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C. James Chou

Title
InstitutionMedical University of South Carolina
DepartmentCOP Drug Discovery and Biomedical Sciences - MUSC Campus
AddressP.O. Box MSC 140
QF307B
280 Calhoun St.
Phone843-792-1289
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    Dr. Chou's research focuses on the use of unique chemical tools to study the roles of mammalian histone deacetylase (HDAC) in physiological and pathological processes. Using selective HDAC inhibitors and unique chemical activity probes developed in his laboratory, he is investigating the biological roles of specific HDACs through chemical means and their therapeutic potential in cancer.

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    Drug Discovery, Biomedical Sciences

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fan J, Alsarraf O, Chou CJ, Yates PW, Goodwin NC, Rice DS, Crosson CE. Ischemic preconditioning, retinal neuroprotection and histone deacetylase activities. Exp Eye Res. 2016 05; 146:269-75. PMID: 27060376.
      View in: PubMed
    2. Harris LG, Wang SH, Mani SK, Kasiganesan H, Chou CJ, Menick DR. Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes. Nucleic Acids Res. 2016 05 05; 44(8):3610-7. PMID: 26704971.
      View in: PubMed
    3. Renaud L, Harris LG, Mani SK, Kasiganesan H, Chou JC, Baicu CF, Van Laer A, Akerman AW, Stroud RE, Jones JA, Zile MR, Menick DR. HDACs Regulate miR-133a Expression in Pressure Overload-Induced Cardiac Fibrosis. Circ Heart Fail. 2015 Nov; 8(6):1094-104. PMID: 26371176.
      View in: PubMed
    4. Duan W, Li J, Inks ES, Chou CJ, Jia Y, Chu X, Li X, Xu W, Zhang Y. Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor. J Med Chem. 2015 May 28; 58(10):4325-38. PMID: 25906087.
      View in: PubMed
    5. Zhang C, McClure J, Chou CJ. Silver-catalyzed direct thiolation of quinones by activation of aryl disulfides to synthesize quinonyl aryl thioethers. J Org Chem. 2015 May 15; 80(10):4919-27. PMID: 25894360.
      View in: PubMed
    6. Soragni E, Chou CJ, Rusche JR, Gottesfeld JM. Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich's Ataxia. Front Neurol. 2015; 6:44. PMID: 25798128.
      View in: PubMed
    7. Alsarraf O, Fan J, Dahrouj M, Chou CJ, Yates PW, Crosson CE. Acetylation preserves retinal ganglion cell structure and function in a chronic model of ocular hypertension. Invest Ophthalmol Vis Sci. 2014 Oct 30; 55(11):7486-93. PMID: 25358731.
      View in: PubMed
    8. Alsarraf O, Fan J, Dahrouj M, Chou CJ, Menick DR, Crosson CE. Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration. Exp Eye Res. 2014 Oct; 127:124-31. PMID: 25064603.
      View in: PubMed
    9. Li X, Inks ES, Li X, Hou J, Chou CJ, Zhang J, Jiang Y, Zhang Y, Xu W. Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity. J Med Chem. 2014 Apr 24; 57(8):3324-41. PMID: 24694055.
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    10. Li X, Liu X, Josey B, Chou CJ, Tan Y, Zhang N, Wen X. Short laminin peptide for improved neural stem cell growth. Stem Cells Transl Med. 2014 May; 3(5):662-70. PMID: 24692587.
      View in: PubMed
    11. Rahn JJ, Bestman JE, Josey BJ, Inks ES, Stackley KD, Rogers CE, Chou CJ, Chan SS. Novel Vitamin K analogs suppress seizures in zebrafish and mouse models of epilepsy. Neuroscience. 2014 Feb 14; 259:142-54. PMID: 24291671.
      View in: PubMed
    12. Zhang Y, Inks ES, Zhu M, Chou CJ, Fang H, Li M, Shen Y, Yi F, Xu W. Discovery of a Pair of Diastereomers as Potent HDACs Inhibitors: Determination of Absolute Configuration, Biological Activity Comparison and Computational Study. RSC Adv. 2013 Nov 21; 3(43). PMID: 24273644.
      View in: PubMed
    13. Zhang L, Zhang Y, Chou CJ, Inks ES, Wang X, Li X, Hou J, Xu W. Histone deacetylase inhibitors with enhanced enzymatic inhibition effects and potent in vitro and in vivo antitumor activities. ChemMedChem. 2014 Mar; 9(3):638-48. PMID: 24227760.
      View in: PubMed
    14. Zhang Y, Liu C, Chou CJ, Wang X, Jia Y, Xu W. Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity. Chem Biol Drug Des. 2013 Aug; 82(2):125-30. PMID: 23581848.
      View in: PubMed
    15. Fan J, Alsarraf O, Dahrouj M, Platt KA, Chou CJ, Rice DS, Crosson CE. Inhibition of HDAC2 protects the retina from ischemic injury. Invest Ophthalmol Vis Sci. 2013 Jun 12; 54(6):4072-80. PMID: 23696608.
      View in: PubMed
    16. Chou CJ, Inks ES, Josey BJ. Vitamin K: a structural basis for the design of novel neuroprotective agents? Future Med Chem. 2013 May; 5(8):857-60. PMID: 23682563.
      View in: PubMed
    17. Josey BJ, Inks ES, Wen X, Chou CJ. Structure-activity relationship study of vitamin k derivatives yields highly potent neuroprotective agents. J Med Chem. 2013 Feb 14; 56(3):1007-22. PMID: 23327468.
      View in: PubMed
    18. Zhang Y, Yang P, Chou CJ, Liu C, Wang X, Xu W. Development of N-Hydroxycinnamamide-Based Histone Deacetylase Inhibitors with Indole-Containing Cap Group. ACS Med Chem Lett. 2013 Feb 14; 4(2):235-238. PMID: 23493449.
      View in: PubMed
    19. Jespersen C, Soragni E, James Chou C, Arora PS, Dervan PB, Gottesfeld JM. Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells. Bioorg Med Chem Lett. 2012 Jun 15; 22(12):4068-71. PMID: 22607671.
      View in: PubMed
    20. Inks ES, Josey BJ, Jesinkey SR, Chou CJ. A novel class of small molecule inhibitors of HDAC6. ACS Chem Biol. 2012 Feb 17; 7(2):331-9. PMID: 22047054.
      View in: PubMed
    21. Rai M, Soragni E, Chou CJ, Barnes G, Jones S, Rusche JR, Gottesfeld JM, Pandolfo M. Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model. PLoS One. 2010 Jan 21; 5(1):e8825. PMID: 20098685.
      View in: PubMed
    22. Minoshima M, Chou JC, Lefebvre S, Bando T, Shinohara K, Gottesfeld JM, Sugiyama H. Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes. Bioorg Med Chem. 2010 Jan 01; 18(1):168-74. PMID: 19962902.
      View in: PubMed
    23. Xu C, Soragni E, Chou CJ, Herman D, Plasterer HL, Rusche JR, Gottesfeld JM. Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing. Chem Biol. 2009 Sep 25; 16(9):980-9. PMID: 19778726.
      View in: PubMed
    24. Hu F, Chou CJ, Gottesfeld JM. Design and synthesis of novel hybrid benzamide-peptide histone deacetylase inhibitors. Bioorg Med Chem Lett. 2009 Jul 15; 19(14):3928-31. PMID: 19362838.
      View in: PubMed
    25. Chou CJ, O'Hare T, Lefebvre S, Alvarez D, Tyner JW, Eide CA, Druker BJ, Gottesfeld JM. Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate. PLoS One. 2008; 3(10):e3593. PMID: 18974832.
      View in: PubMed
    26. Chou CJ, Herman D, Gottesfeld JM. Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J Biol Chem. 2008 Dec 19; 283(51):35402-9. PMID: 18953021.
      View in: PubMed
    27. Chou CJ, Farkas ME, Tsai SM, Alvarez D, Dervan PB, Gottesfeld JM. Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia. Mol Cancer Ther. 2008 Apr; 7(4):769-78. PMID: 18413791.
      View in: PubMed
    28. Wisedchaisri G, Chou CJ, Wu M, Roach C, Rice AE, Holmes RK, Beeson C, Hol WG. Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis. Biochemistry. 2007 Jan 16; 46(2):436-47. PMID: 17209554.
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    29. Tsai SM, Farkas ME, Chou CJ, Gottesfeld JM, Dervan PB. Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates. Nucleic Acids Res. 2007; 35(1):307-16. PMID: 17170006.
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    30. Alvarez D, Chou CJ, Latella L, Zeitlin SG, Ku S, Puri PL, Dervan PB, Gottesfeld JM. A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate. Cell Cycle. 2006 Jul; 5(14):1537-48. PMID: 16861886.
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    31. Chou CJ, Wisedchaisri G, Monfeli RR, Oram DM, Holmes RK, Hol WG, Beeson C. Functional studies of the Mycobacterium tuberculosis iron-dependent regulator. J Biol Chem. 2004 Dec 17; 279(51):53554-61. PMID: 15456786.
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    32. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003 Dec; 112(12):1821-30. PMID: 14679177.
      View in: PubMed
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