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Ayad A. Jaffa

Title
InstitutionMedical University of South Carolina
DepartmentEndocrinology
AddressP.O. Box MSC 776
STB 504
Thurmond Gazes - 30 Courtenay Drive
Phone843-876-5245
Fax843-876-5133
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dagher OK, Jaffa MA, Habib A, Ziyadeh FN, Jaffa AA. Heteromerization fingerprints between bradykinin B2 and thromboxane TP receptors in native cells. PLoS One. 2019; 14(5):e0216908. PMID: 31086419.
      View in: PubMed
    2. El-Achkar GA, Mrad MF, Mouawad CA, Badran B, Jaffa AA, Motterlini R, Hamade E, Habib A. Heme oxygenase-1-Dependent anti-inflammatory effects of atorvastatin in zymosan-injected subcutaneous air pouch in mice. PLoS One. 2019; 14(5):e0216405. PMID: 31071151.
      View in: PubMed
    3. Jaffa MA, Gebregziabher M, Garrett SM, Luttrell DK, Lipson KE, Luttrell LM, Jaffa AA. Analysis of longitudinal semicontinuous data using marginalized two-part model. J Transl Med. 2018 11 06; 16(1):301. PMID: 30400798.
      View in: PubMed
    4. Nokkari A, Abou-El-Hassan H, Mechref Y, Mondello S, Kindy MS, Jaffa AA, Kobeissy F. Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms. Prog Neurobiol. 2018 Jun - Aug; 165-167:26-50. PMID: 29355711.
      View in: PubMed
    5. Hunt KJ, Jaffa MA, Garrett SM, Luttrell DK, Lipson KE, Lopes-Virella MF, Luttrell LM, Jaffa AA. Plasma Connective Tissue Growth Factor (CTGF/CCN2) Levels Predict Myocardial Infarction in the Veterans Affairs Diabetes Trial (VADT) Cohort. Diabetes Care. 2018 04; 41(4):840-846. PMID: 29382658.
      View in: PubMed
    6. Al Hariri M, Elmedawar M, Zhu R, Jaffa MA, Zhao J, Mirzaei P, Ahmed A, Kobeissy F, Ziyadeh FN, Mechref Y, Jaffa AA. Proteome profiling in the aorta and kidney of type 1 diabetic rats. PLoS One. 2017; 12(11):e0187752. PMID: 29121074.
      View in: PubMed
    7. Jaffa MA, Gebregziabher M, Luttrell DK, Luttrell LM, Jaffa AA. Multivariate Generalized Linear Mixed Models With Random Intercepts To Analyze Cardiovascular Risk Markers in Type-1 Diabetic Patients. J Appl Stat. 2016; 43(8):1447-1464. PMID: 27829695.
      View in: PubMed
    8. Jaffa MA, Luttrell D, Schmaier AH, Klein RL, Lopes-Virella M, Luttrell LM, Jaffa AA. Plasma Prekallikrein Is Associated With Carotid Intima-Media Thickness in Type 1 Diabetes. Diabetes. 2016 Feb; 65(2):498-502. PMID: 26603531.
      View in: PubMed
    9. Abou Msallem J, Chalhoub H, Al-Hariri M, Saad L, Jaffa MA, Ziyadeh FN, Jaffa AA. Mechanisms of bradykinin-induced expression of connective tissue growth factor and nephrin in podocytes. Am J Physiol Renal Physiol. 2015 Dec 01; 309(11):F980-90. PMID: 26447218.
      View in: PubMed
    10. Nokkari A, Mouhieddine TH, Itani MM, Abou-Kheir W, Daoud G, Zhu R, Mechref Y, Soueid J, Al Hariri M, Mondello S, Jaffa AA, Kobeissy F. Correction: Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment. PLoS One. 2015; 10(8):e0136345. PMID: 26288275.
      View in: PubMed
    11. Jaffa MA, Gebregziabher M, Jaffa AA. Analysis of multivariate longitudinal kidney function outcomes using generalized linear mixed models. J Transl Med. 2015 Jun 14; 13:192. PMID: 26072119.
      View in: PubMed
    12. Nokkari A, Mouhieddine TH, Itani MM, Abou-Kheir W, Daoud G, Zhu R, Mechref Y, Meshref Y, Soueid J, Al Hariri M, Mondello S, Jaffa AA, Kobeissy F. Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment. PLoS One. 2015; 10(6):e0128601. PMID: 26047500.
      View in: PubMed
    13. Wilson PC, Fitzgibbon WR, Garrett SM, Jaffa AA, Luttrell LM, Brands MW, El-Shewy HM. Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel. Mol Endocrinol. 2015 Jun; 29(6):896-908. PMID: 25871850.
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    14. Jaffa MA, Jaffa AA. Joint Modeling of Covariates and Censoring Process Assuming Non-Constant Dropout Hazard. Stat Methods Appt. 2016 Jun; 25(2):251-267. PMID: 27605892.
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    15. Keum JS, Jaffa MA, Luttrell LM, Jaffa AA. Novel mechanism of plasma prekallikrein (PK) activation by vascular smooth muscle cells: evidence of the presence of PK activator. J Biol Regul Homeost Agents. 2014 Oct-Dec; 28(4):587-603. PMID: 25620170.
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    16. Hasan A, Nurunnabi M, Morshed M, Paul A, Polini A, Kuila T, Al Hariri M, Lee YK, Jaffa AA. Recent advances in application of biosensors in tissue engineering. Biomed Res Int. 2014; 2014:307519. PMID: 25165697.
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    17. Jaffa MA, Gebregziabher M, Jaffa AA. A Joint Modeling Approach for Right Censored High Dimensional Multivariate Longitudinal Data. J Biom Biostat. 2014 Aug; 5(4). PMID: 25688330.
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    18. Ienaga K, Sohn M, Naiki M, Jaffa AA. Creatinine metabolite, HMH (5-hydroxy-1-methylhydantoin; NZ-419), modulates bradykinin-induced changes in vascular smooth muscle cells. J Recept Signal Transduct Res. 2014 Jun; 34(3):195-200. PMID: 24641698.
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    19. Eid S, Maalouf R, Jaffa AA, Nassif J, Hamdy A, Rashid A, Ziyadeh FN, Eid AA. 20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway. PLoS One. 2013; 8(8):e70029. PMID: 23936373.
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    20. Eid S, Abou-Kheir W, Sabra R, Daoud G, Jaffa A, Ziyadeh FN, Roman L, Eid AA. Involvement of renal cytochromes P450 and arachidonic acid metabolites in diabetic nephropathy. J Biol Regul Homeost Agents. 2013 Jul-Sep; 27(3):693-703. PMID: 24152838.
      View in: PubMed
    21. Najjar SM, Ledford KJ, Abdallah SL, Paus A, Russo L, Kaw MK, Ramakrishnan SK, Muturi HT, Raphael CK, Lester SG, Heinrich G, Pierre SV, Benndorf R, Kleff V, Jaffa AA, Lévy E, Vazquez G, Goldberg IJ, Beauchemin N, Scalia R, Ergün S. Ceacam1 deletion causes vascular alterations in large vessels. Am J Physiol Endocrinol Metab. 2013 Aug 15; 305(4):E519-29. PMID: 23800882.
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    22. Wilson PC, Lee MH, Appleton KM, El-Shewy HM, Morinelli TA, Peterson YK, Luttrell LM, Jaffa AA. The arrestin-selective angiotensin AT1 receptor agonist [Sar1,Ile4,Ile8]-AngII negatively regulates bradykinin B2 receptor signaling via AT1-B2 receptor heterodimers. J Biol Chem. 2013 Jun 28; 288(26):18872-84. PMID: 23661707.
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    23. Jaffa MA, Kobeissy F, Al Hariri M, Chalhoub H, Eid A, Ziyadeh FN, Jaffa AA. Global renal gene expression profiling analysis in B2-kinin receptor null mice: impact of diabetes. PLoS One. 2012; 7(9):e44714. PMID: 23028588.
      View in: PubMed
    24. El-Shewy HM, Sohn M, Wilson P, Lee MH, Hammad SM, Luttrell LM, Jaffa AA. Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells. Mol Endocrinol. 2012 May; 26(5):833-45. PMID: 22422617.
      View in: PubMed
    25. Jaffa MA, Jaffa AA, Lipsitz SR. Slope Estimation of Covariates that Influence Renal Outcome following Renal Transplant Adjusting for Informative Right Censoring. J Appl Stat. 2012; 39(3):631-642. PMID: 25729124.
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    26. El-Shewy HM, Abdel-Samie SA, Al Qalam AM, Lee MH, Kitatani K, Anelli V, Jaffa AA, Obeid LM, Luttrell LM. Phospholipase C and protein kinase C-ß 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation. Mol Endocrinol. 2011 Dec; 25(12):2144-56. PMID: 22016563.
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    27. Abdallah RT, Keum JS, El-Shewy HM, Lee MH, Wang B, Gooz M, Luttrell DK, Luttrell LM, Jaffa AA. Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors. J Biol Chem. 2010 Nov 05; 285(45):35206-15. PMID: 20826789.
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    28. Wang B, Carter RE, Jaffa MA, Nakerakanti S, Lackland D, Lopes-Virella M, Trojanowska M, Luttrell LM, Jaffa AA. Genetic variant in the promoter of connective tissue growth factor gene confers susceptibility to nephropathy in type 1 diabetes. J Med Genet. 2010 Jun; 47(6):391-7. PMID: 20522428.
      View in: PubMed
    29. Webb JG, Tan Y, Jaffa MA, Jaffa AA. Evidence for prostacyclin and cAMP upregulation by bradykinin and insulin-like growth factor 1 in vascular smooth muscle cells. J Recept Signal Transduct Res. 2010 Apr; 30(2):61-71. PMID: 20082561.
      View in: PubMed
    30. Jaffa AA, Usinger WR, McHenry MB, Jaffa MA, Lipstiz SR, Lackland D, Lopes-Virella M, Luttrell LM, Wilson PW. Connective tissue growth factor and susceptibility to renal and vascular disease risk in type 1 diabetes. J Clin Endocrinol Metab. 2008 May; 93(5):1893-900. PMID: 18319310.
      View in: PubMed
    31. El-Shewy HM, Lee MH, Obeid LM, Jaffa AA, Luttrell LM. The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells. J Biol Chem. 2007 Sep 07; 282(36):26150-7. PMID: 17620336.
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    32. Tan Y, Keum JS, Wang B, McHenry MB, Lipsitz SR, Jaffa AA. Targeted deletion of B2-kinin receptors protects against the development of diabetic nephropathy. Am J Physiol Renal Physiol. 2007 Oct; 293(4):F1026-35. PMID: 17596525.
      View in: PubMed
    33. El-Shewy HM, Johnson KR, Lee MH, Jaffa AA, Obeid LM, Luttrell LM. Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors. J Biol Chem. 2006 Oct 20; 281(42):31399-407. PMID: 16926156.
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    34. Game BA, He L, Jarido V, Nareika A, Jaffa AA, Lopes-Virella MF, Huang Y. Pioglitazone inhibits connective tissue growth factor expression in advanced atherosclerotic plaques in low-density lipoprotein receptor-deficient mice. Atherosclerosis. 2007 May; 192(1):85-91. PMID: 16901490.
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    35. Shariat-Madar Z, Mahdi F, Warnock M, Homeister JW, Srikanth S, Krijanovski Y, Murphey LJ, Jaffa AA, Schmaier AH. Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclin. Blood. 2006 Jul 01; 108(1):192-9. PMID: 16514058.
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    36. Bergmann S, Zheng D, Barredo J, Abboud MR, Jaffa AA. Renal kallikrein: a risk marker for nephropathy in children with sickle cell disease. J Pediatr Hematol Oncol. 2006 Mar; 28(3):147-53. PMID: 16679937.
      View in: PubMed
    37. Sohn M, Tan Y, Wang B, Klein RL, Trojanowska M, Jaffa AA. Mechanisms of low-density lipoprotein-induced expression of connective tissue growth factor in human aortic endothelial cells. Am J Physiol Heart Circ Physiol. 2006 Apr; 290(4):H1624-34. PMID: 16272194.
      View in: PubMed
    38. Sohn M, Tan Y, Klein RL, Jaffa AA. Evidence for low-density lipoprotein-induced expression of connective tissue growth factor in mesangial cells. Kidney Int. 2005 Apr; 67(4):1286-96. PMID: 15780081.
      View in: PubMed
    39. Tan Y, Wang B, Keum JS, Jaffa AA. Mechanisms through which bradykinin promotes glomerular injury in diabetes. Am J Physiol Renal Physiol. 2005 Mar; 288(3):F483-92. PMID: 15692059.
      View in: PubMed
    40. Tan Y, Hutchison FN, Jaffa AA. Mechanisms of angiotensin II-induced expression of B2 kinin receptors. Am J Physiol Heart Circ Physiol. 2004 Mar; 286(3):H926-32. PMID: 14766673.
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    41. Velarde V, de la Cerda PM, Duarte C, Arancibia F, Abbott E, González A, Moreno F, Jaffa AA. Role of reactive oxygen species in bradykinin-induced proliferation of vascular smooth muscle cells. Biol Res. 2004; 37(3):419-30. PMID: 15515967.
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    42. Jaffa AA, Durazo-Arvizu R, Zheng D, Lackland DT, Srikanth S, Garvey WT, Schmaier AH. Plasma prekallikrein: a risk marker for hypertension and nephropathy in type 1 diabetes. Diabetes. 2003 May; 52(5):1215-21. PMID: 12716755.
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    43. Christopher J, Jaffa AA. Diabetes modulates the expression of glomerular kinin receptors. Int Immunopharmacol. 2002 Dec; 2(13-14):1771-9. PMID: 12489791.
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    44. Morinelli TA, Meier GP, Webb JG, Jaffa AA, Privitera PJ, Margolius HS. Utilization of a radioimmunoassay to detect the generation of Arg-Pro-Pro-Gly-Phe, a stable endproduct of bradykinin metabolism (from cultured rat aortic smooth muscle cells exposed to bradykinin). Int Immunopharmacol. 2002 Dec; 2(13-14):1995-2003. PMID: 12489813.
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    45. Kennedy KJ, Orwig KS, Dix TA, Christopher J, Jaffa AA. Synthesis and analysis of potent, more lipophilic derivatives of the bradykinin B2 receptor antagonist peptide Hoe 140. J Pept Res. 2002 Apr; 59(4):139-48. PMID: 11972749.
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    46. Wei CC, Ferrario CM, Brosnihan KB, Farrell DM, Bradley WE, Jaffa AA, Dell'Italia LJ. Angiotensin peptides modulate bradykinin levels in the interstitium of the dog heart in vivo. J Pharmacol Exp Ther. 2002 Jan; 300(1):324-9. PMID: 11752132.
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    47. Haastrup A, Gadegbeku CA, Zhang D, Mukhin YV, Greene EL, Jaffa AA, Egan BM. Lipids stimulate the production of 6-keto-prostaglandin f(1alpha) in human dorsal hand veins. Hypertension. 2001 Oct; 38(4):858-63. PMID: 11641299.
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    48. Velarde V, Jenkins AJ, Christopher J, Lyons TJ, Jaffa AA. Activation of MAPK by modified low-density lipoproteins in vascular smooth muscle cells. J Appl Physiol (1985). 2001 Sep; 91(3):1412-20. PMID: 11509543.
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    49. Christopher J, Velarde V, Jaffa AA. Induction of B(1)-kinin receptors in vascular smooth muscle cells: cellular mechanisms of map kinase activation. Hypertension. 2001 Sep; 38(3 Pt 2):602-5. PMID: 11566939.
      View in: PubMed
    50. Christopher J, Velarde V, Zhang D, Mayfield D, Mayfield RK, Jaffa AA. Regulation of B(2)-kinin receptors by glucose in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2001 Apr; 280(4):H1537-46. PMID: 11247764.
      View in: PubMed
    51. Mukhin YV, Vlasova T, Jaffa AA, Collinsworth G, Bell JL, Tholanikunnel BG, Pettus T, Fitzgibbon W, Ploth DW, Raymond JR, Garnovskaya MN. Bradykinin B2 receptors activate Na+/H+ exchange in mIMCD-3 cells via Janus kinase 2 and Ca2+/calmodulin. J Biol Chem. 2001 May 18; 276(20):17339-46. PMID: 11278760.
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    52. Morinelli TA, Webb JG, Jaffa AA, Privitera PJ, Margolius HS. A metabolic fragment of bradykinin, Arg-Pro-Pro-Gly-Phe, protects against the deleterious effects of lipopolysaccharide in rats. J Pharmacol Exp Ther. 2001 Jan; 296(1):71-6. PMID: 11123364.
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    53. Douillet CD, Velarde V, Christopher JT, Mayfield RK, Trojanowska ME, Jaffa AA. Mechanisms by which bradykinin promotes fibrosis in vascular smooth muscle cells: role of TGF-beta and MAPK. Am J Physiol Heart Circ Physiol. 2000 Dec; 279(6):H2829-37. PMID: 11087238.
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    54. Jenkins AJ, Velarde V, Klein RL, Joyce KC, Phillips KD, Mayfield RK, Lyons TJ, Jaffa AA. Native and modified LDL activate extracellular signal-regulated kinases in mesangial cells. Diabetes. 2000 Dec; 49(12):2160-9. PMID: 11118021.
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    55. Greene EL, Velarde V, Jaffa AA. Role of reactive oxygen species in bradykinin-induced mitogen-activated protein kinase and c-fos induction in vascular cells. Hypertension. 2000 Apr; 35(4):942-7. PMID: 10775566.
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    56. Naidu PS, Velarde V, Kappler CS, Young RC, Mayfield RK, Jaffa AA. Calcium-calmodulin mediates bradykinin-induced MAPK phosphorylation and c-fos induction in vascular cells. Am J Physiol. 1999 09; 277(3):H1061-8. PMID: 10484429.
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    57. Velarde V, Ullian ME, Morinelli TA, Mayfield RK, Jaffa AA. Mechanisms of MAPK activation by bradykinin in vascular smooth muscle cells. Am J Physiol. 1999 08; 277(2):C253-61. PMID: 10444401.
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    58. Huang Y, Jaffa A, Koskinen S, Takei A, Lopes-Virella MF. Oxidized LDL-containing immune complexes induce Fc gamma receptor I-mediated mitogen-activated protein kinase activation in THP-1 macrophages. Arterioscler Thromb Vasc Biol. 1999 Jul; 19(7):1600-7. PMID: 10397676.
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    59. Willi SM, O'Rear D, Garvey WT, Colwell JA, Buse MG, Jaffa A, Lopes-Virella M, Wood D, Mayfield RK, Wallace P, Hermayer KL, Jenkins AJ, Lyons T, Mayer-Davis E. Diabetes research in South Carolina: past, present, and future. J S C Med Assoc. 1998 Nov; 94(11):502-8. PMID: 9844316.
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    60. Vio CP, Oestreicher E, Olavarria V, Velarde V, Mayfield RK, Jaffa AA. Cellular distribution of exogenous aprotinin in the rat kidney. Biol Chem. 1998 Oct; 379(10):1271-7. PMID: 9820588.
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    61. Lu G, Meier KE, Jaffa AA, Rosenzweig SA, Egan BM. Oleic acid and angiotensin II induce a synergistic mitogenic response in vascular smooth muscle cells. Hypertension. 1998 Apr; 31(4):978-85. PMID: 9535424.
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    62. Jaffa AA, Vio C, Velarde V, LeRoith D, Mayfield RK. Induction of renal kallikrein and renin gene expression by insulin and IGF-I in the diabetic rat. Diabetes. 1997 Dec; 46(12):2049-56. PMID: 9392495.
      View in: PubMed
    63. Jaffa AA, Miller BS, Rosenzweig SA, Naidu PS, Velarde V, Mayfield RK. Bradykinin induces tubulin phosphorylation and nuclear translocation of MAP kinase in mesangial cells. Am J Physiol. 1997 12; 273(6):F916-24. PMID: 9435680.
      View in: PubMed
    64. Morinelli TA, Finley EL, Jaffa AA, Kurtz DT, Ullian ME. Tyrosine phosphorylation of phosphatidylinositol 3-kinase and of the thromboxane A2 (TXA2) receptor by the TXA2 mimetic I-BOP in A7r5 cells. Biochem Pharmacol. 1997 Jun 15; 53(12):1823-32. PMID: 9256157.
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    65. Siragy HM, Jaffa AA, Margolius HS. Bradykinin B2 receptor modulates renal prostaglandin E2 and nitric oxide. Hypertension. 1997 Mar; 29(3):757-62. PMID: 9052892.
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    66. Siragy HM, Jaffa AA, Margolius HS, Carey RM. Renin-angiotensin system modulates renal bradykinin production. Am J Physiol. 1996 Oct; 271(4 Pt 2):R1090-5. PMID: 8898005.
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    67. Jaffa AA, Silva RH, Kim B, Mayfield RK. Modulation of renal kallikrein production by dietary protein in streptozotocin-induced diabetic rats. J Am Soc Nephrol. 1996 May; 7(5):721-7. PMID: 8738807.
      View in: PubMed
    68. Fitzgibbon WR, Jaffa AA, Mayfield RK, Ploth DW. Role of kinins in the renal response to enalaprilat in normotensive and hypertensive rats. Hypertension. 1996 Feb; 27(2):235-44. PMID: 8567046.
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    69. Mayfield RK, Shimojo N, Jaffa AA. Skeletal muscle kallikrein. Potential role in metabolic regulation. Diabetes. 1996 Jan; 45 Suppl 1:S20-3. PMID: 8529795.
      View in: PubMed
    70. Jaffa AA, Rust PF, Mayfield RK. Kinin, a mediator of diabetes-induced glomerular hyperfiltration. Diabetes. 1995 Feb; 44(2):156-60. PMID: 7859934.
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    71. Siragy HM, Ibrahim MM, Jaffa AA, Mayfield R, Margolius HS. Rat renal interstitial bradykinin, prostaglandin E2, and cyclic guanosine 3',5'-monophosphate. Effects of altered sodium intake. Hypertension. 1994 Jun; 23(6 Pt 2):1068-70. PMID: 8206596.
      View in: PubMed
    72. Jaffa AA, LeRoith D, Roberts CT, Rust PF, Mayfield RK. Insulin-like growth factor I produces renal hyperfiltration by a kinin-mediated mechanism. Am J Physiol. 1994 Jan; 266(1 Pt 2):F102-7. PMID: 8304475.
      View in: PubMed
    73. Siragy HM, Jaffa AA, Margolius HS. Stimulation of renal interstitial bradykinin by sodium depletion. Am J Hypertens. 1993 Oct; 6(10):863-6. PMID: 8267942.
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    74. Hutchison FN, Webster SK, Jaffa AA. Altered renal kallikrein and renin gene expression in nephrotic rats and modulation by converting enzyme inhibition. J Clin Invest. 1993 Aug; 92(2):1073-9. PMID: 8349789.
      View in: PubMed
    75. Morinelli TA, Tempel GE, Jaffa AA, Silva RH, Naka M, Folger W, Halushka PV. Thromboxane A2/prostaglandin H2 receptors in streptozotocin-induced diabetes: effects of insulin therapy in the rat. Prostaglandins. 1993 May; 45(5):427-38. PMID: 8321912.
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    76. Harvey JN, Edmundson AW, Jaffa AA, Martin LL, Mayfield RK. Renal excretion of kallikrein and eicosanoids in patients with type 1 (insulin-dependent) diabetes mellitus. Relationship to glomerular and tubular function. Diabetologia. 1992 Sep; 35(9):857-62. PMID: 1397781.
      View in: PubMed
    77. Jaffa AA, Vio CP, Silva RH, Vavrek RJ, Stewart JM, Rust PF, Mayfield RK. Evidence for renal kinins as mediators of amino acid-induced hyperperfusion and hyperfiltration in the rat. J Clin Invest. 1992 May; 89(5):1460-8. PMID: 1373739.
      View in: PubMed
    78. Jaffa AA, Chai KX, Chao J, Chao L, Mayfield RK. Effects of diabetes and insulin on expression of kallikrein and renin genes in the kidney. Kidney Int. 1992 Apr; 41(4):789-95. PMID: 1513101.
      View in: PubMed
    79. Mayfield RK, Jaffa AA, Edmundson AW, Harvey JN. Renal hyperfiltration states: relationship to kallikrein and kinins. Agents Actions Suppl. 1992; 38 ( Pt 3):142-8. PMID: 1281377.
      View in: PubMed
    80. Jaffa AA, Miller DH, Silva RH, Margolius HS, Mayfield RK. Regulation of renal kallikrein synthesis and activation by glucocorticoids. Kidney Int. 1990 Aug; 38(2):212-8. PMID: 2205750.
      View in: PubMed
    81. Harvey JN, Jaffa AA, Margolius HS, Mayfield RK. Renal kallikrein and hemodynamic abnormalities of diabetic kidney. Diabetes. 1990 Mar; 39(3):299-304. PMID: 1689683.
      View in: PubMed
    82. Jaffa AA, Harvey JN, Sutherland SE, Margolius HS, Mayfield RK. Renal kallikrein responses to dietary protein: a possible mediator of hyperfiltration. Kidney Int. 1989 Dec; 36(6):1003-10. PMID: 2601251.
      View in: PubMed
    83. Bolin P, Jaffa AA, Rust PF, Mayfield RK. Acute and chronic responses of human renal kallikrein and kinins to dietary protein. Am J Physiol. 1989 Nov; 257(5 Pt 2):F718-23. PMID: 2589478.
      View in: PubMed
    84. Jaffa AA, Miller DH, Margolius HS, Mayfield RK. The effects of diabetes and insulin on colonic tissue kallikrein. Adv Exp Med Biol. 1989; 247B:669-73. PMID: 2692422.
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    85. Mayfield RK, Sens DA, Jaffa AA, Margolius HS. Studies of sweat kallikrein in normal human subjects. Adv Exp Med Biol. 1989; 247B:649-55. PMID: 2610101.
      View in: PubMed
    86. Harvey JN, Jaffa AA, Loadholt CB, Mayfield RK. Measurement of glomerular filtration rate and renal plasma flow in the diabetic rat by the single-injection isotopic technique: effects of altered distribution volumes of 51Cr-EDTA and 125I-hippuran. Diabetes Res. 1988 Oct; 9(2):67-72. PMID: 3149922.
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    87. Jaffa AA, Miller DH, Bailey GS, Chao J, Margolius HS, Mayfield RK. Abnormal regulation of renal kallikrein in experimental diabetes. Effects of insulin on prokallikrein synthesis and activation. J Clin Invest. 1987 Dec; 80(6):1651-9. PMID: 3316279.
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    88. Jaffa AA, Pratt J, Ashford A, Bailey GS. Studies of the effects of insulin, bradykinin, and captopril on blood glucose levels of alloxan-diabetic rats. Adv Exp Med Biol. 1986; 198 Pt B:373-8. PMID: 3028079.
      View in: PubMed
    89. Jaffa AA, Pratt J, Ashford A, Bailey GS. A study of glandular kallikrein in experimental diabetes. Adv Exp Med Biol. 1986; 198 Pt B:367-71. PMID: 3643733.
      View in: PubMed
    90. Jaffa AA, Hussain M, Rashid Z, Bailey GS. A comparative study of prokallikreins and kallikreins from rat pancreatic tissue and juice. Adv Exp Med Biol. 1986; 198 Pt A:323-7. PMID: 3643715.
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    91. Jaffa AA, Pratt J, Ashford A, Bailey GS. A time-course study of submandibular kallikrein, blood glucose and insulin of alloxan-diabetic and streptozotocin-diabetic rats. Agents Actions. 1984 Dec; 15(5-6):478-81. PMID: 6241788.
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    92. Jaffa AA, Rashid Z, Pratt J, Ashford A, Bailey GS. A quantitative study of the levels of glandular kallikrein in normal and diabetic rats. Biochem Med. 1984 Feb; 31(1):42-6. PMID: 6611154.
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