Keywords
Last Name
Institution

Ann-Marie Broome

Title
InstitutionMedical University of South Carolina
DepartmentCell and Molecular Pharmacology and Experimental Therapeutics
AddressP.O. Box MSC 509
BSB319D
Basic Science Building - 173 Ashley Ave.
Phone843-876-2481
Fax843-792-2475
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    The academic research program of Ann-Marie Broome, Ph.D., MBA, the Director of Molecular Imaging of the Medical University of South Carolina’s Center for Biomedical Imaging and Director of Small Animal Imaging of MUSC’s Hollings Cancer Center, is devoted to the study and understanding of different diseases for the purposes of detecting them earlier and improving therapeutic efficacy–the hallmarks of the molecular imaging field. Molecular imaging, a cross-disciplinary field combining science, engineering and medicine, bridges basic and clinically translatable research. Its ultimate goal is to characterize and measure biological processes at the cellular and molecular levels both noninvasively and in real-time. Dr. Broome’s research utilizes bio-inspired nanotechnology to study cancer in its earliest stages of progression, by developing novel multi-modal contrast agents and multi-functional delivery vehicles to target and monitor therapeutic response. By exploiting unique validated, disease-associated changes in gene and protein expression, also known as the cancer signature, Dr. Broome is able to bioengineer theranostic agents to selectively and robustly image the cellular status of genetically distinct cancers, the gold standard of personalized medicine, thereby facilitating detection, diagnosis, assessment of progression and prediction of treatment outcome. This increased selectivity and sensitivity could also lead to meaningful improvements in determining a tumor’s location, focality, extent and differentiation in relation to the cancer microenvironment.

    Before coming to MUSC, as a primary investigator (PI) and co-PI on several funded NIH and university-sponsored grants, she laid the groundwork for research into the development of platform imaging technologies that can target and visualize multiple biomarkers simultaneously. Additionally, her laboratory engineered several animal models of inaccessible or surgically challenging tumors, such as the orthotopic human brain tumor model for glioblastomas. Currently, Dr. Broome is the PI of a multi-institutional NIH/NIBIB R01 grant investigating novel molecular imaging paradigms to image tumor uptake, accumulation and activation of hydrophobic photosensitizing agents. In this project, she is able to monitor the drug response using the intrinsic fluorescence properties of the drug and to quantify its impact on tumor progression. She is also PI on a Department of Defense Peer-Reviewed Cancer Research Program Idea Award examining split-reporters to achieve chemical resolution of cancer protein profiles using molecular imaging.

    Collapse keywords
    Cell and Molecular Pharmacology and Experimental Therapeutics

    Collapse ORNG Applications 
    Collapse studies/trials

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Jones Buie JN, Zhou Y, Goodwin AJ, Cook JA, Vournakis J, Demcheva M, Broome AM, Dixit S, Halushka PV, Fan H. Application of Deacetylated Poly-N-Acetyl Glucosamine Nanoparticles for the Delivery of miR-126 for the Treatment of Cecal Ligation and Puncture-Induced Sepsis. Inflammation. 2019 Feb; 42(1):170-184. PMID: 30244405.
      View in: PubMed
    2. Bredlau AL, Motamarry A, Chen C, McCrackin MA, Helke K, Armeson KE, Bynum K, Broome AM, Haemmerich D. Localized delivery of therapeutic doxorubicin dose across the canine blood-brain barrier with hyperthermia and temperature sensitive liposomes. Drug Deliv. 2018 Nov; 25(1):973-984. PMID: 29688083.
      View in: PubMed
    3. Zhu P, Atkinson C, Dixit S, Cheng Q, Tran D, Patel K, Jiang YL, Esckilsen S, Miller K, Bazzle G, Allen P, Moore A, Broome AM, Nadig SN. Organ preservation with targeted rapamycin nanoparticles: a pre-treatment strategy preventing chronic rejection in vivo. RSC Adv. 2018 Jul 23; 8(46):25909-25919. PMID: 30220998.
      View in: PubMed
    4. Connor DM, Broome AM. Gold Nanoparticles for the Delivery of Cancer Therapeutics. Adv Cancer Res. 2018; 139:163-184. PMID: 29941104.
      View in: PubMed
    5. Broome AM. Preface. Adv Cancer Res. 2018; 139:xiii-xiv. PMID: 29941109.
      View in: PubMed
    6. Jiang YL, Zhu Y, Moore AB, Miller K, Broome AM. Biotinylated Bioluminescent Probe for Long Lasting Targeted in Vivo Imaging of Xenografted Brain Tumors in Mice. ACS Chem Neurosci. 2018 01 17; 9(1):100-106. PMID: 28532151.
      View in: PubMed
    7. Bredlau AL, Dixit S, Chen C, Broome AM. Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma. Curr Neuropharmacol. 2017; 15(1):104-115. PMID: 26903150.
      View in: PubMed
    8. McKinnon E, Moore A, Dixit S, Zhu Y, Broome AM. Fluorescence and Bioluminescence Imaging of Orthotopic Brain Tumors in Mice. Methods Mol Biol. 2017; 1530:283-305. PMID: 28150209.
      View in: PubMed
    9. Miller K, Dixit S, Bredlau AL, Moore A, McKinnon E, Broome AM. Delivery of a drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers. Nanomedicine (Lond). 2016 Mar; 11(6):581-95. PMID: 27003178.
      View in: PubMed
    10. Bredlau AL, McCrackin MA, Motamarry A, Helke K, Chen C, Broome AM, Haemmerich D. Thermal Therapy Approaches for Treatment of Brain Tumors in Animals and Humans. Crit Rev Biomed Eng. 2016; 44(6):443-457. PMID: 29431091.
      View in: PubMed
    11. Dixit S, Miller K, Zhu Y, McKinnon E, Novak T, Kenney ME, Broome AM. Dual Receptor-Targeted Theranostic Nanoparticles for Localized Delivery and Activation of Photodynamic Therapy Drug in Glioblastomas. Mol Pharm. 2015 Sep 08; 12(9):3250-60. PMID: 26198693.
      View in: PubMed
    12. Durst R, Sauls K, Peal DS, deVlaming A, Toomer K, Leyne M, Salani M, Talkowski ME, Brand H, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, Le Tourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott JJ, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome AM, Williams K, Johnson A, Markwald RR, Jeunemaitre X, Hagege A, Levine RA, Milan DJ, Norris RA, Slaugenhaupt SA. Mutations in DCHS1 cause mitral valve prolapse. Nature. 2015 Sep 03; 525(7567):109-13. PMID: 26258302.
      View in: PubMed
    13. Nadig SN, Dixit SK, Levey N, Esckilsen S, Miller K, Dennis W, Atkinson C, Broome AM. Immunosuppressive nano-therapeutic micelles downregulate endothelial cell inflammation and immunogenicity. RSC Adv. 2015; 5(54):43552-43562. PMID: 26167278.
      View in: PubMed
    14. Meyers JD, Cheng Y, Broome A-M, Agnes RS, Schluchter M, Margevicius S, Wang X, Kenney ME, Burda C, and Basilion JP. Peptide-Targeted Gold Nanoparticles for Photodynamic Therapy of Brain Cancer. Particle & Particle Systems Characterization. 2015; 32(4):448-457.
    15. Meyers JD, Cheng Y, Broome AM, Agnes RS, Schluchter MD, Margevicius S, Wang X, Kenney ME, Burda C, Basilion JP. Peptide-Targeted Gold Nanoparticles for Photodynamic Therapy of Brain Cancer. Part Part Syst Charact. 2015 Apr; 32(4):448-457. PMID: 25999665.
      View in: PubMed
    16. Broome AM, Ramamurthy G, Lavik K, Liggett A, Kinstlinger I, Basilion J. Optical imaging of targeted ß-galactosidase in brain tumors to detect EGFR levels. Bioconjug Chem. 2015 Apr 15; 26(4):660-8. PMID: 25775241.
      View in: PubMed
    17. Dixit S, Novak T, Miller K, Zhu Y, Kenney ME, Broome AM. Transferrin receptor-targeted theranostic gold nanoparticles for photosensitizer delivery in brain tumors. Nanoscale. 2015 Feb 07; 7(5):1782-90. PMID: 25519743.
      View in: PubMed
    18. Perera RH, Solorio L, Wu H, Gangolli M, Silverman E, Hernandez C, Peiris PM, Broome AM, Exner AA. Nanobubble ultrasound contrast agents for enhanced delivery of thermal sensitizer to tumors undergoing radiofrequency ablation. Pharm Res. 2014 Jun; 31(6):1407-17. PMID: 23943542.
      View in: PubMed
    19. Shukla S, Wen AM, Ayat NR, Commandeur U, Gopalkrishnan R, Broome AM, Lozada KW, Keri RA, Steinmetz NF. Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice. Nanomedicine (Lond). 2014 Feb; 9(2):221-35. PMID: 23834501.
      View in: PubMed
    20. Agnes RS, Broome AM, Wang J, Verma A, Lavik K, Basilion JP. An optical probe for noninvasive molecular imaging of orthotopic brain tumors overexpressing epidermal growth factor receptor. Mol Cancer Ther. 2012 Oct; 11(10):2202-11. PMID: 22807580.
      View in: PubMed
    21. Cheng Y, Meyers JD, Agnes RS, Doane TL, Kenney ME, Broome AM, Burda C, Basilion JP. Addressing brain tumors with targeted gold nanoparticles: a new gold standard for hydrophobic drug delivery? Small. 2011 Aug 22; 7(16):2301-6. PMID: 21630446.
      View in: PubMed
    22. Harth KC, Broome AM, Jacobs MR, Blatnik JA, Zeinali F, Bajaksouzian S, Rosen MJ. Bacterial clearance of biologic grafts used in hernia repair: an experimental study. Surg Endosc. 2011 Jul; 25(7):2224-9. PMID: 21298542.
      View in: PubMed
    23. Cheng Y, Meyers JD, Broome AM, Kenney ME, Basilion JP, Burda C. Deep penetration of a PDT drug into tumors by noncovalent drug-gold nanoparticle conjugates. J Am Chem Soc. 2011 Mar 02; 133(8):2583-91. PMID: 21294543.
      View in: PubMed
    24. Perera RH, Krupka TM, Wu H, Traughber B, Dremann D, Broome AM, Exner AA. Role of Pluronic block copolymers in modulation of heat shock protein 70 expression. Int J Hyperthermia. 2011; 27(7):672-81. PMID: 21992560.
      View in: PubMed
    25. Halaweish I, Harth K, Broome AM, Voskerician G, Jacobs MR, Rosen MJ. Novel in vitro model for assessing susceptibility of synthetic hernia repair meshes to Staphylococcus aureus infection using green fluorescent protein-labeled bacteria and modern imaging techniques. Surg Infect (Larchmt). 2010 Oct; 11(5):449-54. PMID: 20815759.
      View in: PubMed
    26. Sandhu GS, Solorio L, Broome AM, Salem N, Kolthammer J, Shah T, Flask C, Duerk JL. Whole animal imaging. Wiley Interdiscip Rev Syst Biol Med. 2010 Jul-Aug; 2(4):398-421. PMID: 20836038.
      View in: PubMed
    27. Broome AM, Bhavsar N, Ramamurthy G, Newton G, Basilion JP. Expanding the utility of beta-galactosidase complementation: piece by piece. Mol Pharm. 2010 Feb 01; 7(1):60-74. PMID: 19899815.
      View in: PubMed
    28. Eckert RL, Sturniolo MT, Broome AM, Ruse M, Rorke EA. Transglutaminase function in epidermis. J Invest Dermatol. 2005 Mar; 124(3):481-92. PMID: 15737187.
      View in: PubMed
    29. Eckert RL, Sturniolo MT, Broome AM, Ruse M, Rorke EA. Transglutaminases in epidermis. Prog Exp Tumor Res. 2005; 38:115-24. PMID: 15746532.
      View in: PubMed
    30. Efimova T, Broome AM, Eckert RL. Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex. Mol Cell Biol. 2004 Sep; 24(18):8167-83. PMID: 15340077.
      View in: PubMed
    31. Eckert RL, Broome AM, Ruse M, Robinson N, Ryan D, Lee K. S100 proteins in the epidermis. J Invest Dermatol. 2004 Jul; 123(1):23-33. PMID: 15191538.
      View in: PubMed
    32. Broome AM, Eckert RL. Microtubule-dependent redistribution of a cytoplasmic cornified envelope precursor. J Invest Dermatol. 2004 Jan; 122(1):29-38. PMID: 14962086.
      View in: PubMed
    33. Sturniolo MT, Dashti SR, Deucher A, Rorke EA, Broome AM, Chandraratna RA, Keepers T, Eckert RL. A novel tumor suppressor protein promotes keratinocyte terminal differentiation via activation of type I transglutaminase. J Biol Chem. 2003 Nov 28; 278(48):48066-73. PMID: 12928434.
      View in: PubMed
    34. Ruse M, Broome AM, Eckert RL. S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes. J Invest Dermatol. 2003 Jul; 121(1):132-41. PMID: 12839573.
      View in: PubMed
    35. Efimova T, Broome AM, Eckert RL. A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation. J Biol Chem. 2003 Sep 05; 278(36):34277-85. PMID: 12810719.
      View in: PubMed
    36. Broome AM, Ryan D, Eckert RL. S100 protein subcellular localization during epidermal differentiation and psoriasis. J Histochem Cytochem. 2003 May; 51(5):675-85. PMID: 12704215.
      View in: PubMed
    37. Morré DJ, Morré DM, Paulik M, Batova A, Broome AM, Pirisi L, Creek KE. Retinoic acid and calcitriol inhibition of growth and NADH oxidase of normal and immortalized human keratinocytes. Biochim Biophys Acta. 1992 Apr 07; 1134(3):217-22. PMID: 1558845.
      View in: PubMed
    Broome's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _