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Deepak Bastia

TitleEndowed Chair, Donnelly for Biomedical Research
InstitutionMedical University of South Carolina
DepartmentBiochemistry and Molecular Biology
AddressP.O. Box MSC 509
313
70 President St.
Phone843-792-0491
Fax843-792-8568
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    Collapse Overview 
    Collapse overview
    The primary focus of our laboratory is on the investigations of the molecular mechanisms of replication fork arrest, genome stability, checkpoint controls using Saccharomyces cerevisiae and Schizosaccharomyces pombe as model systems. These are topics of intense current interest not only from the perspectives of eukaryotic DNA transactions but also of Cancer Biology. Our laboratory is also interested in the molecular analysis of the human “timeless” protein and TIPIN (timeless-interacting protein).

    Molecular Mechanisms of Cellular Aging. Recently, using yeast as a model system, we have worked out one (the major) pathway of cellular aging. We have shown that two molecular mechanisms act in a sequence to control replicative life span: (i) autoinhibition of a replication terminator protein called Fob1 and chromosome kissing. Further work is underway to study the molecular mechanisms that lead to aging and senescence.

    Our laboratory offers outstanding training in nucleic acids biochemistry, enzymology of DNA replication and on protein nucleic acids and protein-protein interactions.

    Collapse keywords
    Mechanism of replication adn transcription termination using yeast genetics, biochemistry adn crystallography, Chromosome kissing and long range protein-protein and protein-DNA interaction in controlling DNA transactions and cancer

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bastia D, Srivastava P, Zaman S, Choudhury M, Mohanty BK, Bacal J, Langston LD, Pasero P, O'Donnell ME. Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):E3639-48. PMID: 27298353.
      View in: PubMed
    2. Zaman S, Choudhury M, Jiang JC, Srivastava P, Mohanty BK, Danielson C, Humphrey SJ, Jazwinski SM, Bastia D. Mechanism of Regulation of Intrachromatid Recombination and Long-Range Chromosome Interactions in Saccharomyces cerevisiae. Mol Cell Biol. 2016 05 15; 36(10):1451-63. PMID: 26951198.
      View in: PubMed
    3. Jaiswal R, Choudhury M, Zaman S, Singh S, Santosh V, Bastia D, Escalante CR. Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):E2267-76. PMID: 27035982.
      View in: PubMed
    4. Tripathy SK, Ranjan R, Dash S, Bastia DL, Baisakh B, Satpathy PC, Sahu S. Isolation of useful scented rice mutants and comparative assessment of genetic diversity. J Environ Biol. 2016 Jan; 37(1):65-73. PMID: 26930862.
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    5. Choudhury M, Zaman S, Jiang JC, Jazwinski SM, Bastia D. Mechanism of regulation of 'chromosome kissing' induced by Fob1 and its physiological significance. Genes Dev. 2015 Jun 01; 29(11):1188-201. PMID: 26063576.
      View in: PubMed
    6. Jaiswal R, Singh SK, Bastia D, Escalante CR. Crystallization and preliminary X-ray characterization of the eukaryotic replication terminator Reb1-Ter DNA complex. Acta Crystallogr F Struct Biol Commun. 2015 Apr; 71(Pt 4):414-8. PMID: 25849502.
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    7. Bastia D, Zaman S. Mechanism and physiological significance of programmed replication termination. Semin Cell Dev Biol. 2014 Jun; 30:165-73. PMID: 24811316.
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    8. Bastia D, Singh SK. "Chromosome kissing" and modulation of replication termination. Bioarchitecture. 2011 Jan; 1(1):24-28. PMID: 21866258.
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    9. Bairwa NK, Mohanty BK, Stamenova R, Curcio MJ, Bastia D. The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces cerevisiae. J Biol Chem. 2011 Jan 28; 286(4):2445-54. PMID: 21087929.
      View in: PubMed
    10. Singh SK, Sabatinos S, Forsburg S, Bastia D. Regulation of replication termination by Reb1 protein-mediated action at a distance. Cell. 2010 Sep 17; 142(6):868-78. PMID: 20850009.
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    11. Bairwa NK, Zzaman S, Mohanty BK, Bastia D. Replication fork arrest and rDNA silencing are two independent and separable functions of the replication terminator protein Fob1 of Saccharomyces cerevisiae. J Biol Chem. 2010 Apr 23; 285(17):12612-9. PMID: 20179323.
      View in: PubMed
    12. Saxena M, Singh S, Zzaman S, Bastia D. Investigations of pi initiator protein-mediated interaction between replication origins alpha and gamma of the plasmid R6K. J Biol Chem. 2010 Feb 19; 285(8):5695-704. PMID: 20029091.
      View in: PubMed
    13. Saxena M, Abhyankar M, Bastia D. Replication initiation at a distance: determination of the cis- and trans-acting elements of replication origin alpha of plasmid R6K. J Biol Chem. 2010 Feb 19; 285(8):5705-12. PMID: 20018882.
      View in: PubMed
    14. Kaplan DL, Bastia D. Mechanisms of polar arrest of a replication fork. Mol Microbiol. 2009 Apr; 72(2):279-85. PMID: 19298368.
      View in: PubMed
    15. Mohanty BK, Bairwa NK, Bastia D. Contrasting roles of checkpoint proteins as recombination modulators at Fob1-Ter complexes with or without fork arrest. Eukaryot Cell. 2009 Apr; 8(4):487-95. PMID: 19234097.
      View in: PubMed
    16. Biswas S, Bastia D. Mechanistic insights into replication termination as revealed by investigations of the Reb1-Ter3 complex of Schizosaccharomyces pombe. Mol Cell Biol. 2008 Nov; 28(22):6844-57. PMID: 18794373.
      View in: PubMed
    17. Bastia D, Zzaman S, Krings G, Saxena M, Peng X, Greenberg MM. Replication termination mechanism as revealed by Tus-mediated polar arrest of a sliding helicase. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12831-6. PMID: 18708526.
      View in: PubMed
    18. Swan MK, Bastia D, Davies C. Crystal structure of pi initiator protein-iteron complex of plasmid R6K: implications for initiation of plasmid DNA replication. Proc Natl Acad Sci U S A. 2006 Dec 05; 103(49):18481-6. PMID: 17124167.
      View in: PubMed
    19. Krings G, Bastia D. Molecular architecture of a eukaryotic DNA replication terminus-terminator protein complex. Mol Cell Biol. 2006 Nov; 26(21):8061-74. PMID: 16940176.
      View in: PubMed
    20. Mohanty BK, Bairwa NK, Bastia D. The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):897-902. PMID: 16418273.
      View in: PubMed
    21. Zzaman S, Bastia D. Oligomeric initiator protein-mediated DNA looping negatively regulates plasmid replication in vitro by preventing origin melting. Mol Cell. 2005 Dec 22; 20(6):833-43. PMID: 16364910.
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    22. Krings G, Bastia D. Sap1p binds to Ter1 at the ribosomal DNA of Schizosaccharomyces pombe and causes polar replication fork arrest. J Biol Chem. 2005 Nov 25; 280(47):39135-42. PMID: 16195226.
      View in: PubMed
    23. Zzaman S, Reddy JM, Bastia D. The DnaK-DnaJ-GrpE chaperone system activates inert wild type pi initiator protein of R6K into a form active in replication initiation. J Biol Chem. 2004 Dec 03; 279(49):50886-94. PMID: 15485812.
      View in: PubMed
    24. Krings G, Bastia D. swi1- and swi3-dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombe. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14085-90. PMID: 15371597.
      View in: PubMed
    25. Zzaman S, Abhyankar MM, Bastia D. Reconstitution of F factor DNA replication in vitro with purified proteins. J Biol Chem. 2004 Apr 23; 279(17):17404-10. PMID: 14973139.
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    26. Abhyankar MM, Reddy JM, Sharma R, Büllesbach E, Bastia D. Biochemical investigations of control of replication initiation of plasmid R6K. J Biol Chem. 2004 Feb 20; 279(8):6711-9. PMID: 14665626.
      View in: PubMed
    27. Mohanty BK, Bastia D. Binding of the replication terminator protein Fob1p to the Ter sites of yeast causes polar fork arrest. J Biol Chem. 2004 Jan 16; 279(3):1932-41. PMID: 14576157.
      View in: PubMed
    28. Abhyankar MM, Zzaman S, Bastia D. Reconstitution of R6K DNA replication in vitro using 22 purified proteins. J Biol Chem. 2003 Nov 14; 278(46):45476-84. PMID: 12970346.
      View in: PubMed
    29. Sharma R, Kachroo A, Bastia D. Mechanistic aspects of DnaA-RepA interaction as revealed by yeast forward and reverse two-hybrid analysis. EMBO J. 2001 Aug 15; 20(16):4577-87. PMID: 11500384.
      View in: PubMed
    30. Mulugu S, Potnis A. Mechanism of termination of DNA replication of Escherichia coli involves helicase-contrahelicase interaction. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9569-74. PMID: 11493686.
      View in: PubMed
    31. Gautam A, Mulugu S, Alexander K, Bastia D. A single domain of the replication termination protein of Bacillus subtilis is involved in arresting both DnaB helicase and RNA polymerase. J Biol Chem. 2001 Jun 29; 276(26):23471-9. PMID: 11313334.
      View in: PubMed
    32. Mohanty BK, Bussiere DE, Sahoo T, Pai KS, Meijer WJ, Bron S, Bastia D. Structural and functional analysis of a bipolar replication terminus. Implications for the origin of polarity of fork arrest. J Biol Chem. 2001 Apr 20; 276(16):13160-8. PMID: 11278792.
      View in: PubMed
    33. Gautam A, Bastia D. A replication terminus located at or near a replication checkpoint of Bacillus subtilis functions independently of stringent control. J Biol Chem. 2001 Mar 23; 276(12):8771-7. PMID: 11124956.
      View in: PubMed
    34. Bussiere DE, Bastia D. Termination of DNA replication of bacterial and plasmid chromosomes. Mol Microbiol. 1999 Mar; 31(6):1611-8. PMID: 10209736.
      View in: PubMed
    35. Datta HJ, Khatri GS, Bastia D. Mechanism of recruitment of DnaB helicase to the replication origin of the plasmid pSC101. Proc Natl Acad Sci U S A. 1999 Jan 05; 96(1):73-8. PMID: 9874774.
      View in: PubMed
    36. Lu YB, Datta HJ, Bastia D. Mechanistic studies of initiator-initiator interaction and replication initiation. EMBO J. 1998 Sep 01; 17(17):5192-200. PMID: 9724655.
      View in: PubMed
    37. Mohanty BK, Sahoo T, Bastia D. Mechanistic studies on the impact of transcription on sequence-specific termination of DNA replication and vice versa. J Biol Chem. 1998 Jan 30; 273(5):3051-9. PMID: 9446621.
      View in: PubMed
    38. Bastia D, Manna AC, Sahoo T. Termination of DNA replication in prokaryotic chromosomes. Genet Eng (N Y). 1997; 19:101-19. PMID: 9193105.
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    39. Manna AC, Pai KS, Bussiere DE, Davies C, White SW, Bastia D. Helicase-contrahelicase interaction and the mechanism of termination of DNA replication. Cell. 1996 Nov 29; 87(5):881-91. PMID: 8945515.
      View in: PubMed
    40. Lu YB, Ratnakar PV, Mohanty BK, Bastia D. Direct physical interaction between DnaG primase and DnaB helicase of Escherichia coli is necessary for optimal synthesis of primer RNA. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):12902-7. PMID: 8917517.
      View in: PubMed
    41. Pai KS, Bussiere DE, Wang F, White SW, Bastia D. Structure of the replication terminus-terminator protein complex as probed by affinity cleavage. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):10647-52. PMID: 8855233.
      View in: PubMed
    42. Pai KS, Bussiere DE, Wang F, Hutchison CA, White SW, Bastia D. The structure and function of the replication terminator protein of Bacillus subtilis: identification of the 'winged helix' DNA-binding domain. EMBO J. 1996 Jun 17; 15(12):3164-73. PMID: 8670817.
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    43. Bastia D. Structural aspects of protein-DNA interactions as revealed by conversion of the interacting protein into a sequence-specific cross-linking agent or a chemical nuclease. Structure. 1996 Jun 15; 4(6):661-4. PMID: 8805548.
      View in: PubMed
    44. Ratnakar PV, Mohanty BK, Lobert M, Bastia D. The replication initiator protein pi of the plasmid R6K specifically interacts with the host-encoded helicase DnaB. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5522-6. PMID: 8643608.
      View in: PubMed
    45. Mohanty BK, Sahoo T, Bastia D. The relationship between sequence-specific termination of DNA replication and transcription. EMBO J. 1996 May 15; 15(10):2530-9. PMID: 8665860.
      View in: PubMed
    46. Manna AC, Pai KS, Bussiere DE, White SW, Bastia D. The dimer-dimer interaction surface of the replication terminator protein of Bacillus subtilis and termination of DNA replication. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3253-8. PMID: 8622923.
      View in: PubMed
    47. Sahoo T, Mohanty BK, Lobert M, Manna AC, Bastia D. The contrahelicase activities of the replication terminator proteins of Escherichia coli and Bacillus subtilis are helicase-specific and impede both helicase translocation and authentic DNA unwinding. J Biol Chem. 1995 Dec 08; 270(49):29138-44. PMID: 7493939.
      View in: PubMed
    48. Bussiere DE, Bastia D, White SW. Crystal structure of the replication terminator protein from B. subtilis at 2.6 A. Cell. 1995 Feb 24; 80(4):651-60. PMID: 7867072.
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    49. Sahoo T, Mohanty BK, Patel I, Bastia D. Termination of DNA replication in vitro: requirement for stereospecific interaction between two dimers of the replication terminator protein of Bacillus subtilis and with the terminator site to elicit polar contrahelicase and fork impedance. EMBO J. 1995 Feb 01; 14(3):619-28. PMID: 7859750.
      View in: PubMed
    50. Kaul S, Mohanty BK, Sahoo T, Patel I, Khan SA, Bastia D. The replication terminator protein of the gram-positive bacterium Bacillus subtilis functions as a polar contrahelicase in gram-negative Escherichia coli. Proc Natl Acad Sci U S A. 1994 Nov 08; 91(23):11143-7. PMID: 7972025.
      View in: PubMed
    51. Miron A, Patel I, Bastia D. Multiple pathways of copy control of gamma replicon of R6K: mechanisms both dependent on and independent of cooperativity of interaction of tau protein with DNA affect the copy number. Proc Natl Acad Sci U S A. 1994 Jul 05; 91(14):6438-42. PMID: 8022801.
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    52. Natarajan S, Kaul S, Miron A, Bastia D. A 27 kd protein of E. coli promotes antitermination of replication in vitro at a sequence-specific replication terminus. Cell. 1993 Jan 15; 72(1):113-20. PMID: 8380756.
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    53. Mehta PP, Bussiere DE, Hoffman DW, Bastia D, White SW. Crystallization and preliminary structural analysis of the replication terminator protein of Bacillus subtilis. J Biol Chem. 1992 Sep 15; 267(26):18885-9. PMID: 1527015.
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    54. Kelley WL, Patel I, Bastia D. Structural and functional analysis of a replication enhancer: separation of the enhancer activity from origin function by mutational dissection of the replication origin gamma of plasmid R6K. Proc Natl Acad Sci U S A. 1992 Jun 01; 89(11):5078-82. PMID: 1594615.
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    55. Kelley WL, Bastia D. Activation in vivo of the minimal replication origin beta of plasmid R6K requires a small target sequence essential for DNA looping. New Biol. 1992 May; 4(5):569-80. PMID: 1515418.
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    56. Miron A, Mukherjee S, Bastia D. Activation of distant replication origins in vivo by DNA looping as revealed by a novel mutant form of an initiator protein defective in cooperativity at a distance. EMBO J. 1992 Mar; 11(3):1205-16. PMID: 1547780.
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    57. Kelley WL, Bastia D. Conformational changes induced by integration host factor at origin gamma of R6K and copy number control. J Biol Chem. 1991 Aug 25; 266(24):15924-37. PMID: 1651928.
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    58. MacAllister TW, Kelley WL, Miron A, Stenzel TT, Bastia D. Replication of plasmid R6K origin gamma in vitro. Dependence on dual initiator proteins and inhibition by transcription. J Biol Chem. 1991 Aug 25; 266(24):16056-62. PMID: 1651932.
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    59. Stenzel TT, MacAllister T, Bastia D. Cooperativity at a distance promoted by the combined action of two replication initiator proteins and a DNA bending protein at the replication origin of pSC101. Genes Dev. 1991 Aug; 5(8):1453-63. PMID: 1869049.
      View in: PubMed
    60. Natarajan S, Kelley WL, Bastia D. Replication terminator protein of Escherichia coli is a transcriptional repressor of its own synthesis. Proc Natl Acad Sci U S A. 1991 May 01; 88(9):3867-71. PMID: 2023933.
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    61. Bedrosian CL, Bastia D. Escherichia coli replication terminator protein impedes simian virus 40 (SV40) DNA replication fork movement and SV40 large tumor antigen helicase activity in vitro at a prokaryotic terminus sequence. Proc Natl Acad Sci U S A. 1991 Apr 01; 88(7):2618-22. PMID: 1849268.
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    62. Sista PR, Hutchinson CA, Bastia D. DNA-protein interaction at the replication termini of plasmid R6K. Genes Dev. 1991 Jan; 5(1):74-82. PMID: 1989907.
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    63. MacAllister T, Khatri GS, Bastia D. Sequence-specific and polarized replication termination in vitro: complementation of extracts of tus- Escherichia coli by purified Ter protein and analysis of termination intermediates. Proc Natl Acad Sci U S A. 1990 Apr; 87(7):2828-32. PMID: 2181452.
      View in: PubMed
    64. Bedrosian CL, Bastia D. The DNA-binding domain of HPV-16 E2 protein interaction with the viral enhancer: protein-induced DNA bending and role of the nonconserved core sequence in binding site affinity. Virology. 1990 Feb; 174(2):557-75. PMID: 2154890.
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    65. Khatri GS, MacAllister T, Sista PR, Bastia D. The replication terminator protein of E. coli is a DNA sequence-specific contra-helicase. Cell. 1989 Nov 17; 59(4):667-74. PMID: 2684415.
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    66. Sista PR, Mukherjee S, Patel P, Khatri GS, Bastia D. A host-encoded DNA-binding protein promotes termination of plasmid replication at a sequence-specific replication terminus. Proc Natl Acad Sci U S A. 1989 May; 86(9):3026-30. PMID: 2654932.
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    67. Mukherjee S, Erickson H, Bastia D. Detection of DNA looping due to simultaneous interaction of a DNA-binding protein with two spatially separated binding sites on DNA. Proc Natl Acad Sci U S A. 1988 Sep; 85(17):6287-91. PMID: 3413096.
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    68. Moskaluk CA, Bastia D. Interaction of the bovine papillomavirus type 1 E2 transcriptional control protein with the viral enhancer: purification of the DNA-binding domain and analysis of its contact points with DNA. J Virol. 1988 Jun; 62(6):1925-31. PMID: 2835497.
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    69. Moskaluk C, Bastia D. DNA bending is induced in an enhancer by the DNA-binding domain of the bovine papillomavirus E2 protein. Proc Natl Acad Sci U S A. 1988 Mar; 85(6):1826-30. PMID: 2831538.
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    70. Mukherjee S, Erickson H, Bastia D. Enhancer-origin interaction in plasmid R6K involves a DNA loop mediated by initiator protein. Cell. 1988 Feb 12; 52(3):375-83. PMID: 3345564.
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    71. Patel I, Bastia D. A replication initiator protein enhances the rate of hybrid formation between a silencer RNA and an activator RNA. Cell. 1987 Nov 06; 51(3):455-62. PMID: 2444344.
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    72. Gaylo PJ, Turjman N, Bastia D. DnaA protein is required for replication of the minimal replicon of the broad-host-range plasmid RK2 in Escherichia coli. J Bacteriol. 1987 Oct; 169(10):4703-9. PMID: 2820940.
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    73. Stenzel TT, Patel P, Bastia D. The integration host factor of Escherichia coli binds to bent DNA at the origin of replication of the plasmid pSC101. Cell. 1987 Jun 05; 49(5):709-17. PMID: 3555843.
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    74. Moskaluk C, Bastia D. The E2 "gene" of bovine papillomavirus encodes an enhancer-binding protein. Proc Natl Acad Sci U S A. 1987 Mar; 84(5):1215-8. PMID: 3029771.
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    75. Patel I, Bastia D. A replication origin is turned off by an origin-"silencer" sequence. Cell. 1986 Dec 05; 47(5):785-92. PMID: 2430721.
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    76. Mukherjee S, Patel I, Bastia D. Conformational changes in a replication origin induced by an initiator protein. Cell. 1985 Nov; 43(1):189-97. PMID: 3000600.
      View in: PubMed
    77. Kelley W, Bastia D. Replication initiator protein of plasmid R6K autoregulates its own synthesis at the transcriptional step. Proc Natl Acad Sci U S A. 1985 May; 82(9):2574-8. PMID: 3857600.
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    78. Vocke C, Bastia D. The replication initiator protein of plasmid pSC101 is a transcriptional repressor of its own cistron. Proc Natl Acad Sci U S A. 1985 Apr; 82(8):2252-6. PMID: 2986108.
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    79. Bastia D, Vocke C, Germino J, Gray J. DNA-protein interaction at the replication origins of plasmid chromosomes. Basic Life Sci. 1985; 30:397-414. PMID: 2990419.
      View in: PubMed
    80. Vocke C, Bastia D. DNA-protein interaction at the origin of DNA replication of the plasmid pSC101. Cell. 1983 Dec; 35(2 Pt 1):495-502. PMID: 6317193.
      View in: PubMed
    81. Vocke C, Bastia D. Primary structure of the essential replicon of the plasmid pSC101. Proc Natl Acad Sci U S A. 1983 Nov; 80(21):6557-61. PMID: 6579542.
      View in: PubMed
    82. Germino J, Gray JG, Charbonneau H, Vanaman T, Bastia D. Use of gene fusions and protein-protein interaction in the isolation of a biologically active regulatory protein: the replication initiator protein of plasmid R6K. Proc Natl Acad Sci U S A. 1983 Nov; 80(22):6848-52. PMID: 6316329.
      View in: PubMed
    83. Germino J, Bastia D. Interaction of the plasmid R6K-encoded replication initiator protein with its binding sites on DNA. Cell. 1983 Aug; 34(1):125-34. PMID: 6224568.
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    84. Germino J, Bastia D. The replication initiator protein of plasmid R6K tagged with beta-galactosidase shows sequence-specific DNA-binding. Cell. 1983 Jan; 32(1):131-40. PMID: 6297781.
      View in: PubMed
    85. Shon M, Germino J, Bastia D. The nucleotide sequence of the replication origin beta of the plasmid R6K. J Biol Chem. 1982 Nov 25; 257(22):13823-7. PMID: 6292210.
      View in: PubMed
    86. Germino J, Bastia D. Primary structure of the replication initiation protein of plasmid R6K. Proc Natl Acad Sci U S A. 1982 Sep; 79(18):5475-9. PMID: 6291046.
      View in: PubMed
    87. Bastia D, Germino J, Crosa JH, Hale P. Molecular cloning of the replication terminus of the plasmid R6K. Gene. 1981 Jun-Jul; 14(1-2):81-9. PMID: 7262563.
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    88. Bastia D, Germino J, Crosa JH, Ram J. The nucleotide sequence surrounding the replication terminus of R6K. Proc Natl Acad Sci U S A. 1981 Apr; 78(4):2095-9. PMID: 6941271.
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    89. Germino J, Bastia D. Termination of DNA replication in vitro at a sequence-specific replication terminus. Cell. 1981 Mar; 23(3):681-7. PMID: 7013986.
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    90. Chan PT, Lebowitz J, Bastia D. Nucleotide sequence determination of a strong promoter of the colicin E 1 plasmid. Analysis of restriction sites protected by RNA polymerase interactions before and after limited transcription. Nucleic Acids Res. 1979 Nov 10; 7(5):1247-62. PMID: 390498.
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    91. Bastia D. Determination of restriction sites and the nucleotide sequence surrounding the relaxation site of ColE1. J Mol Biol. 1978 Oct 05; 124(4):601-39. PMID: 712849.
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    92. Bastia D. The nucleotide sequence surrounding the origin of DNA replication of Col E1. Nucleic Acids Res. 1977 Sep; 4(9):3123-42. PMID: 410007.
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    93. Bastia D, Sueoka N. Studies on the late replication of phage lambda: rolling-circle replication of the wild type and a partially suppressed strain, Oam29 Pam80. J Mol Biol. 1975 Oct 25; 98(2):305-20. PMID: 1195390.
      View in: PubMed
    94. Bastia D, Chiang KS, Swift H, Siersma P. Heterogeneity, complexity, and repetition of the chloroplast DNA of Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A. 1971 Jun; 68(6):1157-61. PMID: 4942181.
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