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Andrew G Jakymiw

Title
InstitutionMedical University of South Carolina
DepartmentOral Health Sciences
AddressP.O. Box MSC 507
230C
Basic Science Building - 173 Ashley Ave.
Phone843-792-2551
Fax843-792-6626
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    Collapse Biography 
    Collapse awards and honors
    2010 - 2012SC COBRE Junior Investigator
    2008 - 2014K99/R00 NIH Pathway to Independence Award
    2008 - 2011Bankhead-Coley Florida Cancer Research Program New Investigator Research Award

    Collapse Overview 
    Collapse overview
    Our research focuses on the study of RNA silencing biology and how dysregulation of its molecular components can contribute to disease, in particular oral cancer. Moreover, our laboratory is also pursuing the study of RNA interference (RNAi)-based therapies for oral cancer. The goal of our research is to gain further insights into the molecular causes of oral cancer, identify novel biomarkers for this disease, and develop improved therapeutic strategies for treating individuals afflicted with this disease.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Alexander-Bryant AA, Zhang H, Attaway CC, Pugh W, Eggart L, Sansevere RM, Andino LM, Dinh L, Cantini LP, Jakymiw A. Dual peptide-mediated targeted delivery of bioactive siRNAs to oral cancer cells in vivo. Oral Oncol. 2017 09; 72:123-131. PMID: 28797448.
      View in: PubMed
    2. Alexander-Bryant AA, Dumitriu A, Attaway CC, Yu H, Jakymiw A. Fusogenic-oligoarginine peptide-mediated silencing of the CIP2A oncogene suppresses oral cancer tumor growth in vivo. J Control Release. 2015 Nov 28; 218:72-81. PMID: 26386438.
      View in: PubMed
    3. Cantini LP, Andino LM, Attaway CC, Butler B, Dumitriu A, Blackshaw A, Jakymiw A. Identification and characterization of Dicer1e, a Dicer1 protein variant, in oral cancer cells. Mol Cancer. 2014 Aug 13; 13:190. PMID: 25115815.
      View in: PubMed
    4. Cantini L, Attaway CC, Butler B, Andino LM, Sokolosky ML, Jakymiw A. Fusogenic-oligoarginine peptide-mediated delivery of siRNAs targeting the CIP2A oncogene into oral cancer cells. PLoS One. 2013; 8(9):e73348. PMID: 24019920.
      View in: PubMed
    5. Jung HM, Phillips BL, Patel RS, Cohen DM, Jakymiw A, Kong WW, Cheng JQ, Chan EK. Keratinization-associated miR-7 and miR-21 regulate tumor suppressor reversion-inducing cysteine-rich protein with kazal motifs (RECK) in oral cancer. J Biol Chem. 2012 Aug 24; 287(35):29261-72. PMID: 22761427.
      View in: PubMed
    6. Qin Z, Jakymiw A, Findlay V, Parsons C. KSHV-Encoded MicroRNAs: Lessons for Viral Cancer Pathogenesis and Emerging Concepts. Int J Cell Biol. 2012; 2012:603961. PMID: 22505930.
      View in: PubMed
    7. Palanisamy V, Jakymiw A, Van Tubergen EA, D'Silva NJ, Kirkwood KL. Control of cytokine mRNA expression by RNA-binding proteins and microRNAs. J Dent Res. 2012 Jul; 91(7):651-8. PMID: 22302144.
      View in: PubMed
    8. Patel RS, Jakymiw A, Yao B, Pauley BA, Carcamo WC, Katz J, Cheng JQ, Chan EK. High resolution of microRNA signatures in human whole saliva. Arch Oral Biol. 2011 Dec; 56(12):1506-13. PMID: 21704302.
      View in: PubMed
    9. Katz J, Jakymiw A, Ducksworth MK, Stewart CM, Bhattacharyya I, Cha S, Chan EK. CIP2A expression and localization in oral carcinoma and dysplasia. Cancer Biol Ther. 2010 Oct 01; 10(7):694-9. PMID: 21068540.
      View in: PubMed
    10. Jakymiw A, Patel RS, Deming N, Bhattacharyya I, Shah P, Lamont RJ, Stewart CM, Cohen DM, Chan EK. Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells. Genes Chromosomes Cancer. 2010 Jun; 49(6):549-59. PMID: 20232482.
      View in: PubMed
    11. Andino LM, Takeda M, Kasahara H, Jakymiw A, Byrne BJ, Lewin AS. AAV-mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes. J Gene Med. 2008 Feb; 10(2):132-42. PMID: 18064719.
      View in: PubMed
    12. Jakymiw A, Pauley KM, Li S, Ikeda K, Lian S, Eystathioy T, Satoh M, Fritzler MJ, Chan EK. The role of GW/P-bodies in RNA processing and silencing. J Cell Sci. 2007 Apr 15; 120(Pt 8):1317-23. PMID: 17401112.
      View in: PubMed
    13. Pauley KM, Eystathioy T, Jakymiw A, Hamel JC, Fritzler MJ, Chan EK. Formation of GW bodies is a consequence of microRNA genesis. EMBO Rep. 2006 Sep; 7(9):904-10. PMID: 16906129.
      View in: PubMed
    14. Lian S, Jakymiw A, Eystathioy T, Hamel JC, Fritzler MJ, Chan EK. GW bodies, microRNAs and the cell cycle. Cell Cycle. 2006 Feb; 5(3):242-5. PMID: 16418578.
      View in: PubMed
    15. Jakymiw A, Ikeda K, Fritzler MJ, Reeves WH, Satoh M, Chan EK. Autoimmune targeting of key components of RNA interference. Arthritis Res Ther. 2006; 8(4):R87. PMID: 16684366.
      View in: PubMed
    16. Jakymiw A, Lian S, Eystathioy T, Li S, Satoh M, Hamel JC, Fritzler MJ, Chan EK. Disruption of GW bodies impairs mammalian RNA interference. Nat Cell Biol. 2005 Dec; 7(12):1267-74. PMID: 16284622.
      View in: PubMed
    17. Yang Z, Jakymiw A, Wood MR, Eystathioy T, Rubin RL, Fritzler MJ, Chan EK. GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation. J Cell Sci. 2004 Nov 01; 117(Pt 23):5567-78. PMID: 15494374.
      View in: PubMed
    18. Babic I, Jakymiw A, Fujita DJ. The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity. Oncogene. 2004 May 06; 23(21):3781-9. PMID: 15021911.
      View in: PubMed
    19. Eystathioy T, Jakymiw A, Chan EK, Séraphin B, Cougot N, Fritzler MJ. The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. RNA. 2003 Oct; 9(10):1171-3. PMID: 13130130.
      View in: PubMed
    20. Bjorge JD, Jakymiw A, Fujita DJ. Selected glimpses into the activation and function of Src kinase. Oncogene. 2000 Nov 20; 19(49):5620-35. PMID: 11114743.
      View in: PubMed
    21. Eystathioy T, Jakymiw A, Fujita DJ, Fritzler MJ, Chan EK. Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen. J Autoimmun. 2000 Mar; 14(2):179-87. PMID: 10677249.
      View in: PubMed
    22. Jakymiw A, Raharjo E, Rattner JB, Eystathioy T, Chan EK, Fujita DJ. Identification and characterization of a novel Golgi protein, golgin-67. J Biol Chem. 2000 Feb 11; 275(6):4137-44. PMID: 10660574.
      View in: PubMed
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