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Last Name
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Adviye Ergul

Title
InstitutionMedical University of South Carolina
DepartmentPathology and Laboratory Medicine
AddressP.O. Box MSC 908
STB 401
Thurmond Gazes - 30 Courtenay Drive
Phone843-876-5958
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    Collapse Biography 
    Collapse education and training
    Cerrahpasa Medical School, Istanbul, TurkeyMD06/1987Medicine
    Haseki Training Hospital, Istanbul, TurkeyResident08/1990Clinical Biochemistry
    University of Miami Miller School of Medicine, Miami, FLPhD05/1995Biochemistry & Mol. Biol.
    University of Georgia, Athens, GAPostdoctoral Fellow06/1996Vascular Biology

    Collapse Overview 
    Collapse overview
    My research program lies at the intersection of vascular biology, endocrinology and neuroscience. My laboratory, my training and expertise are focused on understanding the regulation of vascular function and structure in diabetes and hypertension in order to develop innovative strategies and therapeutics for the prevention and treatment of associated complications including ischemic stroke and cognitive impairment. These comorbidities not only increase the risk but also worsen the recovery and/or progression of cognitive impairment and stroke. All neuroprotective approaches have failed to produce any new therapies for these diseases. As a vascular biologist, I concentrated my efforts on the role of vasculoprotection and vascular restoration on brain repair. I use my uniquely combined expertise in endocrinology, physiology, pharmacology and vascular biology to identify novel treatments for stroke and cognitive impairment in both sexes.

    Collapse keywords
    Diabetes, hypertension, cerebrovascular, vascular restoration, vascular protection, stroke, cognitive impairment, dementia, endothelial phenotype, endothelin

    Collapse Research 
    Collapse research activities and funding
    BX000347     (Ergul)Jan 1, 2010 - Dec 31, 2021
    Veterans Administration BLRD Merit Review
    Cerebral arteriole structure/function in diabetic ischemic brain injury

    IK6 BX004471     (Ergul)Oct 1, 2013 - Sep 30, 2025
    Veterans Administration BLRD Merit Review
    Senior Research Career Scientist Award

    RF1NS083559     (ERGUL, ADVIYE)Feb 1, 2014 - Jan 31, 2025
    NIH
    Vascular Injury and Recovery in Diabetic Ischemic Stroke
    Role: Principal Investigator

    R01NS104573     (ERGUL, ADVIYE)Dec 1, 2018 - Aug 31, 2023
    NIH
    Progressive Post Stroke Cognitive Impairment:Mechanisms & Intervention
    Role: Principal Investigator

    R01 AG068286     (Gavin Wang)Jul 1, 2020 - Jun 30, 2025
    NIH
    Senescence-Induced Progression of Alzheimer’s Disease
    Role: Co-investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Chandran R, Li W, Ahmed HA, Dong G, Ward RA, He L, Doueiry C, Ergul A. Diabetic rats are more susceptible to cognitive decline in a model of microemboli-mediated vascular contributions to cognitive impairment and dementia. Brain Res. 2020 Sep 28; 1749:147132. PMID: 33002484.
      View in: PubMed
    2. Abdul Y, Li W, Ward R, Abdelsaid M, Hafez S, Dong G, Jamil S, Wolf V, Johnson MH, Fagan SC, Ergul A. Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis. Transl Stroke Res. 2020 Sep 01. PMID: 32875455.
      View in: PubMed
    3. Abdul Y, Li W, Vargas JD, Grant E, He L, Jamil S, Ergul A. Diabetes-related sex differences in the brain endothelin system following ischemia in vivo and in human brain endothelial cells in vitro. Can J Physiol Pharmacol. 2020 Aug 20; 1-9. PMID: 32496159.
      View in: PubMed
    4. Jackson L, Dumanli S, Johnson MH, Fagan SC, Ergul A. Microglia knockdown reduces inflammation and preserves cognition in diabetic animals after experimental stroke. J Neuroinflammation. 2020 Apr 28; 17(1):137. PMID: 32345303.
      View in: PubMed
    5. Abdul Y, Jamil S, He L, Li W, Ergul A. Endothelin-1 (ET-1) promotes a proinflammatory microglia phenotype in diabetic conditions. Can J Physiol Pharmacol. 2020 Mar 02; 1-8. PMID: 32119570.
      View in: PubMed
    6. Jackson L, Dong G, Althomali W, Sayed MA, Eldahshan W, Baban B, Johnson MH, Filosa J, Fagan SC, Ergul A. Delayed Administration of Angiotensin II Type 2 Receptor (AT2R) Agonist Compound 21 Prevents the Development of Post-stroke Cognitive Impairment in Diabetes Through the Modulation of Microglia Polarization. Transl Stroke Res. 2019 Dec 03. PMID: 31792796.
      View in: PubMed
    7. Li W, Ward R, Dong G, Ergul A, O'Connor P. Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na+ /H+ exchanger-1 antagonism. Physiol Rep. 2019 08; 7(13):e14142. PMID: 31250553.
      View in: PubMed
    8. Eldahshan W, Fagan SC, Ergul A. Inflammation within the neurovascular unit: Focus on microglia for stroke injury and recovery. Pharmacol Res. 2019 09; 147:104349. PMID: 31315064.
      View in: PubMed
    9. Jackson L, Li W, Abdul Y, Dong G, Baban B, Ergul A. Diabetic Stroke Promotes a Sexually Dimorphic Expansion of T Cells. Neuromolecular Med. 2019 Dec; 21(4):445-453. PMID: 31197651.
      View in: PubMed
    10. Fouda AY, Fagan SC, Ergul A. Brain Vasculature and Cognition. Arterioscler Thromb Vasc Biol. 2019 04; 39(4):593-602. PMID: 30816798.
      View in: PubMed
    11. Eldahshan W, Ishrat T, Pillai B, Sayed MA, Alwhaibi A, Fouda AY, Ergul A, Fagan SC. Angiotensin II type 2 receptor stimulation with compound 21 improves neurological function after stroke in female rats: a pilot study. Am J Physiol Heart Circ Physiol. 2019 May 01; 316(5):H1192-H1201. PMID: 30822121.
      View in: PubMed
    12. Ward R, Li W, Abdul Y, Jackson L, Dong G, Jamil S, Filosa J, Fagan SC, Ergul A. NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia. Pharmacol Res. 2019 04; 142:237-250. PMID: 30818045.
      View in: PubMed
    13. Coucha M, Barrett AC, Elgebaly M, Ergul A, Abdelsaid M. Inhibition of Ephrin-B2 in brain pericytes decreases cerebral pathological neovascularization in diabetic rats. PLoS One. 2019; 14(1):e0210523. PMID: 30620753.
      View in: PubMed
    14. Artham S, Gao F, Verma A, Alwhaibi A, Sabbineni H, Hafez S, Ergul A, Somanath PR. Endothelial stromelysin1 regulation by the forkhead box-O transcription factors is crucial in the exudative phase of acute lung injury. Pharmacol Res. 2019 03; 141:249-263. PMID: 30611853.
      View in: PubMed
    15. Ahmed HA, Ishrat T, Pillai B, Bunting KM, Vazdarjanova A, Waller JL, Ergul A, Fagan SC. Angiotensin receptor (AT2R) agonist C21 prevents cognitive decline after permanent stroke in aged animals-A randomized double- blind pre-clinical study. Behav Brain Res. 2019 02 01; 359:560-569. PMID: 30296528.
      View in: PubMed
    16. Li W, Valenzuela JP, Ward R, Abdelbary M, Dong G, Fagan SC, Ergul A. Post-stroke neovascularization and functional outcomes differ in diabetes depending on severity of injury and sex: Potential link to hemorrhagic transformation. Exp Neurol. 2019 01; 311:106-114. PMID: 30243988.
      View in: PubMed
    17. Ward R, Valenzuela JP, Li W, Dong G, Fagan SC, Ergul A. Poststroke cognitive impairment and hippocampal neurovascular remodeling: the impact of diabetes and sex. Am J Physiol Heart Circ Physiol. 2018 11 01; 315(5):H1402-H1413. PMID: 30118341.
      View in: PubMed
    18. Ahmed HA, Ishrat T, Pillai B, Fouda AY, Sayed MA, Eldahshan W, Waller JL, Ergul A, Fagan SC. RAS modulation prevents progressive cognitive impairment after experimental stroke: a randomized, blinded preclinical trial. J Neuroinflammation. 2018 Aug 13; 15(1):229. PMID: 30103772.
      View in: PubMed
    19. Ishrat T, Soliman S, Eldahshan W, Pillai B, Ergul A, Fagan SC. Silencing VEGF-B Diminishes the Neuroprotective Effect of Candesartan Treatment After Experimental Focal Cerebral Ischemia. Neurochem Res. 2018 Oct; 43(10):1869-1878. PMID: 30088238.
      View in: PubMed
    20. Ward R, Abdul Y, Ergul A. Endothelin-1 inhibition improves the mBDNF/proBDNF ratio in endothelial cells and HT22 neurons under high glucose/palmitate growth conditions. Physiol Res. 2018 06 27; 67(Suppl 1):S237-S246. PMID: 29947543.
      View in: PubMed
    21. Abdul Y, Ward R, Dong G, Ergul A. Lipopolysaccharide-induced necroptosis of brain microvascular endothelial cells can be prevented by inhibition of endothelin receptors. Physiol Res. 2018 06 27; 67(Suppl 1):S227-S236. PMID: 29947542.
      View in: PubMed
    22. Li W, Abdul Y, Ward R, Ergul A. Endothelin and diabetic complications: a brain-centric view. Physiol Res. 2018 06 27; 67(Suppl 1):S83-S94. PMID: 29947530.
      View in: PubMed
    23. Abdul Y, Abdelsaid M, Li W, Webb RC, Sullivan JC, Dong G, Ergul A. Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4. Mol Neurobiol. 2019 Mar; 56(3):1607-1617. PMID: 29909454.
      View in: PubMed
    24. Coucha M, Abdelsaid M, Ward R, Abdul Y, Ergul A. Impact of Metabolic Diseases on Cerebral Circulation: Structural and Functional Consequences. Compr Physiol. 2018 03 25; 8(2):773-799. PMID: 29687902.
      View in: PubMed
    25. Jackson L, Eldahshan W, Fagan SC, Ergul A. Within the Brain: The Renin Angiotensin System. Int J Mol Sci. 2018 Mar 15; 19(3). PMID: 29543776.
      View in: PubMed
    26. Ishrat T, Fouda AY, Pillai B, Eldahshan W, Ahmed H, Waller JL, Ergul A, Fagan SC. Dose-response, therapeutic time-window and tPA-combinatorial efficacy of compound 21: A randomized, blinded preclinical trial in a rat model of thromboembolic stroke. J Cereb Blood Flow Metab. 2019 Aug; 39(8):1635-1647. PMID: 29537907.
      View in: PubMed
    27. Ahmed HA, Ishrat T, Pillai B, Bunting KM, Patel A, Vazdarjanova A, Waller JL, Arbab AS, Ergul A, Fagan SC. Role of angiotensin system modulation on progression of cognitive impairment and brain MRI changes in aged hypertensive animals - A randomized double- blind pre-clinical study. Behav Brain Res. 2018 07 02; 346:29-40. PMID: 29229547.
      View in: PubMed
    28. Hafez S, Abdelsaid M, Fagan SC, Ergul A. Peroxynitrite-Induced Tyrosine Nitration Contributes to Matrix Metalloprotease-3 Activation: Relevance to Hyperglycemic Ischemic Brain Injury and Tissue Plasminogen Activator. Neurochem Res. 2018 Feb; 43(2):259-266. PMID: 28975464.
      View in: PubMed
    29. Fouda AY, Newsome AS, Spellicy S, Waller JL, Zhi W, Hess DC, Ergul A, Edwards DJ, Fagan SC, Switzer JA. Minocycline in Acute Cerebral Hemorrhage: An Early Phase Randomized Trial. Stroke. 2017 10; 48(10):2885-2887. PMID: 28887388.
      View in: PubMed
    30. Alhusban A, Kozak A, Pillai B, Ahmed H, Sayed MA, Johnson MH, Ishrat T, Ergul A, Fagan SC. Mechanisms of acute neurovascular protection with AT1 blockade after stroke: Effect of prestroke hypertension. PLoS One. 2017; 12(6):e0178867. PMID: 28640888.
      View in: PubMed
    31. Li W, Ward R, Valenzuela JP, Dong G, Fagan SC, Ergul A. Diabetes Worsens Functional Outcomes in Young Female Rats: Comparison of Stroke Models, Tissue Plasminogen Activator Effects, and Sexes. Transl Stroke Res. 2017 Mar 01. PMID: 28247188.
      View in: PubMed
    32. Hardigan T, Hernandez C, Ward R, Hoda MN, Ergul A. TLR2 knockout protects against diabetes-mediated changes in cerebral perfusion and cognitive deficits. Am J Physiol Regul Integr Comp Physiol. 2017 06 01; 312(6):R927-R937. PMID: 28336553.
      View in: PubMed
    33. Fouda AY, Pillai B, Dhandapani KM, Ergul A, Fagan SC. Role of interleukin-10 in the neuroprotective effect of the Angiotensin Type 2 Receptor agonist, compound 21, after ischemia/reperfusion injury. Eur J Pharmacol. 2017 Mar 15; 799:128-134. PMID: 28192099.
      View in: PubMed
    34. Abdelsaid M, Coucha M, Hafez S, Yasir A, Johnson MH, Ergul A. Enhanced VEGF signalling mediates cerebral neovascularisation via downregulation of guidance protein ROBO4 in a rat model of diabetes. Diabetologia. 2017 04; 60(4):740-750. PMID: 28116460.
      View in: PubMed
    35. Hardigan T, Ward R, Ergul A. Cerebrovascular complications of diabetes: focus on cognitive dysfunction. Clin Sci (Lond). 2016 10 01; 130(20):1807-22. PMID: 27634842.
      View in: PubMed
    36. Coucha M, Abdelsaid M, Li W, Johnson MH, Orfi L, El-Remessy AB, Fagan SC, Ergul A. Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle. Life Sci. 2016 Oct 15; 163:46-54. PMID: 27558234.
      View in: PubMed
    37. Hardigan T, Yasir A, Abdelsaid M, Coucha M, El-Shaffey S, Li W, Johnson MH, Ergul A. Linagliptin treatment improves cerebrovascular function and remodeling and restores reduced cerebral perfusion in Type 2 diabetes. Am J Physiol Regul Integr Comp Physiol. 2016 09 01; 311(3):R466-77. PMID: 27357799.
      View in: PubMed
    38. Pollock DM, Gulati A, Ergul A. The Fourteenth International Conference on Endothelin (ET-14), Savannah, U.S.A. Life Sci. 2016 Aug 15; 159:2-9. PMID: 27321090.
      View in: PubMed
    39. Alhusban A, Kozak A, Eldahshan W, Ergul A, Fagan SC. Erratum to: Artery reopening is required for the neurorestorative effects of angiotensin modulation after experimental stroke. Exp Transl Stroke Med. 2016; 8:5. PMID: 27303620.
      View in: PubMed
    40. Ward R, Hardigan T, Ergul A. Variations on a theme: ET-14 notes from mentor and trainees. Life Sci. 2016 Aug 15; 159:12-14. PMID: 27234256.
      View in: PubMed
    41. Hafez S, Ergul A. Response to Letter Regarding Article, "Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke". Stroke. 2016 06; 47(6):e173. PMID: 27217515.
      View in: PubMed
    42. Alhusban A, Kozak A, Eldashan W, Ergul A, Fagan SC. Artery reopening is required for the neurorestorative effects of angiotensin modulation after experimental stroke. Exp Transl Stroke Med. 2016; 8:4. PMID: 27127602.
      View in: PubMed
    43. Ergul A, Hafez S, Fouda A, Fagan SC. Impact of Comorbidities on Acute Injury and Recovery in Preclinical Stroke Research: Focus on Hypertension and Diabetes. Transl Stroke Res. 2016 08; 7(4):248-60. PMID: 27026092.
      View in: PubMed
    44. Yasir A, Hardigan T, Ergul A. Diabetes-mediated middle cerebral artery remodeling is restored by linagliptin: Interaction with the vascular smooth muscle cell endothelin system. Life Sci. 2016 Aug 15; 159:76-82. PMID: 26944436.
      View in: PubMed
    45. Lima VV, Giachini FR, Matsumoto T, Li W, Bressan AF, Chawla D, Webb RC, Ergul A, Tostes RC. High-fat diet increases O-GlcNAc levels in cerebral arteries: a link to vascular dysfunction associated with hyperlipidaemia/obesity? Clin Sci (Lond). 2016 06 01; 130(11):871-80. PMID: 26929437.
      View in: PubMed
    46. Hardigan T, Abdul Y, Ergul A. Linagliptin reduces effects of ET-1 and TLR2-mediated cerebrovascular hyperreactivity in diabetes. Life Sci. 2016 Aug 15; 159:90-96. PMID: 26898123.
      View in: PubMed
    47. Ward R, Ergul A. Relationship of endothelin-1 and NLRP3 inflammasome activation in HT22 hippocampal cells in diabetes. Life Sci. 2016 Aug 15; 159:97-103. PMID: 26883974.
      View in: PubMed
    48. Hafez S, Abdelsaid M, El-Shafey S, Johnson MH, Fagan SC, Ergul A. Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke. Stroke. 2016 Mar; 47(3):843-51. PMID: 26839355.
      View in: PubMed
    49. Fouda AY, Alhusban A, Ishrat T, Pillai B, Eldahshan W, Waller JL, Ergul A, Fagan SC. Brain-Derived Neurotrophic Factor Knockdown Blocks the Angiogenic and Protective Effects of Angiotensin Modulation After Experimental Stroke. Mol Neurobiol. 2017 01; 54(1):661-670. PMID: 26758277.
      View in: PubMed
    50. Abdelsaid M, Williams R, Hardigan T, Ergul A. Linagliptin attenuates diabetes-induced cerebral pathological neovascularization in a blood glucose-independent manner: Potential role of ET-1. Life Sci. 2016 Aug 15; 159:83-89. PMID: 26631506.
      View in: PubMed
    51. Thompson JA, Hardigan TA, Carrillo-Sepulveda MA, Mintz JD, Ergul A, Diamond MP, Webb RC. The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity. Placenta. 2015 Oct; 36(10):1204-6. PMID: 26282853.
      View in: PubMed
    52. Abdalla M, Sabbineni H, Prakash R, Ergul A, Fagan SC, Somanath PR. The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFß-induced pulmonary fibrosis. Br J Pharmacol. 2015 Aug; 172(16):4173-88. PMID: 26033700.
      View in: PubMed
    53. Goulopoulou S, Hannan JL, Matsumoto T, Ogbi S, Ergul A, Webb RC. Reduced vascular responses to soluble guanylyl cyclase but increased sensitivity to sildenafil in female rats with type 2 diabetes. Am J Physiol Heart Circ Physiol. 2015 Jul 15; 309(2):H297-304. PMID: 25957216.
      View in: PubMed
    54. Ishrat T, Mohamed IN, Pillai B, Soliman S, Fouda AY, Ergul A, El-Remessy AB, Fagan SC. Erratum to: Thioredoxin-interacting protein: a novel target for neuroprotection in experimental thromboembolic stroke in mice. Mol Neurobiol. 2015 Apr; 51(2):779-80. PMID: 25502293.
      View in: PubMed
    55. Ergul A, Valenzuela JP, Fouda AY, Fagan SC. Cellular connections, microenvironment and brain angiogenesis in diabetes: Lost communication signals in the post-stroke period. Brain Res. 2015 Oct 14; 1623:81-96. PMID: 25749094.
      View in: PubMed
    56. Hafez S, Hoda MN, Guo X, Johnson MH, Fagan SC, Ergul A. Comparative Analysis of Different Methods of Ischemia/Reperfusion in Hyperglycemic Stroke Outcomes: Interaction with tPA. Transl Stroke Res. 2015 Jun; 6(3):171-80. PMID: 25683354.
      View in: PubMed
    57. Coucha M, Li W, Hafez S, Abdelsaid M, Johnson MH, Fagan SC, Ergul A. SOD1 overexpression prevents acute hyperglycemia-induced cerebral myogenic dysfunction: relevance to contralateral hemisphere and stroke outcomes. Am J Physiol Heart Circ Physiol. 2015 Mar 01; 308(5):H456-66. PMID: 25552308.
      View in: PubMed
    58. Abdelsaid M, Prakash R, Li W, Coucha M, Hafez S, Johnson MH, Fagan SC, Ergul A. Metformin treatment in the period after stroke prevents nitrative stress and restores angiogenic signaling in the brain in diabetes. Diabetes. 2015 May; 64(5):1804-17. PMID: 25524911.
      View in: PubMed
    59. Khan MB, Hoda MN, Vaibhav K, Giri S, Wang P, Waller JL, Ergul A, Dhandapani KM, Fagan SC, Hess DC. Remote ischemic postconditioning: harnessing endogenous protection in a murine model of vascular cognitive impairment. Transl Stroke Res. 2015 Feb; 6(1):69-77. PMID: 25351177.
      View in: PubMed
    60. Abdelsaid MA, Matragoon S, Ergul A, El-Remessy AB. Deletion of thioredoxin interacting protein (TXNIP) augments hyperoxia-induced vaso-obliteration in a mouse model of oxygen induced-retinopathy. PLoS One. 2014; 9(10):e110388. PMID: 25329456.
      View in: PubMed
    61. Emoto N, Vignon-Zellweger N, Lopes RA, Cacioppo J, Desbiens L, Kamato D, Leurgans T, Moorhouse R, Straube J, Wurm R, Heiden S, Ergul A, Yanagisawa M, Barton M. 25 years of endothelin research: the next generation. Life Sci. 2014 Nov 24; 118(2):77-86. PMID: 25238993.
      View in: PubMed
    62. Ishrat T, Pillai B, Soliman S, Fouda AY, Kozak A, Johnson MH, Ergul A, Fagan SC. Low-dose candesartan enhances molecular mediators of neuroplasticity and subsequent functional recovery after ischemic stroke in rats. Mol Neurobiol. 2015; 51(3):1542-53. PMID: 25084762.
      View in: PubMed
    63. Ishrat T, Kozak A, Alhusban A, Pillai B, Johnson MH, El-Remessy AB, Ergul A, Fagan SC. Role of matrix metalloproteinase activity in the neurovascular protective effects of Angiotensin antagonism. Stroke Res Treat. 2014; 2014:560491. PMID: 25147751.
      View in: PubMed
    64. Zhang Y, Hoda MN, Zheng X, Li W, Luo P, Maddipati KR, Seki T, Ergul A, Wang MH. Combined therapy with COX-2 inhibitor and 20-HETE inhibitor reduces colon tumor growth and the adverse effects of ischemic stroke associated with COX-2 inhibition. Am J Physiol Regul Integr Comp Physiol. 2014 Sep 15; 307(6):R693-703. PMID: 24990856.
      View in: PubMed
    65. Ishrat T, Mohamed IN, Pillai B, Soliman S, Fouda AY, Ergul A, El-Remessy AB, Fagan SC. Thioredoxin-interacting protein: a novel target for neuroprotection in experimental thromboembolic stroke in mice. Mol Neurobiol. 2015 Apr; 51(2):766-78. PMID: 24939693.
      View in: PubMed
    66. Abdelsaid M, Coucha M, Ergul A. Cerebrovasculoprotective effects of azilsartan medoxomil in diabetes. Transl Res. 2014 Nov; 164(5):424-32. PMID: 24999268.
      View in: PubMed
    67. Coucha M, Li W, Johnson MH, Fagan SC, Ergul A. Reply to "Letter to the editor: 'Targeting cerebrovascular myogenic dysfunction in stroke'". Am J Physiol Heart Circ Physiol. 2014 May 15; 306(10):H1483. PMID: 24833734.
      View in: PubMed
    68. Soliman S, Ishrat T, Pillai A, Somanath PR, Ergul A, El-Remessy AB, Fagan SC. Candesartan induces a prolonged proangiogenic effect and augments endothelium-mediated neuroprotection after oxygen and glucose deprivation: role of vascular endothelial growth factors A and B. J Pharmacol Exp Ther. 2014 Jun; 349(3):444-57. PMID: 24681872.
      View in: PubMed
    69. Hafez S, Coucha M, Bruno A, Fagan SC, Ergul A. Hyperglycemia, acute ischemic stroke, and thrombolytic therapy. Transl Stroke Res. 2014 Aug; 5(4):442-453. PMID: 24619488.
      View in: PubMed
    70. Ergul A, Abdelsaid M, Fouda AY, Fagan SC. Cerebral neovascularization in diabetes: implications for stroke recovery and beyond. J Cereb Blood Flow Metab. 2014 Apr; 34(4):553-63. PMID: 24496174.
      View in: PubMed
    71. Abdelsaid M, Kaczmarek J, Coucha M, Ergul A. Dual endothelin receptor antagonism with bosentan reverses established vascular remodeling and dysfunctional angiogenesis in diabetic rats: relevance to glycemic control. Life Sci. 2014 Nov 24; 118(2):268-73. PMID: 24447630.
      View in: PubMed
    72. Abdelsaid M, Ma H, Coucha M, Ergul A. Late dual endothelin receptor blockade with bosentan restores impaired cerebrovascular function in diabetes. Life Sci. 2014 Nov 24; 118(2):263-7. PMID: 24434796.
      View in: PubMed
    73. Hoda MN, Bhatia K, Hafez SS, Johnson MH, Siddiqui S, Ergul A, Zaidi SK, Fagan SC, Hess DC. Remote ischemic perconditioning is effective after embolic stroke in ovariectomized female mice. Transl Stroke Res. 2014 Aug; 5(4):484-90. PMID: 24385308.
      View in: PubMed
    74. Goulopoulou S, Hannan JL, Matsumoto T, Ergul A, Webb RC. Augmented dilation to nitric oxide in uterine arteries from rats with type 2 diabetes: implications for vascular adaptations to pregnancy. Am J Physiol Heart Circ Physiol. 2014 Feb 15; 306(4):H610-8. PMID: 24337459.
      View in: PubMed
    75. Mohamed IN, Hafez SS, Fairaq A, Ergul A, Imig JD, El-Remessy AB. Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet. Diabetologia. 2014 Feb; 57(2):413-23. PMID: 24201577.
      View in: PubMed
    76. Ishrat T, Pillai B, Ergul A, Hafez S, Fagan SC. Candesartan reduces the hemorrhage associated with delayed tissue plasminogen activator treatment in rat embolic stroke. Neurochem Res. 2013 Dec; 38(12):2668-77. PMID: 24194350.
      View in: PubMed
    77. Li W, Qu Z, Prakash R, Chung C, Ma H, Hoda MN, Fagan SC, Ergul A. Comparative analysis of the neurovascular injury and functional outcomes in experimental stroke models in diabetic Goto-Kakizaki rats. Brain Res. 2013 Dec 06; 1541:106-14. PMID: 24144674.
      View in: PubMed
    78. Coucha M, Li W, Johnson MH, Fagan SC, Ergul A. Protein nitration impairs the myogenic tone of rat middle cerebral arteries in both ischemic and nonischemic hemispheres after ischemic stroke. Am J Physiol Heart Circ Physiol. 2013 Dec; 305(12):H1726-35. PMID: 24097431.
      View in: PubMed
    79. Lynch CM, Kinzenbaw DA, Chen X, Zhan S, Mezzetti E, Filosa J, Ergul A, Faulkner JL, Faraci FM, Didion SP. Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced obesity. Stroke. 2013 Nov; 44(11):3195-201. PMID: 24072007.
      View in: PubMed
    80. Prakash R, Li W, Qu Z, Johnson MA, Fagan SC, Ergul A. Vascularization pattern after ischemic stroke is different in control versus diabetic rats: relevance to stroke recovery. Stroke. 2013 Oct; 44(10):2875-82. PMID: 23920018.
      View in: PubMed
    81. Fagan SC, Lapchak PA, Liebeskind DS, Ishrat T, Ergul A. Recommendations for preclinical research in hemorrhagic transformation. Transl Stroke Res. 2013 Jun; 4(3):322-7. PMID: 23730351.
      View in: PubMed
    82. Lobato NS, Filgueira FP, Prakash R, Giachini FR, Ergul A, Carvalho MH, Webb RC, Tostes RC, Fortes ZB. Reduced endothelium-dependent relaxation to anandamide in mesenteric arteries from young obese Zucker rats. PLoS One. 2013; 8(5):e63449. PMID: 23667622.
      View in: PubMed
    83. Li W, Prakash R, Chawla D, Du W, Didion SP, Filosa JA, Zhang Q, Brann DW, Lima VV, Tostes RC, Ergul A. Early effects of high-fat diet on neurovascular function and focal ischemic brain injury. Am J Physiol Regul Integr Comp Physiol. 2013 Jun 01; 304(11):R1001-8. PMID: 23576615.
      View in: PubMed
    84. Hoda MN, Hess DC, Ergul A, Fagan SC. Response to letter regarding article, "Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type". Stroke. 2013 Apr; 44(4):e37. PMID: 23646369.
      View in: PubMed
    85. Prakash R, Johnson M, Fagan SC, Ergul A. Cerebral neovascularization and remodeling patterns in two different models of type 2 diabetes. PLoS One. 2013; 8(2):e56264. PMID: 23441170.
      View in: PubMed
    86. Kelly-Cobbs AI, Prakash R, Li W, Pillai B, Hafez S, Coucha M, Johnson MH, Ogbi SN, Fagan SC, Ergul A. Targets of vascular protection in acute ischemic stroke differ in type 2 diabetes. Am J Physiol Heart Circ Physiol. 2013 Mar 15; 304(6):H806-15. PMID: 23335797.
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    87. Puttabyatappa Y, Stallone JN, Ergul A, El-Remessy AB, Kumar S, Black S, Johnson M, Owen MP, White RE. Peroxynitrite mediates testosterone-induced vasodilation of microvascular resistance vessels. J Pharmacol Exp Ther. 2013 Apr; 345(1):7-14. PMID: 23318471.
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    88. Dennis BA, Ergul A, Gower BA, Allison JD, Davis CL. Oxidative stress and cardiovascular risk in overweight children in an exercise intervention program. Child Obes. 2013 Feb; 9(1):15-21. PMID: 23270535.
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    89. Alhusban A, Kozak A, Ergul A, Fagan SC. AT1 receptor antagonism is proangiogenic in the brain: BDNF a novel mediator. J Pharmacol Exp Ther. 2013 Feb; 344(2):348-59. PMID: 23211364.
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    90. Hoda MN, Siddiqui S, Herberg S, Periyasamy-Thandavan S, Bhatia K, Hafez SS, Johnson MH, Hill WD, Ergul A, Fagan SC, Hess DC. Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke. Stroke. 2012 Oct; 43(10):2794-9. PMID: 22910893.
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    91. Ergul A, Kelly-Cobbs A, Abdalla M, Fagan SC. Cerebrovascular complications of diabetes: focus on stroke. Endocr Metab Immune Disord Drug Targets. 2012 Jun; 12(2):148-58. PMID: 22236022.
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    92. Ergul A, Alhusban A, Fagan SC. Angiogenesis: a harmonized target for recovery after stroke. Stroke. 2012 Aug; 43(8):2270-4. PMID: 22618382.
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    93. Kelly-Cobbs AI, Prakash R, Coucha M, Knight RA, Li W, Ogbi SN, Johnson M, Ergul A. Cerebral myogenic reactivity and blood flow in type 2 diabetic rats: role of peroxynitrite in hypoxia-mediated loss of myogenic tone. J Pharmacol Exp Ther. 2012 Aug; 342(2):407-15. PMID: 22570365.
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    94. Switzer JA, Sikora A, Ergul A, Waller JL, Hess DC, Fagan SC. Minocycline prevents IL-6 increase after acute ischemic stroke. Transl Stroke Res. 2012 Sep; 3(3):363-8. PMID: 23105953.
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    95. Prakash R, Somanath PR, El-Remessy AB, Kelly-Cobbs A, Stern JE, Dore-Duffy P, Johnson M, Fagan SC, Ergul A. Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling. Diabetes. 2012 Jun; 61(6):1533-42. PMID: 22403298.
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    96. Coucha M, Li W, Ergul A. The effect of endothelin receptor A antagonism on basilar artery endothelium-dependent relaxation after ischemic stroke. Life Sci. 2012 Oct 15; 91(13-14):676-80. PMID: 22365958.
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    97. Hoda MN, Li W, Ahmad A, Ogbi S, Zemskova MA, Johnson MH, Ergul A, Hill WD, Hess DC, Sazonova IY. Sex-independent neuroprotection with minocycline after experimental thromboembolic stroke. Exp Transl Stroke Med. 2011 Dec 16; 3(1):16. PMID: 22177314.
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    98. Elgebaly MM, Ogbi S, Li W, Mezzetti EM, Prakash R, Johnson MH, Bruno A, Fagan SC, Ergul A. Neurovascular injury in acute hyperglycemia and diabetes: A comparative analysis in experimental stroke. Transl Stroke Res. 2011 Sep; 2(3):391-8. PMID: 21909340.
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    99. Guan W, Somanath PR, Kozak A, Goc A, El-Remessy AB, Ergul A, Johnson MH, Alhusban A, Soliman S, Fagan SC. Vascular protection by angiotensin receptor antagonism involves differential VEGF expression in both hemispheres after experimental stroke. PLoS One. 2011; 6(9):e24551. PMID: 21912702.
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    100. Switzer JA, Hess DC, Ergul A, Waller JL, Machado LS, Portik-Dobos V, Pettigrew LC, Clark WM, Fagan SC. Matrix metalloproteinase-9 in an exploratory trial of intravenous minocycline for acute ischemic stroke. Stroke. 2011 Sep; 42(9):2633-5. PMID: 21737808.
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    101. Allahdadi KJ, Hannan JL, Ergul A, Tostes RC, Webb RC. Internal pudendal artery from type 2 diabetic female rats demonstrate elevated endothelin-1-mediated constriction. J Sex Med. 2011 Sep; 8(9):2472-83. PMID: 21718448.
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    102. Li W, Sachidanandam K, Ergul A. Comparison of selective versus dual endothelin receptor antagonism on cerebrovascular dysfunction in diabetes. Neurol Res. 2011 Mar; 33(2):185-91. PMID: 21801593.
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    103. Rigsby CS, Ergul A, Portik Dobos V, Pollock DM, Dorrance AM. Effects of spironolactone on cerebral vessel structure in rats with sustained hypertension. Am J Hypertens. 2011 Jun; 24(6):708-15. PMID: 21350432.
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    104. Ergul A. Endothelin-1 and diabetic complications: focus on the vasculature. Pharmacol Res. 2011 Jun; 63(6):477-82. PMID: 21292003.
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    105. Kelly-Cobbs AI, Harris AK, Elgebaly MM, Li W, Sachidanandam K, Portik-Dobos V, Johnson M, Ergul A. Endothelial endothelin B receptor-mediated prevention of cerebrovascular remodeling is attenuated in diabetes because of up-regulation of smooth muscle endothelin receptors. J Pharmacol Exp Ther. 2011 Apr; 337(1):9-15. PMID: 21205912.
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    106. Carneiro FS, Giachini FR, Carneiro ZN, Lima VV, Ergul A, Webb RC, Tostes RC. Erectile dysfunction in young non-obese type II diabetic Goto-Kakizaki rats is associated with decreased eNOS phosphorylation at Ser1177. J Sex Med. 2010 Nov; 7(11):3620-34. PMID: 20807325.
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    107. Fagan SC, Waller JL, Nichols FT, Edwards DJ, Pettigrew LC, Clark WM, Hall CE, Switzer JA, Ergul A, Hess DC. Minocycline to improve neurologic outcome in stroke (MINOS): a dose-finding study. Stroke. 2010 Oct; 41(10):2283-7. PMID: 20705929.
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    108. Li W, Kelly-Cobbs AI, Mezzetti EM, Fagan SC, Ergul A. Endothelin-1-mediated cerebrovascular remodeling is not associated with increased ischemic brain injury in diabetes. Can J Physiol Pharmacol. 2010 Aug; 88(8):788-95. PMID: 20725136.
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    109. Elgebaly MM, Prakash R, Li W, Ogbi S, Johnson MH, Mezzetti EM, Fagan SC, Ergul A. Vascular protection in diabetic stroke: role of matrix metalloprotease-dependent vascular remodeling. J Cereb Blood Flow Metab. 2010 Dec; 30(12):1928-38. PMID: 20664613.
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    110. Sachidanandam K, Portik-Dobos V, Kelly-Cobbs AI, Ergul A. Dual endothelin receptor antagonism prevents remodeling of resistance arteries in diabetes. Can J Physiol Pharmacol. 2010 Jun; 88(6):616-21. PMID: 20628426.
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    111. Lima VV, Giachini FR, Carneiro FS, Carneiro ZN, Saleh MA, Pollock DM, Fortes ZB, Carvalho MH, Ergul A, Webb RC, Tostes RC. O-GlcNAcylation contributes to augmented vascular reactivity induced by endothelin 1. Hypertension. 2010 Jan; 55(1):180-8. PMID: 19948983.
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    112. Li W, Prakash R, Kelly-Cobbs AI, Ogbi S, Kozak A, El-Remessy AB, Schreihofer DA, Fagan SC, Ergul A. Adaptive cerebral neovascularization in a model of type 2 diabetes: relevance to focal cerebral ischemia. Diabetes. 2010 Jan; 59(1):228-35. PMID: 19808897.
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    113. Machado LS, Sazonova IY, Kozak A, Wiley DC, El-Remessy AB, Ergul A, Hess DC, Waller JL, Fagan SC. Minocycline and tissue-type plasminogen activator for stroke: assessment of interaction potential. Stroke. 2009 Sep; 40(9):3028-33. PMID: 19628804.
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    114. Elewa HF, Kozak A, El-Remessy AB, Frye RF, Johnson MH, Ergul A, Fagan SC. Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats. J Pharmacol Exp Ther. 2009 Aug; 330(2):532-40. PMID: 19478137.
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    115. Deutsch C, Portik-Dobos V, Smith AD, Ergul A, Dorrance AM. Diet-induced obesity causes cerebral vessel remodeling and increases the damage caused by ischemic stroke. Microvasc Res. 2009 Jun; 78(1):100-6. PMID: 19374911.
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    116. Kozak A, Ergul A, El-Remessy AB, Johnson MH, Machado LS, Elewa HF, Abdelsaid M, Wiley DC, Fagan SC. Candesartan augments ischemia-induced proangiogenic state and results in sustained improvement after stroke. Stroke. 2009 May; 40(5):1870-6. PMID: 19265050.
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    117. Ergul A, Li W, Elgebaly MM, Bruno A, Fagan SC. Hyperglycemia, diabetes and stroke: focus on the cerebrovasculature. Vascul Pharmacol. 2009 Jul; 51(1):44-9. PMID: 19258053.
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    118. Sachidanandam K, Hutchinson JR, Elgebaly MM, Mezzetti EM, Dorrance AM, Motamed K, Ergul A. Glycemic control prevents microvascular remodeling and increased tone in type 2 diabetes: link to endothelin-1. Am J Physiol Regul Integr Comp Physiol. 2009 Apr; 296(4):R952-9. PMID: 19176890.
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    119. Giachini FR, Zemse SM, Carneiro FS, Lima VV, Carneiro ZN, Callera GE, Ergul A, Webb RC, Tostes RC. Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway. Am J Physiol Heart Circ Physiol. 2009 Feb; 296(2):H489-96. PMID: 19074677.
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    120. Sachidanandam K, Hutchinson JR, Elgebaly MM, Mezzetti EM, Wang MH, Ergul A. Differential effects of diet-induced dyslipidemia and hyperglycemia on mesenteric resistance artery structure and function in type 2 diabetes. J Pharmacol Exp Ther. 2009 Jan; 328(1):123-30. PMID: 18941121.
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    121. Carneiro FS, Nunes KP, Giachini FR, Lima VV, Carneiro ZN, Nogueira EF, Leite R, Ergul A, Rainey WE, Clinton Webb R, Tostes RC. Activation of the ET-1/ETA pathway contributes to erectile dysfunction associated with mineralocorticoid hypertension. J Sex Med. 2008 Dec; 5(12):2793-807. PMID: 18823320.
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    122. Carneiro FS, Giachini FR, Lima VV, Carneiro ZN, Nunes KP, Ergul A, Leite R, Tostes RC, Webb RC. DOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosum. Can J Physiol Pharmacol. 2008 Jun; 86(6):320-8. PMID: 18516094.
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    123. Elgebaly MM, Kelly A, Harris AK, Elewa H, Portik-Dobos V, Ketsawatsomkron P, Marrero M, Ergul A. Impaired insulin-mediated vasorelaxation in a nonobese model of type 2 diabetes: role of endothelin-1. Can J Physiol Pharmacol. 2008 Jun; 86(6):358-64. PMID: 18516099.
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    124. Sachidanandam K, Elgebaly MM, Harris AK, Hutchinson JR, Mezzetti EM, Portik-Dobos V, Ergul A. Effect of chronic and selective endothelin receptor antagonism on microvascular function in type 2 diabetes. Am J Physiol Heart Circ Physiol. 2008 Jun; 294(6):H2743-9. PMID: 18424628.
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    125. Harris AK, Elgebaly MM, Li W, Sachidanandam K, Ergul A. Effect of chronic endothelin receptor antagonism on cerebrovascular function in type 2 diabetes. Am J Physiol Regul Integr Comp Physiol. 2008 Apr; 294(4):R1213-9. PMID: 18287215.
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    126. Ergul A, Elgebaly MM, Middlemore ML, Li W, Elewa H, Switzer JA, Hall C, Kozak A, Fagan SC. Increased hemorrhagic transformation and altered infarct size and localization after experimental stroke in a rat model type 2 diabetes. BMC Neurol. 2007 Oct 15; 7:33. PMID: 17937795.
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    127. Sachidanandam K, Portik-Dobos V, Harris AK, Hutchinson JR, Muller E, Johnson MH, Ergul A. Evidence for vasculoprotective effects of ETB receptors in resistance artery remodeling in diabetes. Diabetes. 2007 Nov; 56(11):2753-8. PMID: 17670915.
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    128. Elgebaly MM, Portik-Dobos V, Sachidanandam K, Rychly D, Malcom D, Johnson MH, Ergul A. Differential effects of ET(A) and ET(B) receptor antagonism on oxidative stress in type 2 diabetes. Vascul Pharmacol. 2007 Aug-Sep; 47(2-3):125-30. PMID: 17597010.
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    129. Elewa HF, Kozak A, Johnson MH, Ergul A, Fagan SC. Blood pressure lowering after experimental cerebral ischemia provides neurovascular protection. J Hypertens. 2007 Apr; 25(4):855-9. PMID: 17351379.
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    130. Ergul A, Jupin D, Johnson MH, Prisant LM. Elevated endothelin-1 levels are associated with decreased arterial elasticity in hypertensive patients. J Clin Hypertens (Greenwich). 2006 Aug; 8(8):549-54. PMID: 16896270.
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    131. Machado LS, Kozak A, Ergul A, Hess DC, Borlongan CV, Fagan SC. Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke. BMC Neurosci. 2006 Jul 17; 7:56. PMID: 16846501.
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    132. Jafri F, Ergul A. Phosphorylation of endothelin converting enzyme-1 isoforms: relevance to subcellular localization. Exp Biol Med (Maywood). 2006 Jun; 231(6):713-7. PMID: 16740986.
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    133. Sachidanandam K, Harris A, Hutchinson J, Ergul A. Microvascular versus macrovascular dysfunction in type 2 diabetes: differences in contractile responses to endothelin-1. Exp Biol Med (Maywood). 2006 Jun; 231(6):1016-21. PMID: 16741041.
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    134. Fagan SC, Kozak A, Hill WD, Pollock DM, Xu L, Johnson MH, Ergul A, Hess DC. Hypertension after experimental cerebral ischemia: candesartan provides neurovascular protection. J Hypertens. 2006 Mar; 24(3):535-9. PMID: 16467657.
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    135. Song W, Ergul A. Type-2 diabetes-induced changes in vascular extracellular matrix gene expression: relation to vessel size. Cardiovasc Diabetol. 2006 Feb 17; 5:3. PMID: 16503991.
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    136. Portik-Dobos V, Harris AK, Song W, Hutchinson J, Johnson MH, Imig JD, Pollock DM, Ergul A. Endothelin antagonism prevents early EGFR transactivation but not increased matrix metalloproteinase activity in diabetes. Am J Physiol Regul Integr Comp Physiol. 2006 Feb; 290(2):R435-41. PMID: 16239374.
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    137. Harris AK, Hutchinson JR, Sachidanandam K, Johnson MH, Dorrance AM, Stepp DW, Fagan SC, Ergul A. Type 2 diabetes causes remodeling of cerebrovasculature via differential regulation of matrix metalloproteinases and collagen synthesis: role of endothelin-1. Diabetes. 2005 Sep; 54(9):2638-44. PMID: 16123352.
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    138. Harris AK, Ergul A, Kozak A, Machado LS, Johnson MH, Fagan SC. Effect of neutrophil depletion on gelatinase expression, edema formation and hemorrhagic transformation after focal ischemic stroke. BMC Neurosci. 2005 Aug 03; 6:49. PMID: 16078993.
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    139. Johansen JS, Harris AK, Rychly DJ, Ergul A. Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc Diabetol. 2005 Apr 29; 4:5. PMID: 15862133.
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    140. Fagan SC, Hess DC, Machado LS, Hohnadel EJ, Pollock DM, Ergul A. Tactics for vascular protection after acute ischemic stroke. Pharmacotherapy. 2005 Mar; 25(3):387-95. PMID: 15843286.
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    141. Sachidanandam K, Fagan SC, Ergul A. Oxidative stress and cardiovascular disease: antioxidants and unresolved issues. Cardiovasc Drug Rev. 2005; 23(2):115-32. PMID: 16007229.
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    142. Ergul A, Johansen JS, Strømhaug C, Harris AK, Hutchinson J, Tawfik A, Rahimi A, Rhim E, Wells B, Caldwell RW, Anstadt MP. Vascular dysfunction of venous bypass conduits is mediated by reactive oxygen species in diabetes: role of endothelin-1. J Pharmacol Exp Ther. 2005 Apr; 313(1):70-7. PMID: 15608082.
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    143. Ergul A, Portik-Dobos V, Hutchinson J, Franco J, Anstadt MP. Downregulation of vascular matrix metalloproteinase inducer and activator proteins in hypertensive patients. Am J Hypertens. 2004 Sep; 17(9):775-82. PMID: 15363819.
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    144. Fagan SC, Hess DC, Hohnadel EJ, Pollock DM, Ergul A. Targets for vascular protection after acute ischemic stroke. Stroke. 2004 Sep; 35(9):2220-5. PMID: 15284446.
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    145. Ergul S, Brunson CY, Hutchinson J, Tawfik A, Kutlar A, Webb RC, Ergul A. Vasoactive factors in sickle cell disease: in vitro evidence for endothelin-1-mediated vasoconstriction. Am J Hematol. 2004 Jul; 76(3):245-51. PMID: 15224360.
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    146. Anstadt MP, Franga DL, Portik-Dobos V, Pennathur A, Bannan M, Mawulawde K, Ergul A. Native matrix metalloproteinase characteristics may influence early stenosis of venous versus arterial coronary artery bypass grafting conduits. Chest. 2004 May; 125(5):1853-8. PMID: 15136400.
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    147. Mitchell BM, Dorrance AM, Ergul A, Webb RC. Sepiapterin decreases vasorelaxation in nitric oxide synthase inhibition-induced hypertension. J Cardiovasc Pharmacol. 2004 Jan; 43(1):93-8. PMID: 14668573.
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    148. Mehta SH, Webb RC, Ergul A, Tawfik A, Dorrance AM, Tawak A. Neuroprotection by tempol in a model of iron-induced oxidative stress in acute ischemic stroke. Am J Physiol Regul Integr Comp Physiol. 2004 Feb; 286(2):R283-8. PMID: 14592931.
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    149. Jafri F, Ergul A. Nuclear localization of endothelin-converting enzyme-1: subisoform specificity. Arterioscler Thromb Vasc Biol. 2003 Dec; 23(12):2192-6. PMID: 14551152.
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    150. Ergul A, Portik-Dobos V, Giulumian AD, Molero MM, Fuchs LC. Stress upregulates arterial matrix metalloproteinase expression and activity via endothelin A receptor activation. Am J Physiol Heart Circ Physiol. 2003 Nov; 285(5):H2225-32. PMID: 12842810.
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    151. Portik-Dobos V, Anstadt MP, Hutchinson J, Bannan M, Ergul A. Evidence for a matrix metalloproteinase induction/activation system in arterial vasculature and decreased synthesis and activity in diabetes. Diabetes. 2002 Oct; 51(10):3063-8. PMID: 12351448.
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    152. Grubbs AL, Anstadt MP, Ergul A. Saphenous vein endothelin system expression and activity in African American patients. Arterioscler Thromb Vasc Biol. 2002 Jul 01; 22(7):1122-7. PMID: 12117726.
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    153. Anstadt MP, Hutchinson J, Portik-Dobos V, Jafri F, Bannan M, Mawulawde K, Ergul A. Vascular endothelin converting enzyme-1 expression and activity is upregulated in clinical diabetes. Ethn Dis. 2002; 12(4):S3-5-9. PMID: 12477147.
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    154. Brothers TE, Grubbs AL, Zhang Y, Ergul A. Selective downregulation of endothelin-B receptors in diabetic African-American patients. Ethn Dis. 2002; 12(1):S1-46-50. PMID: 11913620.
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    155. Ergul A. Endothelin-1 and endothelin receptor antagonists as potential cardiovascular therapeutic agents. Pharmacotherapy. 2002 Jan; 22(1):54-65. PMID: 11794430.
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    156. Mondy JS, Anstadt MP, Franga DL, Portik-Dobos V, Hutchinson J, Ergul A. Decreased vascular matrix metalloproteinase abundance in diabetic patients with symptomatic macroangiopathy. Ethn Dis. 2002; 12(4):S3-18-22. PMID: 12477149.
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    157. Ergul A, Joffs C, Walker AC, Spinale FG. Potential role of endothelin receptor antagonists in the setting of cardiopulmonary bypass: relevance to myocardial performance. Heart Fail Rev. 2001 Dec; 6(4):287-94. PMID: 11447303.
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    158. Walker CA, Ergul A, Grubbs A, Zile MR, Zellner JL, Crumbley AJ, Spinale FG. beta-Adrenergic and endothelin receptor interaction in dilated human cardiomyopathic myocardium. J Card Fail. 2001 Jun; 7(2):129-37. PMID: 11420764.
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    159. Grubbs AL, Ergul A. A review of endothelin and hypertension in African-American individuals. Ethn Dis. 2001; 11(4):741-8. PMID: 11763297.
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    160. Ergul A, Grubbs AL, Zhang Y, Spinale FG. Selective upregulation of endothelin converting enzyme-1a in the human failing heart. J Card Fail. 2000 Dec; 6(4):314-20. PMID: 11145756.
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    161. Walker CA, Baicu SC, Goldberg AT, Widener CE, Fary DJ, Almany DK, Ergul A, Crawford FA, Spinale FG. Temporal endothelin dynamics of the myocardial interstitium and systemic circulation in cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2000 Nov; 120(5):864-71. PMID: 11044311.
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    162. Ergul A. Hypertension in black patients: an emerging role of the endothelin system in salt-sensitive hypertension. Hypertension. 2000 Jul; 36(1):62-7. PMID: 10904013.
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    163. Ergul A, Walker CA, Goldberg A, Baicu SC, Hendrick JW, King MK, Spinale FG. ET-1 in the myocardial interstitium: relation to myocyte ECE activity and expression. Am J Physiol Heart Circ Physiol. 2000 Jun; 278(6):H2050-6. PMID: 10843904.
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