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Amy Dodd Bradshaw

Title
InstitutionMedical University of South Carolina
DepartmentCardiology
AddressP.O. Box MSC 773
325
Thurmond Gazes - 30 Courtenay Drive
Phone843-792-4959
Fax843-876-4809
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Riley HJ, Bradshaw AD. The Influence of the Extracellular Matrix in Inflammation: Findings from the SPARC-Null Mouse. Anat Rec (Hoboken). 2019 Apr 12. PMID: 30980479.
      View in: PubMed
    2. Bradshaw AD. It's a SMAD, SMAD World: Cell Type-Specific SMAD Signaling in the Heart. JACC Basic Transl Sci. 2019 Feb; 4(1):54-55. PMID: 30847419.
      View in: PubMed
    3. McDonald LT, Zile MR, Zhang Y, Van Laer AO, Baicu CF, Stroud RE, Jones JA, LaRue AC, Bradshaw AD. Increased macrophage-derived SPARC precedes collagen deposition in myocardial fibrosis. Am J Physiol Heart Circ Physiol. 2018 07 01; 315(1):H92-H100. PMID: 29522370.
      View in: PubMed
    4. Bradshaw AD, DeLeon-Pennell KY. Iron overload: what's TIMP-3 got to do with it. Am J Physiol Heart Circ Physiol. 2018 06 01; 314(6):H1259-H1261. PMID: 29522369.
      View in: PubMed
    5. Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M. Cardiac macrophages promote diastolic dysfunction. J Exp Med. 2018 02 05; 215(2):423-440. PMID: 29339450.
      View in: PubMed
    6. Workman G, Bradshaw AD. Production and purification of recombinant human SPARC. Methods Cell Biol. 2018; 143:335-345. PMID: 29310786.
      View in: PubMed
    7. Rosset EM, Trombetta-eSilva J, Hepfer G, Yao H, Bradshaw AD. SPARC and the N-propeptide of collagen I influence fibroblast proliferation and collagen assembly in the periodontal ligament. PLoS One. 2017; 12(2):e0173209. PMID: 28245286.
      View in: PubMed
    8. Stevenson KT, Peterson MN, Bradshaw A. How Climate Change Beliefs among U.S. Teachers Do and Do Not Translate to Students. PLoS One. 2016; 11(9):e0161462. PMID: 27603667.
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    9. Gehwolf R, Wagner A, Lehner C, Bradshaw AD, Scharler C, Niestrawska JA, Holzapfel GA, Bauer HC, Tempfer H, Traweger A. Pleiotropic roles of the matricellular protein Sparc in tendon maturation and ageing. Sci Rep. 2016 09 02; 6:32635. PMID: 27586416.
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    10. Toba H, de Castro Brás LE, Baicu CF, Zile MR, Lindsey ML, Bradshaw AD. Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium. Am J Physiol Endocrinol Metab. 2016 06 01; 310(11):E1027-35. PMID: 27143554.
      View in: PubMed
    11. Rosset EM, Bradshaw AD. SPARC/osteonectin in mineralized tissue. Matrix Biol. 2016 May-Jul; 52-54:78-87. PMID: 26851678.
      View in: PubMed
    12. Bradshaw AD. The role of secreted protein acidic and rich in cysteine (SPARC) in cardiac repair and fibrosis: Does expression of SPARC by macrophages influence outcomes? J Mol Cell Cardiol. 2016 04; 93:156-61. PMID: 26582465.
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    13. Balasubramanian S, Pleasant DL, Kasiganesan H, Quinones L, Zhang Y, Sundararaj KP, Roche S, O'Connor R, Bradshaw AD, Kuppuswamy D. Dasatinib Attenuates Pressure Overload Induced Cardiac Fibrosis in a Murine Transverse Aortic Constriction Model. PLoS One. 2015; 10(10):e0140273. PMID: 26458186.
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    14. Trombetta-eSilva J, Rosset EA, Hepfer RG, Wright GJ, Baicu C, Yao H, Bradshaw AD. Decreased Mechanical Strength and Collagen Content in SPARC-Null Periodontal Ligament Is Reversed by Inhibition of Transglutaminase Activity. J Bone Miner Res. 2015 Oct; 30(10):1914-24. PMID: 25827352.
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    15. Lindner HB, Felmly LM, Demcheva M, Seth A, Norris R, Bradshaw AD, Vournakis J, Muise-Helmericks RC. pGlcNAc Nanofiber Treatment of Cutaneous Wounds Stimulate Increased Tensile Strength and Reduced Scarring via Activation of Akt1. PLoS One. 2015; 10(5):e0127876. PMID: 25955155.
      View in: PubMed
    16. Toba H, de Castro Brás LE, Baicu CF, Zile MR, Lindsey ML, Bradshaw AD. Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization. Am J Physiol Cell Physiol. 2015 Jun 15; 308(12):C972-82. PMID: 25877699.
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    17. Dupuis LE, Berger MG, Feldman S, Doucette L, Fowlkes V, Chakravarti S, Thibaudeau S, Alcala NE, Bradshaw AD, Kern CB. Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly. J Mol Cell Cardiol. 2015 Jul; 84:70-80. PMID: 25886697.
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    18. Zile MR, Baicu CF, Ikonomidis JS, Stroud RE, Nietert PJ, Bradshaw AD, Slater R, Palmer BM, Van Buren P, Meyer M, Redfield MM, Bull DA, Granzier HL, LeWinter MM. Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin. Circulation. 2015 Apr 07; 131(14):1247-59. PMID: 25637629.
      View in: PubMed
    19. de Castro Brás LE, Toba H, Baicu CF, Zile MR, Weintraub ST, Lindsey ML, Bradshaw AD. Age and SPARC change the extracellular matrix composition of the left ventricle. Biomed Res Int. 2014; 2014:810562. PMID: 24783223.
      View in: PubMed
    20. Goldsmith EC, Bradshaw AD, Zile MR, Spinale FG. Myocardial fibroblast-matrix interactions and potential therapeutic targets. J Mol Cell Cardiol. 2014 May; 70:92-9. PMID: 24472826.
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    21. Trombetta-eSilva J, Eadie EP, Zhang Y, Norris RA, Borg TK, Bradshaw AD. The effects of age and the expression of SPARC on extracellular matrix production by cardiac fibroblasts in 3-D cultures. PLoS One. 2013; 8(11):e79715. PMID: 24223185.
      View in: PubMed
    22. Goldsmith EC, Bradshaw AD, Spinale FG. Cellular mechanisms of tissue fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expression. Am J Physiol Cell Physiol. 2013 Mar 01; 304(5):C393-402. PMID: 23174564.
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    23. Balasubramanian S, Quinones L, Kasiganesan H, Zhang Y, Pleasant DL, Sundararaj KP, Zile MR, Bradshaw AD, Kuppuswamy D. ß3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse. PLoS One. 2012; 7(9):e45076. PMID: 22984613.
      View in: PubMed
    24. Baicu CF, Li J, Zhang Y, Kasiganesan H, Cooper G, Zile MR, Bradshaw AD. Time course of right ventricular pressure-overload induced myocardial fibrosis: relationship to changes in fibroblast postsynthetic procollagen processing. Am J Physiol Heart Circ Physiol. 2012 Nov 01; 303(9):H1128-34. PMID: 22942178.
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    25. Trombetta-Esilva J, Bradshaw AD. The Function of SPARC as a Mediator of Fibrosis. Open Rheumatol J. 2012; 6:146-55. PMID: 22802913.
      View in: PubMed
    26. Baicu CF, Zhang Y, Van Laer AO, Renaud L, Zile MR, Bradshaw AD. Effects of the absence of procollagen C-endopeptidase enhancer-2 on myocardial collagen accumulation in chronic pressure overload. Am J Physiol Heart Circ Physiol. 2012 Jul 15; 303(2):H234-40. PMID: 22610170.
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    27. Arnold SA, Rivera LB, Carbon JG, Toombs JE, Chang CL, Bradshaw AD, Brekken RA. Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFß activation. PLoS One. 2012; 7(2):e31384. PMID: 22348081.
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    28. Bradshaw AD. Diverse biological functions of the SPARC family of proteins. Int J Biochem Cell Biol. 2012 Mar; 44(3):480-8. PMID: 22249026.
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    29. Rivera LB, Bradshaw AD, Brekken RA. The regulatory function of SPARC in vascular biology. Cell Mol Life Sci. 2011 Oct; 68(19):3165-73. PMID: 21822645.
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    30. Harris BS, Zhang Y, Card L, Rivera LB, Brekken RA, Bradshaw AD. SPARC regulates collagen interaction with cardiac fibroblast cell surfaces. Am J Physiol Heart Circ Physiol. 2011 Sep; 301(3):H841-7. PMID: 21666116.
      View in: PubMed
    31. McCurdy SM, Dai Q, Zhang J, Zamilpa R, Ramirez TA, Dayah T, Nguyen N, Jin YF, Bradshaw AD, Lindsey ML. SPARC mediates early extracellular matrix remodeling following myocardial infarction. Am J Physiol Heart Circ Physiol. 2011 Aug; 301(2):H497-505. PMID: 21602472.
      View in: PubMed
    32. Card L, Henderson N, Zhang Y, Bornstein P, Bradshaw AD. Expression in SPARC-null mice of collagen type I lacking the globular domain of the a1(I) N-propeptide results in abdominal hernias and loss of dermal collagen. Matrix Biol. 2010 Sep; 29(7):559-64. PMID: 20708079.
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    33. Nie J, Bradshaw AD, Delany AM, Sage EH. Inactivation of SPARC enhances high-fat diet-induced obesity in mice. Connect Tissue Res. 2011 Apr; 52(2):99-108. PMID: 20615096.
      View in: PubMed
    34. Trombetta JM, Bradshaw AD. SPARC/osteonectin functions to maintain homeostasis of the collagenous extracellular matrix in the periodontal ligament. J Histochem Cytochem. 2010 Oct; 58(10):871-9. PMID: 20566756.
      View in: PubMed
    35. Bradshaw AD, Baicu CF, Rentz TJ, Van Laer AO, Bonnema DD, Zile MR. Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing. Am J Physiol Heart Circ Physiol. 2010 Feb; 298(2):H614-22. PMID: 20008277.
      View in: PubMed
    36. Arnold SA, Rivera LB, Miller AF, Carbon JG, Dineen SP, Xie Y, Castrillon DH, Sage EH, Puolakkainen P, Bradshaw AD, Brekken RA. Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma. Dis Model Mech. 2010 Jan-Feb; 3(1-2):57-72. PMID: 20007485.
      View in: PubMed
    37. Bradshaw AD. The role of SPARC in extracellular matrix assembly. J Cell Commun Signal. 2009 Dec; 3(3-4):239-46. PMID: 19798598.
      View in: PubMed
    38. Grant JE, Bradshaw AD, Schwacke JH, Baicu CF, Zile MR, Schey KL. Quantification of protein expression changes in the aging left ventricle of Rattus norvegicus. J Proteome Res. 2009 Sep; 8(9):4252-63. PMID: 19603826.
      View in: PubMed
    39. McCurdy S, Baicu CF, Heymans S, Bradshaw AD. Cardiac extracellular matrix remodeling: fibrillar collagens and Secreted Protein Acidic and Rich in Cysteine (SPARC). J Mol Cell Cardiol. 2010 Mar; 48(3):544-9. PMID: 19577572.
      View in: PubMed
    40. Bradshaw AD, Baicu CF, Rentz TJ, Van Laer AO, Boggs J, Lacy JM, Zile MR. Pressure overload-induced alterations in fibrillar collagen content and myocardial diastolic function: role of secreted protein acidic and rich in cysteine (SPARC) in post-synthetic procollagen processing. Circulation. 2009 Jan 20; 119(2):269-80. PMID: 19118257.
      View in: PubMed
    41. Rentz TJ, Poobalarahi F, Bornstein P, Sage EH, Bradshaw AD. SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts. J Biol Chem. 2007 Jul 27; 282(30):22062-71. PMID: 17522057.
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    42. Poobalarahi F, Baicu CF, Bradshaw AD. Cardiac myofibroblasts differentiated in 3D culture exhibit distinct changes in collagen I production, processing, and matrix deposition. Am J Physiol Heart Circ Physiol. 2006 Dec; 291(6):H2924-32. PMID: 16891407.
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    43. Puolakkainen PA, Bradshaw AD, Brekken RA, Reed MJ, Kyriakides T, Funk SE, Gooden MD, Vernon RB, Wight TN, Bornstein P, Sage EH. SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges. J Histochem Cytochem. 2005 May; 53(5):571-81. PMID: 15872050.
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    44. Brekken RA, Sullivan MM, Workman G, Bradshaw AD, Carbon J, Siadak A, Murri C, Framson PE, Sage EH. Expression and characterization of murine hevin (SC1), a member of the SPARC family of matricellular proteins. J Histochem Cytochem. 2004 Jun; 52(6):735-48. PMID: 15150282.
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    45. Sweetwyne MT, Brekken RA, Workman G, Bradshaw AD, Carbon J, Siadak AW, Murri C, Sage EH. Functional analysis of the matricellular protein SPARC with novel monoclonal antibodies. J Histochem Cytochem. 2004 Jun; 52(6):723-33. PMID: 15150281.
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    46. Delany AM, Kalajzic I, Bradshaw AD, Sage EH, Canalis E. Osteonectin-null mutation compromises osteoblast formation, maturation, and survival. Endocrinology. 2003 Jun; 144(6):2588-96. PMID: 12746322.
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    47. Bradshaw AD, Puolakkainen P, Dasgupta J, Davidson JM, Wight TN, Helene Sage E. SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strength. J Invest Dermatol. 2003 Jun; 120(6):949-55. PMID: 12787119.
      View in: PubMed
    48. Puolakkainen P, Bradshaw AD, Kyriakides TR, Reed M, Brekken R, Wight T, Bornstein P, Ratner B, Sage EH. Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials. Am J Pathol. 2003 Feb; 162(2):627-35. PMID: 12547720.
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    49. Bradshaw AD, Reed MJ, Sage EH. SPARC-null mice exhibit accelerated cutaneous wound closure. J Histochem Cytochem. 2002 Jan; 50(1):1-10. PMID: 11748289.
      View in: PubMed
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