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Last Name
Institution

Andrew James Goodwin

Title
InstitutionMedical University of South Carolina
DepartmentMedicine
AddressP.O. Box MSC 630
Clinical Science Bldg. - 96 Jonathan Lucas St.
Phone843-792-4728
Fax843-876-2057
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    Collapse Biography 
    Collapse awards and honors
    2011 - 2011Hermansky Pudlak Syndrome Travel Award, American Thoracic Society
    2013 - 2015KL2 Scholars Program, Medical University of South Carolina
    2014 - 2016Loan Repayment Program, National Institutes of Health-NHLBI

    Collapse Overview 
    Collapse overview
    I am a pulmonary intensivist dedicated to providing high quality critical care and performing clinical and translational research on critical illness. My research interests include the translational study of endothelial dysfunction in sepsis and ARDS as well as the clinical study of ICU structures and processes and how they influence critical illness outcomes.

    Collapse keywords
    Inflammation, Ethnicity and Disease, Minorities, Genetics

    Collapse ORNG Applications 
    Collapse studies/trials

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Eytan D, Jegatheeswaran A, Mazwi ML, Assadi A, Goodwin AJ, Greer RW, Goodfellow SD, Laussen PC. Temporal Variability in the Sampling of Vital Sign Data Limits the Accuracy of Patient State Estimation. Pediatr Crit Care Med. 2019 May 31. PMID: 31162373.
      View in: PubMed
    2. Nadig NR, Sterba KR, Johnson EE, Goodwin AJ, Ford DW. Inter-ICU transfer of patients with ventilator dependent respiratory failure: Qualitative analysis of family and physician perspectives. Patient Educ Couns. 2019 Apr 05. PMID: 30979579.
      View in: PubMed
    3. Fan H, Goodwin AJ. What's New in Shock, March 2019? Shock. 2019 Mar; 51(3):269-272. PMID: 30475330.
      View in: PubMed
    4. Johnson EE, Sterba KR, Goodwin AJ, Warr EH, Beeks R, Zapka JM, Ford DW. Implementation of an Academic-to-Community Hospital ICU Quality Improvement Program: Qualitative Analysis of Multilevel Facilitators and Barriers. Ann Am Thorac Soc. 2019 Mar 01. PMID: 30822096.
      View in: PubMed
    5. Zhou Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Chang E, Zingarelli B, Fan H. Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury. Crit Care. 2019 02 13; 23(1):44. PMID: 30760290.
      View in: PubMed
    6. Li P, Goodwin AJ, Cook JA, Halushka PV, Zhang XK, Fan H. Fli-1 transcription factor regulates the expression of caspase-1 in lung pericytes. Mol Immunol. 2019 04; 108:1-7. PMID: 30739075.
      View in: PubMed
    7. Jones Buie JN, Zhou Y, Goodwin AJ, Cook JA, Vournakis J, Demcheva M, Broome AM, Dixit S, Halushka PV, Fan H. Application of Deacetylated Poly-N-Acetyl Glucosamine Nanoparticles for the Delivery of miR-126 for the Treatment of Cecal Ligation and Puncture-Induced Sepsis. Inflammation. 2019 Feb; 42(1):170-184. PMID: 30244405.
      View in: PubMed
    8. Higgins RA, Goodwin AJ. Automated assays for von Willebrand factor activity. Am J Hematol. 2019 Apr; 94(4):496-503. PMID: 30592326.
      View in: PubMed
    9. Goodwin AJ. Are Sepsis Outcomes Predetermined? How the Road toward Sepsis May Predict Outcomes. Ann Am Thorac Soc. 2019 Jan; 16(1):57-59. PMID: 30592450.
      View in: PubMed
    10. Goodwin AJ. Can Serial Quick Sequential (Sepsis-Related) Organ Failure Assessment Measurement Aid in Sepsis Identification and Triage Decisions? Crit Care Med. 2018 Dec; 46(12):2046-2048. PMID: 30444809.
      View in: PubMed
    11. Li P, Zhou Y, Goodwin AJ, Cook JA, Halushka PV, Zhang XK, Wilson CL, Schnapp LM, Zingarelli B, Fan H. Fli-1 Governs Pericyte Dysfunction in a Murine Model of Sepsis. J Infect Dis. 2018 Nov 05; 218(12):1995-2005. PMID: 30053030.
      View in: PubMed
    12. Halushka PV, Goodwin AJ, Halushka MK. Opportunities for microRNAs in the Crowded Field of Cardiovascular Biomarkers. Annu Rev Pathol. 2019 Jan 24; 14:211-238. PMID: 30332561.
      View in: PubMed
    13. Goodwin AJ. Critical Care Outcomes Among Opioid Users: Hidden Sequelae of a Growing Crisis? Crit Care Med. 2018 Jun; 46(6):1005-1006. PMID: 29762398.
      View in: PubMed
    14. Goodwin AJ, Ford DW. Readmissions Among Sepsis Survivors: Risk Factors and Prevention. Clin Pulm Med. 2018 May; 25(3):79-83. PMID: 30237689.
      View in: PubMed
    15. Ambaye AB, MacLennan SE, Goodwin AJ, Weaver DL. In Reply. Arch Pathol Lab Med. 2018 03; 142(3):287b-288. PMID: 29494221.
      View in: PubMed
    16. Zhou Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Chang E, Fan H. Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis. Mol Ther. 2018 05 02; 26(5):1375-1384. PMID: 29599080.
      View in: PubMed
    17. Eytan D, Goodwin AJ, Greer R, Guerguerian AM, Mazwi M, Laussen PC. Distributions and Behavior of Vital Signs in Critically Ill Children by Admission Diagnosis. Pediatr Crit Care Med. 2018 02; 19(2):115-124. PMID: 29206728.
      View in: PubMed
    18. Goodwin AJ, Adcock DM. Thrombophilia Testing and Venous Thrombosis. N Engl J Med. 2017 12 07; 377(23):2297-8. PMID: 29215221.
      View in: PubMed
    19. Ambaye AB, Goodwin AJ, MacLennan SE, Naud S, Weaver DL. Recommendations for Pathologic Evaluation of Reduction Mammoplasty Specimens: A Prospective Study With Systematic Tissue Sampling. Arch Pathol Lab Med. 2017 Nov; 141(11):1523-1528. PMID: 28795842.
      View in: PubMed
    20. Nadig NR, Goodwin AJ, Simpson AN, Simpson KN, Richards J, Ford DW. Patient and Hospital Characteristics Associated with Interhospital Transfer for Adults with Ventilator-Dependent Respiratory Failure. Ann Am Thorac Soc. 2017 May; 14(5):730-736. PMID: 28199137.
      View in: PubMed
    21. Eytan D, Goodwin AJ, Greer R, Guerguerian AM, Laussen PC. Heart Rate and Blood Pressure Centile Curves and Distributions by Age of Hospitalized Critically Ill Children. Front Pediatr. 2017; 5:52. PMID: 28367430.
      View in: PubMed
    22. Goodwin AJ, Liu V, Ford DW. Hospital Readmissions in Sepsis Survivors: Are They Preventable? Ann Am Thorac Soc. 2017 02; 14(2):170-171. PMID: 28146387.
      View in: PubMed
    23. Goodwin AJ, Higgins RA, Moser KA, Smock KJ, Chandler WL, Kottke-Marchant K, Hartman SK, Volod O, Brown AF, Johari VP, Burr S, Polyakov N, Chen D. Issues Surrounding Age-Adjusted d-Dimer Cutoffs That Practicing Physicians Need to Know When Evaluating Patients With Suspected Pulmonary Embolism. Ann Intern Med. 2017 Mar 07; 166(5):361-363. PMID: 28024301.
      View in: PubMed
    24. Kalivas BC, Goodwin AJ. A Woman in Her 60s With Fever and Altered Mental Status in a Psychiatric Hospital. Chest. 2016 Dec; 150(6):e171-e174. PMID: 27938775.
      View in: PubMed
    25. Jones Buie JN, Goodwin AJ, Cook JA, Halushka PV, Fan H. The role of miRNAs in cardiovascular disease risk factors. Atherosclerosis. 2016 11; 254:271-281. PMID: 27693002.
      View in: PubMed
    26. Goodwin AJ, Nadig NR, McElligott JT, Simpson KN, Ford DW. Where You Live Matters: The Impact of Place of Residence on Severe Sepsis Incidence and Mortality. Chest. 2016 Oct; 150(4):829-836. PMID: 27445093.
      View in: PubMed
    27. Guo C, Goodwin A, Buie JNJ, Cook J, Halushka P, Argraves K, Zingarelli B, Zhang X, Wang L, Fan H. A Stromal Cell-Derived Factor 1a Analogue Improves Endothelial Cell Function in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome. Mol Med. 2016 Sep; 22:115-123. PMID: 27031787.
      View in: PubMed
    28. Ford DW, Goodwin AJ, Simpson AN, Johnson E, Nadig N, Simpson KN. A Severe Sepsis Mortality Prediction Model and Score for Use With Administrative Data. Crit Care Med. 2016 Feb; 44(2):319-27. PMID: 26496452.
      View in: PubMed
    29. Eytan D, Goodwin A, Laussen P, Guerguerian AM. Insights From Multi-Dimensional Physiological Signals to Predict and Prevent Cardiac Arrests. Pediatr Crit Care Med. 2016 Jan; 17(1):81-2. PMID: 26731319.
      View in: PubMed
    30. Goodwin AJ, Guo C, Cook JA, Wolf B, Halushka PV, Fan H. Plasma levels of microRNA are altered with the development of shock in human sepsis: an observational study. Crit Care. 2015 Dec 18; 19:440. PMID: 26683209.
      View in: PubMed
    31. Velez JC, Kadian M, Taburyanskaya M, Bohm NM, Delay TA, Karakala N, Rockey DC, Nietert PJ, Goodwin AJ, Whelan TP. Hepatorenal Acute Kidney Injury and the Importance of Raising Mean Arterial Pressure. Nephron. 2015; 131(3):191-201. PMID: 26485256.
      View in: PubMed
    32. Goodwin AJ, Rice DA, Simpson KN, Ford DW. The authors reply. Crit Care Med. 2015 Oct; 43(10):e461-2. PMID: 26376264.
      View in: PubMed
    33. Goodwin AJ, Simpson KN, Ford DW. Volume-Mortality Relationships during Hospitalization with Severe Sepsis Exist Only at Low Case Volumes. Ann Am Thorac Soc. 2015 Aug; 12(8):1177-84. PMID: 26086787.
      View in: PubMed
    34. Persing S, Jerome MA, James TA, Callas P, Mace J, Sowden M, Goodwin A, Weaver DL, Sprague BL. Surgical margin reporting in breast conserving surgery: Does compliance with guidelines affect re-excision and mastectomy rates? Breast. 2015 Oct; 24(5):618-22. PMID: 26199197.
      View in: PubMed
    35. Goodwin AJ, Rice DA, Simpson KN, Ford DW. Frequency, cost, and risk factors of readmissions among severe sepsis survivors. Crit Care Med. 2015 Apr; 43(4):738-46. PMID: 25746745.
      View in: PubMed
    36. Feng S, Weaver DL, Carney PA, Reisch LM, Geller BM, Goodwin A, Rendi MH, Onega T, Allison KH, Tosteson AN, Nelson HD, Longton G, Pepe M, Elmore JG. A framework for evaluating diagnostic discordance in pathology discovered during research studies. Arch Pathol Lab Med. 2014 Jul; 138(7):955-61. PMID: 24978923.
      View in: PubMed
    37. Fan H, Goodwin AJ, Chang E, Zingarelli B, Borg K, Guan S, Halushka PV, Cook JA. Endothelial progenitor cells and a stromal cell-derived factor-1a analogue synergistically improve survival in sepsis. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1509-19. PMID: 24707934.
      View in: PubMed
    38. Shi Y, Gochuico BR, Yu G, Tang X, Osorio JC, Fernandez IE, Risquez CF, Patel AS, Shi Y, Wathelet MG, Goodwin AJ, Haspel JA, Ryter SW, Billings EM, Kaminski N, Morse D, Rosas IO. Syndecan-2 exerts antifibrotic effects by promoting caveolin-1-mediated transforming growth factor-ß receptor I internalization and inhibiting transforming growth factor-ß1 signaling. Am J Respir Crit Care Med. 2013 Oct 01; 188(7):831-41. PMID: 23924348.
      View in: PubMed
    39. Goodwin AJ. Critical care clinical trials: getting off the roller coaster. Chest. 2012 Sep; 142(3):563-567. PMID: 22948575.
      View in: PubMed
    40. Shi Y, Cao J, Gao J, Zheng L, Goodwin A, An CH, Patel A, Lee JS, Duncan SR, Kaminski N, Pandit KV, Rosas IO, Choi AM, Morse D. Retinoic acid-related orphan receptor-a is induced in the setting of DNA damage and promotes pulmonary emphysema. Am J Respir Crit Care Med. 2012 Sep 01; 186(5):412-9. PMID: 22744720.
      View in: PubMed
    41. Persing S, James TA, Mace J, Goodwin A, Geller B. Variability in the quality of pathology reporting of margin status following breast cancer surgery. Ann Surg Oncol. 2011 Oct; 18(11):3061-5. PMID: 21947586.
      View in: PubMed
    42. Ambaye AB, MacLennan SE, Goodwin AJ, Suppan T, Naud S, Weaver DL. Carcinoma and atypical hyperplasia in reduction mammaplasty: increased sampling leads to increased detection. A prospective study. Plast Reconstr Surg. 2009 Nov; 124(5):1386-92. PMID: 20009822.
      View in: PubMed
    43. Svensson AM, Waters BL, Laszik ZG, Simmons-Arnold L, Goodwin A, Beatty BG, Bovill EG. The protein C system in placental massive perivillous fibrin deposition. Blood Coagul Fibrinolysis. 2004 Sep; 15(6):491-5. PMID: 15311158.
      View in: PubMed
    44. Goodwin AJ, Rosendaal FR, Kottke-Marchant K, Bovill EG. A review of the technical, diagnostic, and epidemiologic considerations for protein S assays. Arch Pathol Lab Med. 2002 Nov; 126(11):1349-66. PMID: 12421142.
      View in: PubMed
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