Andrew G Jakymiw

Title
InstitutionMedical University of South Carolina
DepartmentOral Health Sciences
AddressP.O. Box MSC 507
230C
Basic Science Building - 173 Ashley Ave.
Phone843-792-2551
Fax843-792-6626
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    Collapse Biography 
    Collapse awards and honors
    2010 - 2012SC COBRE Junior Investigator
    2008 - 2014K99/R00 NIH Pathway to Independence Award
    2008 - 2011Bankhead-Coley Florida Cancer Research Program New Investigator Research Award

    Collapse Overview 
    Collapse overview
    Our research focuses on the study of RNA silencing biology and how dysregulation of its molecular components can contribute to disease, in particular oral cancer. Moreover, our laboratory is also pursuing the study of RNA interference (RNAi)-based therapies for oral cancer. The goal of our research is to gain further insights into the molecular causes of oral cancer, identify novel biomarkers for this disease, and develop improved therapeutic strategies for treating individuals afflicted with this disease.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Holjencin CE, Feinberg CR, Hedrick T, Halsey G, Williams RD, Patel PV, Biles E, Cummings JC, Wagner C, Vyavahare N, Jakymiw A. Advancing peptide siRNA-carrier designs through L/D-amino acid stereochemical modifications to enhance gene silencing. Mol Ther Nucleic Acids. 2021 Jun 04; 24:462-476. PMID: 33868789.
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    2. Cummings JC, Zhang H, Jakymiw A. Peptide carriers to the rescue: overcoming the barriers to siRNA delivery for cancer treatment. Transl Res. 2019 12; 214:92-104. PMID: 31404520.
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    3. Alexander-Bryant AA, Zhang H, Attaway CC, Pugh W, Eggart L, Sansevere RM, Andino LM, Dinh L, Cantini LP, Jakymiw A. Dual peptide-mediated targeted delivery of bioactive siRNAs to oral cancer cells in vivo. Oral Oncol. 2017 09; 72:123-131. PMID: 28797448.
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    4. Alexander-Bryant AA, Dumitriu A, Attaway CC, Yu H, Jakymiw A. Fusogenic-oligoarginine peptide-mediated silencing of the CIP2A oncogene suppresses oral cancer tumor growth in vivo. J Control Release. 2015 Nov 28; 218:72-81. PMID: 26386438.
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    5. Cantini LP, Andino LM, Attaway CC, Butler B, Dumitriu A, Blackshaw A, Jakymiw A. Identification and characterization of Dicer1e, a Dicer1 protein variant, in oral cancer cells. Mol Cancer. 2014 Aug 13; 13:190. PMID: 25115815.
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    6. Cantini L, Attaway CC, Butler B, Andino LM, Sokolosky ML, Jakymiw A. Fusogenic-oligoarginine peptide-mediated delivery of siRNAs targeting the CIP2A oncogene into oral cancer cells. PLoS One. 2013; 8(9):e73348. PMID: 24019920.
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    7. Jung HM, Phillips BL, Patel RS, Cohen DM, Jakymiw A, Kong WW, Cheng JQ, Chan EK. Keratinization-associated miR-7 and miR-21 regulate tumor suppressor reversion-inducing cysteine-rich protein with kazal motifs (RECK) in oral cancer. J Biol Chem. 2012 Aug 24; 287(35):29261-72. PMID: 22761427.
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    8. Qin Z, Jakymiw A, Findlay V, Parsons C. KSHV-Encoded MicroRNAs: Lessons for Viral Cancer Pathogenesis and Emerging Concepts. Int J Cell Biol. 2012; 2012:603961. PMID: 22505930.
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    9. Palanisamy V, Jakymiw A, Van Tubergen EA, D'Silva NJ, Kirkwood KL. Control of cytokine mRNA expression by RNA-binding proteins and microRNAs. J Dent Res. 2012 Jul; 91(7):651-8. PMID: 22302144.
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    10. Patel RS, Jakymiw A, Yao B, Pauley BA, Carcamo WC, Katz J, Cheng JQ, Chan EK. High resolution of microRNA signatures in human whole saliva. Arch Oral Biol. 2011 Dec; 56(12):1506-13. PMID: 21704302.
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    11. Katz J, Jakymiw A, Ducksworth MK, Stewart CM, Bhattacharyya I, Cha S, Chan EK. CIP2A expression and localization in oral carcinoma and dysplasia. . 2010 Oct 01; 10(7):694-9. PMID: 21068540.
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    12. Jakymiw A, Patel RS, Deming N, Bhattacharyya I, Shah P, Lamont RJ, Stewart CM, Cohen DM, Chan EK. Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells. Genes Chromosomes Cancer. 2010 Jun; 49(6):549-59. PMID: 20232482.
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    13. Andino LM, Takeda M, Kasahara H, Jakymiw A, Byrne BJ, Lewin AS. AAV-mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes. J Gene Med. 2008 Feb; 10(2):132-42. PMID: 18064719.
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    14. Jakymiw A, Pauley KM, Li S, Ikeda K, Lian S, Eystathioy T, Satoh M, Fritzler MJ, Chan EK. The role of GW/P-bodies in RNA processing and silencing. J Cell Sci. 2007 Apr 15; 120(Pt 8):1317-23. PMID: 17401112.
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    15. Pauley KM, Eystathioy T, Jakymiw A, Hamel JC, Fritzler MJ, Chan EK. Formation of GW bodies is a consequence of microRNA genesis. . 2006 Sep; 7(9):904-10. PMID: 16906129.
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    16. Lian S, Jakymiw A, Eystathioy T, Hamel JC, Fritzler MJ, Chan EK. GW bodies, microRNAs and the cell cycle. Cell Cycle. 2006 Feb; 5(3):242-5. PMID: 16418578.
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    17. Jakymiw A, Ikeda K, Fritzler MJ, Reeves WH, Satoh M, Chan EK. Autoimmune targeting of key components of RNA interference. Arthritis Res Ther. 2006; 8(4):R87. PMID: 16684366.
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    18. Jakymiw A, Lian S, Eystathioy T, Li S, Satoh M, Hamel JC, Fritzler MJ, Chan EK. Disruption of GW bodies impairs mammalian RNA interference. Nat Cell Biol. 2005 Dec; 7(12):1267-74. PMID: 16284622.
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    19. Yang Z, Jakymiw A, Wood MR, Eystathioy T, Rubin RL, Fritzler MJ, Chan EK. GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation. J Cell Sci. 2004 Nov 01; 117(Pt 23):5567-78. PMID: 15494374.
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    20. Babic I, Jakymiw A, Fujita DJ. The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity. Oncogene. 2004 May 06; 23(21):3781-9. PMID: 15021911.
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    21. Eystathioy T, Jakymiw A, Chan EK, Séraphin B, Cougot N, Fritzler MJ. The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. RNA. 2003 Oct; 9(10):1171-3. PMID: 13130130.
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    22. Bjorge JD, Jakymiw A, Fujita DJ. Selected glimpses into the activation and function of Src kinase. Oncogene. 2000 Nov 20; 19(49):5620-35. PMID: 11114743.
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    23. Eystathioy T, Jakymiw A, Fujita DJ, Fritzler MJ, Chan EK. Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen. J Autoimmun. 2000 Mar; 14(2):179-87. PMID: 10677249.
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    24. Jakymiw A, Raharjo E, Rattner JB, Eystathioy T, Chan EK, Fujita DJ. Identification and characterization of a novel Golgi protein, golgin-67. J Biol Chem. 2000 Feb 11; 275(6):4137-44. PMID: 10660574.
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