDIC. Diabetes. 2020 11; 69(11):2440-2445. PMID: 32826295.
      View in: PubMed
    2. Jaffa MA, Gebregziabher M, Garrett SM, Luttrell DK, Lipson KE, Luttrell LM, Jaffa AA. Analysis of longitudinal semicontinuous data using marginalized two-part model. J Transl Med. 2018 11 06; 16(1):301. PMID: 30400798.
      View in: PubMed
    3. Hunt KJ, Jaffa MA, Garrett SM, Luttrell DK, Lipson KE, Lopes-Virella MF, Luttrell LM, Jaffa AA. Plasma Connective Tissue Growth Factor (CTGF/CCN2) Levels Predict Myocardial Infarction in the Veterans Affairs Diabetes Trial (VADT) Cohort. Diabetes Care. 2018 04; 41(4):840-846. PMID: 29382658.
      View in: PubMed
    4. Jaffa MA, Gebregziabher M, Luttrell DK, Luttrell LM, Jaffa AA. Multivariate Generalized Linear Mixed Models With Random Intercepts To Analyze Cardiovascular Risk Markers in Type-1 Diabetic Patients. J Appl Stat. 2016; 43(8):1447-1464. PMID: 27829695.
      View in: PubMed
    5. Jaffa MA, Luttrell D, Schmaier AH, Klein RL, Lopes-Virella M, Luttrell LM, Jaffa AA. Plasma Prekallikrein Is Associated With Carotid Intima-Media Thickness in Type 1 Diabetes. Diabetes. 2016 Feb; 65(2):498-502. PMID: 26603531.
      View in: PubMed
    6. Li P, Hunt KJ, Taber DJ, Carter RE, Kettinger L, Luttrell D, Egidi MF, Finch NJ, Baliga P, Lin A, Biggins S, Hermayer KL. Inflammatory biomarkers, glycemic variability, hypoglycemia, and renal transplant outcomes: results of a randomized controlled trial. Transplantation. 2014 Sep 27; 98(6):632-9. PMID: 24831919.
      View in: PubMed
    7. Alele JD, Luttrell LM, Hollis BW, Luttrell DK, Hunt KJ. Relationship between vitamin D status and incidence of vascular events in the Veterans Affairs Diabetes Trial. Atherosclerosis. 2013 Jun; 228(2):502-7. PMID: 23608249.
      View in: PubMed
    8. Appleton KM, Lee MH, Alele C, Alele C, Luttrell DK, Peterson YK, Morinelli TA, Luttrell LM. Biasing the parathyroid hormone receptor: relating in vitro ligand efficacy to in vivo biological activity. Methods Enzymol. 2013; 522:229-62. PMID: 23374189.
      View in: PubMed
    9. Kendall RT, Strungs EG, Rachidi SM, Lee MH, El-Shewy HM, Luttrell DK, Janech MG, Luttrell LM. The beta-arrestin pathway-selective type 1A angiotensin receptor (AT1A) agonist [Sar1,Ile4,Ile8]angiotensin II regulates a robust G protein-independent signaling network. J Biol Chem. 2011 Jun 03; 286(22):19880-91. PMID: 21502318.
      View in: PubMed
    10. Abdallah RT, Keum JS, El-Shewy HM, Lee MH, Wang B, Gooz M, Luttrell DK, Luttrell LM, Jaffa AA. Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors. J Biol Chem. 2010 Nov 05; 285(45):35206-15. PMID: 20826789.
      View in: PubMed
    11. Lee MH, Klein RL, El-Shewy HM, Luttrell DK, Luttrell LM. The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth. Biochemistry. 2008 Nov 04; 47(44):11682-92. PMID: 18842004.
      View in: PubMed
    12. Harris PA, Boloor A, Cheung M, Kumar R, Crosby RM, Davis-Ward RG, Epperly AH, Hinkle KW, Hunter RN, Johnson JH, Knick VB, Laudeman CP, Luttrell DK, Mook RA, Nolte RT, Rudolph SK, Szewczyk JR, Truesdale AT, Veal JM, Wang L, Stafford JA. Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008 Aug 14; 51(15):4632-40. PMID: 18620382.
      View in: PubMed
    13. Lee MH, El-Shewy HM, Luttrell DK, Luttrell LM. Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription. J Biol Chem. 2008 Jan 25; 283(4):2088-97. PMID: 18006496.
      View in: PubMed
    14. Kumar R, Knick VB, Rudolph SK, Johnson JH, Crosby RM, Crouthamel MC, Hopper TM, Miller CG, Harrington LE, Onori JA, Mullin RJ, Gilmer TM, Truesdale AT, Epperly AH, Boloor A, Stafford JA, Luttrell DK, Cheung M. Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. . 2007 Jul; 6(7):2012-21. PMID: 17620431.
      View in: PubMed
    15. Jafri F, El-Shewy HM, Lee MH, Kelly M, Luttrell DK, Luttrell LM. Constitutive ERK1/2 activation by a chimeric neurokinin 1 receptor-beta-arrestin1 fusion protein. Probing the composition and function of the G protein-coupled receptor "signalsome". J Biol Chem. 2006 Jul 14; 281(28):19346-57. PMID: 16670094.
      View in: PubMed
    16. Harris PA, Cheung M, Hunter RN, Brown ML, Veal JM, Nolte RT, Wang L, Liu W, Crosby RM, Johnson JH, Epperly AH, Kumar R, Luttrell DK, Stafford JA. Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J Med Chem. 2005 Mar 10; 48(5):1610-9. PMID: 15743202.
      View in: PubMed
    17. Luttrell DK, Luttrell LM. Not so strange bedfellows: G-protein-coupled receptors and Src family kinases. Oncogene. 2004 Oct 18; 23(48):7969-78. PMID: 15489914.
      View in: PubMed
    18. Dev IK, Dornsife RE, Hopper TM, Onori JA, Miller CG, Harrington LE, Dold KM, Mullin RJ, Johnson JH, Crosby RM, Truesdale AT, Epperly AH, Hinkle KW, Cheung M, Stafford JA, Luttrell DK, Kumar R. Antitumour efficacy of VEGFR2 tyrosine kinase inhibitor correlates with expression of VEGF and its receptor VEGFR2 in tumour models. Br J Cancer. 2004 Oct 04; 91(7):1391-8. PMID: 15328520.
      View in: PubMed
    19. Luttrell DK, Luttrell LM. Signaling in time and space: G protein-coupled receptors and mitogen-activated protein kinases. Assay Drug Dev Technol. 2003 Apr; 1(2):327-38. PMID: 15090198.
      View in: PubMed
    20. Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 1999 Jan 29; 283(5402):655-61. PMID: 9924018.
      View in: PubMed
    21. Luttrell LM, van Biesen T, Hawes BE, Della Rocca GJ, Luttrell DK, Lefkowitz RJ. Regulation of mitogen-activated protein kinase pathways by catecholamine receptors. Adv Pharmacol. 1998; 42:466-70. PMID: 9327940.
      View in: PubMed
    22. Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ. Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. J Biol Chem. 1997 Aug 01; 272(31):19125-32. PMID: 9235901.
      View in: PubMed
    23. Luttrell LM, Della Rocca GJ, van Biesen T, Luttrell DK, Lefkowitz RJ. Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. J Biol Chem. 1997 Feb 14; 272(7):4637-44. PMID: 9020193.
      View in: PubMed
    24. Luttrell LM, Hawes BE, van Biesen T, Luttrell DK, Lansing TJ, Lefkowitz RJ. Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases. J Biol Chem. 1996 Aug 09; 271(32):19443-50. PMID: 8702633.
      View in: PubMed
    25. van Biesen T, Hawes BE, Luttrell DK, Krueger KM, Touhara K, Porfiri E, Sakaue M, Luttrell LM, Lefkowitz RJ. Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. Nature. 1995 Aug 31; 376(6543):781-4. PMID: 7651538.
      View in: PubMed
    26. Luttrell DK, Lee A, Lansing TJ, Crosby RM, Jung KD, Willard D, Luther M, Rodriguez M, Berman J, Gilmer TM. Involvement of pp60c-src with two major signaling pathways in human breast cancer. Proc Natl Acad Sci U S A. 1994 Jan 04; 91(1):83-7. PMID: 7506422.
      View in: PubMed
    27. Luttrell DK, Hausdorff WP, Moyers JE, Gilmer TM, Parsons SJ, Caron MG, Lefkowitz RJ. Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase. Cell Signal. 1992 Sep; 4(5):531-41. PMID: 1384635.
      View in: PubMed
    28. Hausdorff WP, Pitcher JA, Luttrell DK, Linder ME, Kurose H, Parsons SJ, Caron MG, Lefkowitz RJ. Tyrosine phosphorylation of G protein alpha subunits by pp60c-src. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):5720-4. PMID: 1378615.
      View in: PubMed
    Luttrell's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description