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Brett E Froeliger

Title
InstitutionMedical University of South Carolina
DepartmentNeuroscience
AddressP.O. Box MSC 510
CRI 216
Children's Research Inst. - 173 Ashley Ave.
Phone843-792-6018
Fax843-792-8626
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    Dr. Froeliger is a cognitive neuroscientist and the Director of the TRAIN Laboratory. The overarching goal of the TRAIN lab is to use cognitive and affective neuroscience research methods to investigate drug addiction - psychiatric comorbidities. The TRAIN lab conducts studies that examine the neural mechanisms underlying addiction and relapse vulnerability, pharmacotherapies for treating the pathophysiology of addiction and mindfulness-based intervention that promote well-being.

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    Breathing, Exercise, Pain, Smoking, Substance Use, Anxiety, Brain, Healthy Volunteer Studies, Mental Health, Nervous System, Physical Therapy, Depression, Environmental Factors, Women-s Health, Central Nervous System, Drug Studies, Men-s Health, Psychiatry, nicotine, opioids, addiction treatment, neuroimaging

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Carpenter MJ, Heckman BW, Wahlquist AE, Wagener TL, Goniewicz ML, Gray KM, Froeliger B, Cummings KM. A Naturalistic, Randomized Pilot Trial of E-Cigarettes: Uptake, Exposure, and Behavioral Effects. Cancer Epidemiol Biomarkers Prev. 2017 Dec; 26(12):1795-1803. PMID: 29127080.
      View in: PubMed
    2. Serfaty S, Gale G, Beadman M, Froeliger B, Kamboj SK. Mindfulness, Acceptance and Defusion Strategies in Smokers: a Systematic Review of Laboratory Studies. Mindfulness (N Y). 2018; 9(1):44-58. PMID: 29387264.
      View in: PubMed
    3. Froeliger B, McConnell PA, Bell S, Sweitzer M, Kozink RV, Eichberg C, Hallyburton M, Kaiser N, Gray KM, McClernon FJ. Association Between Baseline Corticothalamic-Mediated Inhibitory Control and Smoking Relapse Vulnerability. JAMA Psychiatry. 2017 Apr 01; 74(4):379-386. PMID: 28249070.
      View in: PubMed
    4. Froeliger B, Mathew AR, McConnell PA, Eichberg C, Saladin ME, Carpenter MJ, Garland EL. Restructuring Reward Mechanisms in Nicotine Addiction: A Pilot fMRI Study of Mindfulness-Oriented Recovery Enhancement for Cigarette Smokers. Evid Based Complement Alternat Med. 2017; 2017:7018014. PMID: 28373890.
      View in: PubMed
    5. Germeroth LJ, Carpenter MJ, Baker NL, Froeliger B, LaRowe SD, Saladin ME. Effect of a Brief Memory Updating Intervention on Smoking Behavior: A Randomized Clinical Trial. JAMA Psychiatry. 2017 Mar 01; 74(3):214-223. PMID: 28146243.
      View in: PubMed
    6. Garland EL, Howard MO, Zubieta JK, Froeliger B. Restructuring Hedonic Dysregulation in Chronic Pain and Prescription Opioid Misuse: Effects of Mindfulness-Oriented Recovery Enhancement on Responsiveness to Drug Cues and Natural Rewards. Psychother Psychosom. 2017; 86(2):111-112. PMID: 28183077.
      View in: PubMed
    7. Garland EL, Bryan CJ, Nakamura Y, Froeliger B, Howard MO. Deficits in autonomic indices of emotion regulation and reward processing associated with prescription opioid use and misuse. Psychopharmacology (Berl). 2017 Feb; 234(4):621-629. PMID: 27933366.
      View in: PubMed
    8. Badran BW, Austelle CW, Smith NR, Glusman CE, Froeliger B, Garland EL, Borckardt JJ, George MS, Short B. A Double-Blind Study Exploring the Use of Transcranial Direct Current Stimulation (tDCS) to Potentially Enhance Mindfulness Meditation (E-Meditation). Brain Stimul. 2017 Jan - Feb; 10(1):152-154. PMID: 27839723.
      View in: PubMed
    9. Meier E, Wahlquist AE, Heckman BW, Cummings KM, Froeliger B, Carpenter MJ. A Pilot Randomized Crossover Trial of Electronic Cigarette Sampling Among Smokers. Nicotine Tob Res. 2017 Feb; 19(2):176-182. PMID: 27613880.
      View in: PubMed
    10. Osman A, Thrasher JF, Cayir E, Hardin JW, Perez-Hernandez R, Froeliger B. Depressive symptoms and responses to cigarette pack warning labels among Mexican smokers. Health Psychol. 2016 May; 35(5):442-53. PMID: 26867043; PMCID: PMC4833615 [Available on 05/01/17].
    11. McConnell PA, Froeliger B. Mindfulness, Mechanisms and Meaning: Perspectives from the Cognitive Neuroscience of Addiction. Psychol Inq. 2015; 26(4):349-357. PMID: 26924915.
      View in: PubMed
    12. Froeliger B, McConnell PA, Stankeviciute N, McClure EA, Kalivas PW, Gray KM. The effects of N-Acetylcysteine on frontostriatal resting-state functional connectivity, withdrawal symptoms and smoking abstinence: A double-blind, placebo-controlled fMRI pilot study. Drug Alcohol Depend. 2015 Nov 01; 156:234-242. PMID: 26454838; PMCID: PMC4633320 [Available on 11/01/16].
    13. Cortese BM, McConnell PA, Froeliger B, Leslie K, Uhde TW. Burning odor-elicited anxiety in OEF/OIF combat veterans: Inverse relationship to gray matter volume in olfactory cortex. J Psychiatr Res. 2015 Nov; 70:58-66. PMID: 26424424; PMCID: PMC4605869 [Available on 11/01/16].
    14. Heckman BW, Carpenter MJ, Correa JB, Wray JM, Saladin ME, Froeliger B, Drobes DJ, Brandon TH. Effects of experimental negative affect manipulations on ad libitum smoking: a meta-analysis. Addiction. 2015 May; 110(5):751-60. PMID: 25641624; PMCID: PMC4398635.
    15. McClernon FJ, Froeliger B, Rose JE, Kozink RV, Addicott MA, Sweitzer MM, Westman EC, Van Wert DM. The effects of nicotine and non-nicotine smoking factors on working memory and associated brain function. Addict Biol. 2016 Jul; 21(4):954-61. PMID: 25904425; PMCID: PMC4618271 [Available on 07/01/17].
    16. Addicott MA, Sweitzer MM, Froeliger B, Rose JE, McClernon FJ. Increased Functional Connectivity in an Insula-Based Network is Associated with Improved Smoking Cessation Outcomes. Neuropsychopharmacology. 2015 Oct; 40(11):2648-56. PMID: 25895453; PMCID: PMC4569957 [Available on 10/01/16].
    17. Garland EL, Hanley A, Farb NA, Froeliger BE. State Mindfulness During Meditation Predicts Enhanced Cognitive Reappraisal. Mindfulness (N Y). 2015 Apr 01; 6(2):234-242. PMID: 26085851.
      View in: PubMed
    18. Mathew AR, Burris JL, Froeliger B, Saladin ME, Carpenter MJ. Impulsivity and cigarette craving among adolescent daily and occasional smokers. Addict Behav. 2015 Jun; 45:134-8. PMID: 25665916; PMCID: PMC4374009.
    19. Garland EL, Froeliger B, Howard MO. Allostatic dysregulation of natural reward processing in prescription opioid misuse: autonomic and attentional evidence. Biol Psychol. 2015 Feb; 105:124-9. PMID: 25603284; PMCID: PMC4336801.
    20. Newman-Norlund RD, Thrasher JF, Fridriksson J, Brixius W, Froeliger B, Hammond D, Cummings MK. Neural biomarkers for assessing different types of imagery in pictorial health warning labels for cigarette packaging: a cross-sectional study. BMJ Open. 2014 Dec 31; 4(12):e006411. PMID: 25552613; PMCID: PMC4281542.
    21. McConnell PA, Froeliger B, Garland EL, Ives JC, Sforzo GA. Auditory driving of the autonomic nervous system: Listening to theta-frequency binaural beats post-exercise increases parasympathetic activation and sympathetic withdrawal. Front Psychol. 2014; 5:1248. PMID: 25452734; PMCID: PMC4231835.
    22. Garland EL, Froeliger B, Howard MO. Neurophysiological evidence for remediation of reward processing deficits in chronic pain and opioid misuse following treatment with Mindfulness-Oriented Recovery Enhancement: exploratory ERP findings from a pilot RCT. J Behav Med. 2015 Apr; 38(2):327-36. PMID: 25385024; PMCID: PMC4355224.
    23. Addicott MA, Pearson JM, Froeliger B, Platt ML, McClernon FJ. Smoking automaticity and tolerance moderate brain activation during explore-exploit behavior. Psychiatry Res. 2014 Dec 30; 224(3):254-61. PMID: 25453166; PMCID: PMC4254500.
    24. McClure EA, Baker NL, Gipson CD, Carpenter MJ, Roper AP, Froeliger BE, Kalivas PW, Gray KM. An open-label pilot trial of N-acetylcysteine and varenicline in adult cigarette smokers. Am J Drug Alcohol Abuse. 2015 Jan; 41(1):52-6. PMID: 25062287; PMCID: PMC4262740.
    25. Addicott MA, Froeliger B, Kozink RV, Van Wert DM, Westman EC, Rose JE, McClernon FJ. Nicotine and non-nicotine smoking factors differentially modulate craving, withdrawal and cerebral blood flow as measured with arterial spin labeling. Neuropsychopharmacology. 2014 Nov; 39(12):2750-9. PMID: 24820539; PMCID: PMC4200485.
    26. Garland EL, Froeliger B, Howard MO. Effects of Mindfulness-Oriented Recovery Enhancement on reward responsiveness and opioid cue-reactivity. Psychopharmacology (Berl). 2014 Aug; 231(16):3229-38. PMID: 24595503; PMCID: PMC4111972.
    27. Garland EL, Manusov EG, Froeliger B, Kelly A, Williams JM, Howard MO. Mindfulness-oriented recovery enhancement for chronic pain and prescription opioid misuse: results from an early-stage randomized controlled trial. J Consult Clin Psychol. 2014 Jun; 82(3):448-59. PMID: 24491075; PMCID: PMC4076008.
    28. Garland EL, Froeliger B, Howard MO. Mindfulness training targets neurocognitive mechanisms of addiction at the attention-appraisal-emotion interface. Front Psychiatry. 2014 Jan 10; 4:173. PMID: 24454293; PMCID: PMC3887509.
    29. Szabo ST, Fowler JC, Froeliger B, Lee TH. Time-dependent changes in nicotine behavioral responsivity during early withdrawal from chronic cocaine administration and attenuation of cocaine sensitization by mecamylamine. Behav Brain Res. 2014 Apr 01; 262:42-6. PMID: 24412684; PMCID: PMC4024463.
    30. Garland EL, Froeliger B, Zeidan F, Partin K, Howard MO. The downward spiral of chronic pain, prescription opioid misuse, and addiction: cognitive, affective, and neuropsychopharmacologic pathways. Neurosci Biobehav Rev. 2013 Dec; 37(10 Pt 2):2597-607. PMID: 23988582; PMCID: PMC3967721.
    31. Froeliger B, Garland EL, McClernon FJ. Yoga meditation practitioners exhibit greater gray matter volume and fewer reported cognitive failures: results of a preliminary voxel-based morphometric analysis. Evid Based Complement Alternat Med. 2012; 2012:821307. PMID: 23304217; PMCID: PMC3525089.
    32. Froeliger B, Modlin LA, Kozink RV, Wang L, Garland EL, Addicott MA, McClernon FJ. Frontoparietal attentional network activation differs between smokers and nonsmokers during affective cognition. Psychiatry Res. 2013 Jan 30; 211(1):57-63. PMID: 23154092; PMCID: PMC3557750.
    33. Augustus Diggs H, Froeliger B, Carlson JM, Gilbert DG. Smoker-nonsmoker differences in neural response to smoking-related and affective cues: an fMRI investigation. Psychiatry Res. 2013 Jan 30; 211(1):85-7. PMID: 23146252.
      View in: PubMed
    34. Felder JN, Smoski MJ, Kozink RV, Froeliger B, McClernon J, Bizzell J, Petty C, Dichter GS. Neural mechanisms of subclinical depressive symptoms in women: a pilot functional brain imaging study. BMC Psychiatry. 2012 Sep 21; 12:152. PMID: 22998631; PMCID: PMC3500241.
    35. Garland EL, Froeliger BE, Passik SD, Howard MO. Attentional bias for prescription opioid cues among opioid dependent chronic pain patients. J Behav Med. 2013 Dec; 36(6):611-20. PMID: 22968666; PMCID: PMC3548053.
    36. Froeliger BE, Garland EL, Modlin LA, McClernon FJ. Neurocognitive correlates of the effects of yoga meditation practice on emotion and cognition: a pilot study. Front Integr Neurosci. 2012; 6:48. PMID: 22855674; PMCID: PMC3405281.
    37. Froeliger B, Crowell Beckham J, Feldman Dennis M, Victoria Kozink R, Joseph McClernon F. Effects of Nicotine on Emotional Reactivity in PTSD and Non-PTSD Smokers: Results of a Pilot fMRI Study. Adv Pharmacol Sci. 2012; 2012:265724. PMID: 22719754; PMCID: PMC3374941.
    38. Froeliger B, Garland EL, Kozink RV, Modlin LA, Chen NK, McClernon FJ, Greeson JM, Sobin P. Meditation-State Functional Connectivity (msFC): Strengthening of the Dorsal Attention Network and Beyond. Evid Based Complement Alternat Med. 2012; 2012:680407. PMID: 22536289; PMCID: PMC3320106.
    39. Froeliger B, Modlin LA, Kozink RV, Wang L, McClernon FJ. Smoking abstinence and depressive symptoms modulate the executive control system during emotional information processing. Addict Biol. 2012 May; 17(3):668-79. PMID: 22081878; PMCID: PMC3288802.
    40. Froeliger B, Modlin L, Wang L, Kozink RV, McClernon FJ. Nicotine withdrawal modulates frontal brain function during an affective Stroop task. Psychopharmacology (Berl). 2012 Apr; 220(4):707-18. PMID: 21989805; PMCID: PMC3619410.
    41. Rose JE, McClernon FJ, Froeliger B, Behm FM, Preud'homme X, Krystal AD. Repetitive transcranial magnetic stimulation of the superior frontal gyrus modulates craving for cigarettes. Biol Psychiatry. 2011 Oct 15; 70(8):794-9. PMID: 21762878.
      View in: PubMed
    42. Kozink RV, Lutz AM, Rose JE, Froeliger B, McClernon FJ. Smoking withdrawal shifts the spatiotemporal dynamics of neurocognition. Addict Biol. 2010 Oct; 15(4):480-90. PMID: 21040240; PMCID: PMC2996612.
    43. Froeliger B, Kozink RV, Rose JE, Behm FM, Salley AN, McClernon FJ. Hippocampal and striatal gray matter volume are associated with a smoking cessation treatment outcome: results of an exploratory voxel-based morphometric analysis. Psychopharmacology (Berl). 2010 Jul; 210(4):577-83. PMID: 20424827.
      View in: PubMed
    44. Froeliger B, Gilbert DG, McClernon FJ. Effects of nicotine on novelty detection and memory recognition performance: double-blind, placebo-controlled studies of smokers and nonsmokers. Psychopharmacology (Berl). 2009 Sep; 205(4):625-33. PMID: 19488741.
      View in: PubMed
    45. Carlson JM, Gilbert DG, Riise H, Rabinovich NE, Sugai C, Froeliger B. Serotonin transporter genotype and depressive symptoms moderate effects of nicotine on spatial working memory. Exp Clin Psychopharmacol. 2009 Jun; 17(3):173-80. PMID: 19586232.
      View in: PubMed
    46. Gilbert DG, Carlson JM, Riise H, Rabinovich NE, Sugai C, Froeliger B. Effects of nicotine and depressive traits on affective priming of lateralized emotional word identification. Exp Clin Psychopharmacol. 2008 Aug; 16(4):293-300. PMID: 18729683; PMCID: PMC3461268.
    47. Gilbert DG, Sugai C, Zuo Y, Rabinovich NE, McClernon FJ, Froeliger B. Brain indices of nicotine's effects on attentional bias to smoking and emotional pictures and to task-relevant targets. Nicotine Tob Res. 2007 Mar; 9(3):351-63. PMID: 17365767.
      View in: PubMed
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