Arno Wessels

Title
InstitutionMedical University of South Carolina
DepartmentRegenerative Medicine and Cell Biology
AddressP.O. Box MSC 508
BSB 648
Basic Science Building - 173 Ashley Ave.
Phone843-792-8183
Fax843-792-0664
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    Collapse Overview 
    Collapse keywords
    congenital heart disease, development, atrioventricular septal defects, second heart field, anomalous pulmonary venous return, genetics

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Briggs LE, Burns TA, Lockhart MM, Phelps AL, Van den Hoff MJ, Wessels A. Wnt/ß-catenin and sonic hedgehog pathways interact in the regulation of the development of the dorsal mesenchymal protrusion. Dev Dyn. 2016 Feb; 245(2):103-13. PMID: 26297872.
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    2. Durst R, Sauls K, Peal DS, deVlaming A, Toomer K, Leyne M, Salani M, Talkowski ME, Brand H, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, Le Tourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott JJ, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome AM, Williams K, Johnson A, Markwald RR, Jeunemaitre X, Hagege A, Levine RA, Milan DJ, Norris RA, Slaugenhaupt SA. Mutations in DCHS1 cause mitral valve prolapse. Nature. 2015 Sep 03; 525(7567):109-13. PMID: 26258302.
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    3. Dorr KM, Amin NM, Kuchenbrod LM, Labiner H, Charpentier MS, Pevny LH, Wessels A, Conlon FL. Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development. Development. 2015 Jun 01; 142(11):2037-47. PMID: 25953344.
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    4. Lockhart MM, Boukens BJ, Phelps AL, Brown CL, Toomer KA, Burns TA, Mukherjee RD, Norris RA, Trusk TC, van den Hoff MJ, Wessels A. Alk3 mediated Bmp signaling controls the contribution of epicardially derived cells to the tissues of the atrioventricular junction. Dev Biol. 2014 Dec 01; 396(1):8-18. PMID: 25300579.
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    5. Lockhart MM, Phelps AL, van den Hoff MJ, Wessels A. The Epicardium and the Development of the Atrioventricular Junction in the Murine Heart. J Dev Biol. 2014 Mar 01; 2(1):1-17. PMID: 24926431.
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    6. Briggs LE, Phelps AL, Brown E, Kakarla J, Anderson RH, van den Hoff MJ, Wessels A. Expression of the BMP receptor Alk3 in the second heart field is essential for development of the dorsal mesenchymal protrusion and atrioventricular septation. Circ Res. 2013 May 24; 112(11):1420-32. PMID: 23584254.
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    7. Lockhart MM, Wirrig EE, Phelps AL, Ghatnekar AV, Barth JL, Norris RA, Wessels A. Mef2c regulates transcription of the extracellular matrix protein cartilage link protein 1 in the developing murine heart. PLoS One. 2013; 8(2):e57073. PMID: 23468913.
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    8. Sauls K, de Vlaming A, Harris BS, Williams K, Wessels A, Levine RA, Slaugenhaupt SA, Goodwin RL, Pavone LM, Merot J, Schott JJ, Le Tourneau T, Dix T, Jesinkey S, Feng Y, Walsh C, Zhou B, Baldwin S, Markwald RR, Norris RA. Developmental basis for filamin-A-associated myxomatous mitral valve disease. Cardiovasc Res. 2012 Oct 01; 96(1):109-19. PMID: 22843703.
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    9. Briggs LE, Kakarla J, Wessels A. The pathogenesis of atrial and atrioventricular septal defects with special emphasis on the role of the dorsal mesenchymal protrusion. Differentiation. 2012 Jul; 84(1):117-30. PMID: 22709652.
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    10. Wessels A, van den Hoff MJ, Adamo RF, Phelps AL, Lockhart MM, Sauls K, Briggs LE, Norris RA, van Wijk B, Perez-Pomares JM, Dettman RW, Burch JB. Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart. Dev Biol. 2012 Jun 15; 366(2):111-24. PMID: 22546693.
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    11. Dupuis LE, McCulloch DR, McGarity JD, Bahan A, Wessels A, Weber D, Diminich AM, Nelson CM, Apte SS, Kern CB. Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease. Dev Biol. 2011 Sep 01; 357(1):152-64. PMID: 21749862.
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    12. Lockhart M, Wirrig E, Phelps A, Wessels A. Extracellular matrix and heart development. Birth Defects Res A Clin Mol Teratol. 2011 Jun; 91(6):535-50. PMID: 21618406.
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    13. Norris RA, Moreno-Rodriguez R, Wessels A, Merot J, Bruneval P, Chester AH, Yacoub MH, Hagège A, Slaugenhaupt SA, Aikawa E, Schott JJ, Lardeux A, Harris BS, Williams LK, Richards A, Levine RA, Markwald RR. Expression of the familial cardiac valvular dystrophy gene, filamin-A, during heart morphogenesis. Dev Dyn. 2010 Jul; 239(7):2118-27. PMID: 20549728.
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    14. Kern CB, Wessels A, McGarity J, Dixon LJ, Alston E, Argraves WS, Geeting D, Nelson CM, Menick DR, Apte SS. Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies. Matrix Biol. 2010 May; 29(4):304-16. PMID: 20096780.
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    15. Snarr BS, Kern CB, Wessels A. Origin and fate of cardiac mesenchyme. Dev Dyn. 2008 Oct; 237(10):2804-19. PMID: 18816864.
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    16. Cooley MA, Kern CB, Fresco VM, Wessels A, Thompson RP, McQuinn TC, Twal WO, Mjaatvedt CH, Drake CJ, Argraves WS. Fibulin-1 is required for morphogenesis of neural crest-derived structures. Dev Biol. 2008 Jul 15; 319(2):336-45. PMID: 18538758.
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    17. Snarr BS, O'Neal JL, Chintalapudi MR, Wirrig EE, Phelps AL, Kubalak SW, Wessels A. Isl1 expression at the venous pole identifies a novel role for the second heart field in cardiac development. Circ Res. 2007 Nov 09; 101(10):971-4. PMID: 17947796.
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    18. Wirrig EE, Snarr BS, Chintalapudi MR, O'neal JL, Phelps AL, Barth JL, Fresco VM, Kern CB, Mjaatvedt CH, Toole BP, Hoffman S, Trusk TC, Argraves WS, Wessels A. Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development. Dev Biol. 2007 Oct 15; 310(2):291-303. PMID: 17822691.
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    19. Snarr BS, Wirrig EE, Phelps AL, Trusk TC, Wessels A. A spatiotemporal evaluation of the contribution of the dorsal mesenchymal protrusion to cardiac development. Dev Dyn. 2007 May; 236(5):1287-94. PMID: 17265457.
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    20. Moralez I, Phelps A, Riley B, Raines M, Wirrig E, Snarr B, Jin JP, Van Den Hoff M, Hoffman S, Wessels A. Muscularizing tissues in the endocardial cushions of the avian heart are characterized by the expression of h1-calponin. Dev Dyn. 2006 Jun; 235(6):1648-58. PMID: 16502418.
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    21. Drake CJ, Wessels A, Trusk T, Little CD. Elevated vascular endothelial cell growth factor affects mesocardial morphogenesis and inhibits normal heart bending. Dev Dyn. 2006 Jan; 235(1):10-8. PMID: 16170779.
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    22. Norris RA, Kern CB, Wessels A, Wirrig EE, Markwald RR, Mjaatvedt CH. Detection of betaig-H3, a TGFbeta induced gene, during cardiac development and its complementary pattern with periostin. Anat Embryol (Berl). 2005 Aug; 210(1):13-23. PMID: 16034610.
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    23. Yu H, Wessels A, Tint GS, Patel SB. Partial rescue of neonatal lethality of Dhcr7 null mice by a nestin promoter-driven DHCR7 transgene expression. Brain Res Dev Brain Res. 2005 Apr 21; 156(1):46-60. PMID: 15862627.
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    24. Norris RA, Kern CB, Wessels A, Moralez EI, Markwald RR, Mjaatvedt CH. Identification and detection of the periostin gene in cardiac development. Anat Rec A Discov Mol Cell Evol Biol. 2004 Dec; 281(2):1227-33. PMID: 15532025.
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    25. Beon M, Harley RA, Wessels A, Silver RM, Ludwicka-Bradley A. Myofibroblast induction and microvascular alteration in scleroderma lung fibrosis. Clin Exp Rheumatol. 2004 Nov-Dec; 22(6):733-42. PMID: 15638048.
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    26. Mjaatvedt CH, Klewer S, Wessels A, Gourdie RG. Een geslaagd jubileum! The 10th Weinstein Developmental Cardiovascular Conference in Leiden. Dev Dyn. 2004 Nov; 231(3):655-9. PMID: 15376316.
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    27. Yu H, Wessels A, Chen J, Phelps AL, Oatis J, Tint GS, Patel SB. Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome. BMC Dev Biol. 2004 Feb 02; 4:1. PMID: 15005800.
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    28. Wessels A, Pérez-Pomares JM. The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells. Anat Rec A Discov Mol Cell Evol Biol. 2004 Jan; 276(1):43-57. PMID: 14699633.
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    29. Wessels A, Sedmera D. Developmental anatomy of the heart: a tale of mice and man. Physiol Genomics. 2003 Nov 11; 15(3):165-76. PMID: 14612588.
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    30. Reckova M, Rosengarten C, deAlmeida A, Stanley CP, Wessels A, Gourdie RG, Thompson RP, Sedmera D. Hemodynamics is a key epigenetic factor in development of the cardiac conduction system. Circ Res. 2003 Jul 11; 93(1):77-85. PMID: 12775585.
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    31. Pérez-Pomares JM, Phelps A, Sedmerova M, Wessels A. Epicardial-like cells on the distal arterial end of the cardiac outflow tract do not derive from the proepicardium but are derivatives of the cephalic pericardium. Dev Dyn. 2003 May; 227(1):56-68. PMID: 12701099.
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    32. Wessels A, Phelps A, Trusk TC, Davis DL, Edwards AV, Burch JB, Juraszek AL. Mouse models for cardiac conduction system development. Novartis Found Symp. 2003; 250:44-59; discussion 59-67, 276-9. PMID: 12956323.
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    33. Pérez-Pomares JM, Carmona R, González-Iriarte M, Atencia G, Wessels A, Muñoz-Chápuli R. Origin of coronary endothelial cells from epicardial mesothelium in avian embryos. Int J Dev Biol. 2002 Dec; 46(8):1005-13. PMID: 12533024.
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    34. Pérez-Pomares JM, Phelps A, Sedmerova M, Carmona R, González-Iriarte M, Muñoz-Chápuli R, Wessels A. Experimental studies on the spatiotemporal expression of WT1 and RALDH2 in the embryonic avian heart: a model for the regulation of myocardial and valvuloseptal development by epicardially derived cells (EPDCs). Dev Biol. 2002 Jul 15; 247(2):307-26. PMID: 12086469.
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    35. Cheng G, Wessels A, Gourdie RG, Thompson RP. Spatiotemporal and tissue specific distribution of apoptosis in the developing chick heart. Dev Dyn. 2002 Jan; 223(1):119-33. PMID: 11803575.
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    36. McQuinn TC, Miga DE, Mjaatvedt CH, Phelps AL, Wessels A. Cardiopulmonary malformations in the inv/inv mouse. Anat Rec. 2001 05 01; 263(1):62-71. PMID: 11331972.
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    37. Waller BR, McQuinn T, Phelps AL, Markwald RR, Lo CW, Thompson RP, Wessels A. Conotruncal anomalies in the trisomy 16 mouse: an immunohistochemical analysis with emphasis on the involvement of the neural crest. Anat Rec. 2000 11 01; 260(3):279-93. PMID: 11066038.
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    38. Wessels A, Anderson RH, Markwald RR, Webb S, Brown NA, Viragh S, Moorman AF, Lamers WH. Atrial development in the human heart: an immunohistochemical study with emphasis on the role of mesenchymal tissues. Anat Rec. 2000 07 01; 259(3):288-300. PMID: 10861362.
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    39. Wessels A, Markwald R. Cardiac morphogenesis and dysmorphogenesis. I. Normal development. Methods Mol Biol. 2000; 136:239-59. PMID: 10840715.
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    40. Waller BR, Wessels A. Cardiac morphogenesis and dysmorphogenesis. An immunohistochemical approach. Methods Mol Biol. 2000; 135:151-61. PMID: 10791312.
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    41. Zanin MK, Bundy J, Ernst H, Wessels A, Conway SJ, Hoffman S. Distinct spatial and temporal distributions of aggrecan and versican in the embryonic chick heart. Anat Rec. 1999 12 01; 256(4):366-80. PMID: 10589023.
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    42. Lo CW, Wessels A. Cx43 gap junctions in cardiac development. Trends Cardiovasc Med. 1998 Aug; 8(6):264-9. PMID: 14987562.
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