Dan T Simionescu

TitleAssociate Professor
InstitutionClemson University
DepartmentDepartment of Bioengineering
Address301 Rhodes Hall
Clemson, South Carolina 29634
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    1. Madjarov JM, Katz MG, Fazal S, Simionescu DT. External wrapping of ascending aortic dissection with intramural hematoma. J Thorac Cardiovasc Surg. 2021 Mar 05. PMID: 33685730.
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    2. Al Hussein H, Al Hussein H, Sircuta C, Cotoi OS, Movileanu I, Nistor D, Cordos B, Deac R, Suciu H, Brinzaniuc K, Simionescu DT, Harpa MM. Challenges in Perioperative Animal Care for Orthotopic Implantation of Tissue-Engineered Pulmonary Valves in the Ovine Model. Tissue Eng Regen Med. 2020 12; 17(6):847-862. PMID: 32860183.
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    3. Lutter G, Dai H, Hansen JH, Frank D, Haneya A, Simionescu D, Cremer J, Puehler T. Transcatheter mitral valve replacement (TMVR): annular or apical fixation? EuroIntervention. 2020 Aug 07; 16(6):e510-e517. PMID: 31793883.
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    4. Filippi A, Constantin A, Alexandru N, Voicu G, Constantinescu CA, Rebleanu D, Fenyo M, Simionescu D, Simionescu A, Manduteanu I, Georgescu A. Integrins a4ß1 and aVß3 are Reduced in Endothelial Progenitor Cells from Diabetic Dyslipidemic Mice and May Represent New Targets for Therapy in Aortic Valve Disease. Cell Transplant. 2020 Jan-Dec; 29:963689720946277. PMID: 32841051.
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    5. Tucureanu MM, Filippi A, Alexandru N, Ana Constantinescu C, Ciortan L, Macarie R, Vadana M, Voicu G, Frunza S, Nistor D, Simionescu A, Simionescu DT, Georgescu A, Manduteanu I. Diabetes-induced early molecular and functional changes in aortic heart valves in a murine model of atherosclerosis. Diab Vasc Dis Res. 2019 11; 16(6):562-576. PMID: 31530180.
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    6. Patnaik SS, Simionescu DT, Goergen CJ, Hoyt K, Sirsi S, Finol EA. Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics. Ann Biomed Eng. 2019 Jan; 47(1):39-59. PMID: 30298373.
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    7. Haupt J, Lutter G, Gorb SN, Simionescu DT, Frank D, Seiler J, Paur A, Haben I. Detergent-based decellularization strategy preserves macro- and microstructure of heart valves. Interact Cardiovasc Thorac Surg. 2018 02 01; 26(2):230-236. PMID: 29155942.
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    8. Movileanu L, Harpa M, Branzaniuc K, Suciu H, Cotoi OS, Olah P, Simionescu D. A Standardized Dissection Protocol to Generate Aortic Valvular Scaffolds from Porcine Hearts. Acta Med Marisiensis. 2017 Sep; 63(3):133-135. PMID: 31080636.
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    9. Casco M, Olsen T, Herbst A, Evans G, Rothermel T, Pruett L, Simionescu D, Visconti R, Alexis F. Iron Oxide Nanoparticles Stimulates Extra-Cellular Matrix Production in Cellular Spheroids. Bioengineering (Basel). 2017 Jan 21; 4(1). PMID: 28952483.
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    10. Chow JP, Simionescu DT, Carter AL, Simionescu A. Immunomodulatory effects of adipose tissue-derived stem cells on elastin scaffold remodeling in diabetes. Tissue Eng Regen Med. 2016 Dec; 13(6):701-712. PMID: 30603451.
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    11. Olsen TR, Casco M, Herbst A, Evans G, Rothermel T, Pruett L, Reid J, Barry K, Jaeggli MP, Simionescu DT, Visconti RP, Alexis F. Longitudinal Stretching for Maturation of Vascular Tissues Using Magnetic Forces. Bioengineering (Basel). 2016 Nov 16; 3(4). PMID: 28952591.
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    12. Kennamer A, Sierad L, Pascal R, Rierson N, Albers C, Harpa M, Cotoi O, Harceaga L, Olah P, Terezia P, Simionescu A, Simionescu D. Bioreactor Conditioning of Valve Scaffolds Seeded Internally with Adult Stem Cells. Tissue Eng Regen Med. 2016 Oct; 13(5):507-515. PMID: 30337944.
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    13. Harpa M, Movileanu I, Sierad L, Cotoi O, Suciu H, Preda T, Nistor D, Sircuta C, Brânzaniuc K, Deac R, Gurzu S, Harceaga L, Olah P, Simionescu D, Dandel M, Simionescu A. In Vivo Testing of Xenogeneic Acellular Aortic Valves Seeded with Stem Cells. Rev Rom Med Lab. 2016 Sep; 24(3):343-346. PMID: 31098341.
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    14. Deborde C, Simionescu DT, Wright C, Liao J, Sierad LN, Simionescu A. Stabilized Collagen and Elastin-Based Scaffolds for Mitral Valve Tissue Engineering. Tissue Eng Part A. 2016 11; 22(21-22):1241-1251. PMID: 27608885.
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    15. Sierad LN, Shaw EL, Bina A, Brazile B, Rierson N, Patnaik SS, Kennamer A, Odum R, Cotoi O, Terezia P, Branzaniuc K, Smallwood H, Deac R, Egyed I, Pavai Z, Szanto A, Harceaga L, Suciu H, Raicea V, Olah P, Simionescu A, Liao J, Movileanu I, Harpa M, Simionescu DT. Functional Heart Valve Scaffolds Obtained by Complete Decellularization of Porcine Aortic Roots in a Novel Differential Pressure Gradient Perfusion System. Tissue Eng Part C Methods. 2015 Dec; 21(12):1284-96. PMID: 26467108.
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    16. Koleilat I, Jaeggli M, Ewing JA, Androes M, Simionescu DT, Eidt J. Interobserver variability in physician-modified endograft planning by comparison with a three-dimensional printed aortic model. J Vasc Surg. 2016 Dec; 64(6):1789-1796. PMID: 26607872.
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    17. Fercana G, Bowser D, Portilla M, Langan EM, Carsten CG, Cull DL, Sierad LN, Simionescu DT. Platform technologies for decellularization, tunic-specific cell seeding, and in vitro conditioning of extended length, small diameter vascular grafts. Tissue Eng Part C Methods. 2014 Dec; 20(12):1016-27. PMID: 24749889.
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    18. Pennel T, Fercana G, Bezuidenhout D, Simionescu A, Chuang TH, Zilla P, Simionescu D. The performance of cross-linked acellular arterial scaffolds as vascular grafts; pre-clinical testing in direct and isolation loop circulatory models. Biomaterials. 2014 Aug; 35(24):6311-22. PMID: 24816365.
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    19. Mercuri J, Addington C, Pascal R, Gill S, Simionescu D. Development and initial characterization of a chemically stabilized elastin-glycosaminoglycan-collagen composite shape-memory hydrogel for nucleus pulposus regeneration. J Biomed Mater Res A. 2014 Dec; 102(12):4380-93. PMID: 24497431.
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    20. Mattix BM, Olsen TR, Casco M, Reese L, Poole JT, Zhang J, Visconti RP, Simionescu A, Simionescu DT, Alexis F. Janus magnetic cellular spheroids for vascular tissue engineering. Biomaterials. 2014 Jan; 35(3):949-60. PMID: 24183699.
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    21. Mattix B, Olsen TR, Gu Y, Casco M, Herbst A, Simionescu DT, Visconti RP, Kornev KG, Alexis F. Biological magnetic cellular spheroids as building blocks for tissue engineering. Acta Biomater. 2014 Feb; 10(2):623-9. PMID: 24176725.
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    22. Schulte JB, Simionescu A, Simionescu DT. The acellular myocardial flap: a novel extracellular matrix scaffold enriched with patent microvascular networks and biocompatible cell niches. Tissue Eng Part C Methods. 2013 Jul; 19(7):518-30. PMID: 23151037.
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    23. Mercuri JJ, Patnaik S, Dion G, Gill SS, Liao J, Simionescu DT. Regenerative potential of decellularized porcine nucleus pulposus hydrogel scaffolds: stem cell differentiation, matrix remodeling, and biocompatibility studies. Tissue Eng Part A. 2013 Apr; 19(7-8):952-66. PMID: 23140227.
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    24. Chow JP, Simionescu DT, Warner H, Wang B, Patnaik SS, Liao J, Simionescu A. Mitigation of diabetes-related complications in implanted collagen and elastin scaffolds using matrix-binding polyphenol. Biomaterials. 2013 Jan; 34(3):685-95. PMID: 23103157.
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    25. Simionescu DT, Chen J, Jaeggli M, Wang B, Liao J. Form Follows Function: Advances in Trilayered Structure Replication for Aortic Heart Valve Tissue Engineering. J Healthc Eng. 2012 Jun; 3(2):179-202. PMID: 23355946.
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    26. Wang B, Tedder ME, Perez CE, Wang G, de Jongh Curry AL, To F, Elder SH, Williams LN, Simionescu DT, Liao J. Structural and biomechanical characterizations of porcine myocardial extracellular matrix. J Mater Sci Mater Med. 2012 Aug; 23(8):1835-47. PMID: 22584822.
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    27. Simionescu A, Schulte JB, Fercana G, Simionescu DT. Inflammation in cardiovascular tissue engineering: the challenge to a promise: a minireview. Int J Inflam. 2011; 2011:958247. PMID: 21755031.
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    28. Simionescu A, Tedder ME, Chuang TH, Simionescu DT. Lectin and antibody-based histochemical techniques for cardiovascular tissue engineering. J Histotechnol. 2011 Mar; 34(1):20-28. PMID: 25620822.
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    29. Mercuri JJ, Gill SS, Simionescu DT. Novel tissue-derived biomimetic scaffold for regenerating the human nucleus pulposus. J Biomed Mater Res A. 2011 Feb; 96(2):422-35. PMID: 21171162.
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    30. Ariganello MB, Simionescu DT, Labow RS, Lee JM. Macrophage differentiation and polarization on a decellularized pericardial biomaterial. Biomaterials. 2011 Jan; 32(2):439-49. PMID: 20933269.
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    31. Wang B, Borazjani A, Tahai M, Curry AL, Simionescu DT, Guan J, To F, Elder SH, Liao J. Fabrication of cardiac patch with decellularized porcine myocardial scaffold and bone marrow mononuclear cells. J Biomed Mater Res A. 2010 Sep 15; 94(4):1100-10. PMID: 20694977.
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    32. Tedder ME, Simionescu A, Chen J, Liao J, Simionescu DT. Assembly and testing of stem cell-seeded layered collagen constructs for heart valve tissue engineering. Tissue Eng Part A. 2011 Jan; 17(1-2):25-36. PMID: 20673028.
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    33. Sierad LN, Simionescu A, Albers C, Chen J, Maivelett J, Tedder ME, Liao J, Simionescu DT. Design and Testing of a Pulsatile Conditioning System for Dynamic Endothelialization of Polyphenol-Stabilized Tissue Engineered Heart Valves. Cardiovasc Eng Technol. 2010 Jun; 1(2):138-153. PMID: 21340043.
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    34. Luszczyn J, Plonska-Brzezinska ME, Palkar A, Dubis AT, Simionescu A, Simionescu DT, Kalska-Szostko B, Winkler K, Echegoyen L. Small noncytotoxic carbon nano-onions: first covalent functionalization with biomolecules. Chemistry. 2010 Apr 26; 16(16):4870-80. PMID: 20340115.
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    35. Chuang TH, Stabler C, Simionescu A, Simionescu DT. Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts. Tissue Eng Part A. 2009 Oct; 15(10):2837-51. PMID: 19254115.
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    36. Tedder ME, Liao J, Weed B, Stabler C, Zhang H, Simionescu A, Simionescu DT. Stabilized collagen scaffolds for heart valve tissue engineering. Tissue Eng Part A. 2009 Jun; 15(6):1257-68. PMID: 18928400.
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    37. Simionescu A, Simionescu DT, Vyavahare NR. Osteogenic responses in fibroblasts activated by elastin degradation products and transforming growth factor-beta1: role of myofibroblasts in vascular calcification. Am J Pathol. 2007 Jul; 171(1):116-23. PMID: 17591959.
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    38. Isenburg JC, Simionescu DT, Starcher BC, Vyavahare NR. Elastin stabilization for treatment of abdominal aortic aneurysms. Circulation. 2007 Apr 03; 115(13):1729-37. PMID: 17372168.
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    39. Raghavan D, Simionescu DT, Vyavahare NR. Neomycin prevents enzyme-mediated glycosaminoglycan degradation in bioprosthetic heart valves. Biomaterials. 2007 Jun; 28(18):2861-8. PMID: 17353047.
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    40. Kurane A, Simionescu DT, Vyavahare NR. In vivo cellular repopulation of tubular elastin scaffolds mediated by basic fibroblast growth factor. Biomaterials. 2007 Jun; 28(18):2830-8. PMID: 17368531.
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    41. Simpson CL, Lindley S, Eisenberg C, Basalyga DM, Starcher BC, Simionescu DT, Vyavahare NR. Toward cell therapy for vascular calcification: osteoclast-mediated demineralization of calcified elastin. Cardiovasc Pathol. 2007 Jan-Feb; 16(1):29-37. PMID: 17218212.
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    42. Mercuri JJ, Lovekamp JJ, Simionescu DT, Vyavahare NR. Glycosaminoglycan-targeted fixation for improved bioprosthetic heart valve stabilization. Biomaterials. 2007 Jan; 28(3):496-503. PMID: 17030363.
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    43. Isenburg JC, Karamchandani NV, Simionescu DT, Vyavahare NR. Structural requirements for stabilization of vascular elastin by polyphenolic tannins. Biomaterials. 2006 Jul; 27(19):3645-51. PMID: 16527345.
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    44. Lee JS, Basalyga DM, Simionescu A, Isenburg JC, Simionescu DT, Vyavahare NR. Elastin calcification in the rat subdermal model is accompanied by up-regulation of degradative and osteogenic cellular responses. Am J Pathol. 2006 Feb; 168(2):490-8. PMID: 16436663.
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    45. Lovekamp JJ, Simionescu DT, Mercuri JJ, Zubiate B, Sacks MS, Vyavahare NR. Stability and function of glycosaminoglycans in porcine bioprosthetic heart valves. Biomaterials. 2006 Mar; 27(8):1507-18. PMID: 16144707.
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    46. Kasyanov V, Isenburg J, Draughn RA, Hazard S, Hodde J, Ozolanta I, Murovska M, Halkes SB, Vrasidas I, Liskamp RM, Pieters RJ, Simionescu D, Markwald RR, Mironov V. Tannic acid mimicking dendrimers as small intestine submucosa stabilizing nanomordants. Biomaterials. 2006 Feb; 27(5):745-51. PMID: 16102811.
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    47. Simionescu DT, Lu Q, Song Y, Lee JS, Rosenbalm TN, Kelley C, Vyavahare NR. Biocompatibility and remodeling potential of pure arterial elastin and collagen scaffolds. Biomaterials. 2006 Feb; 27(5):702-13. PMID: 16048731.
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    48. Isenburg JC, Simionescu DT, Vyavahare NR. Tannic acid treatment enhances biostability and reduces calcification of glutaraldehyde fixed aortic wall. Biomaterials. 2005 Apr; 26(11):1237-45. PMID: 15475053.
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    49. Simionescu DT. Prevention of calcification in bioprosthetic heart valves: challenges and perspectives. Expert Opin Biol Ther. 2004 Dec; 4(12):1971-85. PMID: 15571459.
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    50. Basalyga DM, Simionescu DT, Xiong W, Baxter BT, Starcher BC, Vyavahare NR. Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinases. Circulation. 2004 Nov 30; 110(22):3480-7. PMID: 15545515.
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    51. Lu Q, Ganesan K, Simionescu DT, Vyavahare NR. Novel porous aortic elastin and collagen scaffolds for tissue engineering. Biomaterials. 2004 Oct; 25(22):5227-37. PMID: 15110474.
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    52. Isenburg JC, Simionescu DT, Vyavahare NR. Elastin stabilization in cardiovascular implants: improved resistance to enzymatic degradation by treatment with tannic acid. Biomaterials. 2004 Jul; 25(16):3293-302. PMID: 14980424.
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    53. Bailey M, Pillarisetti S, Jones P, Xiao H, Simionescu D, Vyavahare N. Involvement of matrix metalloproteinases and tenascin-C in elastin calcification. Cardiovasc Pathol. 2004 May-Jun; 13(3):146-55. PMID: 15081471.
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    54. Simionescu DT, Lovekamp JJ, Vyavahare NR. Extracellular matrix degrading enzymes are active in porcine stentless aortic bioprosthetic heart valves. J Biomed Mater Res A. 2003 Sep 15; 66(4):755-63. PMID: 12926026.
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    55. Simionescu DT, Lovekamp JJ, Vyavahare NR. Glycosaminoglycan-degrading enzymes in porcine aortic heart valves: implications for bioprosthetic heart valve degeneration. J Heart Valve Dis. 2003 Mar; 12(2):217-25. PMID: 12701795.
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    56. Simionescu DT, Lovekamp JJ, Vyavahare NR. Degeneration of bioprosthetic heart valve cusp and wall tissues is initiated during tissue preparation: an ultrastructural study. J Heart Valve Dis. 2003 Mar; 12(2):226-34. PMID: 12701796.
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