Danyelle Townsend

Title
InstitutionMedical University of South Carolina
DepartmentCOP Drug Discovery and Biomedical Sciences - MUSC Campus
AddressP.O. Box MSC505
DD414
70 President St.
Phone843-876-2391
Fax843-876-2353
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhang L, Kim SH, Park KH, Zhi-Wei Y, Jie Z, Townsend DM, Tew KD. Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish. J Pharmacol Exp Ther. 2021 04; 377(1):121-132. PMID: 33514607.
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    2. Zhang J, Ye ZW, Janssen-Heininger Y, Townsend DM, Tew KD. Development of Telintra as an Inhibitor of Glutathione S-Transferase P. Handb Exp Pharmacol. 2021; 264:71-91. PMID: 32767141.
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    3. Mendes Miranda SE, Alcântara Lemos J, Fernandes RS, Silva JO, Ottoni FM, Townsend DM, Rubello D, Alves RJ, Cassali GD, Ferreira LAM, de Barros ALB. Enhanced antitumor efficacy of lapachol-loaded nanoemulsion in breast cancer tumor model. Biomed Pharmacother. 2021 Jan; 133:110936. PMID: 33254016.
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    4. Skanjeti A, Magand N, Defez D, Tordo J, Rode A, Manichon AF, Hallouard F, Clave-Darcissac C, Dhomps A, Townsend DM, Rubello D, Giammarile F. Selective internal radiation therapy of hepatic tumors: Morphologic and functional imaging for voxel-based computer-aided dosimetry. Biomed Pharmacother. 2020 Dec; 132:110865. PMID: 33254427.
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    5. Zhang J, Ye ZW, Chen W, Culpepper J, Jiang H, Ball LE, Mehrotra S, Blumental-Perry A, Tew KD, Townsend DM. Altered redox regulation and S-glutathionylation of BiP contribute to bortezomib resistance in multiple myeloma. Free Radic Biol Med. 2020 11 20; 160:755-767. PMID: 32937189.
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    6. Park KH, Ye ZW, Zhang J, Hammad SM, Townsend DM, Rockey DC, Kim SH. Author Correction: 3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish. Sci Rep. 2020 Jul 15; 10(1):11971. PMID: 32665573.
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    7. Zhang L, Townsend DM, Morris M, Maldonado EN, Jiang YL, Broome AM, Bethard JR, Ball LE, Tew KD. Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone. J Pharmacol Exp Ther. 2020 08; 374(2):308-318. PMID: 32546528.
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    8. Costiniti V, Bomfim GH, Li Y, Mitaishvili E, Ye ZW, Zhang J, Townsend DM, Giacomello M, Lacruz RS. Mitochondrial Function in Enamel Development. Front Physiol. 2020; 11:538. PMID: 32547417.
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    9. Hurst KE, Lawrence KA, Reyes Angeles L, Ye Z, Zhang J, Townsend DM, Dolloff N, Thaxton JE. Endoplasmic Reticulum Protein Disulfide Isomerase Shapes T Cell Efficacy for Adoptive Cellular Therapy of Tumors. Cells. 2019 11 26; 8(12). PMID: 31779147.
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    10. Mazza A, Townsend DM, Schiavon L, Torin G, Lenti S, Rossetti C, Rigatelli G, Rubello D. Long-term effect of the perindopril/indapamide/amlodipine single-pill combination on left ventricular hypertrophy in outpatient hypertensive subjects. Biomed Pharmacother. 2019 Dec; 120:109539. PMID: 31627089.
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    11. Zhang L, Zhang J, Ye Z, Manevich Y, Townsend DM, Marshall DT, Tew KD. S-Glutathionylated Serine Proteinase Inhibitors as Biomarkers for Radiation Exposure in Prostate Cancer Patients. Sci Rep. 2019 09 24; 9(1):13792. PMID: 31551460.
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    12. Kruyer A, Ball LE, Townsend DM, Kalivas PW, Uys JD. Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking. PLoS One. 2019; 14(9):e0223037. PMID: 31550273.
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    13. de Oliveira Silva J, Fernandes RS, Ramos Oda CM, Ferreira TH, Machado Botelho AF, Martins Melo M, de Miranda MC, Assis Gomes D, Dantas Cassali G, Townsend DM, Rubello D, Oliveira MC, de Barros ALB. Folate-coated, long-circulating and pH-sensitive liposomes enhance doxorubicin antitumor effect in a breast cancer animal model. Biomed Pharmacother. 2019 Oct; 118:109323. PMID: 31400669.
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    14. Rahman WT, Wale DJ, Viglianti BL, Townsend DM, Manganaro MS, Gross MD, Wong KK, Rubello D. The impact of infection and inflammation in oncologic 18F-FDG PET/CT imaging. Biomed Pharmacother. 2019 Sep; 117:109168. PMID: 31334700.
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    15. Zhang L, Zhang J, Ye Z, Manevich Y, Ball LE, Bethard JR, Jiang YL, Broome AM, Dalton AC, Wang GY, Townsend DM, Tew KD. Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1. Cancer Res. 2019 08 15; 79(16):4072-4085. PMID: 31227482.
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    16. Tartaglione G, Townsend DM, Bassi PF, Delgado Bolton RC, Giammarile F, Rubello D. Diuresis renography in equivocal urinary tract obstruction. A historical perspective. Biomed Pharmacother. 2019 Aug; 116:108981. PMID: 31136948.
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    17. Zhong G, Qin S, Townsend D, Schulte BA, Tew KD, Wang GY. Oxidative stress induces senescence in breast cancer stem cells. Biochem Biophys Res Commun. 2019 07 05; 514(4):1204-1209. PMID: 31109646.
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    18. Bartolini D, Wang Y, Zhang J, Giustarini D, Rossi R, Wang GY, Torquato P, Townsend DM, Tew KD, Galli F. A seleno-hormetine protects bone marrow hematopoietic cells against ionizing radiation-induced toxicities. PLoS One. 2019; 14(4):e0205626. PMID: 31034521.
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    19. Zhang J, Ye ZW, Townsend DM, Hughes-Halbert C, Tew KD. Racial disparities, cancer and response to oxidative stress. Adv Cancer Res. 2019; 144:343-383. PMID: 31349903.
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    20. Zhang L, Zhang J, Ye Z, Townsend DM, Tew KD. Pharmacology of ME-344, a novel cytotoxic isoflavone. Adv Cancer Res. 2019; 142:187-207. PMID: 30885362.
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    21. Viglianti BL, Wale DJ, Ma T, Johnson TD, Bohnen NI, Wong KK, Ky C, Frey KA, Townsend DM, Rubello D, Gross MD. Effects of plasma glucose levels on regional cerebral 18F-fluorodeoxyglucose uptake: Implications for dementia evaluation with brain PET imaging. Biomed Pharmacother. 2019 Apr; 112:108628. PMID: 30784923.
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    22. Park KH, Ye ZW, Zhang J, Hammad SM, Townsend DM, Rockey DC, Kim SH. 3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish. Sci Rep. 2019 02 04; 9(1):1138. PMID: 30718751.
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    23. Nunes SS, Fernandes RS, Cavalcante CH, da Costa César I, Leite EA, Lopes SCA, Ferretti A, Rubello D, Townsend DM, de Oliveira MC, Cardoso VN, de Barros ALB. Influence of PEG coating on the biodistribution and tumor accumulation of pH-sensitive liposomes. Drug Deliv Transl Res. 2019 02; 9(1):123-130. PMID: 30187353.
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    24. Womersley JS, Townsend DM, Kalivas PW, Uys JD. Targeting redox regulation to treat substance use disorder using N-acetylcysteine Eur J Neurosci. 2019 08; 50(3):2538-2551. PMID: 30144182.
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    25. Mazza A, Lenti S, Schiavon L, Di Giacomo E, Tomasi M, Manunta R, Torin G, Townsend DM, Rubello D. Effect of Monacolin K and COQ10 supplementation in hypertensive and hypercholesterolemic subjects with metabolic syndrome. Biomed Pharmacother. 2018 09; 105:992-996. PMID: 30021394.
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    26. Fernandes RS, Silva JO, Seabra HA, Oliveira MS, Carregal VM, Vilela JMC, Andrade MS, Townsend DM, Colletti PM, Leite EA, Cardoso VN, Ferreira LAM, Rubello D, Barros ALB. a- Tocopherol succinate loaded nano-structed lipid carriers improves antitumor activity of doxorubicin in breast cancer models in vivo. Biomed Pharmacother. 2018 Jul; 103:1348-1354. PMID: 29864917.
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    27. Bräutigam L, Zhang J, Dreij K, Spahiu L, Holmgren A, Abe H, Tew KD, Townsend DM, Kelner MJ, Morgenstern R, Johansson K. MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation. Redox Biol. 2018 07; 17:171-179. PMID: 29702404.
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    28. Zhang J, Ye ZW, Singh S, Townsend DM, Tew KD. An evolving understanding of the S-glutathionylation cycle in pathways of redox regulation. Free Radic Biol Med. 2018 05 20; 120:204-216. PMID: 29578070.
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    29. Zhang J, Ye ZW, Chen W, Manevich Y, Mehrotra S, Ball L, Janssen-Heininger Y, Tew KD, Townsend DM. S-Glutathionylation of estrogen receptor a affects dendritic cell function. J Biol Chem. 2018 03 23; 293(12):4366-4380. PMID: 29374060.
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    30. Monteiro LOF, Fernandes RS, Oda CMR, Lopes SC, Townsend DM, Cardoso VN, Oliveira MC, Leite EA, Rubello D, de Barros ALB. Paclitaxel-loaded folate-coated long circulating and pH-sensitive liposomes as a potential drug delivery system: A biodistribution study. Biomed Pharmacother. 2018 Jan; 97:489-495. PMID: 29091899.
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    31. Fernandes RS, de Aguiar Ferreira C, Soares DCF, Maffione AM, Townsend DM, Rubello D, de Barros ALB. The role of radionuclide probes for monitoring anti-tumor drugs efficacy: A brief review. Biomed Pharmacother. 2017 Nov; 95:469-476. PMID: 28865367.
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    32. Marchiori E, Pelizzo MR, Herten M, Townsend DM, Rubello D, Boschin IM. Specifying the molecular pattern of sporadic parathyroid tumorigenesis-The Y282D variant of the GCM2 gene. Biomed Pharmacother. 2017 Aug; 92:843-848. PMID: 28609842.
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    33. Soares DCF, de Paula Oliveira DC, Barcelos LS, Barbosa AS, Vieira LC, Townsend DM, Rubello D, de Barros ALB, Duarte LP, Silva-Cunha A. Antiangiogenic activity of PLGA-Lupeol implants for potential intravitreal applications. Biomed Pharmacother. 2017 Aug; 92:394-402. PMID: 28558353.
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    34. Manuel AM, Walla MD, Faccenda A, Martin SL, Tanis RM, Piroli GG, Adam J, Kantor B, Mutus B, Townsend DM, Frizzell N. Succination of Protein Disulfide Isomerase Links Mitochondrial Stress and Endoplasmic Reticulum Stress in the Adipocyte During Diabetes. Antioxid Redox Signal. 2017 Dec 01; 27(16):1281-1296. PMID: 28376661.
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    35. Mazza A, Sacco AP, Townsend DM, Bregola G, Contatto E, Cappello I, Schiavon L, Ramazzina E, Rubello D. Cost-benefit effectiveness of angiotensin-II receptor blockers in patients with uncomplicated hypertension: A comparative analysis. Biomed Pharmacother. 2017 Jun; 90:665-669. PMID: 28415046.
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    36. Pulkoski-Gross MJ, Uys JD, Orr-Gandy KA, Coant N, Bialkowska AB, Szulc ZM, Bai A, Bielawska A, Townsend DM, Hannun YA, Obeid LM, Snider AJ. Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis. Prostaglandins Other Lipid Mediat. 2017 05; 130:47-56. PMID: 28377281.
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    37. Monteiro LOF, Fernandes RS, Castro LC, Cardoso VN, Oliveira MC, Townsend DM, Ferretti A, Rubello D, Leite EA, de Barros ALB. Technetium-99m radiolabeled paclitaxel as an imaging probe for breast cancer in vivo. Biomed Pharmacother. 2017 May; 89:146-151. PMID: 28222395.
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    38. Oda CMR, Fernandes RS, de Araújo Lopes SC, de Oliveira MC, Cardoso VN, Santos DM, de Castro Pimenta AM, Malachias A, Paniago R, Townsend DM, Colletti PM, Rubello D, Alves RJ, de Barros ALB, Leite EA. Synthesis, characterization and radiolabeling of polymeric nano-micelles as a platform for tumor delivering. Biomed Pharmacother. 2017 May; 89:268-275. PMID: 28235689.
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    39. Viglianti BL, Wong KK, Wimer SM, Parameswaran A, Nan B, Ky C, Townsend DM, Rubello D, Frey KA, Gross MD. Effect of hyperglycemia on brain and liver 18F-FDG standardized uptake value (FDG SUV) measured by quantitative positron emission tomography (PET) imaging. Biomed Pharmacother. 2017 Apr; 88:1038-1045. PMID: 28192877.
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    40. Ferreira CA, Fuscaldi LL, Townsend DM, Rubello D, Barros ALB. Radiolabeled bombesin derivatives for preclinical oncological imaging. Biomed Pharmacother. 2017 Mar; 87:58-72. PMID: 28040598.
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    41. Mazza A, Lenti S, Schiavon L, Monte AD, Townsend DM, Ramazzina E, Rubello D, Casiglia E. Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population. Biomed Pharmacother. 2017 Feb; 86:590-594. PMID: 28027534.
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    42. Zane M, Parello C, Pennelli G, Townsend DM, Merigliano S, Boscaro M, Toniato A, Baggio G, Pelizzo MR, Rubello D, Boschin IM. Estrogen and thyroid cancer is a stem affair: A preliminary study. Biomed Pharmacother. 2017 Jan; 85:399-411. PMID: 27899250.
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    43. McMillan DH, van der Velden JL, Lahue KG, Qian X, Schneider RW, Iberg MS, Nolin JD, Abdalla S, Casey DT, Tew KD, Townsend DM, Henderson CJ, Wolf CR, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, van der Vliet A, Flemer S, Anathy V, Janssen-Heininger YM. Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase p. JCI Insight. 2016 Jun 02; 1(8). PMID: 27358914.
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    44. Manevich Y, Reyes L, Britten CD, Townsend DM, Tew KD. Redox Signaling and Bioenergetics Influence Lung Cancer Cell Line Sensitivity to the Isoflavone ME-344. J Pharmacol Exp Ther. 2016 08; 358(2):199-208. PMID: 27255112.
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    45. van Gisbergen MW, Cebula M, Zhang J, Ottosson-Wadlund A, Dubois L, Lambin P, Tew KD, Townsend DM, Haenen GR, Drittij-Reijnders MJ, Saneyoshi H, Araki M, Shishido Y, Ito Y, Arnér ES, Abe H, Morgenstern R, Johansson K. Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells. Mol Pharm. 2016 06 06; 13(6):2010-25. PMID: 27093577.
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    46. Jones JT, Qian X, van der Velden JL, Chia SB, McMillan DH, Flemer S, Hoffman SM, Lahue KG, Schneider RW, Nolin JD, Anathy V, van der Vliet A, Townsend DM, Tew KD, Janssen-Heininger YM. Glutathione S-transferase pi modulates NF-?B activation and pro-inflammatory responses in lung epithelial cells. Redox Biol. 2016 08; 8:375-82. PMID: 27058114.
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    47. Ye ZW, Zhang J, Ancrum T, Manevich Y, Townsend DM, Tew KD. Glutathione S-Transferase P-Mediated Protein S-Glutathionylation of Resident Endoplasmic Reticulum Proteins Influences Sensitivity to Drug-Induced Unfolded Protein Response. Antioxid Redox Signal. 2017 02 20; 26(6):247-261. PMID: 26838680.
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    48. Kenche H, Ye ZW, Vedagiri K, Richards DM, Gao XH, Tew KD, Townsend DM, Blumental-Perry A. Adverse Outcomes Associated with Cigarette Smoke Radicals Related to Damage to Protein-disulfide Isomerase. J Biol Chem. 2016 Feb 26; 291(9):4763-78. PMID: 26728460.
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    49. Ye ZW, Zhang J, Townsend DM, Tew KD. Oxidative stress, redox regulation and diseases of cellular differentiation. Biochim Biophys Acta. 2015 Aug; 1850(8):1607-21. PMID: 25445706.
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    50. Zhang J, Ye ZW, Gao P, Reyes L, Jones EE, Branham-O'Connor M, Blumer JB, Drake RR, Manevich Y, Townsend DM, Tew KD. Glutathione S-transferase P influences redox and migration pathways in bone marrow. PLoS One. 2014; 9(9):e107478. PMID: 25216273.
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    51. Grek CL, Reyes L, Townsend DM, Tew KD. S-glutathionylation of buccal cell proteins as biomarkers of exposure to hydrogen peroxide. BBA Clin. 2014 Dec; 2:31-9. PMID: 26673080.
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    52. Qanungo S, Uys JD, Manevich Y, Distler AM, Shaner B, Hill EG, Mieyal JJ, Lemasters JJ, Townsend DM, Nieminen AL. N-acetyl-L-cysteine sensitizes pancreatic cancers to gemcitabine by targeting the NF?B pathway. Biomed Pharmacother. 2014 Sep; 68(7):855-64. PMID: 25257100.
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    53. Uys JD, Mulholland PJ, Townsend DM. Glutathione and redox signaling in substance abuse. Biomed Pharmacother. 2014 Jul; 68(6):799-807. PMID: 25027386.
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    54. Townsend DM, Lushchak VI, Cooper AJ. A comparison of reversible versus irreversible protein glutathionylation. Adv Cancer Res. 2014; 122:177-98. PMID: 24974182.
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    55. Zhang J, Grek C, Ye ZW, Manevich Y, Tew KD, Townsend DM. Pleiotropic functions of glutathione S-transferase P. Adv Cancer Res. 2014; 122:143-75. PMID: 24974181.
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    56. Grek CL, Zhang J, Manevich Y, Townsend DM, Tew KD. Causes and consequences of cysteine S-glutathionylation. J Biol Chem. 2013 Sep 13; 288(37):26497-504. PMID: 23861399.
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    57. Maldonado EN, Sheldon KL, DeHart DN, Patnaik J, Manevich Y, Townsend DM, Bezrukov SM, Rostovtseva TK, Lemasters JJ. Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin. J Biol Chem. 2013 Apr 26; 288(17):11920-9. PMID: 23471966.
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    58. Bowers RR, Manevich Y, Townsend DM, Tew KD. Sulfiredoxin redox-sensitive interaction with S100A4 and non-muscle myosin IIA regulates cancer cell motility. Biochemistry. 2012 Oct 02; 51(39):7740-54. PMID: 22934964.
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    59. Mack JT, Brown CB, Garrett TE, Uys JD, Townsend DM, Tew KD. Ablation of the ATP-binding cassette transporter, Abca2 modifies response to estrogen-based therapies. Biomed Pharmacother. 2012 Sep; 66(6):403-8. PMID: 22898081.
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    60. Tew KD, Townsend DM. Glutathione-s-transferases as determinants of cell survival and death. Antioxid Redox Signal. 2012 Dec 15; 17(12):1728-37. PMID: 22540427.
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    61. Xiong Y, Manevich Y, Tew KD, Townsend DM. S-Glutathionylation of Protein Disulfide Isomerase Regulates Estrogen Receptor a Stability and Function. Int J Cell Biol. 2012; 2012:273549. PMID: 22654912.
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    62. Grek CL, Townsend DM, Uys JD, Manevich Y, Coker WJ, Pazoles CJ, Tew KD. S-glutathionylated serine proteinase inhibitors as plasma biomarkers in assessing response to redox-modulating drugs. Cancer Res. 2012 May 01; 72(9):2383-93. PMID: 22406622.
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    63. Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-ß production by altering Nicastrin maturation and intracellular localization. J Biol Chem. 2012 Jan 06; 287(2):1100-11. PMID: 22086926.
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    64. Uys JD, Knackstedt L, Hurt P, Tew KD, Manevich Y, Hutchens S, Townsend DM, Kalivas PW. Cocaine-induced adaptations in cellular redox balance contributes to enduring behavioral plasticity. Neuropsychopharmacology. 2011 Nov; 36(12):2551-60. PMID: 21796101.
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    65. Xiong Y, Uys JD, Tew KD, Townsend DM. S-glutathionylation: from molecular mechanisms to health outcomes. Antioxid Redox Signal. 2011 Jul 01; 15(1):233-70. PMID: 21235352.
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    66. Tew KD, Manevich Y, Grek C, Xiong Y, Uys J, Townsend DM. The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer. Free Radic Biol Med. 2011 Jul 15; 51(2):299-313. PMID: 21558000.
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    67. Tew KD, Townsend DM. Regulatory functions of glutathione S-transferase P1-1 unrelated to detoxification. Drug Metab Rev. 2011 May; 43(2):179-93. PMID: 21351850.
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    68. Uys JD, Xiong Y, Townsend DM. Nitrosative stress-induced S-glutathionylation of protein disulfide isomerase. Methods Enzymol. 2011; 490:321-32. PMID: 21266258.
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    69. Manevich Y, Townsend DM, Hutchens S, Tew KD. Diazeniumdiolate mediated nitrosative stress alters nitric oxide homeostasis through intracellular calcium and S-glutathionylation of nitric oxide synthetase. PLoS One. 2010 Nov 30; 5(11):e14151. PMID: 21152397.
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    70. Tew KD, Townsend DM. Redox platforms in cancer drug discovery and development. Curr Opin Chem Biol. 2011 Feb; 15(1):156-61. PMID: 21075043.
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    71. Mack JT, Helke KL, Normand G, Green C, Townsend DM, Tew KD. ABCA2 transporter deficiency reduces incidence of TRAMP prostate tumor metastasis and cellular chemotactic migration. Cancer Lett. 2011 Jan 28; 300(2):154-61. PMID: 21041019.
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    72. Grek CL, Townsend DM, Tew KD. The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies. Pharmacol Ther. 2011 Feb; 129(2):172-84. PMID: 20951732.
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    73. Goetzl L, Manevich Y, Roedner C, Praktish A, Hebbar L, Townsend DM. Maternal and fetal oxidative stress and intrapartum term fever. Am J Obstet Gynecol. 2010 Apr; 202(4):363.e1-5. PMID: 20350644.
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    74. Lenna S, Townsend DM, Tan FK, Kapanadze B, Markiewicz M, Trojanowska M, Scorza R. HLA-B35 upregulates endothelin-1 and downregulates endothelial nitric oxide synthase via endoplasmic reticulum stress response in endothelial cells. J Immunol. 2010 May 01; 184(9):4654-61. PMID: 20335527.
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    75. Hutchens S, Manevich Y, He L, Tew KD, Townsend DM. Cellular resistance to a nitric oxide releasing glutathione S-transferase P-activated prodrug, PABA/NO. Invest New Drugs. 2011 Oct; 29(5):719-29. PMID: 20232108.
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    76. Spassieva SD, Mullen TD, Townsend DM, Obeid LM. Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response. Biochem J. 2009 Nov 11; 424(2):273-83. PMID: 19728861.
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    77. Jenderny S, Lin H, Garrett T, Tew KD, Townsend DM. Protective effects of a glutathione disulfide mimetic (NOV-002) against cisplatin induced kidney toxicity. Biomed Pharmacother. 2010 Jan; 64(1):73-6. PMID: 19896793.
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    78. Townsend DM, Manevich Y, He L, Xiong Y, Bowers RR, Hutchens S, Tew KD. Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response. Cancer Res. 2009 Oct 01; 69(19):7626-34. PMID: 19773442.
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    79. Hanigan MH, Townsend DM, Cooper AJ. Metabolism of cisplatin to a nephrotoxin. Toxicology. 2009 Mar 29; 257(3):174-5; author reply 176-7. PMID: 19135119.
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    80. Townsend DM, Manevich Y, He L, Hutchens S, Pazoles CJ, Tew KD. Novel role for glutathione S-transferase pi. Regulator of protein S-Glutathionylation following oxidative and nitrosative stress. J Biol Chem. 2009 Jan 02; 284(1):436-445. PMID: 18990698.
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    81. Townsend DM, Tew KD. Pharmacology of a mimetic of glutathione disulfide, NOV-002. Biomed Pharmacother. 2009 Feb; 63(2):75-8. PMID: 18851905.
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    82. Townsend DM, Tew KD, He L, King JB, Hanigan MH. Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity. Biomed Pharmacother. 2009 Feb; 63(2):79-85. PMID: 18819770.
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    83. Townsend DM, Pazoles CJ, Tew KD. NOV-002, a mimetic of glutathione disulfide. Expert Opin Investig Drugs. 2008 Jul; 17(7):1075-83. PMID: 18549343.
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    84. Townsend DM, He L, Hutchens S, Garrett TE, Pazoles CJ, Tew KD. NOV-002, a glutathione disulfide mimetic, as a modulator of cellular redox balance. Cancer Res. 2008 Apr 15; 68(8):2870-7. PMID: 18413755.
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    85. Townsend DM. S-glutathionylation: indicator of cell stress and regulator of the unfolded protein response. Mol Interv. 2007 Dec; 7(6):313-24. PMID: 18199853.
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    86. Mack JT, Townsend DM, Beljanski V, Tew KD. The ABCA2 transporter: intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds. Curr Drug Metab. 2007 Jan; 8(1):47-57. PMID: 17266523.
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    87. Mack JT, Beljanski V, Soulika AM, Townsend DM, Brown CB, Davis W, Tew KD. "Skittish" Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system. Mol Cell Biol. 2007 Jan; 27(1):44-53. PMID: 17060448.
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    88. Findlay VJ, Townsend DM, Morris TE, Fraser JP, He L, Tew KD. A novel role for human sulfiredoxin in the reversal of glutathionylation. Cancer Res. 2006 Jul 01; 66(13):6800-6. PMID: 16818657.
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    89. Saavedra JE, Srinivasan A, Buzard GS, Davies KM, Waterhouse DJ, Inami K, Wilde TC, Citro ML, Cuellar M, Deschamps JR, Parrish D, Shami PJ, Findlay VJ, Townsend DM, Tew KD, Singh S, Jia L, Ji X, Keefer LK. PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity. J Med Chem. 2006 Feb 09; 49(3):1157-64. PMID: 16451080.
      Citations:    
    90. Townsend DM, Findlay VJ, Fazilev F, Ogle M, Fraser J, Saavedra JE, Ji X, Keefer LK, Tew KD. A glutathione S-transferase pi-activated prodrug causes kinase activation concurrent with S-glutathionylation of proteins. Mol Pharmacol. 2006 Feb; 69(2):501-8. PMID: 16288082.
      Citations:    
    91. Tucker JM, Lipatova Z, Beljanski V, Townsend DM, Tew KD. Evaluation of lipophilins as determinants of tumor cell response to estramustine. J Pharmacol Exp Ther. 2005 Dec; 315(3):1158-62. PMID: 16120813.
      Citations:    
    92. Findlay VJ, Tapiero H, Townsend DM. Sulfiredoxin: a potential therapeutic agent? Biomed Pharmacother. 2005 Aug; 59(7):374-9. PMID: 16102934.
      Citations:    
    93. Beljanski V, Soulika A, Tucker JM, Townsend DM, Davis W, Tew KD. Characterization of the ATPase activity of human ATP-binding cassette transporter-2 (ABCA2). In Vivo. 2005 Jul-Aug; 19(4):657-60. PMID: 15999530.
      Citations:    
    94. Townsend DM, Findlay VL, Tew KD. Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets. Methods Enzymol. 2005; 401:287-307. PMID: 16399394.
      Citations:    
    95. Tew KD, Boyd JT, Chen ZJ, Davis W, Fazilev F, Findlay V, Gaté L, Ile K, Soulika A, Townsend DM. Glutathione and ABC transporters as determinants of sensitivity to oxidative and nitrosative stress. J Nutr. 2004 Nov; 134(11):3205S-3206S. PMID: 15514308.
      Citations:    
    96. Findlay VJ, Townsend DM, Saavedra JE, Buzard GS, Citro ML, Keefer LK, Ji X, Tew KD. Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug. Mol Pharmacol. 2004 May; 65(5):1070-9. PMID: 15102935.
      Citations:    
    97. Tapiero H, Townsend DM, Tew KD. Organosulfur compounds from alliaceae in the prevention of human pathologies. Biomed Pharmacother. 2004 Apr; 58(3):183-93. PMID: 15164729.
      Citations:    
    98. Townsend DM, Tew KD, Tapiero H. Sulfur containing amino acids and human disease. Biomed Pharmacother. 2004 Jan; 58(1):47-55. PMID: 14739061.
      Citations:    
    99. Townsend DM, Tew KD. The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene. 2003 Oct 20; 22(47):7369-75. PMID: 14576844.
      Citations:    
    100. Townsend DM, Marto JA, Deng M, Macdonald TJ, Hanigan MH. High pressure liquid chromatography and mass spectrometry characterization of the nephrotoxic biotransformation products of Cisplatin. Drug Metab Dispos. 2003 Jun; 31(6):705-13. PMID: 12756201.
      Citations:    
    101. Townsend DM, Tew KD, Tapiero H. The importance of glutathione in human disease. Biomed Pharmacother. 2003 May-Jun; 57(3-4):145-55. PMID: 12818476.
      Citations:    
    102. Townsend D, Tew K. Cancer drugs, genetic variation and the glutathione-S-transferase gene family. Am J Pharmacogenomics. 2003; 3(3):157-72. PMID: 12814324.
      Citations:    
    103. Townsend DM, Deng M, Zhang L, Lapus MG, Hanigan MH. Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells. J Am Soc Nephrol. 2003 Jan; 14(1):1-10. PMID: 12506132.
      Citations:    
    104. Townsend DM, Shen H, Staros AL, Gaté L, Tew KD. Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer cells. . 2002 Oct; 1(12):1089-95. PMID: 12481432.
      Citations:    
    105. Townsend DM, Hanigan MH. Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice. J Pharmacol Exp Ther. 2002 Jan; 300(1):142-8. PMID: 11752109.
      Citations:    
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