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Last Name
Institution

Chadrick E Denlinger

TitleEndowed Chair, Flora McLeod Edwards Distinguished Endowed Chair in Cancer Research
InstitutionMedical University of South Carolina
DepartmentSurgery
AddressP.O. Box MSC 295
BM 201
Thurmond Gazes - 30 Courtenay Drive
Phone843-876-4844
Fax843-876-4866
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    Collapse Overview 
    Collapse keywords
    Surgery, Cancer, Cancer/Lung, Lung, Stage I

    Collapse ORNG Applications 
    Collapse studies/trials

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hohenwarter MR, Denlinger CE. Commentary: A life worth living. J Thorac Cardiovasc Surg. 2019 Mar 21. PMID: 31005302.
      View in: PubMed
    2. LeNoir B, Bruner ET, Denlinger CE, Gibney BC. Extramedullary plasmacytoma of the right main bronchus. Ann Thorac Surg. 2019 Jan 22. PMID: 30682355.
      View in: PubMed
    3. Hohenwarter MR, Denlinger CE. Tip of the iceberg. J Thorac Cardiovasc Surg. 2018 Dec 19. PMID: 30638621.
      View in: PubMed
    4. Gibney B, Denlinger CE. This side up. J Thorac Cardiovasc Surg. 2019 Jan; 157(1):434. PMID: 30414776.
      View in: PubMed
    5. Sbrocchi AJ, Denlinger CE. Mentoring never ends. J Thorac Cardiovasc Surg. 2018 Dec; 156(6):2226. PMID: 30449576.
      View in: PubMed
    6. Kern QL, Denlinger CE. Invited Commentary. Ann Thorac Surg. 2018 Dec; 106(6):1690-1691. PMID: 30118713.
      View in: PubMed
    7. Denlinger CE. Searching for the Holy Grail-and Small Pulmonary Nodules. Semin Thorac Cardiovasc Surg. 2018; 30(2):238-239. PMID: 29782914.
      View in: PubMed
    8. Luna BW, Paoletti L, Denlinger CE, Pastis NJ, Whelan TP. Closure of a Post-Transplant Bronchial Dehiscence With Endobronchial Fibrin Sealant. Ann Thorac Surg. 2018 Oct; 106(4):e193-e195. PMID: 29738754.
      View in: PubMed
    9. Blanding WM, Denlinger CE. Restoring the soul. J Thorac Cardiovasc Surg. 2018 Aug; 156(2):836-837. PMID: 29730121.
      View in: PubMed
    10. Sbrocchi AJ, Denlinger CE. Occam's razor: What is the best approach for a lobectomy? J Thorac Cardiovasc Surg. 2018 Jul; 156(1):363-364. PMID: 29655538.
      View in: PubMed
    11. Koci M, Denlinger CE. How close they were to success. J Thorac Cardiovasc Surg. 2018 Aug; 156(2):918-919. PMID: 29559259.
      View in: PubMed
    12. Wrangle JM, Patterson A, Johnson CB, Neitzke DJ, Mehrotra S, Denlinger CE, Paulos CM, Li Z, Cole DJ, Rubinstein MP. IL-2 and Beyond in Cancer Immunotherapy. J Interferon Cytokine Res. 2018 Feb; 38(2):45-68. PMID: 29443657.
      View in: PubMed
    13. Denlinger CE. Hedging our bets. J Thorac Cardiovasc Surg. 2018 May; 155(5):2177-2178. PMID: 29402433.
      View in: PubMed
    14. Felmly LM, Kwon H, Denlinger CE, Klapper JA. Esophageal Perforation: A Common Clinical Problem with Many Different Management Options. Am Surg. 2017 Aug 01; 83(8):911-917. PMID: 28822401.
      View in: PubMed
    15. Klapper JA, Hittinger SA, Denlinger CE. Alternatives to Lobectomy for High-Risk Patients With Early-Stage Non-Small Cell Lung Cancer. Ann Thorac Surg. 2017 Apr; 103(4):1330-1339. PMID: 28359470.
      View in: PubMed
    16. Denlinger CE, LeNoir B, Whelan TP, Paoletti L, Klapper JA. Lung Donation After Death Resulting From a Stanford Type A Aortic Dissection. Ann Thorac Surg. 2017 Mar; 103(3):e273-e275. PMID: 28219568.
      View in: PubMed
    17. Shen KR, Bribriesco A, Crabtree T, Denlinger C, Eby J, Eiken P, Jones DR, Keshavjee S, Maldonado F, Paul S, Kozower B. The American Association for Thoracic Surgery consensus guidelines for the management of empyema. J Thorac Cardiovasc Surg. 2017 Jun; 153(6):e129-e146. PMID: 28274565.
      View in: PubMed
    18. Rice TW, Ishwaran H, Hofstetter WL, Schipper PH, Kesler KA, Law S, Lerut EM, Denlinger CE, Salo JA, Scott WJ, Watson TJ, Allen MS, Chen LQ, Rusch VW, Cerfolio RJ, Luketich JD, Duranceau A, Darling GE, Pera M, Apperson-Hansen C, Blackstone EH. Esophageal Cancer: Associations With (pN+) Lymph Node Metastases. Ann Surg. 2017 01; 265(1):122-129. PMID: 28009736.
      View in: PubMed
    19. Hewett L, Kwon J, Adams JD, Denlinger CE, Klapper JA. Intralobar Pulmonary Sequestration With Aneurysmal Feeding Vessel: Use of Hybrid Surgical Management. Ann Thorac Surg. 2016 Dec; 102(6):e533-e535. PMID: 27847074.
      View in: PubMed
    20. Williams RD, Denlinger CE. Single-agent management of diabetes and ischemia reperfusion injury. J Thorac Cardiovasc Surg. 2017 Mar; 153(3):711-712. PMID: 28065431.
      View in: PubMed
    21. Rice TW, Chen LQ, Hofstetter WL, Smithers BM, Rusch VW, Wijnhoven BP, Chen KL, Davies AR, D'Journo XB, Kesler KA, Luketich JD, Ferguson MK, Räsänen JV, van Hillegersberg R, Fang W, Durand L, Cecconello I, Allum WH, Cerfolio RJ, Pera M, Griffin SM, Burger R, Liu JF, Allen MS, Law S, Watson TJ, Darling GE, Scott WJ, Duranceau A, Denlinger CE, Schipper PH, Lerut TE, Orringer MB, Ishwaran H, Apperson-Hansen C, DiPaola LM, Semple ME, Blackstone EH. Worldwide Esophageal Cancer Collaboration: pathologic staging data. Dis Esophagus. 2016 Oct; 29(7):724-733. PMID: 27731547.
      View in: PubMed
    22. Rice TW, Lerut TE, Orringer MB, Chen LQ, Hofstetter WL, Smithers BM, Rusch VW, van Lanschot J, Chen KN, Davies AR, D'Journo XB, Kesler KA, Luketich JD, Ferguson MK, Räsänen JV, van Hillegersberg R, Fang W, Durand L, Allum WH, Cecconello I, Cerfolio RJ, Pera M, Griffin SM, Burger R, Liu JF, Allen MS, Law S, Watson TJ, Darling GE, Scott WJ, Duranceau A, Denlinger CE, Schipper PH, Ishwaran H, Apperson-Hansen C, DiPaola LM, Semple ME, Blackstone EH. Worldwide Esophageal Cancer Collaboration: neoadjuvant pathologic staging data. Dis Esophagus. 2016 Oct; 29(7):715-723. PMID: 27731548.
      View in: PubMed
    23. Rice TW, Apperson-Hansen C, DiPaola LM, Semple ME, Lerut TE, Orringer MB, Chen LQ, Hofstetter WL, Smithers BM, Rusch VW, Wijnhoven BP, Chen KN, Davies AR, D'Journo XB, Kesler KA, Luketich JD, Ferguson MK, Räsänen JV, van Hillegersberg R, Fang W, Durand L, Allum WH, Cecconello I, Cerfolio RJ, Pera M, Griffin SM, Burger R, Liu JF, Allen MS, Law S, Watson TJ, Darling GE, Scott WJ, Duranceau A, Denlinger CE, Schipper PH, Ishwaran H, Blackstone EH. Worldwide Esophageal Cancer Collaboration: clinical staging data. Dis Esophagus. 2016 Oct; 29(7):707-714. PMID: 27731549.
      View in: PubMed
    24. Paul MR, Levitt NP, Moore DE, Watson PM, Wilson RC, Denlinger CE, Watson DK, Anderson PE. Multivariate models from RNA-Seq SNVs yield candidate molecular targets for biomarker discovery: SNV-DA. BMC Genomics. 2016 Mar 31; 17:263. PMID: 27029813.
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    25. Denlinger CE. Toll-like receptor 4 inhibition attenuates ischemia-reperfusion injury in rats: Will it work in human beings? J Thorac Cardiovasc Surg. 2016 Feb; 151(2):507-8. PMID: 26481282.
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    26. Denlinger CE. Invited Commentary. Ann Thorac Surg. 2015 Aug; 100(2):472-3. PMID: 26234833.
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    27. Denlinger CE. A new outlet for pulmonary arterial hypertension. J Thorac Cardiovasc Surg. 2015 Sep; 150(3):643-4. PMID: 26117491.
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    28. Denlinger CE. Toll-like receptor 4 inhibition in lung ischemia-reperfusion injury: Time for a clinical trial? J Thorac Cardiovasc Surg. 2015 Jun; 149(6):1662-3. PMID: 25829183.
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    29. Denlinger CE. Matrix metalloproteinases and bronchiolitis obliterans: Wrapping the enigma in a riddle. J Thorac Cardiovasc Surg. 2015 Apr; 149(4):1203-4. PMID: 25618413.
      View in: PubMed
    30. Hochster HS, Uboha N, Messersmith W, Gold PJ, ONeil BH, Cohen D, Denlinger C, Cohen S, Leichman CG, Leichman L, Lenz HJ. Phase II study of selumetinib (AZD6244, ARRY-142886) plus irinotecan as second-line therapy in patients with K-RAS mutated colorectal cancer. Cancer Chemother Pharmacol. 2015 Jan; 75(1):17-23. PMID: 25322874.
      View in: PubMed
    31. Klapper JA, Denlinger CE. Pathologic staging of the mediastinum: when and how? J Thorac Cardiovasc Surg. 2014 Oct; 148(4):1177-8. PMID: 25260266.
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    32. Jones EE, Dworski S, Canals D, Casas J, Fabrias G, Schoenling D, Levade T, Denlinger C, Hannun YA, Medin JA, Drake RR. On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem. 2014 Aug 19; 86(16):8303-11. PMID: 25072097.
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    33. Moffatt-Bruce SD, Denlinger CE, Sade RM. Another surgeon's error: must you tell the patient? Ann Thorac Surg. 2014 Aug; 98(2):396-401. PMID: 25087782.
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    34. Denlinger CE. Invited commentary. Ann Thorac Surg. 2014 Aug; 98(2):520. PMID: 25087785.
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    35. Baatz JE, Newton DA, Riemer EC, Denlinger CE, Jones EE, Drake RR, Spyropoulos DD. Cryopreservation of viable human lung tissue for versatile post-thaw analyses and culture. In Vivo. 2014 Jul-Aug; 28(4):411-23. PMID: 24982205.
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    36. Felmly LM, Denino WF, Denlinger CE. Recurrent esophagopericardial fistula in a patient with human immunodeficiency virus. J Thorac Cardiovasc Surg. 2014 Apr; 147(4):e48-9. PMID: 24507983.
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    37. Al-Ayoubi AM, Ralston JS, Richardson SR, Denlinger CE. Diffuse pulmonary neuroendocrine cell hyperplasia involving the chest wall. Ann Thorac Surg. 2014 Jan; 97(1):333-5. PMID: 24384190.
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    38. Doben AR, Eriksson EA, Denlinger CE, Leon SM, Couillard DJ, Fakhry SM, Minshall CT. Surgical rib fixation for flail chest deformity improves liberation from mechanical ventilation. J Crit Care. 2014 Feb; 29(1):139-43. PMID: 24075300.
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    39. Enlow JM, Denlinger CE, Stroud MR, Ralston JS, Reed CE. Adenocarcinoma of the esophagus with signet ring cell features portends a poor prognosis. Ann Thorac Surg. 2013 Dec; 96(6):1927-32. PMID: 23987898.
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    40. Salazar MN, Wray D, Denlinger C, Srinivas T, Thomas B, Posadas A. Mediastinal mass and pericardial tamponade in a renal transplant recipient: A rare case of nocardia infection. Am J Case Rep. 2013; 14:295-9. PMID: 23940824.
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    41. Denlinger CE. Invited commentary. Ann Thorac Surg. 2013 Mar; 95(3):992-3. PMID: 23438527.
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    42. Denlinger CE. Invited commentary. Ann Thorac Surg. 2012 Dec; 94(6):2101-2. PMID: 23176920.
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    43. Denlinger CE, Thompson RK. Molecular basis of esophageal cancer development and progression. Surg Clin North Am. 2012 Oct; 92(5):1089-103. PMID: 23026271.
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    44. Denlinger CE, Reed CE. Contemporary management of esophageal malignancy. Surg Clin North Am. 2012 Oct; 92(5):xvii-xviii. PMID: 23026287.
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    45. Griffin JM, Reed CE, Denlinger CE. Utility of restaging endoscopic ultrasound after neoadjuvant therapy for esophageal cancer. Ann Thorac Surg. 2012 Jun; 93(6):1855-9; discussion 1860. PMID: 22516835.
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    46. Paoletti L, Pastis NJ, Denlinger CE, Silvestri GA. A decade of advances in treatment of early-stage lung cancer. Clin Chest Med. 2011 Dec; 32(4):827-38. PMID: 22054889.
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    47. Denlinger CE. The survival benefit of lung transplantation among patients with advanced pulmonary diseases. J S C Med Assoc. 2011 Aug; 107(4):133-8. PMID: 22057744.
      View in: PubMed
    48. McLaughlin CW, Person TD, Denlinger CE. Management of acute esophageal necrosis syndrome. J Thorac Cardiovasc Surg. 2011 Mar; 141(3):e23-4. PMID: 21335118.
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    49. Denlinger CE, Ikonomidis JS, Reed CE, Spinale FG. Epithelial to mesenchymal transition: the doorway to metastasis in human lung cancers. J Thorac Cardiovasc Surg. 2010 Sep; 140(3):505-13. PMID: 20723721.
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    50. Denlinger CE. A balanced perspective for management of tracheal salivary gland-type carcinomas. J Thorac Cardiovasc Surg. 2010 Aug; 140(2):394. PMID: 20637918.
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    51. Eckhouse SR, Person TD, Reed CE, Ikonomidis JS, Denlinger CE. Sternoclavicular joint infection necessitating through skin and lung parenchyma. Ann Thorac Surg. 2010 Jul; 90(1):309-11. PMID: 20609811.
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    52. Denlinger CE, Fernandez F, Meyers BF, Pratt W, Zoole JB, Patterson GA, Krupnick AS, Kreisel D, Crabtree T. Lymph node evaluation in video-assisted thoracoscopic lobectomy versus lobectomy by thoracotomy. Ann Thorac Surg. 2010 Jun; 89(6):1730-5; discussion 1736. PMID: 20494019.
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    53. Crabtree TD, Denlinger CE, Meyers BF, El Naqa I, Zoole J, Krupnick AS, Kreisel D, Patterson GA, Bradley JD. Stereotactic body radiation therapy versus surgical resection for stage I non-small cell lung cancer. J Thorac Cardiovasc Surg. 2010 Aug; 140(2):377-86. PMID: 20400121.
      View in: PubMed
    54. Fernandez FG, Denlinger CE, Crabtree TD. Primary non-Hodgkin's lymphoma of the trachea. J Thorac Oncol. 2010 Mar; 5(3):403-4. PMID: 20186028.
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    55. Fernandez FG, Denlinger CE, Patterson GA, Kreisel D, Krupnick AS. Massive bilateral chylothoraces complicating mediastinal granulomatous disease. Ann Thorac Surg. 2009 Sep; 88(3):1012-3. PMID: 19699948.
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    56. Denlinger CE, Meyers BF. Update on lung transplantation for emphysema. Thorac Surg Clin. 2009 May; 19(2):275-83. PMID: 19662971.
      View in: PubMed
    57. Denlinger CE, Fernandez FG, Patterson GA, Kreisel D. Fibrosing mediastinitis associated with complete occlusion of the left main pulmonary artery. Ann Thorac Surg. 2009 Jan; 87(1):323. PMID: 19101331.
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    58. Deacon DH, Hogan KT, Swanson EM, Chianese-Bullock KA, Denlinger CE, Czarkowski AR, Schrecengost RS, Patterson JW, Teague MW, Slingluff CL. The use of gamma-irradiation and ultraviolet-irradiation in the preparation of human melanoma cells for use in autologous whole-cell vaccines. BMC Cancer. 2008 Dec 04; 8:360. PMID: 19055839.
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    59. Denlinger CE, Veeramachaneni N, Krupnick AS, Patterson GA, Kreisel D. Nonoperative management of large tracheal injuries. J Thorac Cardiovasc Surg. 2008 Sep; 136(3):782-3, 783.e1. PMID: 18805287.
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    60. Denlinger CE, Slingluff CL, Mihm MC, Patterson JW. Extensive neurocristic hamartoma with skeletal muscle involvement. J Cutan Pathol. 2007 Aug; 34(8):634-9. PMID: 17640234.
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    61. Young JS, Stokes JB, Denlinger CE, Dubose JE. Proactive versus reactive: the effect of experience on performance in a critical care simulator. Am J Surg. 2007 Jan; 193(1):100-4. PMID: 17188098.
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    62. Smith PW, Denlinger CE, Jones DR. Novel targeted therapies for non-small cell lung cancer. Thorac Surg Clin. 2006 Nov; 16(4):353-66. PMID: 17240823.
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    63. Liu Y, Denlinger CE, Rundall BK, Smith PW, Jones DR. Suberoylanilide hydroxamic acid induces Akt-mediated phosphorylation of p300, which promotes acetylation and transcriptional activation of RelA/p65. J Biol Chem. 2006 Oct 20; 281(42):31359-68. PMID: 16926151.
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    64. Jones DR, Daniel TM, Denlinger CE, Rundall BK, Smolkin ME, Wick MR. Stage IB nonsmall cell lung cancers: are they all the same? Ann Thorac Surg. 2006 Jun; 81(6):1958-62; discussion 1962. PMID: 16731113.
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    65. Denlinger CE, Rundall BK, Jones DR. Inhibition of phosphatidylinositol 3-kinase/Akt and histone deacetylase activity induces apoptosis in non-small cell lung cancer in vitro and in vivo. J Thorac Cardiovasc Surg. 2005 Nov; 130(5):1422-9. PMID: 16256798.
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    66. Rundall BK, Denlinger CE, Parrino GP, Foley EF, Jones DR. Laparoscopic gastric bypass complicated by gastric pouch necrosis: considerations in gastroesophageal reconstruction. J Gastrointest Surg. 2005 Sep-Oct; 9(7):938-40. PMID: 16137588.
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    67. Rundall BK, Denlinger CE, Jones DR. Suberoylanilide hydroxamic acid combined with gemcitabine enhances apoptosis in non-small cell lung cancer. Surgery. 2005 Aug; 138(2):360-7. PMID: 16153448.
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    68. Denlinger CE, Rundall BK, Jones DR. Proteasome inhibition sensitizes non-small cell lung cancer to histone deacetylase inhibitor-induced apoptosis through the generation of reactive oxygen species. J Thorac Cardiovasc Surg. 2004 Nov; 128(5):740-8. PMID: 15514602.
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    69. Denlinger CE, Rundall BK, Keller MD, Jones DR. Proteasome inhibition sensitizes non-small-cell lung cancer to gemcitabine-induced apoptosis. Ann Thorac Surg. 2004 Oct; 78(4):1207-14; discussion 1207-14. PMID: 15464472.
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    70. Rundall BK, Denlinger CE, Jones DR. Combined histone deacetylase and NF-kappaB inhibition sensitizes non-small cell lung cancer to cell death. Surgery. 2004 Aug; 136(2):416-25. PMID: 15300209.
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    71. Denlinger CE, Keller MD, Mayo MW, Broad RM, Jones DR. Combined proteasome and histone deacetylase inhibition in non-small cell lung cancer. J Thorac Cardiovasc Surg. 2004 Apr; 127(4):1078-86. PMID: 15052205.
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    72. Denlinger CE, Rundall BK, Jones DR. Modulation of antiapoptotic cell signaling pathways in non-small cell lung cancer: the role of NF-kappaB. Semin Thorac Cardiovasc Surg. 2004; 16(1):28-39. PMID: 15366685.
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    73. Jones DR, Stiles BM, Denlinger CE, Antippa P, Daniel TM. Pulmonary segmentectomy: results and complications. Ann Thorac Surg. 2003 Aug; 76(2):343-8; discussion 348-9. PMID: 12902061.
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    74. Mayo MW, Denlinger CE, Broad RM, Yeung F, Reilly ET, Shi Y, Jones DR. Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway. J Biol Chem. 2003 May 23; 278(21):18980-9. PMID: 12649266.
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    75. Denlinger CE, Egan TM, Jones DR. Acquired systemic-to-pulmonary arteriovenous malformation secondary to Mycobacterium tuberculosis empyema. Ann Thorac Surg. 2002 Oct; 74(4):1229-31. PMID: 12400775.
      View in: PubMed
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