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Adam J. Smolka

Title
InstitutionMedical University of South Carolina
DepartmentMedicine
AddressP.O. Box MSC 637
912
96 Jonathan Lucas St.
Phone843-792-3527
Fax843-792-2358
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    Dr. Smolka is Professor of Medicine in the Division of Gastroenterology and Hepatology at the Medical University of South Carolina. He earned his PhD in Physiology and Biophysics in 1982 at the University of Alabama, Birmingham. Following postdoctoral studies at the University of California, Los Angeles, he was appointed Assistant Professor in the Department of Medicine at UCLA in 1984. Dr. Smolka was appointed Associate Professor in the Department of Anatomy and Cell Biology at MUSC in 1992, and tenured full Professor in the Department of Medicine at MUSC in 1998.

    Dr. Smolka is Course Director of the First Year Curriculum in the MUSC College of Graduate Studies and chair of the College Curriculum Committee. He is a member and fellow
    of the American Gastroenterological Association, American Physiological Association, American Association for the Advancement of Science, American Society for Cell Biology, and the Parietal Cell Club. Additionally, he is a member of Hollings Cancer Center at MUSC, and a past Universities Space Research Association Scholar and member of the NASA Biotechnology Fundamentals Study Section.

    Dr. Smolka’s current research interests include pathophysiology of Helicobacter pylori infection of the gastric mucosa, molecular structure-function relationships in the gastric proton pump, and proteomic analysis of esophageal cancers. Previous research at NASA Marshall Space Flight Center, Huntsville, Alabama, focused on bioseparations technology, including microgravity cell electrophoresis (a sample of his blood was processed in earth orbit on Skylab II), and modification of cell electrophoretic mobility using synthetic polymeric microspheres. Dr. Smolka has published extensively (60 papers, 15 book chapters, and 70 abstracts), and since 1984 has been Principal Investigator on five major National Institutes of Health grant awards, and one NASA award.
    Collapse keywords
    Pathophysiology of Helicobacter pylori, Biochemistry and cell biology of gastric acid secretion, Pharmacological inhibition of acid secretion

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yao X, Smolka AJ. Gastric Parietal Cell Physiology and Helicobacter pylori-Induced Disease. Gastroenterology. 2019 06; 156(8):2158-2173. PMID: 30831083.
      View in: PubMed
    2. Smolka AJ, Schubert ML. Helicobacter pylori-Induced Changes in Gastric Acid Secretion and Upper Gastrointestinal Disease. Curr Top Microbiol Immunol. 2017; 400:227-252. PMID: 28124156.
      View in: PubMed
    3. Gonçalves O, Castro LF, Smolka AJ, Fontainhas A, Wilson JM. The Gastric Phenotype in the Cypriniform Loaches: A Case of Reinvention? PLoS One. 2016; 11(10):e0163696. PMID: 27783698.
      View in: PubMed
    4. Mak MA, Smolka A, Kowalski J, Kuc A, Klausa F, Kremens K, Jarek D, Bachowski R, Skiba J. Can cardiopulmonary bypass system with blood priming become a new standard in coronary surgery? Kardiol Pol. 2016; 74(8):726-732. PMID: 26898969.
      View in: PubMed
    5. Hammond CE, Beeson C, Suarez G, Peek RM, Backert S, Smolka AJ. Helicobacter pylori virulence factors affecting gastric proton pump expression and acid secretion. Am J Physiol Gastrointest Liver Physiol. 2015 Aug 01; 309(3):G193-201. PMID: 26045613.
      View in: PubMed
    6. Smolka AJ, Halushka PV, Garrett-Mayer E. The faculty costs to educate a biomedical sciences graduate student. CBE Life Sci Educ. 2015 Mar 02; 14(1):ar3. PMID: 25673355.
      View in: PubMed
    7. Schwacke J, Millar TP, Hammond CE, Saha A, Hoffman BJ, Romagnuolo J, Hill EG, Smolka AJ. Discrimination of normal and esophageal cancer plasma proteomes by MALDI-TOF mass spectrometry. Dig Dis Sci. 2015 Jun; 60(6):1645-54. PMID: 25577268.
      View in: PubMed
    8. Zhang YM, Noto JM, Hammond CE, Barth JL, Argraves WS, Backert S, Peek RM, Smolka AJ. Helicobacter pylori-induced posttranscriptional regulation of H-K-ATPase a-subunit gene expression by miRNA. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 01; 306(7):G606-13. PMID: 24503769.
      View in: PubMed
    9. Nguyen N, Kozer-Gorevich N, Gliddon BL, Smolka AJ, Clayton AH, Gleeson PA, van Driel IR. Independent trafficking of the KCNQ1 K+ channel and H+-K+-ATPase in gastric parietal cells from mice. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15; 304(2):G157-66. PMID: 23154976.
      View in: PubMed
    10. Smolka AJ, Backert S. How Helicobacter pylori infection controls gastric acid secretion. J Gastroenterol. 2012 Jun; 47(6):609-18. PMID: 22565637.
      View in: PubMed
    11. Mueller D, Tegtmeyer N, Brandt S, Yamaoka Y, De Poire E, Sgouras D, Wessler S, Torres J, Smolka A, Backert S. c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains. J Clin Invest. 2012 Apr; 122(4):1553-66. PMID: 22378042.
      View in: PubMed
    12. Song P, Groos S, Riederer B, Feng Z, Krabbenhöft A, Manns MP, Smolka A, Hagen SJ, Neusch C, Seidler U. Kir4.1 channel expression is essential for parietal cell control of acid secretion. J Biol Chem. 2011 Apr 22; 286(16):14120-8. PMID: 21367857.
      View in: PubMed
    13. Saha A, Hammond CE, Beeson C, Peek RM, Smolka AJ. Helicobacter pylori represses proton pump expression and inhibits acid secretion in human gastric mucosa. Gut. 2010 Jul; 59(7):874-81. PMID: 20581234.
      View in: PubMed
    14. Tegtmeyer N, Hartig R, Delahay RM, Rohde M, Brandt S, Conradi J, Takahashi S, Smolka AJ, Sewald N, Backert S. A small fibronectin-mimicking protein from bacteria induces cell spreading and focal adhesion formation. J Biol Chem. 2010 Jul 23; 285(30):23515-26. PMID: 20507990.
      View in: PubMed
    15. Saha A, Backert S, Hammond CE, Gooz M, Smolka AJ. Helicobacter pylori CagL activates ADAM17 to induce repression of the gastric H, K-ATPase alpha subunit. Gastroenterology. 2010 Jul; 139(1):239-48. PMID: 20303353.
      View in: PubMed
    16. Song P, Groos S, Riederer B, Feng Z, Krabbenhöft A, Smolka A, Seidler U. KCNQ1 is the luminal K+ recycling channel during stimulation of gastric acid secretion. J Physiol. 2009 Aug 01; 587(Pt 15):3955-65. PMID: 19491250.
      View in: PubMed
    17. Saha A, Hammond CE, Gooz M, Smolka AJ. The role of Sp1 in IL-1beta and H. pylori-mediated regulation of H,K-ATPase gene transcription. Am J Physiol Gastrointest Liver Physiol. 2008 Nov; 295(5):G977-86. PMID: 18772363.
      View in: PubMed
    18. Saha A, Hammond CE, Trojanowska M, Smolka AJ. Helicobacter pylori-induced H,K-ATPase alpha-subunit gene repression is mediated by NF-kappaB p50 homodimer promoter binding. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G795-807. PMID: 18202112.
      View in: PubMed
    19. Lapierre LA, Avant KM, Caldwell CM, Ham AJ, Hill S, Williams JA, Smolka AJ, Goldenring JR. Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. Am J Physiol Gastrointest Liver Physiol. 2007 May; 292(5):G1249-62. PMID: 17255364.
      View in: PubMed
    20. Saha A, Hammond CE, Gooz M, Smolka AJ. IL-1beta modulation of H,K-ATPase alpha-subunit gene transcription in Helicobacter pylori infection. Am J Physiol Gastrointest Liver Physiol. 2007 Apr; 292(4):G1055-61. PMID: 17204545.
      View in: PubMed
    21. Karpievitch YV, Hill EG, Smolka AJ, Morris JS, Coombes KR, Baggerly KA, Almeida JS. PrepMS: TOF MS data graphical preprocessing tool. Bioinformatics. 2007 Jan 15; 23(2):264-5. PMID: 17121773.
      View in: PubMed
    22. Göõz M, Tóth M, Vakkuri O, Göõz P, Smolka AJ, de Châtel R, Szalay KS. Endogenous ouabain-like factor (OLF) secretion is modulated by nicotinic mechanisms in rat adrenocortical cells. Life Sci. 2004 Mar 12; 74(17):2111-28. PMID: 14969716.
      View in: PubMed
    23. Smolka AJ, Goldenring JR, Gupta S, Hammond CE. Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000. BMC Gastroenterol. 2004 Feb 10; 4:4. PMID: 15028114.
      View in: PubMed
    24. Gööz M, Shaker M, Gööz P, Smolka AJ. Interleukin 1beta induces gastric epithelial cell matrix metalloproteinase secretion and activation during Helicobacter pylori infection. Gut. 2003 Sep; 52(9):1250-6. PMID: 12912854.
      View in: PubMed
    25. Yang GY, Liao J, Cassai ND, Smolka AJ, Sidhu GS. Parietal cell carcinoma of gastric cardia: immunophenotype and ultrastructure. Ultrastruct Pathol. 2003 Mar-Apr; 27(2):87-94. PMID: 12746199.
      View in: PubMed
    26. Göõz M, Göõz P, Smolka AJ. Epithelial and bacterial metalloproteinases and their inhibitors in H. pylori infection of human gastric cells. Am J Physiol Gastrointest Liver Physiol. 2001 Sep; 281(3):G823-32. PMID: 11518695.
      View in: PubMed
    27. Smolka AJ, Larsen KA, Hammond CE. Location of a cytoplasmic epitope for monoclonal antibody HK 12.18 on H,K-ATPase alpha subunit. Biochem Biophys Res Commun. 2000 Jul 14; 273(3):942-7. PMID: 10891352.
      View in: PubMed
    28. Göõz M, Hammond CE, Larsen K, Mukhin YV, Smolka AJ. Inhibition of human gastric H(+)-K(+)-ATPase alpha-subunit gene expression by Helicobacter pylori. Am J Physiol Gastrointest Liver Physiol. 2000 Jun; 278(6):G981-91. PMID: 10859229.
      View in: PubMed
    29. Smolka AJ, Larsen KA, Schweinfest CW, Hammond CE. H,K-ATPase alpha subunit C-terminal membrane topology: epitope tags in the insect cell expression system. Biochem J. 1999 Jun 15; 340 ( Pt 3):601-11. PMID: 10359643.
      View in: PubMed
    30. Kraut JA, Hiura J, Shin JM, Smolka A, Sachs G, Scott D. The Na(+)-K(+)-ATPase beta 1 subunit is associated with the HK alpha 2 protein in the rat kidney. Kidney Int. 1998 Apr; 53(4):958-62. PMID: 9551404.
      View in: PubMed
    31. Kraut JA, Hiura J, Besancon M, Smolka A, Sachs G, Scott D. Effect of hypokalemia on the abundance of HK alpha 1 and HK alpha 2 protein in the rat kidney. Am J Physiol. 1997 Jun; 272(6 Pt 2):F744-50. PMID: 9227635.
      View in: PubMed
    32. Harris AW, Walker MM, Smolka A, Waller JM, Baron JH, Misiewicz JJ. Parietal cells in the duodenal bulb and their relation to Helicobacter pylori infection. J Clin Pathol. 1996 Apr; 49(4):309-12. PMID: 8655707.
      View in: PubMed
    33. Lacy ER, Cowart KS, King JS, DelValle J, Smolka AJ. Epithelial response of the rat gastric mucosa to chronic superficial injury. Yale J Biol Med. 1996 Mar-Apr; 69(2):105-18. PMID: 9112742.
      View in: PubMed
    34. Walker MM, Smolka A, Waller JM, Evans DJ. Identification of parietal cells in gastric body mucosa with HMFG-2 monoclonal antibody. J Clin Pathol. 1995 Sep; 48(9):832-4. PMID: 7490316.
      View in: PubMed
    35. Wingo CS, Smolka AJ. Function and structure of H-K-ATPase in the kidney. Am J Physiol. 1995 Jul; 269(1 Pt 2):F1-16. PMID: 7631822.
      View in: PubMed
    36. Tyagarajan K, Chow DC, Smolka A, Forte JG. Structural interactions between alpha- and beta-subunits of the gastric H,K-ATPase. Biochim Biophys Acta. 1995 May 24; 1236(1):105-13. PMID: 7794938.
      View in: PubMed
    37. Callaghan JM, Tan SS, Khan MA, Curran KA, Campbell WG, Smolka AJ, Toh BH, Gleeson PA, Wingo CS, Cain BD, et al. Renal expression of the gene encoding the gastric H(+)-K(+)-ATPase beta-subunit. Am J Physiol. 1995 Mar; 268(3 Pt 2):F363-74. PMID: 7900835.
      View in: PubMed
    38. Swenson ER, Fine AD, Maren TH, Reale E, Lacy ER, Smolka AJ. Physiological and immunocytochemical evidence for a putative H-K-ATPase in elasmobranch renal acid secretion. Am J Physiol. 1994 Oct; 267(4 Pt 2):F639-45. PMID: 7943360.
      View in: PubMed
    39. Smolka AJ, Lacy ER, Luciano L, Reale E. Identification of gastric H,K-ATPase in an early vertebrate, the Atlantic stingray Dasyatis sabina. J Histochem Cytochem. 1994 Oct; 42(10):1323-32. PMID: 7930514.
      View in: PubMed
    40. Soroka CJ, Chew CS, Hanzel DK, Smolka A, Modlin IM, Goldenring JR. Characterization of membrane and cytoskeletal compartments in cultured parietal cells: immunofluorescence and confocal microscopic examination. Eur J Cell Biol. 1993 Feb; 60(1):76-87. PMID: 8385019.
      View in: PubMed
    41. Burman P, Kämpe O, Kraaz W, Lööf L, Smolka A, Karlsson A, Karlsson-Parra A. A study of autoimmune gastritis in the postpartum period and at a 5-year follow-up. Gastroenterology. 1992 Sep; 103(3):934-42. PMID: 1323500.
      View in: PubMed
    42. Smolka A, Swiger KM. Site-directed antibodies as topographical probes of the gastric H,K-ATPase alpha-subunit. Biochim Biophys Acta. 1992 Jul 08; 1108(1):75-85. PMID: 1643082.
      View in: PubMed
    43. Smolka A, Alverson L, Fritz R, Swiger K, Swiger R. Gastric H,K-ATPase topography: amino acids 888-907 are cytoplasmic. Biochem Biophys Res Commun. 1991 Nov 14; 180(3):1356-64. PMID: 1659414.
      View in: PubMed
    44. Wingo CS, Madsen KM, Smolka A, Tisher CC. H-K-ATPase immunoreactivity in cortical and outer medullary collecting duct. Kidney Int. 1990 Nov; 38(5):985-90. PMID: 2176257.
      View in: PubMed
    45. Okamoto CT, Karpilow JM, Smolka A, Forte JG. Isolation and characterization of gastric microsomal glycoproteins. Evidence for a glycosylated beta-subunit of the H+/K(+)-ATPase. Biochim Biophys Acta. 1990 Mar 01; 1037(3):360-72. PMID: 1690026.
      View in: PubMed
    46. Smolka A, Donaldson RM. Monoclonal antibodies to human intrinsic factor. Gastroenterology. 1990 Mar; 98(3):607-14. PMID: 2298366.
      View in: PubMed
    47. Smolka A, Sachs G, Lorentzon P. Cell-free synthesis of rat and rabbit gastric proton pump. Gastroenterology. 1989 Oct; 97(4):873-81. PMID: 2550309.
      View in: PubMed
    48. Thomas HA, Machen TE, Smolka A, Baron R, Kopito RR. Identification of a 185-kDa band 3-related polypeptide in oxyntic cells. Am J Physiol. 1989 Sep; 257(3 Pt 1):C537-44. PMID: 2551174.
      View in: PubMed
    49. Helander HF, Anderson D, Helander KG, Smolka A, Sachs G. Immunocytochemical studies of gastric H+,K+-ATPase in the developing rat. Scand J Gastroenterol. 1989 Sep; 24(7):863-9. PMID: 2529628.
      View in: PubMed
    50. Hanzel DK, Urushidani T, Usinger WR, Smolka A, Forte JG. Immunological localization of an 80-kDa phosphoprotein to the apical membrane of gastric parietal cells. Am J Physiol. 1989 Jun; 256(6 Pt 1):G1082-9. PMID: 2472073.
      View in: PubMed
    51. Chew CS, Ljungström M, Smolka A, Brown MR. Primary culture of secretagogue-responsive parietal cells from rabbit gastric mucosa. Am J Physiol. 1989 Jan; 256(1 Pt 1):G254-63. PMID: 2536239.
      View in: PubMed
    52. Fain GL, Smolka A, Cilluffo MC, Fain MJ, Lee DA, Brecha NC, Sachs G. Monoclonal antibodies to the H+-K+ ATPase of gastric mucosa selectively stain the non-pigmented cells of the rabbit ciliary body epithelium. Invest Ophthalmol Vis Sci. 1988 May; 29(5):785-94. PMID: 2452803.
      View in: PubMed
    53. Smolka A, Weinstein WM. Immunoassay of pig and human gastric proton pump. Gastroenterology. 1986 Mar; 90(3):532-9. PMID: 2417911.
      View in: PubMed
    54. Peerce BE, Smolka A, Sachs G. Isolation of pepsinogen granules from rabbit gastric mucosa. J Biol Chem. 1984 Jul 25; 259(14):9255-62. PMID: 6235223.
      View in: PubMed
    55. Smolka A, Helander HF, Sachs G. Monoclonal antibodies against gastric H+ + K+ ATPase. Am J Physiol. 1983 Oct; 245(4):G589-96. PMID: 6312812.
      View in: PubMed
    56. Rabon E, Cuppoletti J, Malinowska D, Smolka A, Helander HF, Mendlein J, Sachs G. Proton secretion by the gastric parietal cell. J Exp Biol. 1983 Sep; 106:119-33. PMID: 6317787.
      View in: PubMed
    57. Faller L, Jackson R, Malinowska D, Mukidjam E, Rabon E, Saccomani G, Sachs G, Smolka A. Mechanistic aspects of gastric (H+ + K+)-ATPase. Ann N Y Acad Sci. 1982; 402:146-63. PMID: 6301328.
      View in: PubMed
    58. Faller LD, Malinowska DH, Rabon E, Smolka A, Sachs G. Mechanistic studies of the gastric (H+ + K)-ATPase. Prog Clin Biol Res. 1981; 73:153-74. PMID: 6275397.
      View in: PubMed
    59. Smolka AJ, Margel S, Nerren BH, Rembaum A. Electrophoretic cell separation by means of microspheres. Biochim Biophys Acta. 1979 Dec 03; 588(2):246-55. PMID: 116687.
      View in: PubMed
    60. Kopwillem A, Merriman WG, Cuddeback RM, Smolka AJ, Bier M. Serum protein fractionation by isotachophoresis using amino acid spacers. J Chromatogr. 1976 Mar 03; 118(1):34-46. PMID: 1249172.
      View in: PubMed
    61. Smolka AJ, Logan EF. Recovery of immunoglobulin G from Cohn fraction II + 3 by forced flow electrophoresis. Prep Biochem. 1972; 2(4):329-45. PMID: 4117266.
      View in: PubMed
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