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Deepak Nihalani

Title
InstitutionMedical University of South Carolina
DepartmentNephrology
AddressP.O. Box MSC 629
Drug Discovery Building, Office 514
Drug Discovery Building - 70 President St.
Phone843-876-2372
Fax843-879-5521
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hammad SM, Twal WO, Arif E, Semler AJ, Klein RL, Nihalani D. Transcriptomics Reveal Altered Metabolic and Signaling Pathways in Podocytes Exposed to C16 Ceramide-Enriched Lipoproteins. Genes (Basel). 2020 Feb 07; 11(2). PMID: 32045989.
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    2. Solanki AK, Srivastava P, Rahman B, Lipschutz JH, Nihalani D, Arif E. The Use of High-Throughput Transcriptomics to Identify Pathways with Therapeutic Significance in Podocytes. Int J Mol Sci. 2019 Dec 31; 21(1). PMID: 31906131.
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    3. Solanki AK, Widmeier E, Arif E, Sharma S, Daga A, Srivastava P, Kwon SH, Hugo H, Nakayama M, Mann N, Majmundar AJ, Tan W, Gee HY, Sadowski CE, Rinat C, Becker-Cohen R, Bergmann C, Rosen S, Somers M, Shril S, Huber TB, Mane S, Hildebrandt F, Nihalani D. Mutations in KIRREL1, a slit diaphragm component, cause steroid-resistant nephrotic syndrome. Kidney Int. 2019 Oct; 96(4):883-889. PMID: 31472902.
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    4. Nihalani D, Solanki AK, Arif E, Srivastava P, Rahman B, Zuo X, Dang Y, Fogelgren B, Fermin D, Gillies CE, Sampson MG, Lipschutz JH. Disruption of the exocyst induces podocyte loss and dysfunction. J Biol Chem. 2019 06 28; 294(26):10104-10119. PMID: 31073028.
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    5. Arif E, Solanki AK, Srivastava P, Rahman B, Fitzgibbon WR, Deng P, Budisavljevic MN, Baicu CF, Zile MR, Megyesi J, Janech MG, Kwon SH, Collier J, Schnellmann RG, Nihalani D. Mitochondrial biogenesis induced by the ß2-adrenergic receptor agonist formoterol accelerates podocyte recovery from glomerular injury. Kidney Int. 2019 Sep; 96(3):656-673. PMID: 31262488.
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    6. Arif E, Nihalani D. Beta2-adrenergic receptor in kidney biology: A current prospective. Nephrology (Carlton). 2019 May; 24(5):497-503. PMID: 30848004.
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    7. Sonoda H, Lee BR, Park KH, Nihalani D, Yoon JH, Ikeda M, Kwon SH. miRNA profiling of urinary exosomes to assess the progression of acute kidney injury. Sci Rep. 2019 Mar 18; 9(1):4692. PMID: 30886169.
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    8. Arif E, Solanki AK, Srivastava P, Rahman B, Tash BR, Holzman LB, Janech MG, Martin R, Knölker HJ, Fitzgibbon WR, Deng P, Budisavljevic MN, Syn WK, Wang C, Lipschutz JH, Kwon SH, Nihalani D. The motor protein Myo1c regulates transforming growth factor-ß-signaling and fibrosis in podocytes. Kidney Int. 2019 Jul; 96(1):139-158. PMID: 31097328.
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    9. Zuo X, Lobo G, Fulmer D, Guo L, Dang Y, Su Y, Ilatovskaya DV, Nihalani D, Rohrer B, Body SC, Norris RA, Lipschutz JH. The exocyst acting through the primary cilium is necessary for renal ciliogenesis, cystogenesis, and tubulogenesis. J Biol Chem. 2019 04 26; 294(17):6710-6718. PMID: 30824539.
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    10. Srivastava P, Solanki AK, Arif E, Wolf BJ, Janech MG, Budisavljevic MN, Kwon SH, Nihalani D. Development of a novel cell-based assay to diagnose recurrent focal segmental glomerulosclerosis patients. Kidney Int. 2019 03; 95(3):708-716. PMID: 30709661.
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    11. Solanki AK, Arif E, Morinelli T, Wilson RC, Hardiman G, Deng P, Arthur JM, Velez JC, Nihalani D, Janech MG, Budisavljevic MN. A Novel CLCN5 Mutation Associated With Focal Segmental Glomerulosclerosis and Podocyte Injury. Kidney Int Rep. 2018 Nov; 3(6):1443-1453. PMID: 30426109.
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    12. Lee HW, Arif E, Altintas MM, Quick K, Maheshwari S, Plezia A, Mahmood A, Reiser J, Nihalani D, Gupta V. High-content screening assay-based discovery of paullones as novel podocyte-protective agents. Am J Physiol Renal Physiol. 2018 02 01; 314(2):F280-F292. PMID: 29046299.
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    13. Sagar A, Arif E, Solanki AK, Srivastava P, Janech MG, Kim SH, Lipschutz JH, Kwon SH, Nihalani D. Targeting Neph1 and ZO-1 protein-protein interaction in podocytes prevents podocyte injury and preserves glomerular filtration function. Sci Rep. 2017 09 21; 7(1):12047. PMID: 28935902.
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    14. Lobo GP, Fulmer D, Guo L, Zuo X, Dang Y, Kim SH, Su Y, George K, Obert E, Fogelgren B, Nihalani D, Norris RA, Rohrer B, Lipschutz JH. The exocyst is required for photoreceptor ciliogenesis and retinal development. J Biol Chem. 2017 09 08; 292(36):14814-14826. PMID: 28729419.
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    15. Gupta P, Martin R, Knölker HJ, Nihalani D, Kumar Sinha D. Myosin-1 inhibition by PClP affects membrane shape, cortical actin distribution and lipid droplet dynamics in early Zebrafish embryos. PLoS One. 2017; 12(7):e0180301. PMID: 28678859.
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    16. Velez JCQ, Arif E, Rodgers J, Hicks MP, Arthur JM, Nihalani D, Bruner ET, Budisavljevic MN, Atkinson C, Fitzgibbon WR, Janech MG. Deficiency of the Angiotensinase Aminopeptidase A Increases Susceptibility to Glomerular Injury. J Am Soc Nephrol. 2017 Jul; 28(7):2119-2132. PMID: 28202497.
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    17. Arif E, Sharma P, Solanki A, Mallik L, Rathore YS, Twal WO, Nath SK, Gandhi D, Holzman LB, Ostap EM, Nihalani D. Structural Analysis of the Myo1c and Neph1 Complex Provides Insight into the Intracellular Movement of Neph1. Mol Cell Biol. 2016 06 01; 36(11):1639-54. PMID: 27044863.
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    18. Arif E, Solanki AK, Nihalani D. Adriamycin susceptibility among C57BL/6 substrains. Kidney Int. 2016 Mar; 89(3):721-3. PMID: 26880466.
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    19. Spinale JM, Mariani LH, Kapoor S, Zhang J, Weyant R, Song PX, Wong HN, Troost JP, Gadegbeku CA, Gipson DS, Kretzler M, Nihalani D, Holzman LB. A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease. Kidney Int. 2015 Mar; 87(3):564-74. PMID: 25354239.
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    20. Solanki AK, Rathore YS, Badmalia MD, Dhoke RR, Nath SK, Nihalani D. Global shape and ligand binding efficiency of the HIV-1-neutralizing antibodies differ from those of antibodies that cannot neutralize HIV-1. J Biol Chem. 2014 Dec 12; 289(50):34780-800. PMID: 25331945.
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    21. Arif E, Rathore YS, Kumari B, Ashish F, Wong HN, Holzman LB, Nihalani D. Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injury. J Biol Chem. 2014 Apr 04; 289(14):9502-18. PMID: 24554715.
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    22. George B, Fan Q, Dlugos CP, Soofi AA, Zhang J, Verma R, Park TJ, Wong H, Curran T, Nihalani D, Holzman LB. Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis. Kidney Int. 2014 Jun; 85(6):1382-1394. PMID: 24499776.
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    23. Nihalani D, Susztak K. Sirt1-Claudin-1 crosstalk regulates renal function. Nat Med. 2013 Nov; 19(11):1371-2. PMID: 24202384.
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    24. Arif E, Kumari B, Wagner MC, Zhou W, Holzman LB, Nihalani D. Myo1c is an unconventional myosin required for zebrafish glomerular development. Kidney Int. 2013 Dec; 84(6):1154-65. PMID: 23715127.
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    25. Arif E, Nihalani D. Glomerular Filtration Barrier Assembly: An insight. Postdoc J. 2013 Apr; 1(4):33-45. PMID: 27583259.
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    26. Johnstone DB, Shegokar V, Nihalani D, Rathore YS, Mallik L, Zare V, Ikizler HO, Powar R, Holzman LB. APOL1 null alleles from a rural village in India do not correlate with glomerulosclerosis. PLoS One. 2012; 7(12):e51546. PMID: 23300552.
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    27. Tiwari A, Jung JJ, Inamdar SM, Nihalani D, Choudhury A. The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling. Am J Physiol Heart Circ Physiol. 2013 Mar 01; 304(5):H687-96. PMID: 23262137.
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    28. Helmstädter M, Lüthy K, Gödel M, Simons M, Nihalani D, Rensing SA, Fischbach KF, Huber TB. Functional study of mammalian Neph proteins in Drosophila melanogaster. PLoS One. 2012; 7(7):e40300. PMID: 22792268.
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    29. George B, Verma R, Soofi AA, Garg P, Zhang J, Park TJ, Giardino L, Ryzhova L, Johnstone DB, Wong H, Nihalani D, Salant DJ, Hanks SK, Curran T, Rastaldi MP, Holzman LB. Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease. J Clin Invest. 2012 Feb; 122(2):674-92. PMID: 22251701.
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    30. Mallik L, Arif E, Sharma P, Rathore YS, Wong HN, Holzman LB, Nihalani D. Solution structure analysis of cytoplasmic domain of podocyte protein Neph1 using small/wide angle x-ray scattering (SWAXS). J Biol Chem. 2012 Mar 16; 287(12):9441-53. PMID: 22262837.
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    31. Garg R, Peddada N, Sagar A, Nihalani D. Visual insight into how low pH alone can induce actin-severing ability in gelsolin under calcium-free conditions. J Biol Chem. 2011 Jun 10; 286(23):20387-97. PMID: 21498516.
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    32. Arif E, Wagner MC, Johnstone DB, Wong HN, George B, Pruthi PA, Lazzara MJ, Nihalani D. Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane. Mol Cell Biol. 2011 May; 31(10):2134-50. PMID: 21402783.
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    33. Wagner MC, Rhodes G, Wang E, Pruthi V, Arif E, Saleem MA, Wean SE, Garg P, Verma R, Holzman LB, Gattone V, Molitoris BA, Nihalani D. Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1. J Biol Chem. 2008 Dec 19; 283(51):35579-89. PMID: 18922801.
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    34. Garg P, Verma R, Nihalani D, Johnstone DB, Holzman LB. Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization. Mol Cell Biol. 2007 Dec; 27(24):8698-712. PMID: 17923684.
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    35. Nihalani D, Wong H, Verma R, Holzman LB. Src family kinases directly regulate JIP1 module dynamics and activation. Mol Cell Biol. 2007 Apr; 27(7):2431-41. PMID: 17242197.
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    36. Verma R, Kovari I, Soofi A, Nihalani D, Patrie K, Holzman LB. Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest. 2006 May; 116(5):1346-59. PMID: 16543952.
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    37. Oetjen E, Lechleiter A, Blume R, Nihalani D, Holzman L, Knepel W. Inhibition of membrane depolarisation-induced transcriptional activity of cyclic AMP response element binding protein (CREB) by the dual-leucine-zipper-bearing kinase in a pancreatic islet beta cell line. Diabetologia. 2006 Feb; 49(2):332-42. PMID: 16369771.
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    38. Nihalani D, Wong HN, Holzman LB. Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation. J Biol Chem. 2003 Aug 01; 278(31):28694-702. PMID: 12756254.
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    39. Verma R, Wharram B, Kovari I, Kunkel R, Nihalani D, Wary KK, Wiggins RC, Killen P, Holzman LB. Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin. J Biol Chem. 2003 Jun 06; 278(23):20716-23. PMID: 12668668.
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    40. Cai Y, Lechner MS, Nihalani D, Prindle MJ, Holzman LB, Dressler GR. Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation. J Biol Chem. 2002 Jan 11; 277(2):1217-22. PMID: 11700324.
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    41. Nihalani D, Meyer D, Pajni S, Holzman LB. Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components. EMBO J. 2001 Jul 02; 20(13):3447-58. PMID: 11432832.
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    42. Nihalani D, Merritt S, Holzman LB. Identification of structural and functional domains in mixed lineage kinase dual leucine zipper-bearing kinase required for complex formation and stress-activated protein kinase activation. J Biol Chem. 2000 Mar 10; 275(10):7273-9. PMID: 10702297.
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    43. Merritt SE, Mata M, Nihalani D, Zhu C, Hu X, Holzman LB. The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate. J Biol Chem. 1999 Apr 09; 274(15):10195-202. PMID: 10187804.
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    44. Nihalani D, Raghava GP, Sahni G. Mapping of the plasminogen binding site of streptokinase with short synthetic peptides. Protein Sci. 1997 Jun; 6(6):1284-92. PMID: 9194188.
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