Christina L Grek

Title
InstitutionMedical University of South Carolina
DepartmentCell and Molecular Pharmacology and Experimental Therapeutics
AddressCR 304
173 Ashley Ave.
Phone843-792-2112
Fax843-792-8801
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hansen RS, Thuesen KKH, Bregnhøj A, Moldovan LI, Kristensen LS, Grek CL, Ghatnekar GS, Iversen L, Johansen C. The HSP90 inhibitor RGRN-305 exhibits strong immunomodulatory effects in human keratinocytes. Exp Dermatol. 2021 Feb 14. PMID: 33583094.
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    2. Roberts R, Smyth JW, Will J, Roberts P, Grek CL, Ghatnekar GS, Sheng Z, Gourdie RG, Lamouille S, Foster EJ. Development of PLGA nanoparticles for sustained release of a connexin43 mimetic peptide to target glioblastoma cells. Mater Sci Eng C Mater Biol Appl. 2020 Mar; 108:110191. PMID: 31923988.
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    3. Montgomery J, Ghatnekar GS, Grek CL, Moyer KE, Gourdie RG. Connexin 43-Based Therapeutics for Dermal Wound Healing. Int J Mol Sci. 2018 06 15; 19(6). PMID: 29914066.
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    4. Grek CL, Sheng Z, Naus CC, Sin WC, Gourdie RG, Ghatnekar GG. Novel approach to temozolomide resistance in malignant glioma: connexin43-directed therapeutics. Curr Opin Pharmacol. 2018 08; 41:79-88. PMID: 29803991.
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    5. Cox AA, Sagot Y, Hedou G, Grek C, Wilkes T, Vinik AI, Ghatnekar G. Low-Dose Pulsatile Interleukin-6 As a Treatment Option for Diabetic Peripheral Neuropathy. Front Endocrinol (Lausanne). 2017; 8:89. PMID: 28512447.
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    6. Obert E, Strauss R, Brandon C, Grek C, Ghatnekar G, Gourdie R, Rohrer B. Targeting the tight junction protein, zonula occludens-1, with the connexin43 mimetic peptide, aCT1, reduces VEGF-dependent RPE pathophysiology. J Mol Med (Berl). 2017 05; 95(5):535-552. PMID: 28132078.
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    7. Grek CL, Montgomery J, Sharma M, Ravi A, Rajkumar JS, Moyer KE, Gourdie RG, Ghatnekar GS. A Multicenter Randomized Controlled Trial Evaluating a Cx43-Mimetic Peptide in Cutaneous Scarring. J Invest Dermatol. 2017 03; 137(3):620-630. PMID: 27856288.
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    8. Grek CL, Rhett JM, Bruce JS, Ghatnekar GS, Yeh ES. Connexin 43, breast cancer tumor suppressor: Missed connections? Cancer Lett. 2016 Apr 28; 374(1):117-126. PMID: 26884256.
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    9. Abt MA, Grek CL, Ghatnekar GS, Yeh ES. Evaluation of Lung Metastasis in Mouse Mammary Tumor Models by Quantitative Real-time PCR. J Vis Exp. 2016 Jan 29; (107):e53329. PMID: 26862835.
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    10. Grek CL, Prasad GM, Viswanathan V, Armstrong DG, Gourdie RG, Ghatnekar GS. Topical administration of a connexin43-based peptide augments healing of chronic neuropathic diabetic foot ulcers: A multicenter, randomized trial. Wound Repair Regen. 2015 Mar-Apr; 23(2):203-12. PMID: 25703647.
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    11. Grek CL, Rhett JM, Bruce JS, Abt MA, Ghatnekar GS, Yeh ES. Targeting connexin 43 with a-connexin carboxyl-terminal (ACT1) peptide enhances the activity of the targeted inhibitors, tamoxifen and lapatinib, in breast cancer: clinical implication for ACT1. BMC Cancer. 2015 Apr 03; 15:296. PMID: 25881004.
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    12. Grek CL, Reyes L, Townsend DM, Tew KD. S-glutathionylation of buccal cell proteins as biomarkers of exposure to hydrogen peroxide. BBA Clin. 2014 Dec; 2:31-9. PMID: 26673080.
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    13. Ghatnekar GS, Grek CL, Armstrong DG, Desai SC, Gourdie RG. The effect of a connexin43-based Peptide on the healing of chronic venous leg ulcers: a multicenter, randomized trial. J Invest Dermatol. 2015 Jan; 135(1):289-298. PMID: 25072595.
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    14. Grek CL, Rhett JM, Ghatnekar GS. Cardiac to cancer: connecting connexins to clinical opportunity. FEBS Lett. 2014 Apr 17; 588(8):1349-64. PMID: 24607540.
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    15. Zhang J, Grek C, Ye ZW, Manevich Y, Tew KD, Townsend DM. Pleiotropic functions of glutathione S-transferase P. Adv Cancer Res. 2014; 122:143-75. PMID: 24974181.
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    16. Grek CL, Zhang J, Manevich Y, Townsend DM, Tew KD. Causes and consequences of cysteine S-glutathionylation. J Biol Chem. 2013 Sep 13; 288(37):26497-504. PMID: 23861399.
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    17. Grek CL, Townsend DM, Uys JD, Manevich Y, Coker WJ, Pazoles CJ, Tew KD. S-glutathionylated serine proteinase inhibitors as plasma biomarkers in assessing response to redox-modulating drugs. Cancer Res. 2012 May 01; 72(9):2383-93. PMID: 22406622.
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    18. Tew KD, Manevich Y, Grek C, Xiong Y, Uys J, Townsend DM. The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer. Free Radic Biol Med. 2011 Jul 15; 51(2):299-313. PMID: 21558000.
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    19. Grek CL, Townsend DM, Tew KD. The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies. Pharmacol Ther. 2011 Feb; 129(2):172-84. PMID: 20951732.
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    20. Grek CL, Tew KD. Redox metabolism and malignancy. Curr Opin Pharmacol. 2010 Aug; 10(4):362-8. PMID: 20627682.
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    21. Grek CL, Newton DA, Spyropoulos DD, Baatz JE. Hypoxia up-regulates expression of hemoglobin in alveolar epithelial cells. Am J Respir Cell Mol Biol. 2011 Apr; 44(4):439-47. PMID: 20508070.
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    22. Grek CL, Newton DA, Qiu Y, Wen X, Spyropoulos DD, Baatz JE. Characterization of alveolar epithelial cells cultured in semipermeable hollow fibers. Exp Lung Res. 2009 Mar; 35(2):155-74. PMID: 19263283.
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