Constance Guille

Title
InstitutionMedical University of South Carolina
DepartmentPsychiatry and Behavioral Sciences
AddressP.O. Box MSC 861
5 South
100 Doughty St.
Phone843-792-6489
Fax843-792-3388
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    Constance Guille, M.D., is an Assistant Professor of Psychiatry at the Medical University of South Carolina. She completed her Psychiatry Residency Training at Yale University where she was a program-wide Chief Resident and Chief Resident on the Clinical Neuroscience Research Unit. She received additional training at Yale University in the sub-specialty of Perinatal Psychiatry before arriving at MUSC where she completed a brief post-doctoral research fellowship at the National Crime Victims Research and Treatment Center. Dr. Guille recently received a BIRCWH (Building Interdisciplinary Research Careers in Women’s Health) career development award and has transitioned her research into the area of Perinatal Psychiatry investigating biological markers of postpartum depression. Dr. Guille is an early career investigator, educator and practitioner. Her clinical practice focuses on the management of mental health problems in pregnancy and postpartum and provides educational opportunities for medical students and residents in this area.
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    Depression, Genetics, Hormones, Metabolism, Post Partum Depression, Psychiatry, Women-s Health, Immune System, Pain, Pregnancy

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rotenstein LS, Torre M, Cleary JL, Sen S, Guille C, Mata DA. Differences in Gender Representation in the Altmetric Top 100. J Gen Intern Med. 2021 May 04. PMID: 33945112.
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    2. Guille C. Rate of Suicide Among Women Nurses Compared With Women in the General Population Before the COVID-19 Global Pandemic. JAMA Psychiatry. 2021 Apr 14. PMID: 33851990.
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    3. Guille C, McCauley JL, Moreland A. Leveraging Telehealth in the United States to Increase Access to Opioid Use Disorder Treatment in Pregnancy and Postpartum During the COVID-19 Pandemic. Am J Psychiatry. 2021 04 01; 178(4):290-293. PMID: 33789451.
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    4. Summers RF, Gorrindo T, Hwang S, Aggarwal R, Guille C. Psychiatrist Burnout: Response to Schonfeld and Bianchi. Am J Psychiatry. 2021 02 01; 178(2):204-205. PMID: 33517753.
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    5. Moreland A, Guille C, McCauley JL. Increased availability of telehealth mental health and substance abuse treatment for peripartum and postpartum women: A unique opportunity to increase telehealth treatment. J Subst Abuse Treat. 2021 04; 123:108268. PMID: 33612199.
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    6. Summers RF, Gorrindo T, Hwang S, Aggarwal R, Guille C. Well-Being, Burnout, and Depression Among North American Psychiatrists: The State of Our Profession. Am J Psychiatry. 2020 10 01; 177(10):955-964. PMID: 32660300.
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    7. Carroll AJ, Jaffe AE, Stanton K, Guille C, Lazenby GB, Soper DE, Gilmore AK, Holland-Carter L. Program Evaluation of an Integrated Behavioral Health Clinic in an Outpatient Women's Health Clinic: Challenges and Considerations. J Clin Psychol Med Settings. 2020 06; 27(2):207-216. PMID: 31858362.
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    8. Kalmbach DA, Cheng P, O'Brien LM, Swanson LM, Sangha R, Sen S, Guille C, Cuamatzi-Castelan A, Henry AL, Roth T, Drake CL. A randomized controlled trial of digital cognitive behavioral therapy for insomnia in pregnant women. Sleep Med. 2020 08; 72:82-92. PMID: 32559716.
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    9. Rotenstein LS, Zhao Z, Mata DA, Guille C, Sen S. Substantial Overlap Between Factors Predicting Symptoms of Depression and Burnout Among Medical Interns. J Gen Intern Med. 2021 01; 36(1):240-242. PMID: 32026254.
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    10. Zandi PP, Wang YH, Patel PD, Katzelnick D, Turvey CL, Wright JH, Ajilore O, Coryell W, Schneck CD, Guille C, Saunders EFH, Lazarus SA, Cuellar VA, Selvaraj S, Dill Rinvelt P, Greden JF, DePaulo JR. Development of the National Network of Depression Centers Mood Outcomes Program: A Multisite Platform for Measurement-Based Care. Psychiatr Serv. 2020 May 01; 71(5):456-464. PMID: 31960777.
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    11. Guille C, Simpson AN, Douglas E, Boyars L, Cristaldi K, McElligott J, Johnson D, Brady K. Treatment of Opioid Use Disorder in Pregnant Women via Telemedicine: A Nonrandomized Controlled Trial. JAMA Netw Open. 2020 01 03; 3(1):e1920177. PMID: 32003816.
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    12. Conradt E, Flannery T, Aschner JL, Annett RD, Croen LA, Duarte CS, Friedman AM, Guille C, Hedderson MM, Hofheimer JA, Jones MR, Ladd-Acosta C, McGrath M, Moreland A, Neiderhiser JM, Nguyen RHN, Posner J, Ross JL, Savitz DA, Ondersma SJ, Lester BM. Prenatal Opioid Exposure: Neurodevelopmental Consequences and Future Research Priorities. Pediatrics. 2019 09; 144(3). PMID: 31462446.
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    13. Frank E, Zhao Z, Sen S, Guille C. Gender Disparities in Work and Parental Status Among Early Career Physicians. JAMA Netw Open. 2019 08 02; 2(8):e198340. PMID: 31373646.
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    14. Moreland A, McCauley J, Barth K, Bogdon C, Killeen T, Haynes L, Jennings L, Guille C, Goldsby S, Brady K. Assessing the needs of front-line providers in addressing the opioid crisis in South Carolina. J Subst Abuse Treat. 2020 01; 108:4-8. PMID: 31303360.
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    15. Zhou Z, Bian C, Luo Z, Guille C, Ogunrinde E, Wu J, Zhao M, Fitting S, Kamen DL, Oates JC, Gilkeson G, Jiang W. Progesterone decreases gut permeability through upregulating occludin expression in primary human gut tissues and Caco-2 cells. Sci Rep. 2019 06 10; 9(1):8367. PMID: 31182728.
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    16. Pereira-Lima K, Gupta RR, Guille C, Sen S. Residency Program Factors Associated With Depressive Symptoms in Internal Medicine Interns: A Prospective Cohort Study. Acad Med. 2019 06; 94(6):869-875. PMID: 30570500.
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    17. Lazenby GB, Orr C, Guille C, Meissner EG. Increasing Prevalence of Chronic Hepatitis C Virus Infection in a Southern Academic Obstetrical Clinic. South Med J. 2019 06; 112(6):325-330. PMID: 31158887.
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    18. Kious BM, Bakian A, Zhao J, Mickey B, Guille C, Renshaw P, Sen S. Altitude and risk of depression and anxiety: findings from the intern health study. Int Rev Psychiatry. 2019 Nov - Dec; 31(7-8):637-645. PMID: 31084447.
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    19. Ridout KK, Ridout SJ, Guille C, Mata DA, Akil H, Sen S. Physician-Training Stress and Accelerated Cellular Aging. Biol Psychiatry. 2019 11 01; 86(9):725-730. PMID: 31230727.
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    20. Guille C, Aujla R. Developmental Consequences of Prenatal Substance Use in Children and Adolescents. J Child Adolesc Psychopharmacol. 2019 08; 29(7):479-486. PMID: 31038354.
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    21. Ecker J, Abuhamad A, Hill W, Bailit J, Bateman BT, Berghella V, Blake-Lamb T, Guille C, Landau R, Minkoff H, Prabhu M, Rosenthal E, Terplan M, Wright TE, Yonkers KA. Substance use disorders in pregnancy: clinical, ethical, and research imperatives of the opioid epidemic: a report of a joint workshop of the Society for Maternal-Fetal Medicine, American College of Obstetricians and Gynecologists, and American Society of Addiction Medicine. Am J Obstet Gynecol. 2019 07; 221(1):B5-B28. PMID: 30928567.
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    22. Gilmore AK, Guille C, Baker NL, Brady KT, Hahn CK, Davis CM, McCauley JL, Back SE. Gender differences in subjective stress and neuroendocrine response to a stress task among individuals with opioid dependence: A pilot study. Addict Behav. 2019 05; 92:148-154. PMID: 30640146.
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    23. Howell AN, Rheingold AA, Uhde TW, Guille C. Web-based CBT for the prevention of anxiety symptoms among medical and health science graduate students. Cogn Behav Ther. 2019 09; 48(5):385-405. PMID: 30526364.
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    24. Rotenstein LS, Torre M, Ramos MA, Rosales RC, Guille C, Sen S, Mata DA. Prevalence of Burnout Among Physicians: A Systematic Review. JAMA. 2018 09 18; 320(11):1131-1150. PMID: 30326495.
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    25. Boyars L, Guille C. Treatment of Perinatal Opioid Use Disorder. Obstet Gynecol Clin North Am. 2018 Sep; 45(3):511-524. PMID: 30092925.
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    26. Guille C, Newman RB. Treatment of Peripartum Mental Health Disorders: An Essential Element of Prenatal Care. Obstet Gynecol Clin North Am. 2018 09; 45(3):xv-xvi. PMID: 30092931.
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    27. Rosen T, Zivin K, Eisenberg D, Guille C, Sen S. The Cost of Depression-Related Presenteeism in Resident Physicians. Acad Psychiatry. 2018 Feb; 42(1):84-87. PMID: 29256035.
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    28. Guille C, Frank E, Zhao Z, Kalmbach DA, Nietert PJ, Mata DA, Sen S. Work-Family Conflict and the Sex Difference in Depression Among Training Physicians. JAMA Intern Med. 2017 12 01; 177(12):1766-1772. PMID: 29084311.
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    29. Zhou Z, Guille C, Ogunrinde E, Liu R, Luo Z, Powell A, Jiang W. Increased systemic microbial translocation is associated with depression during early pregnancy. J Psychiatr Res. 2018 02; 97:54-57. PMID: 29179013.
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    30. Buchanan C, Nahhas GJ, Guille C, Cummings KM, Wheeler C, McClure EA. Tobacco Use Prevalence and Outcomes Among Perinatal Patients Assessed Through an "Opt-out" Cessation and Follow-Up Clinical Program. Matern Child Health J. 2017 Sep; 21(9):1790-1797. PMID: 28702864.
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    31. Flynn HA, Spino C, Guille C, Deligiannidis KM, Maki P, Jahnke J, Rosenblum KL, Epperson CN, Weiss SJ. A Collaborative, Network-Based Approach to Advance Women's Depression Research in the United States: Preliminary Findings. J Womens Health (Larchmt). 2018 01; 27(1):51-57. PMID: 28727948.
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    32. Putnam KT, Wilcox M, Robertson-Blackmore E, Sharkey K, Bergink V, Munk-Olsen T, Deligiannidis KM, Payne J, Altemus M, Newport J, Apter G, Devouche E, Viktorin A, Magnusson P, Penninx B, Buist A, Bilszta J, O'Hara M, Stuart S, Brock R, Roza S, Tiemeier H, Guille C, Epperson CN, Kim D, Schmidt P, Martinez P, Di Florio A, Wisner KL, Stowe Z, Jones I, Sullivan PF, Rubinow D, Wildenhaus K, Meltzer-Brody S. Clinical phenotypes of perinatal depression and time of symptom onset: analysis of data from an international consortium. Lancet Psychiatry. 2017 06; 4(6):477-485. PMID: 28476427.
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    33. Grobman WA, Wing DA, Albert P, Kim S, Grewal J, Guille C, Newman R, Chien EK, Owen J, D'Alton ME, Wapner R, Sciscione A, Grantz KL. Maternal Depressive Symptoms, Perceived Stress, and Fetal Growth. J Ultrasound Med. 2017 Aug; 36(8):1639-1648. PMID: 28393386.
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    34. Barth KS, Guille C, McCauley J, Brady KT. Targeting practitioners: A review of guidelines, training, and policy in pain management. Drug Alcohol Depend. 2017 Apr 01; 173 Suppl 1:S22-S30. PMID: 28363316.
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    35. Guille C, Barth KS, Mateus J, McCauley JL, Brady KT. Treatment of Prescription Opioid Use Disorder in Pregnant Women. Am J Psychiatry. 2017 03 01; 174(3):208-214. PMID: 28245688.
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    36. Kalmbach DA, Arnedt JT, Song PX, Guille C, Sen S. Sleep Disturbance and Short Sleep as Risk Factors for Depression and Perceived Medical Errors in First-Year Residents. Sleep. 2017 03 01; 40(3). PMID: 28369654.
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    37. Rotenstein LS, Ramos MA, Torre M, Segal JB, Peluso MJ, Guille C, Sen S, Mata DA. Prevalence of Depression, Depressive Symptoms, and Suicidal Ideation Among Medical Students: A Systematic Review and Meta-Analysis. JAMA. 2016 Dec 06; 316(21):2214-2236. PMID: 27923088.
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    38. Guille C, Douglas E. Telephone delivery of interpersonal psychotherapy by certified nurse-midwives may help reduce symptoms of postpartum depression. Evid Based Nurs. 2017 01; 20(1):12-13. PMID: 27879285.
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    39. Tobin CD, Wilson SH, Hebbar L, Roberts LL, Wolf BJ, Guille C. Labor Epidural Analgesia and Postpartum Depression. Arch Depress Anxiety. 2017; 2(2):044-46. PMID: 32500106.
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    40. Mata DA, Ramos MA, Kim MM, Guille C, Sen S. In Their Own Words: An Analysis of the Experiences of Medical Interns Participating in a Prospective Cohort Study of Depression. Acad Med. 2016 09; 91(9):1244-50. PMID: 27166863.
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    41. Guille C, Zhao Z, Krystal J, Nichols B, Brady K, Sen S. Web-Based Cognitive Behavioral Therapy Intervention for the Prevention of Suicidal Ideation in Medical Interns: A Randomized Clinical Trial. Mo Med. 2016 Jan-Feb; 113(1):19. PMID: 30228438.
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    42. Mata DA, Ramos MA, Bansal N, Khan R, Guille C, Di Angelantonio E, Sen S. Prevalence of Depression and Depressive Symptoms Among Resident Physicians: A Systematic Review and Meta-analysis. JAMA. 2015 Dec 08; 314(22):2373-83. PMID: 26647259.
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    43. Guille C, Zhao Z, Krystal J, Nichols B, Brady K, Sen S. Web-Based Cognitive Behavioral Therapy Intervention for the Prevention of Suicidal Ideation in Medical Interns: A Randomized Clinical Trial. JAMA Psychiatry. 2015 Dec; 72(12):1192-8. PMID: 26535958.
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    44. Fried EI, Nesse RM, Guille C, Sen S. The differential influence of life stress on individual symptoms of depression. Acta Psychiatr Scand. 2015 Jun; 131(6):465-71. PMID: 25650176.
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    45. Sahlem GL, Kalivas B, Fox JB, Lamb K, Roper A, Williams EN, Williams NR, Korte JE, Zuschlag ZD, El Sabbagh S, Guille C, Barth KS, Uhde TW, George MS, Short EB. Adjunctive triple chronotherapy (combined total sleep deprivation, sleep phase advance, and bright light therapy) rapidly improves mood and suicidality in suicidal depressed inpatients: an open label pilot study. J Psychiatr Res. 2014 Dec; 59:101-7. PMID: 25231629.
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    46. Fried EI, Nesse RM, Zivin K, Guille C, Sen S. Depression is more than the sum score of its parts: individual DSM symptoms have different risk factors. Psychol Med. 2014 Jul; 44(10):2067-76. PMID: 24289852.
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    47. Guille C, Newman R, Fryml LD, Lifton CK, Epperson CN. Management of postpartum depression. J Midwifery Womens Health. 2013 Nov-Dec; 58(6):643-53. PMID: 24131708.
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    48. Grant F, Guille C, Sen S. Well-being and the risk of depression under stress. PLoS One. 2013; 8(7):e67395. PMID: 23840872.
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    49. Walsh K, Nugent NR, Kotte A, Amstadter AB, Wang S, Guille C, Acierno R, Kilpatrick DG, Resnick HS. Cortisol at the emergency room rape visit as a predictor of PTSD and depression symptoms over time. Psychoneuroendocrinology. 2013 Nov; 38(11):2520-8. PMID: 23806832.
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    50. Guille C, Epperson CN. Relapse of major depression in women who continue or discontinue antidepressant medication during pregnancy. Am J Psychiatry. 2013 May; 170(5):558. PMID: 23632837.
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    51. Sen S, Kranzler HR, Didwania AK, Schwartz AC, Amarnath S, Kolars JC, Dalack GW, Nichols B, Guille C. Effects of the 2011 duty hour reforms on interns and their patients: a prospective longitudinal cohort study. JAMA Intern Med. 2013 Apr 22; 173(8):657-62; discussion 663. PMID: 23529201.
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    52. Guille C, Clark S, Amstadter AB, Sen S. Trajectories of depressive symptoms in response to prolonged stress in medical interns. Acta Psychiatr Scand. 2014 Feb; 129(2):109-15. PMID: 23581856.
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    53. Guille C, Sen S. Prescription drug use and self-prescription among training physicians. Arch Intern Med. 2012 Feb 27; 172(4):371-2. PMID: 22371930.
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    54. Guille C, Speller H, Laff R, Epperson CN, Sen S. Utilization and barriers to mental health services among depressed medical interns: a prospective multisite study. J Grad Med Educ. 2010 Jun; 2(2):210-4. PMID: 21975622.
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    55. Sen S, Kranzler HR, Krystal JH, Speller H, Chan G, Gelernter J, Guille C. A prospective cohort study investigating factors associated with depression during medical internship. Arch Gen Psychiatry. 2010 Jun; 67(6):557-65. PMID: 20368500.
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    56. Guille C, Spencer S, Cavus I, Epperson CN. The role of sex steroids in catamenial epilepsy and premenstrual dysphoric disorder: implications for diagnosis and treatment. Epilepsy Behav. 2008 Jul; 13(1):12-24. PMID: 18346939.
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    57. Guille C, Sachs G. Clinical outcome of adjunctive topiramate treatment in a sample of refractory bipolar patients with comorbid conditions. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Oct; 26(6):1035-9. PMID: 12452523.
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    58. Sachs GS, Guille C, McMurrich SL. A clinical monitoring form for mood disorders. Bipolar Disord. 2002 Oct; 4(5):323-7. PMID: 12479665.
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