Amy Dodd Bradshaw

Title
InstitutionMedical University of South Carolina
DepartmentMedicine
AddressP.O. Box MSC 773
325
Thurmond Gazes - 30 Courtenay Drive
Phone843-792-4959
Fax843-876-4809
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neff LS, Bradshaw AD. Cross your heart? Collagen cross-links in cardiac health and disease. Cell Signal. 2021 Mar; 79:109889. PMID: 33347984.
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    2. Riley HJ, Kelly RR, Van Laer AO, Neff LS, Dasgupta S, Baicu CF, McDonald LT, LaRue AC, Zile MR, Bradshaw AD. SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload. Am J Physiol Heart Circ Physiol. 2021 02 01; 320(2):H604-H612. PMID: 33306449.
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    3. Nguyen XX, Nishimoto T, Takihara T, Mlakar L, Bradshaw AD, Feghali-Bostwick C. Lysyl oxidase directly contributes to extracellular matrix production and fibrosis in systemic sclerosis. Am J Physiol Lung Cell Mol Physiol. 2021 01 01; 320(1):L29-L40. PMID: 33026236.
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    4. O'Brien M, Baicu CF, Van Laer AO, Zhang Y, McDonald LT, LaRue AC, Zile MR, Bradshaw AD. Pressure overload generates a cardiac-specific profile of inflammatory mediators. Am J Physiol Heart Circ Physiol. 2020 08 01; 319(2):H331-H340. PMID: 32589444.
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    5. Durham E, Zhang Y, LaRue A, Bradshaw A, Cray J. Selective serotonin reuptake inhibitors (SSRI) affect murine bone lineage cells. Life Sci. 2020 Aug 15; 255:117827. PMID: 32450170.
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    6. Lindsey ML, Deleon-Pennell KY, Bradshaw AD, Larue RAC, Anderson DR, Thiele GM, Baicu CF, Jones JA, Menick DR, Zile MR, Spinale FG. Focusing Heart Failure Research on Myocardial Fibrosis to Prioritize Translation. J Card Fail. 2020 Oct; 26(10):876-884. PMID: 32446948.
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    7. Bradshaw AD, DeLeon-Pennell KY. T-cell regulation of fibroblasts and cardiac fibrosis. Matrix Biol. 2020 09; 91-92:167-175. PMID: 32438054.
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    8. Moore Rosset E, Trombetta-eSilva J, Hepfer G, Chen P, Yao H, Bradshaw AD. Inhibition of transglutaminase activity in periodontitis rescues periodontal ligament collagen content and architecture. J Periodontal Res. 2020 Jan; 55(1):107-115. PMID: 31552683.
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    9. Yuan C, Wang Z, Borg TK, Ye T, Baicu C, Bradshaw A, Zile M, Runyan RB, Shao Y, Gao BZ. Changes in the crystallographic structures of cardiac myosin filaments detected by polarization-dependent second harmonic generation microscopy. Biomed Opt Express. 2019 Jul 01; 10(7):3183-3195. PMID: 31360597.
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    10. Riley HJ, Bradshaw AD. The Influence of the Extracellular Matrix in Inflammation: Findings from the SPARC-Null Mouse. Anat Rec (Hoboken). 2020 06; 303(6):1624-1629. PMID: 30980479.
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    11. Bradshaw AD. It's a SMAD, SMAD World: Cell Type-Specific SMAD Signaling in the Heart. JACC Basic Transl Sci. 2019 Feb; 4(1):54-55. PMID: 30847419.
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    12. Bradshaw AD, DeLeon-Pennell KY. Iron overload: what's TIMP-3 got to do with it. . 2018 06 01; 314(6):H1259-H1261. PMID: 29522369.
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    13. McDonald LT, Zile MR, Zhang Y, Van Laer AO, Baicu CF, Stroud RE, Jones JA, LaRue AC, Bradshaw AD. Increased macrophage-derived SPARC precedes collagen deposition in myocardial fibrosis. . 2018 07 01; 315(1):H92-H100. PMID: 29522370.
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    14. Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M. Cardiac macrophages promote diastolic dysfunction. J Exp Med. 2018 02 05; 215(2):423-440. PMID: 29339450.
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    15. Workman G, Bradshaw AD. Production and purification of recombinant human SPARC. Methods Cell Biol. 2018; 143:335-345. PMID: 29310786.
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    16. Tamaddon M, Burrows M, Ferreira SA, Dazzi F, Apperley JF, Bradshaw A, Brand DD, Czernuszka J, Gentleman E. Monomeric, porous type II collagen scaffolds promote chondrogenic differentiation of human bone marrow mesenchymal stem cells in vitro. Sci Rep. 2017 03 03; 7:43519. PMID: 28256634.
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    17. Rosset EM, Trombetta-eSilva J, Hepfer G, Yao H, Bradshaw AD. SPARC and the N-propeptide of collagen I influence fibroblast proliferation and collagen assembly in the periodontal ligament. PLoS One. 2017; 12(2):e0173209. PMID: 28245286.
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    18. Stevenson KT, Peterson MN, Bradshaw A. How Climate Change Beliefs among U.S. Teachers Do and Do Not Translate to Students. PLoS One. 2016; 11(9):e0161462. PMID: 27603667.
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    19. Gehwolf R, Wagner A, Lehner C, Bradshaw AD, Scharler C, Niestrawska JA, Holzapfel GA, Bauer HC, Tempfer H, Traweger A. Pleiotropic roles of the matricellular protein Sparc in tendon maturation and ageing. Sci Rep. 2016 09 02; 6:32635. PMID: 27586416.
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    20. Toba H, de Castro Brás LE, Baicu CF, Zile MR, Lindsey ML, Bradshaw AD. Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium. Am J Physiol Endocrinol Metab. 2016 06 01; 310(11):E1027-35. PMID: 27143554.
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    21. Rosset EM, Bradshaw AD. SPARC/osteonectin in mineralized tissue. Matrix Biol. 2016 May-Jul; 52-54:78-87. PMID: 26851678.
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    22. Bradshaw AD. The role of secreted protein acidic and rich in cysteine (SPARC) in cardiac repair and fibrosis: Does expression of SPARC by macrophages influence outcomes? J Mol Cell Cardiol. 2016 04; 93:156-61. PMID: 26582465.
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    23. Balasubramanian S, Pleasant DL, Kasiganesan H, Quinones L, Zhang Y, Sundararaj KP, Roche S, O'Connor R, Bradshaw AD, Kuppuswamy D. Dasatinib Attenuates Pressure Overload Induced Cardiac Fibrosis in a Murine Transverse Aortic Constriction Model. PLoS One. 2015; 10(10):e0140273. PMID: 26458186.
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    24. Trombetta-eSilva J, Rosset EA, Hepfer RG, Wright GJ, Baicu C, Yao H, Bradshaw AD. Decreased Mechanical Strength and Collagen Content in SPARC-Null Periodontal Ligament Is Reversed by Inhibition of Transglutaminase Activity. J Bone Miner Res. 2015 Oct; 30(10):1914-24. PMID: 25827352.
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    25. Lindner HB, Felmly LM, Demcheva M, Seth A, Norris R, Bradshaw AD, Vournakis J, Muise-Helmericks RC. pGlcNAc Nanofiber Treatment of Cutaneous Wounds Stimulate Increased Tensile Strength and Reduced Scarring via Activation of Akt1. PLoS One. 2015; 10(5):e0127876. PMID: 25955155.
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    26. Toba H, de Castro Brás LE, Baicu CF, Zile MR, Lindsey ML, Bradshaw AD. Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization. . 2015 Jun 15; 308(12):C972-82. PMID: 25877699.
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    27. Dupuis LE, Berger MG, Feldman S, Doucette L, Fowlkes V, Chakravarti S, Thibaudeau S, Alcala NE, Bradshaw AD, Kern CB. Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly. J Mol Cell Cardiol. 2015 Jul; 84:70-80. PMID: 25886697.
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    28. Zile MR, Baicu CF, Ikonomidis JS, Stroud RE, Nietert PJ, Bradshaw AD, Slater R, Palmer BM, Van Buren P, Meyer M, Redfield MM, Bull DA, Granzier HL, LeWinter MM. Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin. Circulation. 2015 Apr 07; 131(14):1247-59. PMID: 25637629.
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    29. de Castro Brás LE, Toba H, Baicu CF, Zile MR, Weintraub ST, Lindsey ML, Bradshaw AD. Age and SPARC change the extracellular matrix composition of the left ventricle. Biomed Res Int. 2014; 2014:810562. PMID: 24783223.
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    30. Goldsmith EC, Bradshaw AD, Zile MR, Spinale FG. Myocardial fibroblast-matrix interactions and potential therapeutic targets. J Mol Cell Cardiol. 2014 May; 70:92-9. PMID: 24472826.
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    31. Trombetta-eSilva J, Eadie EP, Zhang Y, Norris RA, Borg TK, Bradshaw AD. The effects of age and the expression of SPARC on extracellular matrix production by cardiac fibroblasts in 3-D cultures. PLoS One. 2013; 8(11):e79715. PMID: 24223185.
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    32. Shi C, Wright GJ, Ex-Lubeskie CL, Bradshaw AD, Yao H. Relationship between anisotropic diffusion properties and tissue morphology in porcine TMJ disc. Osteoarthritis Cartilage. 2013 Apr; 21(4):625-33. PMID: 23353670.
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    33. Goldsmith EC, Bradshaw AD, Spinale FG. Cellular mechanisms of tissue fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expression. . 2013 Mar 01; 304(5):C393-402. PMID: 23174564.
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    34. Balasubramanian S, Quinones L, Kasiganesan H, Zhang Y, Pleasant DL, Sundararaj KP, Zile MR, Bradshaw AD, Kuppuswamy D. ß3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse. PLoS One. 2012; 7(9):e45076. PMID: 22984613.
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    35. Baicu CF, Li J, Zhang Y, Kasiganesan H, Cooper G, Zile MR, Bradshaw AD. Time course of right ventricular pressure-overload induced myocardial fibrosis: relationship to changes in fibroblast postsynthetic procollagen processing. . 2012 Nov 01; 303(9):H1128-34. PMID: 22942178.
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    36. Trombetta-Esilva J, Bradshaw AD. The Function of SPARC as a Mediator of Fibrosis. Open Rheumatol J. 2012; 6:146-55. PMID: 22802913.
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    37. Baicu CF, Zhang Y, Van Laer AO, Renaud L, Zile MR, Bradshaw AD. Effects of the absence of procollagen C-endopeptidase enhancer-2 on myocardial collagen accumulation in chronic pressure overload. . 2012 Jul 15; 303(2):H234-40. PMID: 22610170.
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    38. Arnold SA, Rivera LB, Carbon JG, Toombs JE, Chang CL, Bradshaw AD, Brekken RA. Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFß activation. PLoS One. 2012; 7(2):e31384. PMID: 22348081.
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    39. Bradshaw AD. Diverse biological functions of the SPARC family of proteins. Int J Biochem Cell Biol. 2012 Mar; 44(3):480-8. PMID: 22249026.
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    40. Rivera LB, Bradshaw AD, Brekken RA. The regulatory function of SPARC in vascular biology. Cell Mol Life Sci. 2011 Oct; 68(19):3165-73. PMID: 21822645.
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    41. Harris BS, Zhang Y, Card L, Rivera LB, Brekken RA, Bradshaw AD. SPARC regulates collagen interaction with cardiac fibroblast cell surfaces. . 2011 Sep; 301(3):H841-7. PMID: 21666116.
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    42. McCurdy SM, Dai Q, Zhang J, Zamilpa R, Ramirez TA, Dayah T, Nguyen N, Jin YF, Bradshaw AD, Lindsey ML. SPARC mediates early extracellular matrix remodeling following myocardial infarction. . 2011 Aug; 301(2):H497-505. PMID: 21602472.
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    43. Trombetta-Esilva J, Yu H, Arias DN, Rossa C, Kirkwood KL, Bradshaw AD. LPS induces greater bone and PDL loss in SPARC-null mice. J Dent Res. 2011 Apr; 90(4):477-82. PMID: 21191126.
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    44. Card L, Henderson N, Zhang Y, Bornstein P, Bradshaw AD. Expression in SPARC-null mice of collagen type I lacking the globular domain of the a1(I) N-propeptide results in abdominal hernias and loss of dermal collagen. Matrix Biol. 2010 Sep; 29(7):559-64. PMID: 20708079.
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    45. Nie J, Bradshaw AD, Delany AM, Sage EH. Inactivation of SPARC enhances high-fat diet-induced obesity in mice. Connect Tissue Res. 2011 Apr; 52(2):99-108. PMID: 20615096.
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    46. Trombetta JM, Bradshaw AD. SPARC/osteonectin functions to maintain homeostasis of the collagenous extracellular matrix in the periodontal ligament. J Histochem Cytochem. 2010 Oct; 58(10):871-9. PMID: 20566756.
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    47. Bradshaw AD, Baicu CF, Rentz TJ, Van Laer AO, Bonnema DD, Zile MR. Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing. . 2010 Feb; 298(2):H614-22. PMID: 20008277.
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    48. Arnold SA, Rivera LB, Miller AF, Carbon JG, Dineen SP, Xie Y, Castrillon DH, Sage EH, Puolakkainen P, Bradshaw AD, Brekken RA. Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma. Dis Model Mech. 2010 Jan-Feb; 3(1-2):57-72. PMID: 20007485.
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    49. Bradshaw AD. The role of SPARC in extracellular matrix assembly. J Cell Commun Signal. 2009 Dec; 3(3-4):239-46. PMID: 19798598.
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    50. Grant JE, Bradshaw AD, Schwacke JH, Baicu CF, Zile MR, Schey KL. Quantification of protein expression changes in the aging left ventricle of Rattus norvegicus. J Proteome Res. 2009 Sep; 8(9):4252-63. PMID: 19603826.
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    51. McCurdy S, Baicu CF, Heymans S, Bradshaw AD. Cardiac extracellular matrix remodeling: fibrillar collagens and Secreted Protein Acidic and Rich in Cysteine (SPARC). J Mol Cell Cardiol. 2010 Mar; 48(3):544-9. PMID: 19577572.
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    52. Bradshaw AD, Baicu CF, Rentz TJ, Van Laer AO, Boggs J, Lacy JM, Zile MR. Pressure overload-induced alterations in fibrillar collagen content and myocardial diastolic function: role of secreted protein acidic and rich in cysteine (SPARC) in post-synthetic procollagen processing. Circulation. 2009 Jan 20; 119(2):269-80. PMID: 19118257.
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    53. Rentz TJ, Poobalarahi F, Bornstein P, Sage EH, Bradshaw AD. SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts. J Biol Chem. 2007 Jul 27; 282(30):22062-71. PMID: 17522057.
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    54. Poobalarahi F, Baicu CF, Bradshaw AD. Cardiac myofibroblasts differentiated in 3D culture exhibit distinct changes in collagen I production, processing, and matrix deposition. . 2006 Dec; 291(6):H2924-32. PMID: 16891407.
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    55. Reed MJ, Bradshaw AD, Shaw M, Sadoun E, Han N, Ferara N, Funk S, Puolakkainen P, Sage EH. Enhanced angiogenesis characteristic of SPARC-null mice disappears with age. J Cell Physiol. 2005 Sep; 204(3):800-7. PMID: 15795937.
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    56. Puolakkainen PA, Bradshaw AD, Brekken RA, Reed MJ, Kyriakides T, Funk SE, Gooden MD, Vernon RB, Wight TN, Bornstein P, Sage EH. SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges. J Histochem Cytochem. 2005 May; 53(5):571-81. PMID: 15872050.
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    57. Brekken RA, Sullivan MM, Workman G, Bradshaw AD, Carbon J, Siadak A, Murri C, Framson PE, Sage EH. Expression and characterization of murine hevin (SC1), a member of the SPARC family of matricellular proteins. J Histochem Cytochem. 2004 Jun; 52(6):735-48. PMID: 15150282.
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    58. Sweetwyne MT, Brekken RA, Workman G, Bradshaw AD, Carbon J, Siadak AW, Murri C, Sage EH. Functional analysis of the matricellular protein SPARC with novel monoclonal antibodies. J Histochem Cytochem. 2004 Jun; 52(6):723-33. PMID: 15150281.
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    59. Bradshaw AD, Puolakkainen P, Dasgupta J, Davidson JM, Wight TN, Helene Sage E. SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strength. J Invest Dermatol. 2003 Jun; 120(6):949-55. PMID: 12787119.
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    60. Delany AM, Kalajzic I, Bradshaw AD, Sage EH, Canalis E. Osteonectin-null mutation compromises osteoblast formation, maturation, and survival. Endocrinology. 2003 Jun; 144(6):2588-96. PMID: 12746322.
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    61. Bradshaw AD, Graves DC, Motamed K, Sage EH. SPARC-null mice exhibit increased adiposity without significant differences in overall body weight. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):6045-50. PMID: 12721366.
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    62. Puolakkainen P, Bradshaw AD, Kyriakides TR, Reed M, Brekken R, Wight T, Bornstein P, Ratner B, Sage EH. Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials. Am J Pathol. 2003 Feb; 162(2):627-35. PMID: 12547720.
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    63. Bradshaw AD, Reed MJ, Sage EH. SPARC-null mice exhibit accelerated cutaneous wound closure. J Histochem Cytochem. 2002 Jan; 50(1):1-10. PMID: 11748289.
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    64. Bradshaw AD, Reed MJ, Carbon JG, Pinney E, Brekken RA, Sage EH. Increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges in SPARC-null mice. Wound Repair Regen. 2001 Nov-Dec; 9(6):522-30. PMID: 11896995.
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    65. Bradshaw AD, Sage EH. SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury. J Clin Invest. 2001 May; 107(9):1049-54. PMID: 11342565.
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    66. Bradshaw AD, Bassuk JA, Francki A, Sage EH. Expression and purification of recombinant human SPARC produced by baculovirus. Mol Cell Biol Res Commun. 2000 Jun; 3(6):345-51. PMID: 11032756.
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    67. Bassuk JA, Pichler R, Rothmier JD, Pippen J, Gordon K, Meek RL, Bradshaw AD, Lombardi D, Strandjord TP, Reed M, Sage EH, Couser WG, Johnson R. Induction of TGF-beta1 by the matricellular protein SPARC in a rat model of glomerulonephritis. Kidney Int. 2000 Jan; 57(1):117-28. PMID: 10620193.
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    68. Francki A, Bradshaw AD, Bassuk JA, Howe CC, Couser WG, Sage EH. SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells. J Biol Chem. 1999 Nov 05; 274(45):32145-52. PMID: 10542250.
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    69. Bradshaw AD, Francki A, Motamed K, Howe C, Sage EH. Primary mesenchymal cells isolated from SPARC-null mice exhibit altered morphology and rates of proliferation. Mol Biol Cell. 1999 May; 10(5):1569-79. PMID: 10233163.
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    70. Bassuk JA, Birkebak T, Rothmier JD, Clark JM, Bradshaw A, Muchowski PJ, Howe CC, Clark JI, Sage EH. Disruption of the Sparc locus in mice alters the differentiation of lenticular epithelial cells and leads to cataract formation. Exp Eye Res. 1999 Mar; 68(3):321-31. PMID: 10079140.
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    71. Cann GM, Bradshaw AD, Gervin DB, Hunter AW, Clegg DO. Widespread expression of beta1 integrins in the developing chick retina: evidence for a role in migration of retinal ganglion cells. Dev Biol. 1996 Nov 25; 180(1):82-96. PMID: 8948576.
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    72. Smith BE, Bradshaw AD, Choi ES, Rouselle P, Wayner EA, Clegg DO. Human SY5Y neuroblastoma cell interactions with laminin isoforms: neurite outgrowth on laminin-5 is mediated by integrin alpha 3 beta 1. Cell Adhes Commun. 1996 Apr; 3(6):451-62. PMID: 8807189.
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    73. Bradshaw AD, McNagny KM, Gervin DB, Cann GM, Graf T, Clegg DO. Integrin alpha 2 beta 1 mediates interactions between developing embryonic retinal cells and collagen. Development. 1995 Nov; 121(11):3593-602. PMID: 8582273.
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